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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Nfic_Nfib
Z-value: 2.06
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Transcription factors associated with Nfic_Nfib
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfib | rn6_v1_chr5_-_100647298_100647298 | 0.67 | 2.7e-43 | Click! |
| Nfic | rn6_v1_chr7_+_11152038_11152038 | 0.63 | 1.9e-37 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_27815261 Show fit | 182.81 |
ENSRNOT00000032992
|
kelch-like family member 33 |
|
| chr5_-_134526089 Show fit | 94.70 |
ENSRNOT00000013321
|
cytochrome P450, family 4, subfamily b, polypeptide 1 |
|
| chr1_-_89543967 Show fit | 81.57 |
ENSRNOT00000079631
|
hepsin |
|
| chr9_-_82008620 Show fit | 71.34 |
ENSRNOT00000023365
|
protein kinase AMP-activated non-catalytic subunit gamma 3 |
|
| chr16_+_54291251 Show fit | 66.73 |
ENSRNOT00000079006
|
microtubule associated tumor suppressor 1 |
|
| chr10_+_57278307 Show fit | 64.19 |
ENSRNOT00000005612
|
enolase 3 |
|
| chr5_-_101166651 Show fit | 62.48 |
ENSRNOT00000078862
|
Fras1 related extracellular matrix 1 |
|
| chr1_-_100530183 Show fit | 61.21 |
ENSRNOT00000067754
|
myosin binding protein C, fast-type |
|
| chr9_-_80167033 Show fit | 60.48 |
ENSRNOT00000023530
|
insulin-like growth factor binding protein 5 |
|
| chr9_-_20195566 Show fit | 59.96 |
ENSRNOT00000015223
|
adhesion G protein-coupled receptor F5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfic_Nfib
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 29.5 | 118.0 | GO:1904204 | regulation of skeletal muscle hypertrophy(GO:1904204) |
| 3.3 | 91.3 | GO:0035313 | wound healing, spreading of epidermal cells(GO:0035313) |
| 12.9 | 90.0 | GO:0018879 | biphenyl metabolic process(GO:0018879) |
| 9.8 | 88.2 | GO:0071073 | positive regulation of phospholipid biosynthetic process(GO:0071073) |
| 27.2 | 81.6 | GO:0034769 | basement membrane disassembly(GO:0034769) |
| 27.0 | 80.9 | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway(GO:2000661) |
| 1.4 | 71.3 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 22.8 | 68.3 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
| 1.7 | 67.8 | GO:0043403 | skeletal muscle tissue regeneration(GO:0043403) |
| 3.3 | 62.5 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 319.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.4 | 272.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.7 | 159.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.4 | 118.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 19.7 | 118.0 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 1.1 | 101.7 | GO:0005604 | basement membrane(GO:0005604) |
| 0.4 | 78.7 | GO:0031012 | extracellular matrix(GO:0031012) |
| 2.4 | 77.8 | GO:0008305 | integrin complex(GO:0008305) |
| 12.7 | 76.1 | GO:0030478 | actin cap(GO:0030478) |
| 4.0 | 71.3 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 135.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 14.8 | 133.1 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 6.1 | 116.0 | GO:0015643 | toxic substance binding(GO:0015643) |
| 16.3 | 81.6 | GO:0005534 | galactose binding(GO:0005534) |
| 6.8 | 81.6 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 27.0 | 80.9 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
| 7.2 | 79.3 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.4 | 75.9 | GO:0008237 | metallopeptidase activity(GO:0008237) |
| 4.8 | 71.3 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 3.2 | 69.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 399.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.7 | 173.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 4.1 | 98.5 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 1.9 | 93.7 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 2.4 | 89.4 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 2.6 | 80.4 | PID ALK1 PATHWAY | ALK1 signaling events |
| 2.0 | 76.2 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 3.6 | 68.9 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.4 | 61.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.0 | 50.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 135.4 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
| 6.3 | 133.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 1.3 | 105.9 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 2.1 | 83.2 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 1.9 | 83.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 1.7 | 80.5 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 2.6 | 76.5 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 7.9 | 71.3 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 7.4 | 66.7 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.3 | 52.1 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |