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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nkx2-3

Z-value: 1.10

Motif logo

Transcription factors associated with Nkx2-3

Gene Symbol Gene ID Gene Info
ENSRNOG00000016656 NK2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-3rn6_v1_chr1_+_263367266_263367266-0.326.6e-09Click!

Activity profile of Nkx2-3 motif

Sorted Z-values of Nkx2-3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_118197217 72.62 ENSRNOT00000090922
5-hydroxytryptamine receptor 2C
chr14_+_39663421 60.70 ENSRNOT00000003197
gamma-aminobutyric acid type A receptor alpha2 subunit
chr6_+_58468155 43.33 ENSRNOT00000091263
ets variant 1
chr9_-_30844199 42.25 ENSRNOT00000017169
collagen type XIX alpha 1 chain
chr9_+_73418607 40.00 ENSRNOT00000092547
microtubule-associated protein 2
chr9_+_73334618 37.42 ENSRNOT00000092717
microtubule-associated protein 2
chr1_-_70235091 35.84 ENSRNOT00000075745
antisense paternally expressed gene 3
chr14_+_99529284 35.03 ENSRNOT00000006897
ENSRNOT00000067134
V-set and transmembrane domain containing 2A
chr8_-_82533689 32.86 ENSRNOT00000014124
tropomodulin 2
chr6_+_64789940 32.74 ENSRNOT00000085979
ENSRNOT00000059739
ENSRNOT00000051908
ENSRNOT00000082793
ENSRNOT00000078583
ENSRNOT00000091677
ENSRNOT00000093241
neuronal cell adhesion molecule
chr3_+_48082935 32.65 ENSRNOT00000087711
ENSRNOT00000067545
solute carrier family 4 member 10
chrX_+_107496072 32.63 ENSRNOT00000003283
proteolipid protein 1
chr4_-_55011415 30.52 ENSRNOT00000056996
glutamate metabotropic receptor 8
chr2_+_144861455 30.26 ENSRNOT00000093284
ENSRNOT00000019748
ENSRNOT00000072110
doublecortin-like kinase 1
chrX_+_114930457 30.12 ENSRNOT00000089141
p21 (RAC1) activated kinase 3
chr2_-_35104963 29.29 ENSRNOT00000018058
regulator of G-protein signaling 7-binding protein
chr3_-_51612397 29.14 ENSRNOT00000081401
sodium voltage-gated channel alpha subunit 3
chr2_+_136993208 28.09 ENSRNOT00000040187
ENSRNOT00000066542
protocadherin 10
chr10_-_108691367 28.02 ENSRNOT00000005067
neuronal pentraxin 1
chr4_+_172942020 28.01 ENSRNOT00000072450
LIM domain only 3
chr9_-_63641400 27.78 ENSRNOT00000087684
SATB homeobox 2
chr15_+_56666012 27.02 ENSRNOT00000013408
5-hydroxytryptamine receptor 2A
chr1_+_256955652 26.17 ENSRNOT00000020411
leucine-rich, glioma inactivated 1
chr3_+_177310753 25.59 ENSRNOT00000031448
myelin transcription factor 1
chr17_-_9762813 25.43 ENSRNOT00000033749
solute carrier family 34 member 1
chr3_-_26056818 25.31 ENSRNOT00000044209
LDL receptor related protein 1B
chr18_-_24182012 24.57 ENSRNOT00000023594
synaptotagmin 4
chr5_-_130085838 24.38 ENSRNOT00000035252
ELAV like RNA binding protein 4
chr4_-_184096806 23.42 ENSRNOT00000055433
mKIAA1238 protein-like
chr8_+_82038967 23.39 ENSRNOT00000079535
myosin VA
chr15_+_87886783 22.16 ENSRNOT00000065710
SLAIN motif family, member 1
chr4_-_15859132 21.66 ENSRNOT00000082161
calcium voltage-gated channel auxiliary subunit alpha2delta 1
chr6_+_73553210 21.05 ENSRNOT00000006562
A-kinase anchoring protein 6
chr2_-_5577369 20.86 ENSRNOT00000093420
nuclear receptor subfamily 2, group F, member 1
chr10_-_82229140 20.60 ENSRNOT00000004400
epsin 3
chr3_-_105470475 20.59 ENSRNOT00000011078
gap junction protein, delta 2
chr10_-_18942540 20.58 ENSRNOT00000007187
potassium voltage-gated channel interacting protein 1
chr5_+_119727839 19.04 ENSRNOT00000014354
cache domain containing 1
chr15_+_59678165 18.77 ENSRNOT00000074868
ecto-NOX disulfide-thiol exchanger 1
chr1_-_93949187 18.70 ENSRNOT00000018956
zinc finger protein 536
chr13_+_87986240 18.58 ENSRNOT00000003705
regulator of G-protein signaling 5
chr14_-_46153212 18.54 ENSRNOT00000079269
NACHT and WD repeat domain containing 2
chr20_+_25990656 18.48 ENSRNOT00000081254
leucine rich repeat transmembrane neuronal 3
chr5_-_65073012 18.33 ENSRNOT00000007957
glutamate ionotropic receptor NMDA type subunit 3A
chr18_+_27632786 18.29 ENSRNOT00000073564
ENSRNOT00000078969
receptor accessory protein 2
chr10_-_66848388 17.91 ENSRNOT00000018891
oligodendrocyte-myelin glycoprotein
chr17_-_63994169 17.72 ENSRNOT00000075651
cholinergic receptor, muscarinic 3
chrX_+_6273733 17.43 ENSRNOT00000074275
NDP, norrin cystine knot growth factor
chr4_+_110699557 17.20 ENSRNOT00000030588
ENSRNOT00000092261
leucine rich repeat transmembrane neuronal 4
chr18_+_54108493 17.08 ENSRNOT00000029239
similar to DD1
chrX_-_82743753 17.05 ENSRNOT00000003512
ribosomal protein S6 kinase A6
chr9_+_62291405 16.74 ENSRNOT00000051463
phospholipase C-like 1
chr9_+_86874685 16.60 ENSRNOT00000041337
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr7_+_44009069 16.49 ENSRNOT00000005523
MGAT4 family, member C
chr16_-_73152921 16.49 ENSRNOT00000048602
zinc finger, matrin type 4
chr7_-_52404774 16.32 ENSRNOT00000082100
neuron navigator 3
chr2_-_96509424 16.14 ENSRNOT00000090866
zinc finger, C2HC-type containing 1A
chr4_+_64088900 16.12 ENSRNOT00000075341
cholinergic receptor, muscarinic 2
chr9_+_47281961 15.83 ENSRNOT00000065234
solute carrier family 9 member A4
chr1_-_173764246 15.42 ENSRNOT00000019690
ENSRNOT00000086944
LIM domain only 1
chr7_+_42304534 15.42 ENSRNOT00000085097
KIT ligand
chr10_-_91986632 15.28 ENSRNOT00000087824
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
chr2_-_188559882 15.19 ENSRNOT00000088199
tripartite motif-containing 46
chr5_-_93244202 14.91 ENSRNOT00000075474
protein tyrosine phosphatase, receptor type, D
chr9_+_60039297 14.88 ENSRNOT00000016262
solute carrier family 39 member 10
chr4_+_96562725 14.78 ENSRNOT00000009094
neuron-derived neurotrophic factor
chr3_-_45169118 14.40 ENSRNOT00000086371
coiled-coil domain containing 148
chr1_+_61786900 14.36 ENSRNOT00000090287

chr9_+_25410669 13.70 ENSRNOT00000030912
ENSRNOT00000090920
transcription factor AP-2 beta
chr18_+_29999290 13.50 ENSRNOT00000027372
protocadherin alpha 4
chr6_+_106496992 13.42 ENSRNOT00000086136
ENSRNOT00000058181
regulator of G-protein signaling 6
chr18_+_30424814 13.39 ENSRNOT00000073425
protocadherin beta 7
chr16_+_22361998 13.36 ENSRNOT00000016193
solute carrier family 18 member A1
chr5_-_39215102 13.10 ENSRNOT00000050653
kelch-like family member 32
chr2_+_72006099 12.87 ENSRNOT00000034044
cadherin 12
chr10_-_86004096 12.81 ENSRNOT00000091978
ENSRNOT00000066855
SH3 and cysteine rich domain 2
chr14_+_37130743 12.77 ENSRNOT00000031756
leucine rich repeat containing 66
chr5_+_25349928 12.54 ENSRNOT00000020826
GTP binding protein overexpressed in skeletal muscle
chr8_-_21384131 12.19 ENSRNOT00000071010
zinc finger protein 560
chr1_-_43638161 12.17 ENSRNOT00000024460
interaction protein for cytohesin exchange factors 1
chr12_-_44520341 12.04 ENSRNOT00000066810
nitric oxide synthase 1
chr1_-_90520344 11.95 ENSRNOT00000078598
potassium channel tetramerization domain containing 15
chr3_+_128828331 11.60 ENSRNOT00000045393
phospholipase C, beta 4
chr6_-_114476723 11.30 ENSRNOT00000005162
deiodinase, iodothyronine, type II
chr10_-_74679858 11.14 ENSRNOT00000003859
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr13_-_76049363 11.12 ENSRNOT00000075865
ENSRNOT00000007455
BMP/retinoic acid inducible neural specific 2
chrX_-_121731543 11.06 ENSRNOT00000018788
kelch-like family member 13
chr9_-_121725716 10.81 ENSRNOT00000087405
adenylate cyclase activating polypeptide 1
chr3_+_38559914 10.80 ENSRNOT00000085545
formin-like 2
chr18_-_26656879 10.77 ENSRNOT00000086729
erythrocyte membrane protein band 4.1 like 4A
chr2_+_11658568 10.53 ENSRNOT00000076408
ENSRNOT00000076416
ENSRNOT00000076992
ENSRNOT00000075931
ENSRNOT00000076136
ENSRNOT00000076481
ENSRNOT00000076084
ENSRNOT00000076230
ENSRNOT00000076710
ENSRNOT00000076239
myocyte enhancer factor 2C
chr11_-_768644 10.51 ENSRNOT00000090197
Eph receptor A3
chr18_+_30820321 10.47 ENSRNOT00000060472
protocadherin gamma subfamily A, 3
chr14_+_104250617 10.27 ENSRNOT00000079874
sprouty-related, EVH1 domain containing 2
chr6_+_76745981 10.23 ENSRNOT00000076784
breast cancer metastasis-suppressor 1-like
chr16_-_6245644 10.14 ENSRNOT00000040759
calcium voltage-gated channel subunit alpha1 D
chr2_+_4252496 9.98 ENSRNOT00000071535
similar to KIAA0825 protein
chr13_+_106463368 9.92 ENSRNOT00000003489
estrogen-related receptor gamma
chrX_+_25016401 9.73 ENSRNOT00000059270
chloride voltage-gated channel 4
chr8_+_122076759 9.70 ENSRNOT00000012545
cytoplasmic linker associated protein 2
chr6_-_67084234 9.43 ENSRNOT00000050372
NOVA alternative splicing regulator 1
chr9_+_51302151 9.22 ENSRNOT00000085908
GULP, engulfment adaptor PTB domain containing 1
chr2_+_153803349 9.11 ENSRNOT00000088565
membrane metallo-endopeptidase
chr1_+_89215266 9.04 ENSRNOT00000093612
ENSRNOT00000084799
dermokine
chr2_-_199971965 8.95 ENSRNOT00000087026
phosphodiesterase 4D interacting protein
chr16_-_2602103 8.83 ENSRNOT00000018413
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
chr17_-_81187739 8.70 ENSRNOT00000063911
3-hydroxyacyl-CoA dehydratase 1
chrX_-_10031167 8.62 ENSRNOT00000060988
G protein-coupled receptor 34
chrX_-_64908682 8.58 ENSRNOT00000084107
zinc finger C4H2-type containing
chr3_-_141411170 8.48 ENSRNOT00000017364
NK2 homeobox 2
chr5_+_146656049 8.38 ENSRNOT00000036029
CUB and Sushi multiple domains 2
chr12_+_2140203 8.34 ENSRNOT00000084906
calmodulin regulated spectrin-associated protein family, member 3
chr14_-_79988110 8.34 ENSRNOT00000090597
actin filament associated protein 1
chr19_+_46733633 8.21 ENSRNOT00000016307
C-type lectin domain family 3, member A
chrX_+_63542191 8.21 ENSRNOT00000073955
apolipoprotein O
chrX_+_40460047 8.18 ENSRNOT00000010970
phosphate regulating endopeptidase homolog, X-linked
chr7_-_40316532 8.14 ENSRNOT00000083347
similar to RIKEN cDNA C430008C19
chr8_-_12993651 8.00 ENSRNOT00000033932
lysine demethylase 4D
chr2_+_204427608 7.79 ENSRNOT00000083374
nescient helix loop helix 2
chr13_+_98231326 7.72 ENSRNOT00000003837
CDC42 binding protein kinase alpha
chr2_+_145174876 7.66 ENSRNOT00000040631
mab-21 like 1
chr13_-_102857551 7.63 ENSRNOT00000080309
microtubule affinity regulating kinase 1
chrX_-_153878806 7.48 ENSRNOT00000087990
AF4/FMR2 family, member 2
chr1_+_53220397 7.44 ENSRNOT00000089989

chr4_+_2055615 7.34 ENSRNOT00000007646
ring finger protein 32
chr11_-_782954 7.33 ENSRNOT00000040065
Eph receptor A3
chr2_-_184263564 7.28 ENSRNOT00000015279
F-box and WD repeat domain containing 7
chr5_-_106923132 7.25 ENSRNOT00000046207
interferon, alpha 4
chr5_-_99033107 7.22 ENSRNOT00000041306
heat shock protein family A (Hsp70) member 8
chr3_-_21904133 7.15 ENSRNOT00000090576
ENSRNOT00000087611
ENSRNOT00000066377
spermatid perinuclear RNA binding protein
chr17_+_11683862 7.13 ENSRNOT00000024766
msh homeobox 2
chr19_-_56983807 7.07 ENSRNOT00000043529
cytochrome c oxidase subunit VIc, pseudogene
chrX_-_25590048 6.95 ENSRNOT00000004873
midline 1
chr10_-_45812641 6.89 ENSRNOT00000038951
zinc finger protein 867
chr19_+_39229754 6.84 ENSRNOT00000050612
vacuolar protein sorting 4 homolog A
chrX_+_158835811 6.64 ENSRNOT00000071888
ENSRNOT00000080110
integrator complex subunit 6 like
chr2_+_266315036 6.50 ENSRNOT00000055245
wntless Wnt ligand secretion mediator
chr3_-_77227036 6.41 ENSRNOT00000072638
olfactory receptor 4P4-like
chr5_+_58995249 6.39 ENSRNOT00000023411
coiled-coil domain containing 107
chr6_+_22696397 6.20 ENSRNOT00000011630
anaplastic lymphoma receptor tyrosine kinase
chr2_-_199354793 6.18 ENSRNOT00000023548
B-cell CLL/lymphoma 9
chr4_+_87608301 6.16 ENSRNOT00000058702
vomeronasal 1 receptor 71
chr6_-_51018050 6.15 ENSRNOT00000082691
G protein-coupled receptor 22
chr20_-_27117663 5.97 ENSRNOT00000000434
phenazine biosynthesis-like protein domain containing 1
chrX_+_9956370 5.96 ENSRNOT00000082316
peripheral plasma membrane protein CASK-like
chr14_-_79987915 5.95 ENSRNOT00000089006
actin filament associated protein 1
chr18_-_75207306 5.91 ENSRNOT00000021717
SET binding protein 1
chr19_-_49510901 5.84 ENSRNOT00000082929
ENSRNOT00000079969
hypothetical protein LOC687399
chrX_-_40086870 5.76 ENSRNOT00000010027
small muscle protein, X-linked
chr8_-_18037774 5.71 ENSRNOT00000074948
olfactory receptor 1137
chr3_-_64364101 5.63 ENSRNOT00000089065
zinc finger protein 385B
chr15_-_37831031 5.59 ENSRNOT00000091562
eukaryotic translation elongation factor 1 alpha lysine methyltransferase 1
chr10_+_74436534 5.48 ENSRNOT00000008298
tripartite motif-containing 37
chr19_+_39357791 5.41 ENSRNOT00000086435
ENSRNOT00000015006
cytochrome b5 type B
chr1_+_217459215 5.39 ENSRNOT00000092386
ENSRNOT00000092357
SH3 and multiple ankyrin repeat domains 2
chr8_+_52127399 5.38 ENSRNOT00000052392
cell adhesion molecule 1
chr2_+_86891092 5.36 ENSRNOT00000077162
ENSRNOT00000083066
zinc finger protein 457-like
chr7_-_55604403 5.34 ENSRNOT00000088732
ataxin 7-like 3B
chr7_-_4216833 5.31 ENSRNOT00000003174
olfactory receptor 982
chr2_+_122865100 5.28 ENSRNOT00000067090
regulator of sex-limitation candidate 18
chr4_-_167068838 5.13 ENSRNOT00000029713
taste receptor, type 2, member 125
chr7_+_42269784 5.13 ENSRNOT00000008471
ENSRNOT00000007231
KIT ligand
chr14_+_62309299 5.12 ENSRNOT00000048309
vomeronasal 1 receptor 26
chrX_+_136488691 5.08 ENSRNOT00000093432
Rho GTPase activating protein 36
chr9_+_66888393 5.05 ENSRNOT00000023536
calcium responsive transcription factor
chr2_+_186980992 5.03 ENSRNOT00000020717
Rho guanine nucleotide exchange factor 11
chr1_-_99632845 4.99 ENSRNOT00000049123
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 pseudogene
chr6_-_106971250 4.98 ENSRNOT00000010926
double PHD fingers 3
chr2_+_177651241 4.97 ENSRNOT00000047593

chr1_-_204275803 4.83 ENSRNOT00000066711
carbohydrate sulfotransferase 15
chrX_+_54062935 4.81 ENSRNOT00000004854
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr1_-_149633029 4.81 ENSRNOT00000048861
olfactory receptor 14A2-like
chr2_-_45518502 4.79 ENSRNOT00000014627
heat shock protein family B (small) member 3
chr7_+_18120715 4.78 ENSRNOT00000068151
vomeronasal 1 receptor 108
chr8_+_52127632 4.76 ENSRNOT00000079797
cell adhesion molecule 1
chr1_-_219369587 4.67 ENSRNOT00000000599
aryl-hydrocarbon receptor-interacting protein
chr3_+_168124673 4.62 ENSRNOT00000070809
prefoldin subunit 4
chr15_-_95514259 4.60 ENSRNOT00000038433
SLIT and NTRK-like family, member 6
chr1_+_95397991 4.58 ENSRNOT00000039649
zinc finger protein 939
chr12_+_38377034 4.55 ENSRNOT00000088002
CAP-GLY domain containing linker protein 1
chr19_+_25043680 4.52 ENSRNOT00000043971
adhesion G protein-coupled receptor L1
chr14_+_104480662 4.51 ENSRNOT00000078710
RAB1A, member RAS oncogene family
chr3_-_102672294 4.48 ENSRNOT00000030909
olfactory receptor 760
chr10_+_94260197 4.37 ENSRNOT00000063973
translational activator of cytochrome c oxidase I
chr4_+_31333970 4.34 ENSRNOT00000064866
coiled-coil domain-containing protein 132-like
chr6_+_28382962 4.31 ENSRNOT00000016976
proopiomelanocortin
chr2_-_173836854 4.21 ENSRNOT00000074278
WD repeat domain 49
chr9_-_66019065 4.18 ENSRNOT00000088729
ALS2, alsin Rho guanine nucleotide exchange factor
chr8_+_100260049 4.08 ENSRNOT00000011090

chr6_+_72124417 3.96 ENSRNOT00000040548
sec1 family domain containing 1
chr2_-_177950517 3.77 ENSRNOT00000012792
Rap guanine nucleotide exchange factor 2
chr4_+_21872856 3.73 ENSRNOT00000044810
cyclin D binding myb-like transcription factor 1
chr2_+_256609787 3.71 ENSRNOT00000047564
ENSRNOT00000088437
adhesion G protein-coupled receptor L4
chr4_+_88694583 3.58 ENSRNOT00000009202
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chrX_-_42329232 3.41 ENSRNOT00000045705
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4
chrX_+_69730242 3.35 ENSRNOT00000075980
ENSRNOT00000076425
ectodysplasin-A
chr2_+_243018975 3.32 ENSRNOT00000081989
DnaJ heat shock protein family (Hsp40) member B14
chr5_-_147584038 3.23 ENSRNOT00000010983
zinc finger and BTB domain containing 8a
chr7_-_95310005 3.21 ENSRNOT00000005815
mitochondrial ribosomal protein L13
chr6_-_105261549 3.20 ENSRNOT00000009122
synaptojanin 2 binding protein

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
33.2 99.6 GO:0007208 phospholipase C-activating serotonin receptor signaling pathway(GO:0007208)
8.5 25.4 GO:2000118 dentinogenesis(GO:0097187) regulation of sodium-dependent phosphate transport(GO:2000118)
7.0 35.0 GO:0070350 white fat cell proliferation(GO:0070343) positive regulation of fat cell proliferation(GO:0070346) regulation of white fat cell proliferation(GO:0070350)
6.8 33.8 GO:0007207 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
5.9 17.8 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
5.8 23.4 GO:0051643 endoplasmic reticulum localization(GO:0051643)
5.3 21.0 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
5.1 25.4 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
4.9 24.6 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
4.3 17.1 GO:0061738 late endosomal microautophagy(GO:0061738)
4.1 20.5 GO:0070662 negative regulation of mast cell apoptotic process(GO:0033026) mast cell proliferation(GO:0070662) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
3.9 15.4 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
3.8 15.3 GO:0035494 SNARE complex disassembly(GO:0035494)
3.8 30.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
3.6 32.7 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
3.6 43.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
3.6 21.7 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048) positive regulation of high voltage-gated calcium channel activity(GO:1901843)
3.5 28.0 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
3.5 10.5 GO:0060988 lipid tube assembly(GO:0060988)
3.0 32.6 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
2.9 29.1 GO:0046684 response to pyrethroid(GO:0046684)
2.9 17.4 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
2.9 8.7 GO:0071529 cementum mineralization(GO:0071529)
2.9 22.8 GO:0032596 protein transport into membrane raft(GO:0032596)
2.8 8.5 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
2.8 27.8 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.8 30.5 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
2.7 8.2 GO:1904383 response to sodium phosphate(GO:1904383)
2.7 10.8 GO:0002877 regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
2.7 8.0 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
2.6 10.5 GO:2000111 positive regulation of macrophage apoptotic process(GO:2000111) epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
2.5 28.0 GO:0060385 axonogenesis involved in innervation(GO:0060385)
2.4 7.3 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
2.4 7.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of mesenchymal cell apoptotic process(GO:2001055)
2.4 94.1 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
2.3 25.6 GO:0060539 diaphragm development(GO:0060539)
2.3 13.7 GO:0097070 ductus arteriosus closure(GO:0097070)
2.3 9.1 GO:0071492 cellular response to UV-A(GO:0071492)
2.3 9.0 GO:1903575 cornified envelope assembly(GO:1903575)
2.2 6.5 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
2.1 20.9 GO:0021796 cerebral cortex regionalization(GO:0021796)
2.1 18.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
2.1 6.2 GO:0090648 response to environmental enrichment(GO:0090648)
2.1 6.2 GO:0014908 myotube differentiation involved in skeletal muscle regeneration(GO:0014908)
2.0 10.1 GO:0009826 unidimensional cell growth(GO:0009826)
2.0 6.0 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
1.9 14.9 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
1.8 14.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
1.8 77.4 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
1.8 8.9 GO:0035063 nuclear speck organization(GO:0035063)
1.7 31.9 GO:0021860 pyramidal neuron development(GO:0021860)
1.7 8.3 GO:0045218 zonula adherens maintenance(GO:0045218)
1.5 18.5 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
1.5 15.2 GO:0099612 protein localization to axon(GO:0099612)
1.5 3.0 GO:0071338 submandibular salivary gland formation(GO:0060661) positive regulation of hair follicle cell proliferation(GO:0071338)
1.5 14.9 GO:0097105 presynaptic membrane assembly(GO:0097105)
1.4 5.5 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
1.3 15.8 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
1.3 17.0 GO:2000381 negative regulation of mesoderm development(GO:2000381)
1.3 18.3 GO:0060134 prepulse inhibition(GO:0060134)
1.3 30.1 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
1.3 11.3 GO:0042447 phenol-containing compound catabolic process(GO:0019336) hormone catabolic process(GO:0042447)
1.2 20.6 GO:0045760 positive regulation of action potential(GO:0045760)
1.2 4.7 GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
1.1 2.3 GO:0060166 olfactory pit development(GO:0060166)
1.1 2.3 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
1.1 3.4 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
1.0 3.1 GO:0043132 NAD transport(GO:0043132)
1.0 6.2 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.9 4.6 GO:0060005 vestibular reflex(GO:0060005)
0.9 10.0 GO:0097113 AMPA glutamate receptor clustering(GO:0097113)
0.9 30.3 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.8 4.8 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.8 7.7 GO:0007097 nuclear migration(GO:0007097)
0.8 3.8 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.7 11.1 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.7 2.0 GO:0015692 nickel cation transport(GO:0015675) vanadium ion transport(GO:0015676) lead ion transport(GO:0015692) nickel cation transmembrane transport(GO:0035444)
0.6 7.1 GO:0007638 mechanosensory behavior(GO:0007638)
0.6 17.9 GO:0048679 regulation of axon regeneration(GO:0048679)
0.6 7.2 GO:0033139 regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033139) positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.6 5.4 GO:0099562 maintenance of postsynaptic specialization structure(GO:0098880) maintenance of postsynaptic density structure(GO:0099562)
0.6 4.2 GO:0051036 regulation of endosome size(GO:0051036)
0.6 10.3 GO:0010801 negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.6 4.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.5 2.1 GO:0006824 cobalt ion transport(GO:0006824)
0.5 1.6 GO:0071611 negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859) negative regulation of interferon-alpha production(GO:0032687) granulocyte colony-stimulating factor production(GO:0071611) regulation of granulocyte colony-stimulating factor production(GO:0071655)
0.5 8.2 GO:0042407 cristae formation(GO:0042407)
0.5 2.3 GO:0023021 termination of signal transduction(GO:0023021)
0.5 5.0 GO:0035865 cellular response to potassium ion(GO:0035865)
0.4 18.6 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.4 4.0 GO:1902902 regulation of ER to Golgi vesicle-mediated transport(GO:0060628) negative regulation of autophagosome assembly(GO:1902902)
0.4 2.7 GO:0002238 response to molecule of fungal origin(GO:0002238)
0.4 9.4 GO:0007602 phototransduction(GO:0007602)
0.4 3.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.4 24.4 GO:1990090 cellular response to nerve growth factor stimulus(GO:1990090)
0.4 1.1 GO:0021590 cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699)
0.3 2.1 GO:0070827 chromatin maintenance(GO:0070827)
0.3 10.8 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.3 1.6 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.3 2.4 GO:0015866 ADP transport(GO:0015866)
0.3 4.5 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.3 1.8 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.3 1.1 GO:0009597 detection of virus(GO:0009597)
0.3 37.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 7.5 GO:0044705 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.2 3.2 GO:0048312 positive regulation of activin receptor signaling pathway(GO:0032927) intracellular distribution of mitochondria(GO:0048312)
0.2 1.7 GO:0009642 response to light intensity(GO:0009642)
0.2 2.5 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.2 9.7 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.2 2.4 GO:0006108 malate metabolic process(GO:0006108)
0.2 9.2 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.2 21.3 GO:0007601 visual perception(GO:0007601)
0.2 2.3 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.2 35.9 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.2 26.2 GO:0050806 positive regulation of synaptic transmission(GO:0050806)
0.2 8.8 GO:0090003 regulation of establishment of protein localization to plasma membrane(GO:0090003)
0.2 1.7 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.2 0.8 GO:0097052 L-kynurenine metabolic process(GO:0097052)
0.2 3.9 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.2 0.5 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.1 2.1 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 0.9 GO:0046836 glycolipid transport(GO:0046836)
0.1 14.3 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.1 0.9 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 0.9 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 10.2 GO:0016575 histone deacetylation(GO:0016575)
0.1 0.3 GO:1990164 histone H2A phosphorylation(GO:1990164)
0.1 2.3 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 1.9 GO:0045116 protein neddylation(GO:0045116)
0.1 1.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 3.4 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.1 9.4 GO:0050684 regulation of mRNA processing(GO:0050684)
0.1 2.9 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 1.7 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799)
0.1 0.1 GO:0038001 paracrine signaling(GO:0038001)
0.1 7.6 GO:0030010 establishment of cell polarity(GO:0030010)
0.1 0.3 GO:1900153 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.1 5.6 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1 4.8 GO:0019319 hexose biosynthetic process(GO:0019319)
0.1 0.2 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.1 0.9 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 4.8 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 6.8 GO:0006457 protein folding(GO:0006457)
0.0 6.3 GO:0001505 regulation of neurotransmitter levels(GO:0001505)
0.0 6.6 GO:0009566 fertilization(GO:0009566)
0.0 0.6 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.4 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 11.9 GO:0051260 protein homooligomerization(GO:0051260)
0.0 5.7 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.0 1.2 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.7 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 1.1 GO:0051310 metaphase plate congression(GO:0051310)
0.0 1.4 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.5 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.3 GO:0035404 histone-serine phosphorylation(GO:0035404)
0.0 2.4 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.6 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
12.2 110.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
7.8 23.4 GO:0042642 actomyosin, myosin complex part(GO:0042642)
7.0 21.0 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
3.4 10.2 GO:1990836 lysosomal matrix(GO:1990836)
3.0 15.2 GO:1990769 proximal neuron projection(GO:1990769)
2.7 16.1 GO:0032280 symmetric synapse(GO:0032280)
2.7 37.2 GO:0070852 cell body fiber(GO:0070852)
2.6 60.7 GO:1902711 GABA-A receptor complex(GO:1902711)
2.4 24.4 GO:0042788 polysomal ribosome(GO:0042788)
2.3 27.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
1.8 32.7 GO:0043194 axon initial segment(GO:0043194)
1.6 24.6 GO:0031045 dense core granule(GO:0031045)
1.5 29.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
1.5 7.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
1.4 9.7 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
1.2 8.3 GO:0036449 microtubule minus-end(GO:0036449)
1.2 17.7 GO:0032279 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
1.2 8.2 GO:0061617 MICOS complex(GO:0061617)
1.2 5.8 GO:0005927 muscle tendon junction(GO:0005927)
1.1 18.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.0 6.8 GO:0090543 Flemming body(GO:0090543)
0.9 4.7 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.7 15.4 GO:0005922 connexon complex(GO:0005922)
0.7 5.4 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.7 12.0 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.7 2.0 GO:0070826 paraferritin complex(GO:0070826)
0.6 4.6 GO:0016272 prefoldin complex(GO:0016272)
0.6 17.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.6 2.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.5 29.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.5 6.9 GO:0017119 Golgi transport complex(GO:0017119)
0.4 8.8 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.4 19.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.4 35.0 GO:0042734 presynaptic membrane(GO:0042734)
0.3 5.0 GO:0071565 nBAF complex(GO:0071565)
0.3 20.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.3 25.4 GO:0031526 brush border membrane(GO:0031526)
0.3 11.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.3 5.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 12.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 22.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 8.0 GO:0005721 pericentric heterochromatin(GO:0005721)
0.3 2.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.2 6.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 20.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 40.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.2 8.0 GO:0016235 aggresome(GO:0016235)
0.2 2.1 GO:0072546 ER membrane protein complex(GO:0072546)
0.2 14.3 GO:0005884 actin filament(GO:0005884)
0.2 27.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 3.1 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2 10.8 GO:0043195 terminal bouton(GO:0043195)
0.1 2.9 GO:0060170 ciliary membrane(GO:0060170)
0.1 9.7 GO:0031902 early endosome membrane(GO:0031901) late endosome membrane(GO:0031902)
0.1 120.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 3.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.9 GO:0001651 dense fibrillar component(GO:0001651)
0.1 6.2 GO:0005801 cis-Golgi network(GO:0005801)
0.1 41.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 9.1 GO:0008021 synaptic vesicle(GO:0008021)
0.1 6.5 GO:0042641 actomyosin(GO:0042641)
0.1 12.6 GO:0030426 growth cone(GO:0030426)
0.1 2.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 10.3 GO:0030658 transport vesicle membrane(GO:0030658)
0.1 33.1 GO:0045202 synapse(GO:0045202)
0.1 1.6 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 1.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 6.6 GO:0030133 transport vesicle(GO:0030133)
0.1 1.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 3.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.6 GO:0001772 immunological synapse(GO:0001772)
0.1 8.2 GO:0030027 lamellipodium(GO:0030027)
0.1 7.3 GO:0001650 fibrillar center(GO:0001650)
0.1 3.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.1 GO:0051233 spindle midzone(GO:0051233)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.9 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 1.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
33.2 99.6 GO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding(GO:0071886)
12.1 60.7 GO:0008503 benzodiazepine receptor activity(GO:0008503)
7.8 23.4 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
7.6 30.5 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
7.2 21.7 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
6.8 33.8 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
5.1 25.4 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
4.9 39.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
4.9 24.6 GO:0030348 syntaxin-3 binding(GO:0030348)
4.5 13.4 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
4.4 30.8 GO:0005173 stem cell factor receptor binding(GO:0005173)
3.8 87.1 GO:0002162 dystroglycan binding(GO:0002162)
3.6 32.7 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
3.2 3.2 GO:0070699 type II activin receptor binding(GO:0070699)
2.9 8.7 GO:0102345 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
2.7 32.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
2.6 10.2 GO:0031686 A1 adenosine receptor binding(GO:0031686)
2.5 9.9 GO:0050682 AF-2 domain binding(GO:0050682)
2.5 29.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
2.4 12.0 GO:0004517 nitric-oxide synthase activity(GO:0004517)
2.3 21.0 GO:0043495 protein anchor(GO:0043495)
2.1 38.7 GO:0043008 ATP-dependent protein binding(GO:0043008)
1.8 18.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.8 17.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
1.7 30.1 GO:0005523 tropomyosin binding(GO:0005523)
1.6 4.8 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
1.6 15.8 GO:0015386 potassium:proton antiporter activity(GO:0015386)
1.5 7.3 GO:0050816 phosphothreonine binding(GO:0050816)
1.3 28.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
1.2 4.7 GO:0036004 GAF domain binding(GO:0036004)
1.1 29.1 GO:0031402 sodium ion binding(GO:0031402)
1.1 4.3 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
1.1 10.5 GO:0003680 AT DNA binding(GO:0003680)
1.0 6.2 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
1.0 4.1 GO:0015087 cobalt ion transmembrane transporter activity(GO:0015087)
1.0 3.0 GO:0032427 GBD domain binding(GO:0032427)
0.9 24.4 GO:0017091 AU-rich element binding(GO:0017091)
0.9 7.5 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.9 24.5 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.8 2.4 GO:0008948 oxaloacetate decarboxylase activity(GO:0008948)
0.8 8.3 GO:0051011 microtubule minus-end binding(GO:0051011)
0.7 7.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.7 2.1 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.7 15.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.6 3.8 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.6 3.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.6 7.6 GO:0050321 tau-protein kinase activity(GO:0050321)
0.6 14.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.6 13.7 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.6 1.7 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.5 8.8 GO:0043422 protein kinase B binding(GO:0043422)
0.5 9.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.4 3.9 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.4 10.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.4 6.8 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.4 17.4 GO:0005109 frizzled binding(GO:0005109)
0.4 5.4 GO:0098919 structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
0.3 2.4 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.3 2.7 GO:0008430 selenium binding(GO:0008430)
0.3 1.6 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.3 10.2 GO:0004407 histone deacetylase activity(GO:0004407)
0.3 0.9 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.3 6.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.3 34.1 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.3 0.9 GO:0034512 box C/D snoRNA binding(GO:0034512)
0.3 2.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.3 0.8 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.3 5.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.3 10.8 GO:0017048 Rho GTPase binding(GO:0017048)
0.2 7.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 4.5 GO:0015643 toxic substance binding(GO:0015643)
0.2 8.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 14.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 2.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.2 2.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 0.9 GO:0017089 glycolipid transporter activity(GO:0017089)
0.2 4.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.2 5.1 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 5.4 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.7 GO:0070915 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 5.4 GO:0009055 electron carrier activity(GO:0009055)
0.2 48.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 24.5 GO:0047485 protein N-terminus binding(GO:0047485)
0.2 0.5 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
0.2 1.2 GO:0001055 RNA polymerase II activity(GO:0001055)
0.2 2.1 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 1.3 GO:0008527 taste receptor activity(GO:0008527)
0.1 9.4 GO:0019003 GDP binding(GO:0019003)
0.1 17.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 59.4 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 0.5 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 10.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 1.7 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 2.1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 6.2 GO:0019199 transmembrane receptor protein tyrosine kinase activity(GO:0004714) transmembrane receptor protein kinase activity(GO:0019199)
0.1 0.9 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.1 5.6 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.1 1.8 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.1 3.3 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 6.2 GO:0008013 beta-catenin binding(GO:0008013)
0.1 6.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 10.1 GO:0030165 PDZ domain binding(GO:0030165)
0.1 2.4 GO:0035064 methylated histone binding(GO:0035064)
0.1 18.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 16.0 GO:0016758 transferase activity, transferring hexosyl groups(GO:0016758)
0.1 8.1 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 2.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 20.2 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.1 4.6 GO:0051082 unfolded protein binding(GO:0051082)
0.1 11.4 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 1.9 GO:0042169 SH2 domain binding(GO:0042169)
0.1 7.5 GO:0008201 heparin binding(GO:0008201)
0.0 10.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.8 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 2.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 42.1 GO:0042802 identical protein binding(GO:0042802)
0.0 30.9 GO:0008270 zinc ion binding(GO:0008270)
0.0 5.7 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 1.7 GO:0019843 rRNA binding(GO:0019843)
0.0 4.5 GO:0003924 GTPase activity(GO:0003924)
0.0 4.3 GO:0019904 protein domain specific binding(GO:0019904)
0.0 1.4 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.2 GO:0005212 structural constituent of eye lens(GO:0005212)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 43.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
1.4 77.4 PID LKB1 PATHWAY LKB1 signaling events
0.8 33.1 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.7 0.7 PID LPA4 PATHWAY LPA4-mediated signaling events
0.6 17.8 PID EPHA FWDPATHWAY EPHA forward signaling
0.6 12.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.4 21.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.4 10.0 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.4 11.6 ST G ALPHA I PATHWAY G alpha i Pathway
0.3 17.1 NABA COLLAGENS Genes encoding collagen proteins
0.3 4.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.3 7.3 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.2 17.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.2 11.1 PID AURORA B PATHWAY Aurora B signaling
0.2 6.3 ST GA13 PATHWAY G alpha 13 Pathway
0.2 4.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 36.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 5.8 PID ARF6 PATHWAY Arf6 signaling events
0.1 7.7 PID CDC42 PATHWAY CDC42 signaling events
0.1 6.8 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.1 8.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 1.9 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 9.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 3.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 4.5 PID PLK1 PATHWAY PLK1 signaling events
0.1 1.8 PID FOXO PATHWAY FoxO family signaling
0.1 6.2 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 2.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 99.6 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
3.6 60.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
1.8 17.7 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
1.4 30.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.0 16.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.9 32.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.9 20.5 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.9 23.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.9 14.9 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.9 15.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.8 15.3 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.8 17.0 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.6 16.1 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.6 8.8 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.6 13.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.6 10.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.5 14.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.5 13.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.4 4.8 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.4 30.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.4 4.3 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.4 12.0 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.4 8.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.4 5.7 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.3 6.8 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.3 33.1 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 16.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.3 24.2 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.2 10.8 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.2 4.6 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.2 7.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 4.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 3.1 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 0.7 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 15.6 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 1.7 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 2.1 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.2 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 0.8 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 2.7 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.1 2.3 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.1 2.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.9 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 2.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 6.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.5 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)