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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Nkx2-3
Z-value: 1.10
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Transcription factors associated with Nkx2-3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx2-3 | rn6_v1_chr1_+_263367266_263367266 | -0.32 | 6.6e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nkx2-3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 33.2 | 99.6 | GO:0007208 | phospholipase C-activating serotonin receptor signaling pathway(GO:0007208) |
| 2.4 | 94.1 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 1.8 | 77.4 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 3.6 | 43.3 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.3 | 37.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.2 | 35.9 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
| 7.0 | 35.0 | GO:0070350 | white fat cell proliferation(GO:0070343) positive regulation of fat cell proliferation(GO:0070346) regulation of white fat cell proliferation(GO:0070350) |
| 6.8 | 33.8 | GO:0007207 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 3.6 | 32.7 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 3.0 | 32.6 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 120.4 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 12.2 | 110.1 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 2.6 | 60.7 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 41.6 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.2 | 40.6 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 2.7 | 37.2 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.4 | 35.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 33.1 | GO:0045202 | synapse(GO:0045202) |
| 1.8 | 32.7 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.5 | 29.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 33.2 | 99.6 | GO:0071886 | 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding(GO:0071886) |
| 3.8 | 87.1 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 12.1 | 60.7 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.1 | 59.4 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.2 | 48.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 42.1 | GO:0042802 | identical protein binding(GO:0042802) |
| 4.9 | 39.6 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 2.1 | 38.7 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
| 0.3 | 34.1 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 6.8 | 33.8 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 77.4 | PID LKB1 PATHWAY | LKB1 signaling events |
| 1.7 | 43.3 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.2 | 36.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.8 | 33.1 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.4 | 21.5 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.2 | 17.9 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.6 | 17.8 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.3 | 17.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.6 | 12.2 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.4 | 11.6 | ST G ALPHA I PATHWAY | G alpha i Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.1 | 99.6 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 3.6 | 60.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 33.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.9 | 32.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.4 | 30.5 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.4 | 30.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 24.2 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.9 | 23.4 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.9 | 20.5 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 1.8 | 17.7 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |