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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nkx2-1

Z-value: 0.38

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Transcription factors associated with Nkx2-1

Gene Symbol Gene ID Gene Info
Nkx2-1
ENSRNOG00000008644 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-1rn6_v1_chr6_-_77421286_774212860.211.8e-04Click!

Activity profile of Nkx2-1 motif

Sorted Z-values of Nkx2-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_100166863 12.44 ENSRNOT00000014505
Sftpb
surfactant protein B
chr10_+_11240138 11.91 ENSRNOT00000048687
Srl
sarcalumenin
chr11_+_66713888 8.81 ENSRNOT00000003340
Fbxo40
F-box protein 40
chr10_+_40247436 7.95 ENSRNOT00000079830
Gpx3
glutathione peroxidase 3
chr13_-_82005741 6.91 ENSRNOT00000076404
Mettl11b
methyltransferase like 11B
chr1_+_33910912 5.15 ENSRNOT00000044690
Irx1
iroquois homeobox 1
chr5_-_22769907 4.66 ENSRNOT00000047805
ENSRNOT00000076167
ENSRNOT00000076507
ENSRNOT00000076113
ENSRNOT00000083779
Asph
aspartate-beta-hydroxylase
chr2_+_202200797 4.11 ENSRNOT00000042263
ENSRNOT00000071938
Spag17
sperm associated antigen 17
chr12_+_41486076 3.52 ENSRNOT00000057242
Rita1
RBPJ interacting and tubulin associated 1
chr5_+_2353468 3.52 ENSRNOT00000090346
Stau2
staufen double-stranded RNA binding protein 2
chr1_-_207811008 3.38 ENSRNOT00000080506
Clrn3
clarin 3
chr3_-_168018410 3.11 ENSRNOT00000087579
Bcas1
breast carcinoma amplified sequence 1
chr1_+_222519615 2.92 ENSRNOT00000083585
Rcor2
REST corepressor 2
chr1_-_207766250 2.53 ENSRNOT00000031397
Clrn3
clarin 3
chr1_-_141470380 2.33 ENSRNOT00000065759
Plin1
perilipin 1
chr2_-_193101051 2.27 ENSRNOT00000065242
AABR07012318.1

chr2_-_193063357 2.19 ENSRNOT00000072995
AABR07012317.2

chr16_+_86631064 2.00 ENSRNOT00000019675
Efnb2
ephrin B2
chr10_-_62664466 1.99 ENSRNOT00000078730
Git1
GIT ArfGAP 1
chr10_+_89069256 1.96 ENSRNOT00000008576
Tubg2
tubulin, gamma 2
chr1_+_86949413 1.81 ENSRNOT00000064153
Sirt2
sirtuin 2
chr10_+_16635989 1.63 ENSRNOT00000028155
Nkx2-5
NK2 homeobox 5
chr2_-_250232295 1.49 ENSRNOT00000082132
Lmo4
LIM domain only 4
chr6_-_98666007 1.35 ENSRNOT00000082695
AABR07064867.1

chr4_-_145454834 1.24 ENSRNOT00000013154
ENSRNOT00000056493
Prrt3
proline-rich transmembrane protein 3
chr18_+_30172740 1.21 ENSRNOT00000027340
Pcdha4
protocadherin alpha 4
chr1_+_243589607 1.13 ENSRNOT00000021792
Dmrt3
doublesex and mab-3 related transcription factor 3
chr10_-_90393317 1.12 ENSRNOT00000028563
Fam171a2
family with sequence similarity 171, member A2
chrX_+_136460215 1.10 ENSRNOT00000093538
Arhgap36
Rho GTPase activating protein 36
chr2_+_188844073 1.06 ENSRNOT00000028117
Kcnn3
potassium calcium-activated channel subfamily N member 3
chr2_-_188553289 0.95 ENSRNOT00000088822
Trim46
tripartite motif-containing 46
chr4_-_165787668 0.83 ENSRNOT00000044029
Tas2r106
taste receptor, type 2, member 106
chr17_-_43640387 0.71 ENSRNOT00000087731
Hist1h1c
histone cluster 1 H1 family member c
chr6_+_128973956 0.71 ENSRNOT00000075399
Fam181a
family with sequence similarity 181, member A
chr6_+_101924000 0.70 ENSRNOT00000092157
Mpp5
membrane palmitoylated protein 5
chr11_-_78456200 0.64 ENSRNOT00000067251
ENSRNOT00000036179
Tp63
tumor protein p63
chr5_-_145423172 0.60 ENSRNOT00000081919
Gjb5
gap junction protein, beta 5
chr7_+_28654733 0.54 ENSRNOT00000006174
Pmch
pro-melanin-concentrating hormone
chr7_+_107467260 0.48 ENSRNOT00000009240
ENSRNOT00000077382
Tg
thyroglobulin
chr6_+_101923785 0.44 ENSRNOT00000012005
Mpp5
membrane palmitoylated protein 5
chr1_-_40921508 0.43 ENSRNOT00000026433
Zbtb2
zinc finger and BTB domain containing 2
chr10_-_90096096 0.43 ENSRNOT00000081539
Tmem101
transmembrane protein 101
chr20_-_4391402 0.41 ENSRNOT00000090518
ENSRNOT00000083489
Ppt2
palmitoyl-protein thioesterase 2
chr11_-_78456501 0.40 ENSRNOT00000036193
Tp63
tumor protein p63
chr7_+_116745061 0.37 ENSRNOT00000076174
Rhpn1
rhophilin, Rho GTPase binding protein 1
chr1_-_170694872 0.37 ENSRNOT00000075443
LOC100911839
olfactory receptor 2D3-like
chr1_-_227441442 0.37 ENSRNOT00000028433
Ms4a1
membrane spanning 4-domains A1
chr7_+_16304954 0.36 ENSRNOT00000050751
Olr927
olfactory receptor 927
chr5_-_127273656 0.36 ENSRNOT00000057341
Dmrtb1
DMRT-like family B with proline-rich C-terminal, 1
chrX_+_86126157 0.31 ENSRNOT00000006992
Klhl4
kelch-like family member 4
chr7_-_69982592 0.31 ENSRNOT00000040010
RGD1564306
similar to developmental pluripotency associated 5
chr18_-_75207306 0.30 ENSRNOT00000021717
Setbp1
SET binding protein 1
chr6_+_27241919 0.28 ENSRNOT00000013123
Cib4
calcium and integrin binding family member 4
chr1_-_255976425 0.25 ENSRNOT00000085303
Ide
insulin degrading enzyme
chr13_+_47935163 0.20 ENSRNOT00000006768
Eif2d
eukaryotic translation initiation factor 2D
chr9_+_10061978 0.19 ENSRNOT00000075180
Acer1
alkaline ceramidase 1
chr1_-_233140237 0.17 ENSRNOT00000083372
Psat1
phosphoserine aminotransferase 1
chr6_+_115170865 0.16 ENSRNOT00000005671
Tshr
thyroid stimulating hormone receptor
chr4_-_71080499 0.14 ENSRNOT00000074623
RGD1562066
similar to odorant receptor ORZ6
chr10_-_84789832 0.14 ENSRNOT00000071719
Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr17_+_1305016 0.13 ENSRNOT00000025965
Ercc6l2
ERCC excision repair 6 like 2
chrX_+_145558840 0.11 ENSRNOT00000032522
4931400O07Rik
RIKEN cDNA 4931400O07 gene
chr16_+_49185560 0.06 ENSRNOT00000014360
Helt
helt bHLH transcription factor
chr15_-_51386190 0.05 ENSRNOT00000022706
R3hcc1
R3H domain and coiled-coil containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 11.9 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
2.5 12.4 GO:0050828 regulation of liquid surface tension(GO:0050828)
2.3 6.9 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
1.3 5.2 GO:0072268 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
1.1 7.9 GO:0002238 response to molecule of fungal origin(GO:0002238)
1.0 4.1 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.9 4.7 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.9 3.5 GO:0098961 dendritic transport of ribonucleoprotein complex(GO:0098961) dendritic transport of messenger ribonucleoprotein complex(GO:0098963) anterograde dendritic transport of messenger ribonucleoprotein complex(GO:0098964)
0.7 2.0 GO:1903849 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.6 1.8 GO:1900195 positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.5 1.6 GO:0003285 atrioventricular node development(GO:0003162) right ventricular cardiac muscle tissue morphogenesis(GO:0003221) septum secundum development(GO:0003285) His-Purkinje system cell differentiation(GO:0060932)
0.3 1.0 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.1 0.6 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 3.5 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 0.5 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.1 2.0 GO:0001771 immunological synapse formation(GO:0001771)
0.1 1.1 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.1 0.7 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.2 GO:1901143 insulin catabolic process(GO:1901143)
0.1 2.0 GO:0007020 microtubule nucleation(GO:0007020)
0.1 1.5 GO:0042659 regulation of cell fate specification(GO:0042659)
0.1 2.3 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 0.9 GO:0099612 protein localization to axon(GO:0099612)
0.1 1.1 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1 0.5 GO:0015705 iodide transport(GO:0015705)
0.1 0.2 GO:1905225 response to thyrotropin-releasing hormone(GO:1905225)
0.0 0.2 GO:0010446 response to alkaline pH(GO:0010446)
0.0 0.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.2 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.2 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 8.3 GO:0042692 muscle cell differentiation(GO:0042692)
0.0 1.1 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 12.4 GO:0097208 alveolar lamellar body(GO:0097208)
0.8 4.1 GO:1990716 axonemal central apparatus(GO:1990716)
0.4 4.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 3.0 GO:0043219 lateral loop(GO:0043219)
0.2 0.9 GO:1990769 proximal neuron projection(GO:1990769)
0.2 3.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 2.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 2.3 GO:0005811 lipid particle(GO:0005811)
0.0 2.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.6 GO:0005922 connexon complex(GO:0005922)
0.0 0.7 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.2 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 1.1 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.9 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
1.0 7.9 GO:0008430 selenium binding(GO:0008430)
0.6 1.8 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.2 1.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 3.7 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 1.0 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 2.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 13.0 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 8.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.2 GO:0043559 insulin binding(GO:0043559)
0.0 11.6 GO:0005525 GTP binding(GO:0005525)
0.0 1.6 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 0.2 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 2.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.5 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 12.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 2.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 1.5 PID SHP2 PATHWAY SHP2 signaling
0.0 1.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.2 2.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 0.7 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.6 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors