ISMARA results: Nkx2-2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nkx2-2

Z-value: 0.90

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Transcription factors associated with Nkx2-2

Gene Symbol	Gene ID	Gene Info
Nkx2-2 NCBI RGD Ensembl	ENSRNOG00000012728	NK2 homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nkx2-2	rn6_v1_chr3_-_141411170_141411170	0.26	1.6e-06	Click!

Activity profile of Nkx2-2 motif

Sorted Z-values of Nkx2-2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_+_28654733 Show fit	33.32	ENSRNOT00000006174	Pmch NCBI RGD Ensembl Show fit	pro-melanin-concentrating hormone
chrX_+_78372257 Show fit	29.42	ENSRNOT00000046164	Gpr174 NCBI RGD Ensembl Show fit	G protein-coupled receptor 174
chr1_-_104202591 Show fit	27.71	ENSRNOT00000035512	E2f8 NCBI RGD Ensembl Show fit	E2F transcription factor 8
chr4_+_101882994 Show fit	26.50	ENSRNOT00000087773	AABR07060963.1 NCBI RGD Ensembl Show fit
chr8_+_55603968 Show fit	25.77	ENSRNOT00000066848	Pou2af1 NCBI RGD Ensembl Show fit	POU class 2 associating factor 1
chr1_+_192379543 Show fit	24.16	ENSRNOT00000078705	Prkcb NCBI RGD Ensembl Show fit	protein kinase C, beta
chr14_-_43992587 Show fit	23.56	ENSRNOT00000003425	Rhoh NCBI RGD Ensembl Show fit	ras homolog family member H
chr13_+_91954138 Show fit	20.00	ENSRNOT00000074608 ENSRNOT00000037655	Aim2 NCBI RGD Ensembl Show fit	absent in melanoma 2
chr17_+_44763598 Show fit	19.71	ENSRNOT00000079880	Hist1h3b NCBI RGD Ensembl Show fit	histone cluster 1, H3b
chr3_+_16413080 Show fit	19.11	ENSRNOT00000040386	LOC100912707 NCBI RGD Ensembl Show fit	Ig kappa chain V19-17-like

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.7	33.3	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.5	29.4	GO:0043029	T cell homeostasis(GO:0043029)
4.6	27.7	GO:0060718	chorionic trophoblast cell differentiation(GO:0060718)
0.3	26.7	GO:0045576	mast cell activation(GO:0045576)
8.1	24.2	GO:0035408	histone H3-T6 phosphorylation(GO:0035408)
2.9	20.0	GO:0070269	pyroptosis(GO:0070269)
0.1	19.8	GO:0071804	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.4	17.4	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
3.9	15.4	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
2.1	14.6	GO:2000348	regulation of CD40 signaling pathway(GO:2000348)

Showing 1 to 10 of 133 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	43.2	GO:0009897	external side of plasma membrane(GO:0009897)
0.3	25.5	GO:0031526	brush border membrane(GO:0031526)
0.2	24.0	GO:0000786	nucleosome(GO:0000786)
0.6	23.6	GO:0001772	immunological synapse(GO:0001772)
0.2	22.5	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.1	22.5	GO:0005667	transcription factor complex(GO:0005667)
4.0	20.0	GO:0097169	AIM2 inflammasome complex(GO:0097169)
0.3	19.5	GO:0030118	clathrin coat(GO:0030118)
0.3	17.2	GO:0009925	basal plasma membrane(GO:0009925)
0.4	15.2	GO:0005834	heterotrimeric G-protein complex(GO:0005834)

Showing 1 to 10 of 80 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	33.3	GO:0071855	neuropeptide receptor binding(GO:0071855)
0.2	27.7	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.6	26.0	GO:0045125	bioactive lipid receptor activity(GO:0045125)
0.5	25.8	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.2	25.3	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
8.1	24.2	GO:0035403	histone kinase activity (H3-T6 specific)(GO:0035403)
0.2	21.5	GO:0019210	kinase inhibitor activity(GO:0019210)
0.0	21.2	GO:0046982	protein heterodimerization activity(GO:0046982)
0.2	19.8	GO:0005249	voltage-gated potassium channel activity(GO:0005249)
0.9	18.8	GO:0023026	MHC class II protein complex binding(GO:0023026)

Showing 1 to 10 of 104 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	24.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.5	19.5	PID BARD1 PATHWAY	BARD1 signaling events
0.1	17.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.9	13.8	PID S1P S1P4 PATHWAY	S1P4 pathway
0.2	13.1	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.2	12.3	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.5	9.9	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.6	8.0	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.2	7.1	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.4	6.0	PID CIRCADIAN PATHWAY	Circadian rhythm pathway

Showing 1 to 10 of 32 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	57.4	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
1.5	29.0	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
1.3	24.2	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.8	19.7	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	19.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
1.0	18.7	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.4	18.4	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.5	15.1	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
1.5	14.6	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.4	14.4	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane

Showing 1 to 10 of 46 entries

Results for Nkx2-2

Z-value: 0.90

Motif logo

Transcription factors associated with Nkx2-2

Activity-expression correlation:

Activity profile of Nkx2-2 motif

Sorted Z-values of Nkx2-2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: