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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nkx2-5

Z-value: 0.70

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Transcription factors associated with Nkx2-5

Gene Symbol Gene ID Gene Info
Nkx2-5
ENSRNOG00000020747 NK2 homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-5rn6_v1_chr10_+_16635989_166359890.561.7e-27Click!

Activity profile of Nkx2-5 motif

Sorted Z-values of Nkx2-5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_164808323 41.95 ENSRNOT00000011005
Nppa
natriuretic peptide A
chr16_+_18716019 41.27 ENSRNOT00000047870
Sftpa1
surfactant protein A1
chr4_+_100166863 32.75 ENSRNOT00000014505
Sftpb
surfactant protein B
chr7_+_60099120 31.81 ENSRNOT00000007338
LOC100911101
leucine-rich repeat-containing protein 10-like
chr7_+_60087429 27.85 ENSRNOT00000073117
Lrrc10
leucine-rich repeat-containing 10
chr15_-_14510828 11.75 ENSRNOT00000039347
Sntn
sentan, cilia apical structure protein
chr1_+_177569618 11.36 ENSRNOT00000090042
Tead1
TEA domain transcription factor 1
chr13_-_82005741 10.86 ENSRNOT00000076404
Mettl11b
methyltransferase like 11B
chr10_+_40247436 10.00 ENSRNOT00000079830
Gpx3
glutathione peroxidase 3
chr10_-_43512287 9.11 ENSRNOT00000036481
Faxdc2
fatty acid hydroxylase domain containing 2
chr18_+_56071478 8.32 ENSRNOT00000025344
ENSRNOT00000025354
Cd74
CD74 molecule
chr16_-_64806050 6.87 ENSRNOT00000015725
Dusp26
dual specificity phosphatase 26
chr7_-_23594133 6.83 ENSRNOT00000005746
Timp3
TIMP metallopeptidase inhibitor 3
chrX_+_37329779 6.00 ENSRNOT00000038352
ENSRNOT00000088802
Pdha1
pyruvate dehydrogenase (lipoamide) alpha 1
chr17_-_55709740 5.89 ENSRNOT00000033359
RGD1562037
similar to OTTHUMP00000046255
chr10_-_44147035 5.82 ENSRNOT00000041113
Olr1424
olfactory receptor 1424
chr15_+_23777856 5.62 ENSRNOT00000060847
Samd4a
sterile alpha motif domain containing 4A
chr7_-_114690642 5.56 ENSRNOT00000078097
AABR07058406.1

chr7_-_119797098 4.98 ENSRNOT00000009994
Rac2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr13_-_107886476 4.97 ENSRNOT00000077282
Kcnk2
potassium two pore domain channel subfamily K member 2
chr14_-_114047527 4.72 ENSRNOT00000083199
AABR07016779.1

chr10_+_49472460 4.66 ENSRNOT00000038276
Tekt3
tektin 3
chr1_-_141470380 4.66 ENSRNOT00000065759
Plin1
perilipin 1
chr14_-_34561696 4.44 ENSRNOT00000059763
Srd5a3
steroid 5 alpha-reductase 3
chr2_-_198458041 3.98 ENSRNOT00000082450
Fcgr1a
Fc fragment of IgG receptor Ia
chr2_-_185444897 3.65 ENSRNOT00000016329
Rps3a
ribosomal protein S3a
chr10_+_104523996 3.32 ENSRNOT00000065339
ENSRNOT00000086747
Itgb4
integrin subunit beta 4
chr1_+_197813963 3.22 ENSRNOT00000045531
LOC100361060
ribosomal protein L36-like
chr12_-_19159901 2.90 ENSRNOT00000045401
Rpl31l4
ribosomal protein L31-like 4
chr5_-_154438361 2.87 ENSRNOT00000085003
AC141344.2

chr8_-_43480777 2.83 ENSRNOT00000060074
LOC688473
similar to 40S ribosomal protein S2
chr16_+_49185560 2.81 ENSRNOT00000014360
Helt
helt bHLH transcription factor
chr10_+_14828597 2.63 ENSRNOT00000025434
Tekt4
tektin 4
chr6_+_28515025 2.33 ENSRNOT00000088033
ENSRNOT00000005317
ENSRNOT00000081141
Dnajc27
DnaJ heat shock protein family (Hsp40) member C27
chr14_-_85088523 2.33 ENSRNOT00000010690
Nf2
neurofibromin 2
chr2_-_23260965 2.24 ENSRNOT00000046772
LOC103691423
60S ribosomal protein L36 pseudogene
chr12_-_13462038 2.21 ENSRNOT00000043110
LOC100360439
ribosomal protein L36-like
chr5_-_78393143 2.10 ENSRNOT00000043610
LOC100910017
60S ribosomal protein L31-like
chr20_-_4390436 1.99 ENSRNOT00000000497
ENSRNOT00000077655
Ppt2
palmitoyl-protein thioesterase 2
chr1_-_89258935 1.98 ENSRNOT00000003180
LOC100361079
ribosomal protein L36-like
chr3_+_20965751 1.93 ENSRNOT00000010450
Olr417
olfactory receptor 417
chr17_+_36956385 1.92 ENSRNOT00000024854
Cdkal1
CDK5 regulatory subunit associated protein 1-like 1
chr5_-_83648044 1.88 ENSRNOT00000046725
RGD1561195
similar to ribosomal protein L31
chr14_+_82769642 1.87 ENSRNOT00000065393
Ctbp1
C-terminal binding protein 1
chr9_-_60923706 1.78 ENSRNOT00000047517
AABR07067749.1

chr4_+_121760773 1.75 ENSRNOT00000087069
Vom1r92
vomeronasal 1 receptor 92
chr3_-_102589260 1.74 ENSRNOT00000091642
AC121203.1

chr10_-_44157330 1.60 ENSRNOT00000047242
Olr1425
olfactory receptor 1425
chr7_-_143473697 1.60 ENSRNOT00000055336
ENSRNOT00000083027
Krt77
keratin 77
chr11_-_61530567 1.53 ENSRNOT00000076277
Naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr3_+_33440191 1.51 ENSRNOT00000034632
ENSRNOT00000092907
Mbd5
methyl-CpG binding domain protein 5
chr1_+_86362432 1.45 ENSRNOT00000052300
Vom1r2
vomeronasal 1 receptor 2
chr9_+_44567206 1.41 ENSRNOT00000088544
NEWGENE_1308196
mitochondrial ribosomal protein L30
chr5_-_155709215 1.29 ENSRNOT00000018118
Cdc42
cell division cycle 42
chr4_+_121912352 1.26 ENSRNOT00000086882
Vom1r98
vomeronasal 1 receptor 98
chr10_+_53595854 1.22 ENSRNOT00000044116
Sco1
SCO1 cytochrome c oxidase assembly protein
chr3_+_102841615 1.21 ENSRNOT00000075178
Olr770
olfactory receptor 770
chr17_-_36438752 1.18 ENSRNOT00000048997
RGD1561310
similar to ribosomal protein L37
chr10_-_44095775 1.14 ENSRNOT00000047892
Olr1422
olfactory receptor 1422
chr1_-_230649938 1.12 ENSRNOT00000017615
Olr377
olfactory receptor 377
chr20_-_4391402 1.12 ENSRNOT00000090518
ENSRNOT00000083489
Ppt2
palmitoyl-protein thioesterase 2
chr1_-_228558593 1.09 ENSRNOT00000028606
Olr326
olfactory receptor 326
chr8_+_3638921 1.05 ENSRNOT00000075829
Vom1r24
vomeronasal 1 receptor 24
chr13_-_91638661 0.96 ENSRNOT00000045429
Olr1579
olfactory receptor 1579
chr9_-_99365192 0.94 ENSRNOT00000047012
RGD1564730
similar to ribosomal protein L36
chr15_+_31178339 0.90 ENSRNOT00000089064
AABR07017798.2

chrX_+_15114892 0.83 ENSRNOT00000078168
Wdr13
WD repeat domain 13
chr6_-_142534112 0.82 ENSRNOT00000073598
Ighv1-49
immunoglobulin heavy variable 1-49
chr3_+_20993205 0.81 ENSRNOT00000010465
Olr419
olfactory receptor 419
chr6_+_58388333 0.79 ENSRNOT00000036337
LOC680646
similar to 40S ribosomal protein S2
chr3_-_139735397 0.75 ENSRNOT00000088315
AABR07054088.1

chr7_+_140107488 0.66 ENSRNOT00000043467
Olr1111
olfactory receptor 1111
chrX_+_20216587 0.65 ENSRNOT00000073114
AABR07037412.2
FYVE, RhoGEF and PH domain-containing protein 1
chr20_+_5527181 0.60 ENSRNOT00000091364
Phf1
PHD finger protein 1
chr3_-_78340788 0.54 ENSRNOT00000041870
Olr713
olfactory receptor 713
chr3_-_103043741 0.47 ENSRNOT00000052294
Olr775
olfactory receptor 775
chrX_-_81817101 0.47 ENSRNOT00000003730
AABR07039648.1

chr15_+_32160364 0.43 ENSRNOT00000072888
AABR07017875.1

chr1_+_68221395 0.36 ENSRNOT00000075596
Vom1r29
vomeronasal 1 receptor 29
chr1_-_169892850 0.36 ENSRNOT00000037868
Olr183
olfactory receptor 183
chr13_+_92412612 0.36 ENSRNOT00000004728
Olr1601
olfactory receptor 1601
chr6_+_115170865 0.29 ENSRNOT00000005671
Tshr
thyroid stimulating hormone receptor
chr1_-_166912524 0.26 ENSRNOT00000092952
Inppl1
inositol polyphosphate phosphatase-like 1
chr10_-_53595827 0.20 ENSRNOT00000004560
Adprm
ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
chr20_+_1861272 0.14 ENSRNOT00000044570
Olr1744
olfactory receptor 1744
chr8_+_43733545 0.12 ENSRNOT00000082000
Olr1326
olfactory receptor 1326
chr19_+_28377249 0.12 ENSRNOT00000059668
Vom1r21
vomeronasal 1 receptor 21
chr3_-_166993940 0.09 ENSRNOT00000034669
Zfp217
zinc finger protein 217
chr14_-_45165207 0.09 ENSRNOT00000002960
Klf3
Kruppel like factor 3
chr5_-_151029233 0.06 ENSRNOT00000089155
Ppp1r8
protein phosphatase 1, regulatory subunit 8
chr20_+_1781320 0.04 ENSRNOT00000040388
Olr1737
olfactory receptor 1737
chr3_-_166994286 0.02 ENSRNOT00000081593
Zfp217
zinc finger protein 217

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
14.0 41.9 GO:1902304 positive regulation of potassium ion export(GO:1902304)
6.5 32.7 GO:0050828 regulation of liquid surface tension(GO:0050828)
5.9 41.3 GO:0008228 opsonization(GO:0008228)
3.6 10.9 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
2.3 6.9 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
2.0 6.0 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
1.7 6.8 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
1.7 8.3 GO:0002901 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
1.7 5.0 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
1.5 7.3 GO:0080154 regulation of fertilization(GO:0080154)
1.4 10.0 GO:0002238 response to molecule of fungal origin(GO:0002238)
1.3 4.0 GO:0001802 antibody-dependent cellular cytotoxicity(GO:0001788) type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.9 4.4 GO:0016095 polyprenol catabolic process(GO:0016095)
0.9 11.4 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.6 1.9 GO:0035600 tRNA methylthiolation(GO:0035600)
0.6 5.0 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.5 1.5 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.5 1.9 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.4 1.3 GO:0071338 submandibular salivary gland formation(GO:0060661) positive regulation of hair follicle cell proliferation(GO:0071338)
0.4 3.1 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.4 3.3 GO:0061450 nail development(GO:0035878) trophoblast cell migration(GO:0061450)
0.3 27.8 GO:0055013 cardiac muscle cell development(GO:0055013)
0.3 2.3 GO:0035330 regulation of hippo signaling(GO:0035330)
0.2 5.6 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.2 3.0 GO:0019236 response to pheromone(GO:0019236)
0.2 1.5 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.2 2.8 GO:0001967 suckling behavior(GO:0001967)
0.1 4.7 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 0.3 GO:1905225 response to thyrotropin-releasing hormone(GO:1905225)
0.1 1.2 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.1 0.6 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 0.8 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.1 2.3 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.0 3.6 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
0.0 0.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.4 GO:0071148 TEAD-1-YAP complex(GO:0071148)
2.8 8.3 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
2.3 32.7 GO:0097208 alveolar lamellar body(GO:0097208)
2.0 6.0 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
1.5 41.9 GO:0042629 mast cell granule(GO:0042629)
1.2 41.3 GO:0005771 multivesicular body(GO:0005771)
0.6 5.0 GO:0044305 calyx of Held(GO:0044305)
0.3 1.2 GO:0033648 host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648)
0.2 1.5 GO:0031415 NatA complex(GO:0031415)
0.2 1.3 GO:0000322 storage vacuole(GO:0000322)
0.2 4.7 GO:0002080 acrosomal membrane(GO:0002080)
0.2 3.3 GO:0030056 hemidesmosome(GO:0030056)
0.1 2.6 GO:0097225 sperm midpiece(GO:0097225)
0.1 27.8 GO:0030017 sarcomere(GO:0030017)
0.1 1.5 GO:0010369 chromocenter(GO:0010369)
0.1 4.7 GO:0005811 lipid particle(GO:0005811)
0.1 6.8 GO:0005604 basement membrane(GO:0005604)
0.1 2.3 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 3.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 4.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 5.0 GO:0005884 actin filament(GO:0005884)
0.0 0.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.6 GO:0045095 keratin filament(GO:0045095)
0.0 1.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 4.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 5.9 GO:0005911 cell-cell junction(GO:0005911)
0.0 2.0 GO:0005840 ribosome(GO:0005840)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.9 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
2.3 6.9 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
1.7 41.9 GO:0051428 peptide hormone receptor binding(GO:0051428)
1.5 6.0 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
1.4 8.3 GO:0042289 MHC class II protein binding(GO:0042289)
1.3 10.0 GO:0008430 selenium binding(GO:0008430)
1.1 4.4 GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
1.0 5.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.8 4.0 GO:0019770 IgG receptor activity(GO:0019770)
0.7 3.3 GO:0038132 neuregulin binding(GO:0038132)
0.6 1.9 GO:0035596 methylthiotransferase activity(GO:0035596) transferase activity, transferring alkylthio groups(GO:0050497)
0.6 27.8 GO:0051393 alpha-actinin binding(GO:0051393)
0.6 6.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.6 11.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.4 3.1 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.4 1.3 GO:0032427 GBD domain binding(GO:0032427)
0.2 5.6 GO:0030371 translation repressor activity(GO:0030371)
0.1 3.6 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 41.3 GO:0030246 carbohydrate binding(GO:0030246)
0.1 32.7 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.1 1.5 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 5.8 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 1.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.2 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.3 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0 7.3 GO:0003924 GTPase activity(GO:0003924)
0.0 2.3 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 2.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 3.4 GO:0003735 structural constituent of ribosome(GO:0003735)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 41.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.5 41.9 PID AP1 PATHWAY AP-1 transcription factor network
0.2 32.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 3.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 5.0 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 1.3 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 2.3 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 1.9 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 6.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 PID EPHA2 FWD PATHWAY EPHA2 forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 53.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.4 6.0 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.4 5.0 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.4 4.4 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.3 4.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 6.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 4.0 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 3.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 3.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.3 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors