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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nkx2-2

Z-value: 0.90

Motif logo

Transcription factors associated with Nkx2-2

Gene Symbol Gene ID Gene Info
ENSRNOG00000012728 NK2 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-2rn6_v1_chr3_-_141411170_1414111700.261.6e-06Click!

Activity profile of Nkx2-2 motif

Sorted Z-values of Nkx2-2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_28654733 33.32 ENSRNOT00000006174
pro-melanin-concentrating hormone
chrX_+_78372257 29.42 ENSRNOT00000046164
G protein-coupled receptor 174
chr1_-_104202591 27.71 ENSRNOT00000035512
E2F transcription factor 8
chr4_+_101882994 26.50 ENSRNOT00000087773

chr8_+_55603968 25.77 ENSRNOT00000066848
POU class 2 associating factor 1
chr1_+_192379543 24.16 ENSRNOT00000078705
protein kinase C, beta
chr14_-_43992587 23.56 ENSRNOT00000003425
ras homolog family member H
chr13_+_91954138 20.00 ENSRNOT00000074608
ENSRNOT00000037655
absent in melanoma 2
chr17_+_44763598 19.71 ENSRNOT00000079880
histone cluster 1, H3b
chr3_+_16413080 19.11 ENSRNOT00000040386
Ig kappa chain V19-17-like
chr1_-_227441442 18.78 ENSRNOT00000028433
membrane spanning 4-domains A1
chr9_-_92775816 17.67 ENSRNOT00000029635
similar to Nuclear autoantigen Sp-100 (Speckled 100 kDa)
chr6_-_137664133 17.40 ENSRNOT00000018613
G protein-coupled receptor 132
chr1_+_227670159 15.74 ENSRNOT00000072077
membrane-spanning 4-domains, subfamily A, member 6C
chr13_-_74520634 15.42 ENSRNOT00000077169
Ral GEF with PH domain and SH3 binding motif 2
chr4_+_145489869 14.65 ENSRNOT00000082618
Fanconi anemia, complementation group D2
chr17_-_85557939 14.40 ENSRNOT00000022375
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
chr11_+_85263536 14.04 ENSRNOT00000046465

chr7_-_104556419 13.94 ENSRNOT00000090784
family with sequence similarity 49, member B
chr4_-_28310178 13.23 ENSRNOT00000084021
similar to OEF2
chr14_+_44889287 12.69 ENSRNOT00000091312
ENSRNOT00000032273
transmembrane protein 156
chr8_-_132919110 12.35 ENSRNOT00000008747
X-C motif chemokine receptor 1
chr4_+_101639641 12.15 ENSRNOT00000058282

chr19_+_56220755 12.13 ENSRNOT00000023452
tubulin, beta 3 class III
chrX_+_78259409 11.90 ENSRNOT00000049779
similar to RIKEN cDNA A630033H20 gene
chr1_+_98398660 11.62 ENSRNOT00000047473
CD33 molecule
chr8_+_79054237 11.59 ENSRNOT00000077613
meiosis-specific nuclear structural 1
chr7_-_54778848 11.41 ENSRNOT00000005399
GLI pathogenesis-related 1
chr12_-_2826378 11.37 ENSRNOT00000061749
C-type lectin domain family 4 member M
chr14_+_88549947 10.71 ENSRNOT00000086177
heterogeneous nuclear ribonucleoprotein C
chr2_-_149444548 10.60 ENSRNOT00000018600
purinergic receptor P2Y12
chr9_-_101038625 10.54 ENSRNOT00000025743
programmed cell death 1
chr11_+_20474483 10.53 ENSRNOT00000082417
ENSRNOT00000002895
neural cell adhesion molecule 2
chr14_+_100135271 9.89 ENSRNOT00000032965
F-box protein 48
chr13_-_95348913 9.87 ENSRNOT00000057879
AKT serine/threonine kinase 3
chr10_-_90994437 9.80 ENSRNOT00000093167
glial fibrillary acidic protein
chr7_+_133856101 9.53 ENSRNOT00000038686
PDZ domain containing RING finger 4
chr20_-_14620019 9.49 ENSRNOT00000001779
G protein subunit alpha z
chr15_+_31642169 9.45 ENSRNOT00000072362

chrX_-_138435391 9.43 ENSRNOT00000043258
muscleblind-like splicing regulator 3
chr9_-_27761733 9.30 ENSRNOT00000040034
potassium voltage-gated channel subfamily Q member 5
chr7_+_126736732 9.19 ENSRNOT00000022012
G-2 and S-phase expressed 1
chr9_-_27761365 9.09 ENSRNOT00000018552
potassium voltage-gated channel subfamily Q member 5
chr2_+_34312766 8.98 ENSRNOT00000060962
centromere protein K
chr6_+_8669722 8.87 ENSRNOT00000048550
calmodulin-lysine N-methyltransferase
chr1_-_198476476 8.68 ENSRNOT00000027525
kinesin family member 22
chr4_-_135069970 8.66 ENSRNOT00000008221
contactin 3
chr13_-_91981432 8.57 ENSRNOT00000004637

chr4_+_146276862 8.37 ENSRNOT00000009705
solute carrier family 6 member 1
chr9_-_61418679 8.36 ENSRNOT00000078800
ankyrin repeat domain 44
chr15_+_4850122 7.89 ENSRNOT00000071133
G protein subunit gamma 2
chr17_-_42422053 7.77 ENSRNOT00000048298
family with sequence similarity 65, member B
chr3_+_19174027 7.75 ENSRNOT00000074445

chr1_+_173252058 7.58 ENSRNOT00000073421
similar to very large inducible GTPase 1 isoform A
chr7_-_142063212 7.53 ENSRNOT00000089912
solute carrier family 11 member 2
chr4_-_180234804 7.43 ENSRNOT00000070957
basic helix-loop-helix family, member e41
chr19_-_9843673 7.17 ENSRNOT00000015795
GINS complex subunit 3
chr20_-_22459025 7.07 ENSRNOT00000000792
early growth response 2
chr5_+_122019301 7.07 ENSRNOT00000068158
phosphodiesterase 4B
chr4_-_164304532 6.87 ENSRNOT00000089484
Ly49 inhibitory receptor 5
chr5_+_173542358 6.82 ENSRNOT00000027347
similar to RIKEN cDNA 9430015G10
chr5_+_169288871 6.69 ENSRNOT00000055466
TNF receptor superfamily member 25
chr1_+_101249522 6.68 ENSRNOT00000033882
solute carrier family 6, member 16
chr9_-_101319845 6.61 ENSRNOT00000074915
programmed cell death 1
chr3_+_172550258 6.56 ENSRNOT00000075148
tubulin, beta 1 class VI
chr16_+_10417185 6.56 ENSRNOT00000082186
annexin A8
chr1_-_82004538 6.45 ENSRNOT00000087572
POU class 2 homeobox 2
chr10_-_85825735 6.39 ENSRNOT00000055379
F-box protein 47
chr5_+_122100099 6.17 ENSRNOT00000007738
phosphodiesterase 4B
chr2_-_91497091 6.13 ENSRNOT00000015185
proprotein convertase subtilisin/kexin type 1
chr12_-_51965779 6.10 ENSRNOT00000056733
replication protein A3-like
chr10_+_72147816 5.96 ENSRNOT00000090085
SUMO-conjugating enzyme UBC9-like
chrX_+_71335491 5.96 ENSRNOT00000076003
non-POU domain containing, octamer-binding
chr1_+_16478127 5.88 ENSRNOT00000019076
Abelson helper integration site 1
chrX_+_14019961 5.72 ENSRNOT00000004785
synaptotagmin-like 5
chr6_-_140715174 5.55 ENSRNOT00000085345

chr10_-_66848388 5.54 ENSRNOT00000018891
oligodendrocyte-myelin glycoprotein
chr7_-_104800536 5.51 ENSRNOT00000085650
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr16_-_32439421 5.49 ENSRNOT00000043100
NIMA-related kinase 1
chr2_+_4989295 5.48 ENSRNOT00000041541
family with sequence similarity 172, member A
chr9_+_91001828 5.44 ENSRNOT00000080956

chr8_-_21492801 5.43 ENSRNOT00000077465
zinc finger protein 426
chr9_+_92681078 5.43 ENSRNOT00000034152
SP100 nuclear antigen
chr4_+_119842013 5.43 ENSRNOT00000057286
5-hydroxymethylcytosine (hmC) binding, ES cell-specific
chr2_+_143895982 5.32 ENSRNOT00000080026
SPT20 homolog, SAGA complex component
chr3_+_48626038 5.29 ENSRNOT00000009697
grancalcin
chr3_-_26056818 5.28 ENSRNOT00000044209
LDL receptor related protein 1B
chr9_+_4421069 5.27 ENSRNOT00000065721
shugoshin 1
chr2_-_39007976 5.20 ENSRNOT00000064292
zinc finger, SWIM-type containing 6
chr2_-_88414012 5.17 ENSRNOT00000014762
leucine rich repeat and coiled-coil centrosomal protein 1
chr1_-_201942344 5.15 ENSRNOT00000027956
similar to RIKEN cDNA 2310057M21
chr18_-_86279680 5.12 ENSRNOT00000006169
hypothetical protein LOC689166
chr13_-_89874008 5.05 ENSRNOT00000051368
prothymosin alpha
chr11_+_47146308 5.03 ENSRNOT00000002191
centrosomal protein 97
chr3_+_11554457 5.00 ENSRNOT00000073087
family with sequence similarity 102, member A
chr3_+_112950890 4.95 ENSRNOT00000015472
cyclin D1 binding protein 1
chr5_-_62187930 4.93 ENSRNOT00000011787
coronin 2A
chr18_+_3163214 4.87 ENSRNOT00000017291
RB binding protein 8, endonuclease
chr8_-_2045817 4.87 ENSRNOT00000009542
ENSRNOT00000081171
ENSRNOT00000078765
glutamate ionotropic receptor AMPA type subunit 4
chr8_-_55276070 4.70 ENSRNOT00000041555
60S ribosomal protein L27a-like
chr1_-_20962526 4.70 ENSRNOT00000061332
ENSRNOT00000017322
ENSRNOT00000017412
ENSRNOT00000079688
ENSRNOT00000017417
erythrocyte membrane protein band 4.1-like 2
chr2_-_165591110 4.64 ENSRNOT00000091140
intraflagellar transport 80
chr9_-_46309451 4.64 ENSRNOT00000018684
ring finger protein 149
chr3_+_47677720 4.54 ENSRNOT00000065340
T-box, brain, 1
chr16_-_64778486 4.53 ENSRNOT00000031701
ring finger protein 122
chr1_-_211956858 4.47 ENSRNOT00000054886
cilia and flagella associated protein 46
chr5_-_155709215 4.35 ENSRNOT00000018118
cell division cycle 42
chr8_-_96985558 4.33 ENSRNOT00000018553
similar to UPF0258 protein KIAA1024
chr18_-_1828606 4.31 ENSRNOT00000033312
establishment of sister chromatid cohesion N-acetyltransferase 1
chr3_-_61494778 4.31 ENSRNOT00000068018
lunapark, ER junction formation factor
chrX_-_113228265 4.28 ENSRNOT00000060001
similar to 40S ribosomal protein S9
chr5_-_9094616 4.28 ENSRNOT00000072210
serum/glucocorticoid regulated kinase family, member 3
chr9_-_80295446 4.28 ENSRNOT00000023769
transition protein 1
chr4_-_119591817 4.24 ENSRNOT00000048768

chr13_-_26769374 4.18 ENSRNOT00000003768
BCL2, apoptosis regulator
chr19_+_26022849 4.18 ENSRNOT00000014887
deoxyribonuclease 2, lysosomal
chr5_-_19559244 4.14 ENSRNOT00000014289
ENSRNOT00000089666
neutral sphingomyelinase activation associated factor
chr2_-_184263564 4.12 ENSRNOT00000015279
F-box and WD repeat domain containing 7
chr10_-_103340922 4.07 ENSRNOT00000004191
BTB domain containing 17
chr8_+_36766977 4.03 ENSRNOT00000017648
pseudouridylate synthase 3
chr3_+_160467552 3.99 ENSRNOT00000066657
serine/threonine kinase 4
chr14_+_81858737 3.89 ENSRNOT00000029784
ENSRNOT00000058068
ENSRNOT00000058067
DNA polymerase nu
chr14_-_44225713 3.88 ENSRNOT00000049161
similar to ribosomal protein L14
chr2_-_207350812 3.87 ENSRNOT00000056015
capping actin protein of muscle Z-line alpha subunit 1
chr8_+_99636749 3.84 ENSRNOT00000086524
phospholipid scramblase 1
chrX_-_15504165 3.83 ENSRNOT00000006233
OTU deubiquitinase 5
chr2_+_92559929 3.80 ENSRNOT00000033404
GTPase activating protein testicular GAP1
chr17_-_27452314 3.75 ENSRNOT00000018936
RIO kinase 1
chr2_+_243422811 3.75 ENSRNOT00000014694
tRNA methyltransferase 10A
chr11_+_64472072 3.75 ENSRNOT00000042756
similar to ribosomal protein L27
chr18_+_86116044 3.74 ENSRNOT00000058160
ENSRNOT00000076159
rotatin
chr17_-_42226377 3.69 ENSRNOT00000024536
similar to mKIAA0319 protein
chr18_-_6782757 3.68 ENSRNOT00000068150
aquaporin 4
chr5_+_144031402 3.63 ENSRNOT00000011694
colony stimulating factor 3 receptor
chr4_-_98593664 3.59 ENSRNOT00000007927
ribose 5-phosphate isomerase A
chr1_-_169534896 3.58 ENSRNOT00000082645
tripartite motif-containing 30C
chr1_+_228690119 3.57 ENSRNOT00000087169
pore forming protein-like
chr15_+_80040842 3.49 ENSRNOT00000043065
similar to RIKEN cDNA 4921530L21
chr2_+_43271092 3.49 ENSRNOT00000017571
mesoderm induction early response 1, family member 3
chr10_-_110701137 3.46 ENSRNOT00000074193
zinc finger protein 750
chr1_+_93242050 3.46 ENSRNOT00000013741
similar to 60S ribosomal protein L27a
chr1_+_266781617 3.46 ENSRNOT00000027417
internexin neuronal intermediate filament protein, alpha
chr17_+_16242365 3.43 ENSRNOT00000022669
PHD finger protein 2
chr18_-_57515834 3.42 ENSRNOT00000026098
adrenoceptor beta 2
chr18_-_74151950 3.40 ENSRNOT00000023101
HAUS augmin-like complex, subunit 1
chr4_+_110699557 3.38 ENSRNOT00000030588
ENSRNOT00000092261
leucine rich repeat transmembrane neuronal 4
chr3_-_105470475 3.35 ENSRNOT00000011078
gap junction protein, delta 2
chr11_+_74984613 3.35 ENSRNOT00000035049
ATPase 13A5
chr20_-_6195463 3.31 ENSRNOT00000092474
peroxisomal, testis specific 1
chr1_-_233140237 3.26 ENSRNOT00000083372
phosphoserine aminotransferase 1
chr4_-_129430251 3.25 ENSRNOT00000067881
family with sequence similarity 19 member A4, C-C motif chemokine like
chr2_-_43067956 3.20 ENSRNOT00000090616
GC-rich promoter binding protein 1
chr4_-_28437676 3.18 ENSRNOT00000012995
HEPACAM family member 2
chr16_-_54137660 3.16 ENSRNOT00000085435
pericentriolar material 1
chr11_-_46693565 3.16 ENSRNOT00000044900
interphotoreceptor matrix proteoglycan 2
chr10_-_56429748 3.11 ENSRNOT00000020675
ENSRNOT00000092704
spermatid maturation 1
chrY_-_1238420 3.07 ENSRNOT00000092078
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3
chr2_-_128675408 3.06 ENSRNOT00000019256
sodium channel and clathrin linker 1
chr1_+_212578450 3.05 ENSRNOT00000064501
polyamine oxidase
chr1_-_98570949 3.04 ENSRNOT00000033648
sialic acid binding Ig-like lectin 5
chr2_-_144808245 3.04 ENSRNOT00000087849
uncharacterized LOC102552324
chr3_+_149466770 3.02 ENSRNOT00000065104
BPI fold containing family A, member 6
chr9_+_94928489 3.00 ENSRNOT00000087366
ENSRNOT00000085770
ENSRNOT00000024733
S-antigen visual arrestin
chr14_+_33247274 2.97 ENSRNOT00000075226
serine peptidase inhibitor, Kazal type 2
chr18_-_6782996 2.87 ENSRNOT00000090320
aquaporin 4
chr1_-_44615760 2.87 ENSRNOT00000022148
NADPH oxidase 3
chr2_-_244335165 2.85 ENSRNOT00000084860
Rap1 GTPase-GDP dissociation stimulator 1
chr5_+_173340060 2.83 ENSRNOT00000067841
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr12_-_21450204 2.82 ENSRNOT00000065866
zinc finger CW-type PWWP domain protein 1-like
chr16_-_54137485 2.81 ENSRNOT00000014202
pericentriolar material 1
chr2_-_250923744 2.73 ENSRNOT00000084996
chloride channel accessory 1
chr13_+_90116843 2.71 ENSRNOT00000006306
Cd48 molecule
chr14_-_44375804 2.71 ENSRNOT00000042825
ribosomal protein P2-like
chrX_+_6273733 2.69 ENSRNOT00000074275
NDP, norrin cystine knot growth factor
chr7_+_42304534 2.66 ENSRNOT00000085097
KIT ligand
chr4_-_120041238 2.65 ENSRNOT00000073799
40S ribosomal protein S25-like
chr1_-_245514252 2.64 ENSRNOT00000033724
pumilio RNA-binding family member 3
chr18_+_30023828 2.64 ENSRNOT00000079008
protocadherin alpha 4
chr3_-_133232322 2.63 ENSRNOT00000034487
ESF1 nucleolar pre-rRNA processing protein homolog
chr8_+_117126692 2.59 ENSRNOT00000083046
ENSRNOT00000085609
ubiquitin specific peptidase 4
chr15_-_29922522 2.59 ENSRNOT00000081778

chr7_+_27620458 2.57 ENSRNOT00000059532
similar to FLJ25323 protein
chr2_+_71753816 2.57 ENSRNOT00000025809

chr8_-_6034142 2.52 ENSRNOT00000014560
baculoviral IAP repeat-containing 2
chr3_+_81134505 2.50 ENSRNOT00000067664
PHD finger protein 21A
chr14_+_88543630 2.35 ENSRNOT00000060515
heterogeneous nuclear ribonucleoprotein C
chr8_-_114766803 2.33 ENSRNOT00000047563
collagen, type VI, alpha 4
chr1_+_101410019 2.27 ENSRNOT00000042039
luteinizing hormone beta polypeptide
chr1_+_102924059 2.26 ENSRNOT00000078137

chr6_-_98666007 2.24 ENSRNOT00000082695

chr1_-_262013619 2.22 ENSRNOT00000021278
HPS1, biogenesis of lysosomal organelles complex 3 subunit 1
chr10_-_90501819 2.22 ENSRNOT00000050474
G patch domain containing 8
chrX_-_135419704 2.21 ENSRNOT00000044435
zinc finger protein 280C
chr10_+_14062331 2.16 ENSRNOT00000029652
NADPH oxidase organizer 1
chr20_-_4390436 2.14 ENSRNOT00000000497
ENSRNOT00000077655
palmitoyl-protein thioesterase 2
chr7_+_27089278 2.14 ENSRNOT00000082398
nuclear transcription factor Y subunit beta
chr3_-_3691972 2.13 ENSRNOT00000061735
quiescin sulfhydryl oxidase 2
chr1_+_193844538 2.13 ENSRNOT00000065311

chr4_-_142970245 2.09 ENSRNOT00000067815

chrX_+_22313028 2.06 ENSRNOT00000082725
lysine demethylase 5C

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.1 24.2 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
6.7 33.3 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
4.6 13.9 GO:2000567 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
4.6 27.7 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
3.9 15.4 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
3.5 10.6 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
3.5 10.5 GO:0002644 negative regulation of tolerance induction(GO:0002644)
2.9 20.0 GO:0070269 pyroptosis(GO:0070269)
2.5 7.5 GO:0035444 nickel cation transport(GO:0015675) vanadium ion transport(GO:0015676) lead ion transport(GO:0015692) nickel cation transmembrane transport(GO:0035444)
2.4 7.1 GO:0021569 rhombomere 3 development(GO:0021569)
2.2 13.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
2.2 13.1 GO:0090367 negative regulation of mRNA modification(GO:0090367)
2.1 6.4 GO:0002380 immunoglobulin secretion involved in immune response(GO:0002380)
2.1 14.6 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
2.0 9.8 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
1.8 5.4 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
1.7 13.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.6 6.6 GO:0060354 negative regulation of cell adhesion molecule production(GO:0060354)
1.5 6.1 GO:0010157 response to chlorate(GO:0010157)
1.5 5.9 GO:0039020 pronephric nephron tubule development(GO:0039020)
1.5 4.4 GO:0060661 submandibular salivary gland formation(GO:0060661) positive regulation of hair follicle cell proliferation(GO:0071338)
1.4 4.2 GO:0006808 regulation of nitrogen utilization(GO:0006808) nitrogen utilization(GO:0019740) negative regulation of retinal cell programmed cell death(GO:0046671)
1.4 5.5 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
1.4 4.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
1.3 3.8 GO:1905077 regulation of interleukin-17 secretion(GO:1905076) negative regulation of interleukin-17 secretion(GO:1905077)
1.1 3.4 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
1.1 3.4 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025) diaphragm contraction(GO:0002086)
1.1 4.3 GO:0034421 post-translational protein acetylation(GO:0034421)
1.0 11.4 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
1.0 4.0 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
1.0 4.0 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
1.0 11.6 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.9 6.6 GO:0032429 regulation of phospholipase A2 activity(GO:0032429)
0.9 3.6 GO:0006014 D-ribose metabolic process(GO:0006014)
0.9 5.3 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.9 6.0 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.8 2.5 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.8 8.4 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
0.8 4.9 GO:0071684 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.7 11.6 GO:0070986 left/right axis specification(GO:0070986)
0.7 7.4 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.7 2.7 GO:0033026 negative regulation of mast cell apoptotic process(GO:0033026) mast cell proliferation(GO:0070662) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.7 6.0 GO:1903376 neuron intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0036480) regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903376) negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.7 3.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.6 4.3 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.6 4.3 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.6 3.1 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.6 4.5 GO:0001661 conditioned taste aversion(GO:0001661)
0.5 3.8 GO:2000371 phosphatidylserine exposure on apoptotic cell surface(GO:0070782) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.5 29.4 GO:0043029 T cell homeostasis(GO:0043029)
0.5 4.6 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.5 11.2 GO:0045793 positive regulation of cell size(GO:0045793)
0.4 2.7 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.4 1.8 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.4 5.3 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.4 2.9 GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration(GO:0032471)
0.4 5.0 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.4 17.4 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.4 2.6 GO:0010835 regulation of protein ADP-ribosylation(GO:0010835)
0.4 3.8 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.4 11.9 GO:0051482 positive regulation of Rho protein signal transduction(GO:0035025) positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.4 2.9 GO:0048840 otolith development(GO:0048840)
0.4 1.1 GO:0042245 RNA repair(GO:0042245)
0.3 3.5 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.3 1.0 GO:1990167 protein K27-linked deubiquitination(GO:1990167)
0.3 3.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.3 1.7 GO:0043418 homocysteine catabolic process(GO:0043418)
0.3 26.7 GO:0045576 mast cell activation(GO:0045576)
0.3 9.4 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.3 5.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.3 4.2 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.3 1.5 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.3 2.6 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.3 2.2 GO:1903232 melanosome assembly(GO:1903232)
0.3 3.0 GO:0002176 male germ cell proliferation(GO:0002176)
0.3 5.0 GO:0043486 histone exchange(GO:0043486)
0.3 3.4 GO:0097113 AMPA glutamate receptor clustering(GO:0097113)
0.3 1.3 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.2 0.5 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.2 4.9 GO:0060992 response to fungicide(GO:0060992)
0.2 6.5 GO:0007413 axonal fasciculation(GO:0007413)
0.2 3.9 GO:0036297 interstrand cross-link repair(GO:0036297)
0.2 4.3 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.2 1.5 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.2 2.1 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.2 12.3 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.2 2.5 GO:0001967 suckling behavior(GO:0001967)
0.2 0.5 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.2 5.5 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.2 2.0 GO:0008343 adult feeding behavior(GO:0008343)
0.2 8.7 GO:0007062 sister chromatid cohesion(GO:0007062)
0.2 1.9 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.2 9.5 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.1 3.9 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.1 1.0 GO:0043615 astrocyte cell migration(GO:0043615)
0.1 0.4 GO:0060988 lipid tube assembly(GO:0060988)
0.1 6.0 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.4 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.1 4.7 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 0.4 GO:1903925 response to bisphenol A(GO:1903925)
0.1 2.3 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 3.7 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.1 5.2 GO:2001222 regulation of neuron migration(GO:2001222)
0.1 2.9 GO:0097186 amelogenesis(GO:0097186)
0.1 5.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 6.7 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1 2.3 GO:0030823 regulation of cGMP metabolic process(GO:0030823)
0.1 3.3 GO:0051930 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.1 19.8 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 1.1 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 8.9 GO:0018022 peptidyl-lysine methylation(GO:0018022)
0.1 3.2 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 2.1 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.1 1.2 GO:0042772 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.1 4.6 GO:0035690 cellular response to drug(GO:0035690)
0.1 1.0 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 2.2 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.1 1.2 GO:0007567 parturition(GO:0007567)
0.1 1.3 GO:0030488 tRNA methylation(GO:0030488)
0.0 1.6 GO:0097502 mannosylation(GO:0097502)
0.0 0.8 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.8 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) peptidyl-arginine modification(GO:0018195) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 4.3 GO:0016579 protein deubiquitination(GO:0016579)
0.0 3.1 GO:0030317 sperm motility(GO:0030317)
0.0 0.2 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 1.8 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 5.1 GO:0007411 axon guidance(GO:0007411)
0.0 0.2 GO:0032264 IMP salvage(GO:0032264)
0.0 0.9 GO:0000060 protein import into nucleus, translocation(GO:0000060)
0.0 1.5 GO:0008033 tRNA processing(GO:0008033)
0.0 0.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 2.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.8 GO:0030490 maturation of SSU-rRNA(GO:0030490)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 13.1 GO:1990826 nucleoplasmic periphery of the nuclear pore complex(GO:1990826)
4.0 20.0 GO:0097169 AIM2 inflammasome complex(GO:0097169)
2.5 7.5 GO:0070826 paraferritin complex(GO:0070826)
2.5 9.8 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
1.1 3.2 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.9 6.0 GO:0042382 paraspeckles(GO:0042382)
0.8 4.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.8 4.9 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.8 5.4 GO:0030870 Mre11 complex(GO:0030870)
0.8 5.4 GO:0000322 storage vacuole(GO:0000322)
0.7 13.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.6 3.9 GO:0071203 WASH complex(GO:0071203)
0.6 23.6 GO:0001772 immunological synapse(GO:0001772)
0.5 5.0 GO:0043020 NADPH oxidase complex(GO:0043020)
0.5 11.5 GO:0000242 pericentriolar material(GO:0000242)
0.4 2.2 GO:0031085 BLOC-3 complex(GO:0031085)
0.4 5.3 GO:0000124 SAGA complex(GO:0000124)
0.4 3.5 GO:0005883 neurofilament(GO:0005883)
0.4 15.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 3.8 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.3 3.4 GO:0070652 HAUS complex(GO:0070652)
0.3 19.5 GO:0030118 clathrin coat(GO:0030118)
0.3 17.2 GO:0009925 basal plasma membrane(GO:0009925)
0.3 1.6 GO:0031501 mannosyltransferase complex(GO:0031501)
0.3 25.5 GO:0031526 brush border membrane(GO:0031526)
0.3 2.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.3 11.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 1.5 GO:0030677 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.2 1.5 GO:0097443 sorting endosome(GO:0097443)
0.2 24.0 GO:0000786 nucleosome(GO:0000786)
0.2 2.5 GO:0035631 CD40 receptor complex(GO:0035631)
0.2 22.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 5.3 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.2 4.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.2 3.4 GO:0005922 connexon complex(GO:0005922)
0.2 3.1 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 2.3 GO:0036038 MKS complex(GO:0036038)
0.1 13.3 GO:0005776 autophagosome(GO:0005776)
0.1 2.6 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 43.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 9.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.8 GO:0035371 microtubule plus-end(GO:0035371)
0.1 5.5 GO:0002102 podosome(GO:0002102)
0.1 0.4 GO:0044317 rod spherule(GO:0044317)
0.1 12.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 8.7 GO:0072686 mitotic spindle(GO:0072686)
0.1 5.2 GO:0032420 stereocilium(GO:0032420)
0.1 11.6 GO:0036126 sperm flagellum(GO:0036126)
0.1 3.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.8 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 4.9 GO:0005903 brush border(GO:0005903)
0.1 3.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 22.5 GO:0005667 transcription factor complex(GO:0005667)
0.1 2.5 GO:1990391 DNA repair complex(GO:1990391)
0.1 3.4 GO:0000776 kinetochore(GO:0000776)
0.1 4.6 GO:0031901 early endosome membrane(GO:0031901)
0.1 10.6 GO:0000793 condensed chromosome(GO:0000793)
0.1 1.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 14.2 GO:0005874 microtubule(GO:0005874)
0.1 0.5 GO:0043196 varicosity(GO:0043196)
0.1 1.3 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 3.7 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.7 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.2 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 7.2 GO:0005769 early endosome(GO:0005769)
0.0 6.5 GO:0043204 perikaryon(GO:0043204)
0.0 2.7 GO:0030175 filopodium(GO:0030175)
0.0 0.5 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.8 GO:0031201 SNARE complex(GO:0031201)
0.0 4.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 5.7 GO:0070382 exocytic vesicle(GO:0070382)
0.0 1.9 GO:0005884 actin filament(GO:0005884)
0.0 3.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.8 GO:0030686 90S preribosome(GO:0030686)
0.0 2.4 GO:0005819 spindle(GO:0005819)
0.0 1.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.5 GO:0008180 COP9 signalosome(GO:0008180)
0.0 6.0 GO:0030424 axon(GO:0030424)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.1 24.2 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
4.8 14.4 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
4.6 13.9 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
2.5 7.5 GO:0015099 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) nickel cation transmembrane transporter activity(GO:0015099) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639) chromium ion transmembrane transporter activity(GO:0070835)
1.6 13.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
1.6 26.0 GO:0045125 bioactive lipid receptor activity(GO:0045125)
1.5 10.6 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
1.5 4.4 GO:0032427 GBD domain binding(GO:0032427)
1.4 8.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
1.4 4.1 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
1.4 9.5 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
1.2 3.6 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
1.1 3.4 GO:0031711 beta-adrenergic receptor activity(GO:0004939) bradykinin receptor binding(GO:0031711)
1.1 7.4 GO:0043426 MRF binding(GO:0043426)
1.0 3.1 GO:0046592 polyamine oxidase activity(GO:0046592)
1.0 7.9 GO:0031681 G-protein beta-subunit binding(GO:0031681)
1.0 4.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.9 4.7 GO:0042731 PH domain binding(GO:0042731)
0.9 18.8 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.9 14.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.9 33.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.8 4.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.8 3.0 GO:0002046 opsin binding(GO:0002046)
0.8 3.8 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.7 2.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.7 4.2 GO:0051434 BH3 domain binding(GO:0051434)
0.7 6.1 GO:0043559 insulin binding(GO:0043559)
0.7 5.4 GO:0070087 chromo shadow domain binding(GO:0070087)
0.6 2.6 GO:0031685 adenosine receptor binding(GO:0031685)
0.6 3.8 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.6 11.4 GO:0001618 virus receptor activity(GO:0001618) mannose binding(GO:0005537)
0.5 25.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.5 6.6 GO:0015250 water channel activity(GO:0015250)
0.5 12.3 GO:0004950 chemokine receptor activity(GO:0004950)
0.4 4.9 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.4 7.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.4 2.7 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.4 3.6 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.3 1.7 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.3 3.8 GO:0042609 CD4 receptor binding(GO:0042609)
0.3 1.3 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.3 6.7 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.3 2.9 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.3 6.0 GO:0019789 SUMO transferase activity(GO:0019789)
0.3 7.1 GO:0071837 HMG box domain binding(GO:0071837)
0.3 4.6 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.3 6.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 4.2 GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.3 1.4 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-dependent protein binding(GO:0032767) copper-transporting ATPase activity(GO:0043682)
0.3 2.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.3 1.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.3 3.9 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.2 25.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 2.1 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.2 4.3 GO:0017081 chloride channel regulator activity(GO:0017081)
0.2 5.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 21.5 GO:0019210 kinase inhibitor activity(GO:0019210)
0.2 27.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 5.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2 3.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.2 19.8 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.2 1.8 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.2 1.5 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 8.9 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.1 2.7 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 3.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 7.0 GO:0005080 protein kinase C binding(GO:0005080)
0.1 8.6 GO:0030276 clathrin binding(GO:0030276)
0.1 4.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 2.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 0.4 GO:1903924 estradiol binding(GO:1903924)
0.1 5.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 6.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 1.6 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 3.5 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.1 2.7 GO:0005109 frizzled binding(GO:0005109)
0.1 8.8 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 1.9 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 5.3 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.0 4.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 2.7 GO:0003823 antigen binding(GO:0003823)
0.0 0.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 3.1 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 21.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 1.7 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.4 GO:0019864 IgG binding(GO:0019864)
0.0 0.2 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)
0.0 0.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.5 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 2.0 GO:0019843 rRNA binding(GO:0019843)
0.0 4.6 GO:0051015 actin filament binding(GO:0051015)
0.0 1.5 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.2 GO:0003684 p53 binding(GO:0002039) damaged DNA binding(GO:0003684)
0.0 0.5 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 7.1 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 2.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 18.5 GO:0003677 DNA binding(GO:0003677)
0.0 0.5 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 3.6 GO:0004674 protein serine/threonine kinase activity(GO:0004674)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 24.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.9 13.8 PID S1P S1P4 PATHWAY S1P4 pathway
0.6 8.0 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.5 5.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5 9.9 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.5 19.5 PID BARD1 PATHWAY BARD1 signaling events
0.4 4.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.4 6.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.2 5.5 PID ARF 3PATHWAY Arf1 pathway
0.2 12.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 7.1 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.2 13.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 2.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 4.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 3.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.0 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 17.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 5.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 5.5 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 3.4 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 3.4 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 2.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 1.9 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 4.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.2 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 2.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.4 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.5 PID FGF PATHWAY FGF signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 29.0 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
1.5 14.6 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
1.3 24.2 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
1.2 9.9 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
1.0 18.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.9 10.6 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.8 19.7 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.7 10.5 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.7 8.4 REACTOME PEPTIDE HORMONE BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.5 6.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.5 15.1 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.4 13.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.4 14.4 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.4 9.0 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 8.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.4 18.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.4 57.4 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.3 3.9 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.3 8.7 REACTOME KINESINS Genes involved in Kinesins
0.3 7.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.3 4.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.2 4.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 2.7 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.2 4.4 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.2 4.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 2.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 3.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 9.8 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 3.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.2 7.4 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 4.9 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.2 5.5 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 19.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.1 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 11.4 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 3.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 5.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 3.3 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 6.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 2.5 REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.1 1.6 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 8.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.8 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 2.7 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage