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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Nfia
Z-value: 3.04
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Transcription factors associated with Nfia
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfia | rn6_v1_chr5_+_116420690_116420690 | 0.48 | 1.4e-19 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_159775643 Show fit | 147.09 |
ENSRNOT00000010939
|
junctophilin 2 |
|
| chr1_-_213650247 Show fit | 119.80 |
ENSRNOT00000019679
|
cytochrome c oxidase, subunit VIIIb |
|
| chr15_+_4077951 Show fit | 115.78 |
ENSRNOT00000085266
|
myozenin 1 |
|
| chr15_-_27815261 Show fit | 105.62 |
ENSRNOT00000032992
|
kelch-like family member 33 |
|
| chr10_+_53778662 Show fit | 99.40 |
ENSRNOT00000045718
|
myosin heavy chain 2 |
|
| chr10_+_86337728 Show fit | 98.90 |
ENSRNOT00000085408
|
titin-cap |
|
| chr3_-_63568464 Show fit | 97.24 |
ENSRNOT00000068494
|
|
|
| chr9_-_73958480 Show fit | 97.19 |
ENSRNOT00000017838
|
myosin, light chain 1 |
|
| chr17_+_47397558 Show fit | 93.59 |
ENSRNOT00000085923
|
ependymin related 1 |
|
| chrX_-_64715823 Show fit | 88.22 |
ENSRNOT00000076297
|
ankyrin repeat and SOCS box-containing 12 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfia
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 468.9 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 64.5 | 258.1 | GO:0035995 | detection of muscle stretch(GO:0035995) |
| 16.8 | 201.5 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 15.4 | 184.4 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 37.8 | 151.1 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 50.1 | 150.4 | GO:0006480 | N-terminal protein amino acid methylation(GO:0006480) |
| 21.0 | 147.1 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 14.0 | 139.5 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 9.1 | 118.8 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 3.1 | 115.8 | GO:0030239 | myofibril assembly(GO:0030239) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 889.8 | GO:0031674 | I band(GO:0031674) |
| 0.0 | 242.8 | GO:0016021 | integral component of membrane(GO:0016021) |
| 12.6 | 201.5 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 18.5 | 166.2 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 18.4 | 147.1 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 36.0 | 144.1 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.6 | 137.5 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.4 | 137.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.7 | 117.4 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 10.9 | 98.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 468.9 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.4 | 224.6 | GO:0005509 | calcium ion binding(GO:0005509) |
| 42.9 | 214.7 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.6 | 205.7 | GO:0003779 | actin binding(GO:0003779) |
| 50.7 | 203.0 | GO:0061629 | RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629) |
| 6.7 | 201.5 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 50.1 | 150.4 | GO:0071885 | N-terminal protein N-methyltransferase activity(GO:0071885) |
| 10.5 | 147.1 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 1.5 | 116.8 | GO:0005518 | collagen binding(GO:0005518) |
| 1.8 | 111.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 306.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 4.2 | 188.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 3.3 | 165.8 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.6 | 131.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.9 | 130.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 2.2 | 103.2 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 1.1 | 64.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 1.4 | 58.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 2.7 | 43.1 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.8 | 42.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.6 | 492.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 5.6 | 222.6 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 2.9 | 123.2 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.5 | 88.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 3.3 | 86.5 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 1.8 | 85.5 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 7.9 | 79.2 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 3.1 | 72.1 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 1.4 | 70.5 | REACTOME TRIGLYCERIDE BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 4.2 | 58.1 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |