ISMARA results: Nhlh1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nhlh1

Z-value: 1.29

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Transcription factors associated with Nhlh1

Gene Symbol	Gene ID	Gene Info
Nhlh1 NCBI RGD Ensembl	ENSRNOG00000005166	nescient helix loop helix 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nhlh1	rn6_v1_chr13_-_90443157_90443157	0.53	1.5e-24	Click!

Activity profile of Nhlh1 motif

Sorted Z-values of Nhlh1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_176666282 Show fit	46.19	ENSRNOT00000016947	Eef1a2 NCBI RGD Ensembl Show fit	eukaryotic translation elongation factor 1 alpha 2
chr8_+_111600532 Show fit	42.44	ENSRNOT00000081952	Rab6b NCBI RGD Ensembl Show fit	RAB6B, member RAS oncogene family
chr1_+_265298868 Show fit	39.63	ENSRNOT00000023278	Dpcd NCBI RGD Ensembl Show fit	deleted in primary ciliary dyskinesia
chr5_-_109651730 Show fit	39.43	ENSRNOT00000093032	Elavl2 NCBI RGD Ensembl Show fit	ELAV like RNA binding protein 2
chr1_-_89560719 Show fit	37.82	ENSRNOT00000028653	Scn1b NCBI RGD Ensembl Show fit	sodium voltage-gated channel beta subunit 1
chr18_+_79406381 Show fit	37.47	ENSRNOT00000022303 ENSRNOT00000058295 ENSRNOT00000058296 ENSRNOT00000022280	Mbp NCBI RGD Ensembl Show fit	myelin basic protein
chr13_+_92569785 Show fit	36.72	ENSRNOT00000082700	Fmn2 NCBI RGD Ensembl Show fit	formin 2
chr15_+_44799334 Show fit	32.93	ENSRNOT00000018599	Nefl NCBI RGD Ensembl Show fit	neurofilament light
chr6_-_42473738 Show fit	31.56	ENSRNOT00000033327	Kcnf1 NCBI RGD Ensembl Show fit	potassium voltage-gated channel modifier subfamily F member 1
chr11_+_72705129 Show fit	30.13	ENSRNOT00000073330	Apod NCBI RGD Ensembl Show fit	apolipoprotein D

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Nhlh1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
17.1	85.6	GO:0021966	corticospinal neuron axon guidance(GO:0021966)
1.5	61.9	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.5	60.7	GO:0007612	learning(GO:0007612)
2.0	59.9	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
2.9	55.8	GO:2001014	regulation of skeletal muscle cell differentiation(GO:2001014)
15.2	45.7	GO:0021678	third ventricle development(GO:0021678)
14.8	44.5	GO:0070649	formin-nucleated actin cable assembly(GO:0070649)
3.1	43.7	GO:0086016	AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027)
3.0	42.5	GO:0016127	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.6	40.8	GO:0035249	synaptic transmission, glutamatergic(GO:0035249)

Showing 1 to 10 of 432 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.3	125.6	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.6	121.5	GO:0045211	postsynaptic membrane(GO:0045211)
1.2	97.2	GO:0030315	T-tubule(GO:0030315)
0.2	83.8	GO:0043025	neuronal cell body(GO:0043025)
0.9	79.0	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
1.0	69.8	GO:0031594	neuromuscular junction(GO:0031594)
0.5	64.0	GO:0043204	perikaryon(GO:0043204)
0.3	59.4	GO:0043209	myelin sheath(GO:0043209)
0.7	53.6	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
2.8	50.5	GO:0033268	node of Ranvier(GO:0033268)

Showing 1 to 10 of 162 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	106.5	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
17.1	85.6	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.9	71.8	GO:0005249	voltage-gated potassium channel activity(GO:0005249)
0.2	69.1	GO:0003779	actin binding(GO:0003779)
2.2	66.8	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
2.2	53.5	GO:0005112	Notch binding(GO:0005112)
6.2	49.8	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
2.3	49.6	GO:0003746	translation elongation factor activity(GO:0003746)
2.2	49.5	GO:0031489	myosin V binding(GO:0031489)
3.8	46.2	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)

Showing 1 to 10 of 302 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	92.5	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.3	63.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
4.2	29.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
1.0	27.2	PID CONE PATHWAY	Visual signal transduction: Cones
0.6	26.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.3	23.2	PID NOTCH PATHWAY	Notch signaling pathway
0.4	20.2	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
1.4	18.5	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
1.1	16.7	PID S1P S1P4 PATHWAY	S1P4 pathway
0.5	14.8	PID WNT SIGNALING PATHWAY	Wnt signaling network

Showing 1 to 10 of 45 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.3	149.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
7.2	135.9	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
3.6	61.6	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
3.8	56.7	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
1.1	47.8	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.5	38.3	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.3	34.3	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
1.5	32.3	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.6	31.2	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
1.7	30.7	REACTOME SHC MEDIATED SIGNALLING	Genes involved in SHC-mediated signalling

Showing 1 to 10 of 92 entries

Results for Nhlh1

Z-value: 1.29

Motif logo

Transcription factors associated with Nhlh1

Activity-expression correlation:

Activity profile of Nhlh1 motif

Sorted Z-values of Nhlh1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nhlh1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: