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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nkx1-1_Nkx1-2

Z-value: 0.40

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Transcription factors associated with Nkx1-1_Nkx1-2

Gene Symbol Gene ID Gene Info
Nkx1-1
ENSRNOG00000005113 NK1 homeobox 1
Nkx1-2
ENSRNOG00000017006 NK1 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx1-2rn6_v1_chr1_-_204605552_204605552-0.323.8e-09Click!
Nkx1-1rn6_v1_chr14_+_82603671_82603671-0.081.4e-01Click!

Activity profile of Nkx1-1_Nkx1-2 motif

Sorted Z-values of Nkx1-1_Nkx1-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_168734296 19.09 ENSRNOT00000066120
Camta1
calmodulin binding transcription activator 1
chrX_+_14019961 13.67 ENSRNOT00000004785
Sytl5
synaptotagmin-like 5
chr12_-_35979193 11.82 ENSRNOT00000071104
Tmem132b
transmembrane protein 132B
chr9_+_73418607 9.60 ENSRNOT00000092547
Map2
microtubule-associated protein 2
chr2_+_145174876 9.28 ENSRNOT00000040631
Mab21l1
mab-21 like 1
chrX_+_15113878 8.52 ENSRNOT00000007464
Wdr13
WD repeat domain 13
chr4_-_168656673 7.50 ENSRNOT00000009341
Gpr19
G protein-coupled receptor 19
chr1_+_278557792 7.15 ENSRNOT00000023414
Atrnl1
attractin like 1
chr7_-_76488216 6.78 ENSRNOT00000080024
Ncald
neurocalcin delta
chrX_+_106360393 6.31 ENSRNOT00000004260
Gprasp2
G protein-coupled receptor associated sorting protein 2
chr19_+_45938915 6.29 ENSRNOT00000065508
Mon1b
MON1 homolog B, secretory trafficking associated
chr7_+_2752680 5.91 ENSRNOT00000033726
Cs
citrate synthase
chr8_-_84506328 5.79 ENSRNOT00000064754
Mlip
muscular LMNA-interacting protein
chr1_+_59156251 5.62 ENSRNOT00000017442
Lix1
limb and CNS expressed 1
chr4_-_157304653 5.34 ENSRNOT00000051613
Lrrc23
leucine rich repeat containing 23
chr9_+_20241062 5.17 ENSRNOT00000071593
LOC100911585
leucine-rich repeat-containing protein 23-like
chr3_-_120076788 5.02 ENSRNOT00000047158
Kcnip3
potassium voltage-gated channel interacting protein 3
chr16_-_3765917 4.80 ENSRNOT00000088284
Duxbl1
double homeobox B-like 1
chr17_+_63635086 4.66 ENSRNOT00000020634
Dip2c
disco-interacting protein 2 homolog C
chr12_-_46493203 4.53 ENSRNOT00000057036
Cit
citron rho-interacting serine/threonine kinase
chr12_+_49665282 4.27 ENSRNOT00000086397
Grk3
G protein-coupled receptor kinase 3
chr4_-_55011415 4.23 ENSRNOT00000056996
Grm8
glutamate metabotropic receptor 8
chr17_-_52477575 4.15 ENSRNOT00000081290
Gli3
GLI family zinc finger 3
chr5_+_71742911 3.98 ENSRNOT00000047225
Zfp462
zinc finger protein 462
chr1_-_261179790 3.88 ENSRNOT00000074420
ENSRNOT00000072073
Exosc1
exosome component 1
chr5_-_161981441 3.87 ENSRNOT00000020316
Pdpn
podoplanin
chr6_+_111076351 3.66 ENSRNOT00000089644
Tmem63c
transmembrane protein 63c
chr17_-_87826421 3.60 ENSRNOT00000068156
Arhgap21
Rho GTPase activating protein 21
chr9_+_71915421 3.35 ENSRNOT00000020447
Pikfyve
phosphoinositide kinase, FYVE-type zinc finger containing
chr1_-_100926335 3.27 ENSRNOT00000020304
Ap2a1
adaptor-related protein complex 2, alpha 1 subunit
chr15_+_43582020 3.25 ENSRNOT00000013001
Pnma2
paraneoplastic Ma antigen 2
chr13_+_92569785 3.20 ENSRNOT00000082700
Fmn2
formin 2
chr8_+_22648323 3.10 ENSRNOT00000013165
Smarca4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr1_+_53360157 2.99 ENSRNOT00000017809
Rps6ka2
ribosomal protein S6 kinase A2
chr6_-_108660063 2.82 ENSRNOT00000006240
Arel1
apoptosis resistant E3 ubiquitin protein ligase 1
chr2_-_149432106 2.77 ENSRNOT00000051027
P2ry13
purinergic receptor P2Y13
chr18_-_16543992 2.74 ENSRNOT00000036306
Slc39a6
solute carrier family 39 member 6
chr9_-_30844199 2.73 ENSRNOT00000017169
Col19a1
collagen type XIX alpha 1 chain
chr17_-_14627937 2.64 ENSRNOT00000020532
NEWGENE_1308171
osteoglycin
chr2_-_196177775 2.59 ENSRNOT00000028553
Zfp687
zinc finger protein 687
chr5_+_58995249 2.58 ENSRNOT00000023411
Ccdc107
coiled-coil domain containing 107
chr1_+_101687855 2.47 ENSRNOT00000028546
ENSRNOT00000091597
Dbp
D-box binding PAR bZIP transcription factor
chr8_-_21492801 2.46 ENSRNOT00000077465
Zfp426
zinc finger protein 426
chr10_+_29289203 2.45 ENSRNOT00000067013
Pwwp2a
PWWP domain containing 2A
chr12_-_12738620 2.41 ENSRNOT00000078603
ENSRNOT00000067021
Pms2
PMS1 homolog 2, mismatch repair system component
chr16_+_60307148 2.30 ENSRNOT00000015239
Eri1
exoribonuclease 1
chr1_-_84008293 2.28 ENSRNOT00000002053
Snrpa
small nuclear ribonucleoprotein polypeptide A
chr4_+_158088505 2.28 ENSRNOT00000026643
Vwf
von Willebrand factor
chr10_+_74413989 2.28 ENSRNOT00000036098
Ska2
spindle and kinetochore associated complex subunit 2
chr4_-_131694755 2.23 ENSRNOT00000013271
Foxp1
forkhead box P1
chr18_-_69944632 2.13 ENSRNOT00000047271
Mapk4
mitogen-activated protein kinase 4
chr5_+_131380297 2.12 ENSRNOT00000010548
Agbl4
ATP/GTP binding protein-like 4
chr1_+_220869805 2.11 ENSRNOT00000015962
Cfl1
cofilin 1
chr1_+_15834779 2.10 ENSRNOT00000079069
ENSRNOT00000083012
Bclaf1
BCL2-associated transcription factor 1
chr3_+_62648447 2.10 ENSRNOT00000002111
Agps
alkylglycerone phosphate synthase
chr10_+_92628356 2.08 ENSRNOT00000072480
Myl4
myosin, light chain 4
chr10_+_48569555 2.08 ENSRNOT00000003966
Adora2b
adenosine A2B receptor
chr16_-_10802512 1.96 ENSRNOT00000079554
Bmpr1a
bone morphogenetic protein receptor type 1A
chr20_+_6211420 1.96 ENSRNOT00000000624
Kctd20
potassium channel tetramerization domain containing 20
chr1_-_215284548 1.95 ENSRNOT00000090375
Cttn
cortactin
chr8_-_78096302 1.91 ENSRNOT00000086185
ENSRNOT00000077999
Myzap
myocardial zonula adherens protein
chr8_-_33121002 1.89 ENSRNOT00000047211
LOC100362981
LRRGT00010-like
chr7_+_35773928 1.86 ENSRNOT00000034639
Cep83
centrosomal protein 83
chr8_+_42663633 1.84 ENSRNOT00000048537
Olr1266
olfactory receptor 1266
chr1_+_141767940 1.80 ENSRNOT00000064034
Zfp710
zinc finger protein 710
chr11_+_31389514 1.77 ENSRNOT00000000325
Olig2
oligodendrocyte lineage transcription factor 2
chr13_+_67611708 1.67 ENSRNOT00000063833
Tpr
translocated promoter region, nuclear basket protein
chr5_+_107369730 1.65 ENSRNOT00000046837
LOC100912314
interferon alpha-1-like
chr17_-_78812111 1.65 ENSRNOT00000021506
Dclre1c
DNA cross-link repair 1C
chr1_+_7252349 1.61 ENSRNOT00000030329
Plagl1
PLAG1 like zinc finger 1
chr6_-_44361908 1.57 ENSRNOT00000009491
Id2
inhibitor of DNA binding 2, HLH protein
chr1_+_229416489 1.46 ENSRNOT00000028617
Olr336
olfactory receptor 336
chr1_-_64147251 1.45 ENSRNOT00000088502
Cnot3
CCR4-NOT transcription complex, subunit 3
chrX_+_73390903 1.40 ENSRNOT00000077002
Zfp449
zinc finger protein 449
chr12_+_12738812 1.39 ENSRNOT00000092233
ENSRNOT00000001379
Aimp2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr15_-_80713153 1.32 ENSRNOT00000063800
Klhl1
kelch-like family member 1
chr3_+_14889510 1.28 ENSRNOT00000080760
Dab2ip
DAB2 interacting protein
chr13_-_50916982 1.23 ENSRNOT00000004408
Btg2
BTG anti-proliferation factor 2
chr1_+_211582077 1.21 ENSRNOT00000023619
Pwwp2b
PWWP domain containing 2B
chr14_-_34528262 1.11 ENSRNOT00000003010
Tmem165
transmembrane protein 165
chr6_+_18880737 1.11 ENSRNOT00000003432
Alkbh8
alkB homolog 8, tRNA methyltransferase
chr2_-_33025271 1.10 ENSRNOT00000074941
NEWGENE_1310139
microtubule associated serine/threonine kinase family member 4
chr14_+_106393959 1.07 ENSRNOT00000092168
Wdpcp
WD repeat containing planar cell polarity effector
chr20_+_12944786 1.04 ENSRNOT00000048218
Pcnt
pericentrin
chr5_-_107447636 1.02 ENSRNOT00000040254
Ifna16l1
interferon, alpha 16-like 1
chr14_-_113644779 1.02 ENSRNOT00000005306
Cfap36
cilia and flagella associated protein 36
chr1_+_224998172 0.97 ENSRNOT00000026321
Zbtb3
zinc finger and BTB domain containing 3
chr14_+_84465515 0.91 ENSRNOT00000035591
Osm
oncostatin M
chr16_+_7035241 0.89 ENSRNOT00000084977
Nek4
NIMA-related kinase 4
chr3_-_124879216 0.83 ENSRNOT00000028886
Tmem230
transmembrane protein 230
chr1_-_173393390 0.78 ENSRNOT00000050657
Olr285
olfactory receptor 285
chr5_-_154222702 0.77 ENSRNOT00000080069
Pnrc2
proline-rich nuclear receptor coactivator 2
chr5_+_165405168 0.77 ENSRNOT00000014934
Srm
spermidine synthase
chr1_-_216663720 0.76 ENSRNOT00000078944
ENSRNOT00000077409
Cdkn1c
cyclin-dependent kinase inhibitor 1C
chr3_+_80081647 0.73 ENSRNOT00000057161
Arfgap2
ADP-ribosylation factor GTPase activating protein 2
chr5_+_36566783 0.72 ENSRNOT00000077650
Fbxl4
F-box and leucine-rich repeat protein 4
chr7_+_71157664 0.71 ENSRNOT00000005919
Sdr9c7
short chain dehydrogenase/reductase family 9C, member 7
chr10_+_87759769 0.70 ENSRNOT00000017378
ENSRNOT00000046526
Krtap9-1
keratin associated protein 9-1
chr16_+_39145230 0.65 ENSRNOT00000092942
Adam21
ADAM metallopeptidase domain 21
chr7_+_3246220 0.60 ENSRNOT00000009155
Sarnp
SAP domain containing ribonucleoprotein
chrX_+_111396995 0.60 ENSRNOT00000087634
Pih1d3
PIH1 domain containing 3
chr3_-_90751055 0.59 ENSRNOT00000040741
LOC499843
LRRGT00091
chr13_-_35933243 0.53 ENSRNOT00000039074
Tmem177
transmembrane protein 177
chr11_-_51202703 0.50 ENSRNOT00000002719
ENSRNOT00000077220
Cblb
Cbl proto-oncogene B
chr10_-_65502936 0.49 ENSRNOT00000089615
Supt6h
SPT6 homolog, histone chaperone
chr5_+_144114012 0.48 ENSRNOT00000035597
Stk40
serine/threonine kinase 40
chr18_+_16544508 0.46 ENSRNOT00000020601
Elp2
elongator acetyltransferase complex subunit 2
chr8_-_43796224 0.45 ENSRNOT00000084315
Olr1330
olfactory receptor 1330
chr1_-_89007041 0.41 ENSRNOT00000032363
Proser3
proline and serine rich 3
chr3_+_16241573 0.41 ENSRNOT00000082831
Olr407
olfactory receptor 407
chr1_-_101123402 0.40 ENSRNOT00000027976
Rpl13a

chr5_+_154311998 0.38 ENSRNOT00000084085
Gale
UDP-galactose-4-epimerase
chr16_+_39353283 0.37 ENSRNOT00000080125
LOC108348202
disintegrin and metalloproteinase domain-containing protein 21-like
chr6_+_137323713 0.35 ENSRNOT00000029017
Pld4
phospholipase D family, member 4
chr1_+_252284464 0.32 ENSRNOT00000027969
Lipf
lipase F, gastric type
chr5_-_106865746 0.30 ENSRNOT00000008224
Ifnb1
interferon beta 1
chrX_+_140878216 0.30 ENSRNOT00000075840
ENSRNOT00000077026
Zic3
Zic family member 3
chr6_-_59950586 0.28 ENSRNOT00000005800
Arl4a
ADP-ribosylation factor like GTPase 4A
chr8_-_19333047 0.19 ENSRNOT00000048500
Olr1144
olfactory receptor 1144
chr14_+_81858737 0.16 ENSRNOT00000029784
ENSRNOT00000058068
ENSRNOT00000058067
Poln
DNA polymerase nu
chr10_-_31052102 0.16 ENSRNOT00000007917
Thg1l
tRNA-histidine guanylyltransferase 1-like
chr5_-_154223536 0.16 ENSRNOT00000012258
Pnrc2
proline-rich nuclear receptor coactivator 2
chr2_+_248398917 0.13 ENSRNOT00000045855
Gbp1
guanylate binding protein 1
chr1_-_169770188 0.10 ENSRNOT00000072602
Olr165
olfactory receptor 165
chr14_+_36216002 0.09 ENSRNOT00000038506
Scfd2
sec1 family domain containing 2
chr2_-_219458271 0.08 ENSRNOT00000064735
Cdc14a
cell division cycle 14A
chr16_+_7035068 0.07 ENSRNOT00000024296
Nek4
NIMA-related kinase 4
chr4_-_170740274 0.05 ENSRNOT00000012212
Gucy2c
guanylate cyclase 2C

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0019086 late viral transcription(GO:0019086)
1.4 4.3 GO:0042441 eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474) rhodopsin metabolic process(GO:0046154)
1.1 3.3 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
1.1 3.2 GO:0070649 meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649)
1.0 4.1 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
1.0 3.1 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
0.9 3.6 GO:0051684 maintenance of Golgi location(GO:0051684)
0.7 2.2 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.7 2.1 GO:2000771 regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771)
0.7 2.0 GO:0048372 lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378) regulation of cardiac ventricle development(GO:1904412)
0.6 6.1 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.6 1.8 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.6 8.5 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.6 1.7 GO:0045799 MAPK import into nucleus(GO:0000189) regulation of chromatin assembly(GO:0010847) positive regulation of chromatin assembly or disassembly(GO:0045799)
0.5 1.6 GO:0001966 thigmotaxis(GO:0001966)
0.5 3.9 GO:0015884 folic acid transport(GO:0015884)
0.5 1.4 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.4 3.0 GO:0002035 brain renin-angiotensin system(GO:0002035)
0.4 4.2 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.4 1.1 GO:0032472 Golgi calcium ion transport(GO:0032472)
0.4 1.1 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.4 2.1 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.3 2.1 GO:0010701 positive regulation of chronic inflammatory response(GO:0002678) positive regulation of norepinephrine secretion(GO:0010701)
0.3 2.3 GO:0000467 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.3 2.1 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.3 2.3 GO:0070417 cellular response to cold(GO:0070417)
0.2 2.7 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.2 3.0 GO:0033141 regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033139) positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.2 1.9 GO:0098885 modification of postsynaptic actin cytoskeleton(GO:0098885)
0.2 9.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.2 19.1 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.2 1.9 GO:0051660 establishment of centrosome localization(GO:0051660)
0.2 2.8 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.2 0.9 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.2 5.8 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.2 1.6 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.2 11.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 4.2 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.2 5.0 GO:0048266 behavioral response to pain(GO:0048266)
0.2 2.4 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.2 4.5 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.2 5.6 GO:0097352 autophagosome maturation(GO:0097352)
0.2 0.8 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.2 2.3 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.1 0.9 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 3.3 GO:0032288 myelin assembly(GO:0032288)
0.1 0.8 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.1 1.2 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.1 1.1 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.5 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.1 2.1 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.1 1.0 GO:0001302 replicative cell aging(GO:0001302)
0.1 1.0 GO:1990403 embryonic brain development(GO:1990403)
0.1 7.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 0.5 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 4.0 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.1 1.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.4 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.3 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 1.3 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.0 2.6 GO:0048662 negative regulation of smooth muscle cell proliferation(GO:0048662)
0.0 4.0 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 2.3 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.0 0.4 GO:1904627 cellular response to UV-B(GO:0071493) response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.0 0.5 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.6 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 0.5 GO:0003016 respiratory system process(GO:0003016)
0.0 1.6 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 2.1 GO:2001022 positive regulation of response to DNA damage stimulus(GO:2001022)
0.0 2.7 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 2.8 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 5.7 GO:0043010 camera-type eye development(GO:0043010)
0.0 0.2 GO:0019985 translesion synthesis(GO:0019985)
0.0 2.5 GO:0001889 liver development(GO:0001889)
0.0 0.6 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 9.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.5 3.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.5 8.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.5 2.4 GO:0032389 MutLalpha complex(GO:0032389)
0.4 1.3 GO:1990032 parallel fiber(GO:1990032)
0.4 2.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.4 3.9 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.3 1.9 GO:0099571 postsynaptic actin cytoskeleton(GO:0098871) postsynaptic cytoskeleton(GO:0099571)
0.3 1.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.3 3.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 2.3 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.2 4.3 GO:0044292 dendrite terminus(GO:0044292)
0.2 3.3 GO:0032433 filopodium tip(GO:0032433)
0.2 1.6 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.2 1.7 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.2 2.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 1.9 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 2.3 GO:0005685 U1 snRNP(GO:0005685)
0.1 1.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 0.4 GO:0097452 GAIT complex(GO:0097452)
0.1 0.5 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 4.1 GO:0016592 mediator complex(GO:0016592)
0.1 1.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 5.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 14.5 GO:0070382 exocytic vesicle(GO:0070382)
0.1 4.2 GO:0042734 presynaptic membrane(GO:0042734)
0.1 5.8 GO:0016605 PML body(GO:0016605)
0.0 4.5 GO:0031985 Golgi cisterna(GO:0031985)
0.0 1.1 GO:0044447 axoneme part(GO:0044447)
0.0 1.0 GO:0000242 pericentriolar material(GO:0000242)
0.0 2.1 GO:0031672 A band(GO:0031672)
0.0 0.1 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 2.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 3.2 GO:0005902 microvillus(GO:0005902)
0.0 1.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.6 GO:0000346 transcription export complex(GO:0000346)
0.0 0.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 2.1 GO:0005814 centriole(GO:0005814)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 17.6 GO:0005730 nucleolus(GO:0005730)
0.0 4.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.6 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 4.5 GO:0005815 microtubule organizing center(GO:0005815)
0.0 0.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 2.5 GO:0005819 spindle(GO:0005819)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 5.9 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.1 4.2 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.7 3.0 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.7 4.3 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.6 2.4 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.6 2.3 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.5 3.9 GO:0008517 folic acid transporter activity(GO:0008517)
0.4 3.3 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.4 9.6 GO:0002162 dystroglycan binding(GO:0002162)
0.4 3.1 GO:0001164 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.3 2.0 GO:0098821 BMP receptor activity(GO:0098821)
0.3 3.0 GO:0005132 type I interferon receptor binding(GO:0005132)
0.3 2.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.3 2.8 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.3 1.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.3 8.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 6.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 1.6 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.2 1.3 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.2 1.7 GO:0043495 protein anchor(GO:0043495)
0.2 6.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 11.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 0.5 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.1 1.9 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 4.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 3.9 GO:0004532 exoribonuclease activity(GO:0004532)
0.1 2.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 2.3 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.1 5.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 2.1 GO:0071949 FAD binding(GO:0071949)
0.1 1.8 GO:0071837 HMG box domain binding(GO:0071837)
0.1 2.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 3.7 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 5.8 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.1 2.1 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.9 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.5 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 2.2 GO:0050681 androgen receptor binding(GO:0050681)
0.1 18.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 0.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 4.5 GO:0097110 scaffold protein binding(GO:0097110)
0.1 1.4 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.3 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.2 GO:0070568 guanylyltransferase activity(GO:0070568)
0.0 0.7 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.1 GO:0019002 GMP binding(GO:0019002)
0.0 0.4 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 3.3 GO:0008565 protein transporter activity(GO:0008565)
0.0 2.1 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 0.2 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 1.4 GO:0032947 protein complex scaffold(GO:0032947)
0.0 1.0 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 4.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.6 GO:0044325 ion channel binding(GO:0044325)
0.0 1.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 3.7 GO:0000976 transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.0 0.8 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 4.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 3.1 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.2 9.6 PID LKB1 PATHWAY LKB1 signaling events
0.1 6.9 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 3.3 PID ARF 3PATHWAY Arf1 pathway
0.1 1.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 1.6 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 4.5 PID RHOA PATHWAY RhoA signaling pathway
0.1 4.1 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.7 NABA COLLAGENS Genes encoding collagen proteins
0.1 0.3 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.9 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.3 PID RAS PATHWAY Regulation of Ras family activation
0.0 2.0 PID BMP PATHWAY BMP receptor signaling
0.0 0.5 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 1.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 3.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 2.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.5 PID CD40 PATHWAY CD40/CD40L signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 5.9 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.3 3.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.3 3.9 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.3 4.9 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.2 6.3 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.2 4.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 2.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 2.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 2.1 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 2.1 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 2.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 2.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.7 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 2.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 2.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.3 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.5 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes