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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Nfe2l2
Z-value: 0.99
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Transcription factors associated with Nfe2l2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfe2l2 | rn6_v1_chr3_-_62524996_62524996 | 0.21 | 1.7e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_90602365 Show fit | 29.54 |
ENSRNOT00000009344
|
calsequestrin 1 |
|
| chr15_+_2733114 Show fit | 28.38 |
ENSRNOT00000074545
|
dual specificity protein phosphatase 13 |
|
| chr15_+_2526368 Show fit | 28.11 |
ENSRNOT00000048713
ENSRNOT00000074803 |
dual specificity phosphatase 13 dual specificity phosphatase 13 |
|
| chr19_+_52077109 Show fit | 27.91 |
ENSRNOT00000020225
|
oxidative stress induced growth inhibitor 1 |
|
| chr19_+_52077501 Show fit | 25.90 |
ENSRNOT00000079240
|
oxidative stress induced growth inhibitor 1 |
|
| chr1_-_198232344 Show fit | 25.61 |
ENSRNOT00000080988
|
aldolase, fructose-bisphosphate A |
|
| chr4_-_44136815 Show fit | 23.50 |
ENSRNOT00000086810
|
transcription factor EC |
|
| chr20_+_295250 Show fit | 23.28 |
ENSRNOT00000000955
|
chloride intracellular channel 2 |
|
| chr1_+_12915734 Show fit | 21.99 |
ENSRNOT00000089066
|
taxilin beta |
|
| chr5_+_90338795 Show fit | 19.91 |
ENSRNOT00000077864
ENSRNOT00000058882 |
similar to RIKEN cDNA 2310003M01 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfe2l2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 53.8 | GO:0030308 | negative regulation of cell growth(GO:0030308) |
| 7.9 | 39.3 | GO:0014722 | regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) |
| 0.3 | 34.1 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.1 | 28.9 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 1.8 | 25.6 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 3.3 | 23.3 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315) |
| 0.3 | 22.6 | GO:0034605 | cellular response to heat(GO:0034605) |
| 1.1 | 20.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 19.7 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 1.8 | 17.9 | GO:1902031 | regulation of NADP metabolic process(GO:1902031) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 35.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 33.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 7.4 | 29.5 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.8 | 26.2 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 1.5 | 25.6 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.4 | 23.3 | GO:0034707 | chloride channel complex(GO:0034707) |
| 1.0 | 20.6 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.3 | 19.5 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 17.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.8 | 16.8 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 56.5 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.3 | 48.1 | GO:0008083 | growth factor activity(GO:0008083) |
| 3.7 | 25.6 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.1 | 23.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 22.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 22.0 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.2 | 22.0 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.8 | 21.5 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.5 | 20.6 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.3 | 20.4 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 23.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 18.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.6 | 17.4 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.3 | 11.0 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 11.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 8.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 7.9 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.3 | 7.8 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.2 | 7.0 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 35.9 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.7 | 25.6 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.5 | 25.4 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.7 | 20.6 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 17.9 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.4 | 16.3 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.5 | 14.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 14.1 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 13.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.8 | 13.0 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |