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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Nfe2_Bach1_Mafk
Z-value: 1.23
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Transcription factors associated with Nfe2_Bach1_Mafk
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfe2 | rn6_v1_chr7_-_144880092_144880092 | -0.56 | 2.0e-27 | Click! |
| Bach1 | rn6_v1_chr11_+_27364916_27364916 | -0.52 | 4.2e-23 | Click! |
| Mafk | rn6_v1_chr12_-_16934706_16934706 | -0.29 | 9.3e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_64929721 Show fit | 59.32 |
ENSRNOT00000068633
|
aldehyde oxidase 1 |
|
| chr19_+_52077109 Show fit | 59.17 |
ENSRNOT00000020225
|
oxidative stress induced growth inhibitor 1 |
|
| chr1_-_198232344 Show fit | 58.10 |
ENSRNOT00000080988
|
aldolase, fructose-bisphosphate A |
|
| chr19_+_52077501 Show fit | 54.74 |
ENSRNOT00000079240
|
oxidative stress induced growth inhibitor 1 |
|
| chr8_-_94368834 Show fit | 49.74 |
ENSRNOT00000078977
|
malic enzyme 1 |
|
| chr3_-_10371240 Show fit | 48.20 |
ENSRNOT00000012075
|
argininosuccinate synthase 1 |
|
| chr4_+_163293724 Show fit | 41.54 |
ENSRNOT00000077356
|
GABA type A receptor associated protein like 1 |
|
| chr14_+_2050483 Show fit | 40.94 |
ENSRNOT00000000047
|
solute carrier family 26 member 1 |
|
| chrX_-_31968152 Show fit | 39.27 |
ENSRNOT00000004884
|
pirin |
|
| chr19_+_38422164 Show fit | 31.76 |
ENSRNOT00000017174
|
NAD(P)H quinone dehydrogenase 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfe2_Bach1_Mafk
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 110.7 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.5 | 103.2 | GO:0030308 | negative regulation of cell growth(GO:0030308) |
| 11.9 | 59.3 | GO:0009115 | xanthine catabolic process(GO:0009115) |
| 4.5 | 58.1 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 1.9 | 57.4 | GO:0019430 | removal of superoxide radicals(GO:0019430) |
| 4.5 | 49.7 | GO:1902031 | regulation of NADP metabolic process(GO:1902031) |
| 16.1 | 48.2 | GO:0000053 | argininosuccinate metabolic process(GO:0000053) |
| 0.4 | 43.2 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 1.0 | 39.7 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.1 | 38.6 | GO:0006914 | autophagy(GO:0006914) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 111.8 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 68.2 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 3.4 | 58.1 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 3.0 | 48.2 | GO:0070852 | cell body fiber(GO:0070852) |
| 1.3 | 41.5 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 1.4 | 38.8 | GO:0022624 | proteasome accessory complex(GO:0022624) |
| 0.1 | 37.8 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.1 | 37.4 | GO:0016604 | nuclear body(GO:0016604) |
| 2.3 | 36.6 | GO:0031045 | dense core granule(GO:0031045) |
| 1.5 | 30.3 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 100.1 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.2 | 64.3 | GO:0005549 | odorant binding(GO:0005549) |
| 12.1 | 60.7 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 11.9 | 59.3 | GO:0004854 | aldehyde oxidase activity(GO:0004031) xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726) |
| 8.3 | 58.1 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 3.1 | 55.7 | GO:0015643 | toxic substance binding(GO:0015643) |
| 16.6 | 49.7 | GO:0008948 | oxaloacetate decarboxylase activity(GO:0008948) |
| 0.1 | 46.4 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.8 | 43.2 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 4.5 | 40.1 | GO:0030957 | Tat protein binding(GO:0030957) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 62.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.8 | 40.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 24.7 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.4 | 23.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.5 | 20.7 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.5 | 19.1 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 13.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 13.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 12.8 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.9 | 12.6 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 90.9 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 1.5 | 58.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.4 | 54.9 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.4 | 54.2 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 3.9 | 46.3 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.3 | 33.2 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.6 | 28.3 | REACTOME TRIGLYCERIDE BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 2.4 | 26.0 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.3 | 25.1 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.9 | 24.7 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |