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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nfe2_Bach1_Mafk

Z-value: 1.23

Motif logo

Transcription factors associated with Nfe2_Bach1_Mafk

Gene Symbol Gene ID Gene Info
ENSRNOG00000036837 nuclear factor, erythroid 2
ENSRNOG00000001582 BTB domain and CNC homolog 1
ENSRNOG00000001277 MAF bZIP transcription factor K

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfe2rn6_v1_chr7_-_144880092_144880092-0.562.0e-27Click!
Bach1rn6_v1_chr11_+_27364916_27364916-0.524.2e-23Click!
Mafkrn6_v1_chr12_-_16934706_16934706-0.299.3e-08Click!

Activity profile of Nfe2_Bach1_Mafk motif

Sorted Z-values of Nfe2_Bach1_Mafk motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_64929721 59.32 ENSRNOT00000068633
aldehyde oxidase 1
chr19_+_52077109 59.17 ENSRNOT00000020225
oxidative stress induced growth inhibitor 1
chr1_-_198232344 58.10 ENSRNOT00000080988
aldolase, fructose-bisphosphate A
chr19_+_52077501 54.74 ENSRNOT00000079240
oxidative stress induced growth inhibitor 1
chr8_-_94368834 49.74 ENSRNOT00000078977
malic enzyme 1
chr3_-_10371240 48.20 ENSRNOT00000012075
argininosuccinate synthase 1
chr4_+_163293724 41.54 ENSRNOT00000077356
GABA type A receptor associated protein like 1
chr14_+_2050483 40.94 ENSRNOT00000000047
solute carrier family 26 member 1
chrX_-_31968152 39.27 ENSRNOT00000004884
pirin
chr19_+_38422164 31.76 ENSRNOT00000017174
NAD(P)H quinone dehydrogenase 1
chr11_+_30363280 28.98 ENSRNOT00000002885
superoxide dismutase 1, soluble
chrX_-_54303729 28.34 ENSRNOT00000087919
ENSRNOT00000064340
ENSRNOT00000051249
ENSRNOT00000087547
glycerol kinase
chr1_+_199248470 27.21 ENSRNOT00000025933
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
chr14_-_115052450 26.07 ENSRNOT00000067998
acylphosphatase 2
chr1_-_221917901 26.01 ENSRNOT00000092270
solute carrier family 22 member 12
chr5_+_135536413 25.62 ENSRNOT00000023132
peroxiredoxin 1
chr15_+_2733114 24.88 ENSRNOT00000074545
dual specificity protein phosphatase 13
chr2_+_225827504 24.73 ENSRNOT00000018343
glutamate cysteine ligase, modifier subunit
chr18_-_27749235 23.01 ENSRNOT00000026696
heat shock protein family A member 9
chrX_+_17171605 22.84 ENSRNOT00000048236
nudix (nucleoside diphosphate linked moiety X)-type motif 10
chr4_+_30807879 21.75 ENSRNOT00000013184
dynein cytoplasmic 1 intermediate chain 1
chr7_+_59200918 21.60 ENSRNOT00000085073
protein tyrosine phosphatase, receptor type, R
chr15_+_2526368 20.83 ENSRNOT00000048713
ENSRNOT00000074803
dual specificity phosphatase 13
dual specificity phosphatase 13
chr19_-_64303 20.30 ENSRNOT00000015451
carboxylesterase 2A
chr8_-_130550388 19.13 ENSRNOT00000026355
cytochrome P450, family 8, subfamily b, polypeptide 1
chr10_-_35716260 19.12 ENSRNOT00000004308
ENSRNOT00000059255
sequestosome 1
chr16_-_14382641 18.61 ENSRNOT00000018723
growth hormone inducible transmembrane protein
chr13_-_99287887 16.02 ENSRNOT00000004780
epoxide hydrolase 1
chr1_+_282568287 16.00 ENSRNOT00000015997
carboxylesterase 2I
chr4_-_115332052 15.51 ENSRNOT00000017643
C-type lectin domain family 4, member F
chr6_-_129010271 14.99 ENSRNOT00000075378
serpin family A member 10
chr6_+_42092467 14.99 ENSRNOT00000060499
E2F transcription factor 6
chr1_-_166943592 14.98 ENSRNOT00000026962
folate receptor 1
chr8_+_42613601 14.53 ENSRNOT00000040297
olfactory receptor 1264
chr7_-_123630045 14.14 ENSRNOT00000050002
cytochrome P450, family 2, subfamily d, polypeptide 1
chr6_+_128073344 13.81 ENSRNOT00000014073
Ab1-233
chr13_-_36101411 13.80 ENSRNOT00000074471
transmembrane protein 37
chr8_-_73194837 13.38 ENSRNOT00000024885
ENSRNOT00000081450
ENSRNOT00000064613
talin 2
chr1_+_277068761 12.93 ENSRNOT00000044183
ENSRNOT00000022382
hyaluronan binding protein 2
chr9_+_17817721 12.78 ENSRNOT00000086986
ENSRNOT00000026920
heat shock protein 90 alpha family class B member 1
chr3_+_152552822 12.27 ENSRNOT00000089719
erythrocyte membrane protein band 4.1-like 1
chr5_-_58445953 12.11 ENSRNOT00000046102
valosin-containing protein
chr9_+_93080615 12.07 ENSRNOT00000024306
proteasome 26S subunit, non-ATPase 1
chr11_+_86797557 11.79 ENSRNOT00000083049
ENSRNOT00000046594
transport and golgi organization 2 homolog
chr1_+_282567674 11.65 ENSRNOT00000090543
carboxylesterase 2I
chr8_+_43705216 11.63 ENSRNOT00000090425

chr9_+_10963723 11.54 ENSRNOT00000075424
perilipin 4
chr7_+_3355116 10.99 ENSRNOT00000030453
ENSRNOT00000061657
integrin subunit alpha 7
chrX_-_142248369 10.95 ENSRNOT00000091330
fibroblast growth factor 13
chr17_+_53102534 10.64 ENSRNOT00000021433
mitochondrial ribosomal protein L32
chr9_+_51298426 10.60 ENSRNOT00000065212
GULP, engulfment adaptor PTB domain containing 1
chr2_+_242882306 10.52 ENSRNOT00000013661
DNA-damage-inducible transcript 4-like
chr2_-_220535751 10.46 ENSRNOT00000089082
palmdelphin
chr18_-_59086251 10.32 ENSRNOT00000025510
ENSRNOT00000083831
thioredoxin-like 1
chr6_+_64224861 10.23 ENSRNOT00000093159
ENSRNOT00000093664
patatin-like phospholipase domain containing 8
chr9_+_119353840 10.07 ENSRNOT00000085362
myomesin 1
chr5_-_33892462 9.73 ENSRNOT00000009334
ATPase H+ transporting V0 subunit D2
chr7_-_117680004 9.60 ENSRNOT00000040422
solute carrier family 39 member 4
chr1_+_79989019 9.43 ENSRNOT00000020428
dystrophia myotonica-protein kinase
chr18_+_56364620 9.23 ENSRNOT00000068535
ENSRNOT00000086033
platelet derived growth factor receptor beta
chr20_-_422464 9.01 ENSRNOT00000051646
olfactory receptor 1673
chr11_+_87435185 8.69 ENSRNOT00000002558
purinergic receptor P2X 6
chr2_+_60180215 8.64 ENSRNOT00000084624
prolactin receptor
chr20_+_5008508 8.60 ENSRNOT00000001153
von Willebrand factor A domain containing 7
chr10_-_18574710 8.49 ENSRNOT00000079031
potassium voltage-gated channel interacting protein 1
chr3_-_8981362 8.23 ENSRNOT00000086717
carnitine O-acetyltransferase
chr7_-_117254765 8.11 ENSRNOT00000006311
plectin
chr17_-_87826421 8.01 ENSRNOT00000068156
Rho GTPase activating protein 21
chr3_-_159802952 7.70 ENSRNOT00000011610
oxidative stress responsive serine-rich 1
chr9_-_85243001 7.67 ENSRNOT00000020219
secretogranin II
chr4_-_113902399 7.54 ENSRNOT00000087788
T-cell leukemia homeobox 2
chr14_-_72380330 7.52 ENSRNOT00000082653
ENSRNOT00000081878
ENSRNOT00000006727
cytoplasmic polyadenylation element binding protein 2
chr15_-_44860604 7.47 ENSRNOT00000018637
neurofilament medium
chr14_+_107750162 7.35 ENSRNOT00000012767
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1
chr4_-_97784842 7.29 ENSRNOT00000007698
growth arrest and DNA-damage-inducible, alpha
chr11_+_66713888 7.16 ENSRNOT00000003340
F-box protein 40
chr1_+_41192824 7.11 ENSRNOT00000082133
estrogen receptor 1
chrX_-_104791210 6.98 ENSRNOT00000004921
synaptotagmin-like 4
chr6_+_93423002 6.98 ENSRNOT00000010753
proteasome subunit alpha 3
chr1_+_193187972 6.98 ENSRNOT00000090172
ENSRNOT00000065342
solute carrier family 5 member 11
chr5_+_64294321 6.93 ENSRNOT00000083796
Myb/SANT DNA binding domain containing 3
chr1_+_264507985 6.91 ENSRNOT00000085811
paired box 2
chr3_-_11410732 6.88 ENSRNOT00000034930
similar to Hypothetical UPF0184 protein C9orf16 homolog
chr8_+_70712513 6.81 ENSRNOT00000079548
poly (ADP-ribose) polymerase family, member 16
chr12_+_39554171 6.57 ENSRNOT00000024347
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
chr17_-_53102342 6.49 ENSRNOT00000073834
proteasome subunit alpha 2
chr5_-_113578928 6.40 ENSRNOT00000010621
phospholipase A2, activating protein
chr16_+_20336638 6.21 ENSRNOT00000080467
potassium calcium-activated channel subfamily N member 1
chr8_+_42009816 6.17 ENSRNOT00000071964
olfactory receptor 143-like
chr16_+_23317953 6.08 ENSRNOT00000075287

chr11_-_76888178 6.05 ENSRNOT00000049841
osteocrin
chr14_+_2892753 6.04 ENSRNOT00000061630
ecotropic viral integration site 5
chr7_-_117267402 5.93 ENSRNOT00000088945
plectin
chr19_-_22626653 5.87 ENSRNOT00000078348
glutamic--pyruvic transaminase 2
chr19_-_39646693 5.79 ENSRNOT00000019104
proteasome 26S subunit, non-ATPase 7
chr16_+_10727571 5.72 ENSRNOT00000084422
multimerin 2
chr10_-_16045835 5.57 ENSRNOT00000064832
cytoplasmic polyadenylation element binding protein 4
chr5_+_128629942 5.42 ENSRNOT00000010462
ENSRNOT00000010440
nardilysin convertase
chr7_-_130120579 5.27 ENSRNOT00000044376
mitogen-activated protein kinase 12
chr12_-_6784111 5.25 ENSRNOT00000078541

chr1_-_31881531 5.25 ENSRNOT00000081225
tubulin polymerization promoting protein
chr4_-_114768029 5.08 ENSRNOT00000083404
T-cell leukemia homeobox 2
chr7_-_117267803 5.08 ENSRNOT00000082271
plectin
chr1_+_167719947 5.08 ENSRNOT00000024971
olfactory receptor 43
chr15_+_8730871 5.01 ENSRNOT00000081845
nuclear receptor subfamily 1, group D, member 2
chr5_+_59063531 4.98 ENSRNOT00000085311
ENSRNOT00000065909
cAMP responsive element binding protein 3
chr2_-_187914905 4.97 ENSRNOT00000026974
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr2_+_211050360 4.90 ENSRNOT00000026928
proteasome subunit alpha 5
chr7_-_117265493 4.86 ENSRNOT00000083429
plectin
chr10_+_65780494 4.86 ENSRNOT00000013100
DNA polymerase delta interacting protein 2
chr8_-_40564556 4.85 ENSRNOT00000075779
olfactory receptor 883
chr14_-_21127868 4.73 ENSRNOT00000020608
ENSRNOT00000092172
RUN and FYVE domain containing 3
chr1_-_256013495 4.72 ENSRNOT00000023342
insulin degrading enzyme
chr1_-_100671074 4.66 ENSRNOT00000027132
myosin heavy chain 14
chr6_+_54488038 4.61 ENSRNOT00000084661
ENSRNOT00000005637
sorting nexin 13
chr10_-_16046033 4.60 ENSRNOT00000089460
cytoplasmic polyadenylation element binding protein 4
chr11_-_86328469 4.57 ENSRNOT00000071493
ubiquitin fusion degradation 1 like (yeast)
chr8_-_43055175 4.50 ENSRNOT00000074413
olfactory receptor 8G1-like
chr18_-_59975192 4.46 ENSRNOT00000024328
ferrochelatase
chr7_-_26984400 4.44 ENSRNOT00000013613
thioredoxin reductase 1
chr1_+_198690794 4.43 ENSRNOT00000023999
zinc finger protein 771
chr3_-_23020441 4.42 ENSRNOT00000017651
nuclear receptor subfamily 5, group A, member 1
chr10_+_110346453 4.38 ENSRNOT00000054928
testis expressed 19.1
chrX_+_62754634 4.36 ENSRNOT00000016669
phosphate cytidylyltransferase 1, choline, beta
chr7_+_2479311 4.35 ENSRNOT00000003787
prostaglandin E synthase 3
chr8_+_43566788 4.35 ENSRNOT00000087263
olfactory receptor 1316
chr3_-_72289310 4.34 ENSRNOT00000038250
reticulon 4 receptor-like 2
chr15_-_41316203 4.32 ENSRNOT00000065261
TNF receptor superfamily member 19
chr7_+_11152038 4.30 ENSRNOT00000006168
nuclear factor I/C
chr1_+_105094411 4.27 ENSRNOT00000036258
HIV-1 Tat interactive protein 2
chr4_+_71376535 4.26 ENSRNOT00000021832
seminal vesicle antigen-like 1
chr20_-_33322966 4.25 ENSRNOT00000000459
ROS proto-oncogene 1 , receptor tyrosine kinase
chr15_+_35843533 4.11 ENSRNOT00000087987

chr3_+_58164931 4.10 ENSRNOT00000002078
distal-less homeobox 1
chr1_+_100297152 4.09 ENSRNOT00000026100
SH3 and multiple ankyrin repeat domains 1
chr1_-_170318935 4.07 ENSRNOT00000024119
protein kinase C, delta binding protein
chr1_+_25174456 4.06 ENSRNOT00000092830
clavesin 2
chr2_+_227455722 4.02 ENSRNOT00000064809
SEC24 homolog D, COPII coat complex component
chr15_-_52317219 4.02 ENSRNOT00000016555
dematin actin binding protein
chr3_+_175548174 4.02 ENSRNOT00000091941
adhesion regulating molecule 1
chr5_+_90338795 3.99 ENSRNOT00000077864
ENSRNOT00000058882
similar to RIKEN cDNA 2310003M01
chr19_+_52566607 3.96 ENSRNOT00000022432
ubiquitin specific peptidase 10
chr16_-_84939323 3.94 ENSRNOT00000022742
myosin XVI
chr8_+_80965255 3.92 ENSRNOT00000079508
WD repeat domain 72
chr1_+_238843338 3.87 ENSRNOT00000024583
zinc finger AN1-type containing 5
chr3_+_111597102 3.85 ENSRNOT00000081462
TYRO3 protein tyrosine kinase
chr9_-_113328428 3.85 ENSRNOT00000086340
VAMP associated protein A
chr8_+_116324040 3.84 ENSRNOT00000081353
hyaluronoglucosaminidase 2
chr3_+_103747654 3.80 ENSRNOT00000006887
NOP10 ribonucleoprotein
chr3_+_58084606 3.79 ENSRNOT00000084797
methionyl aminopeptidase type 1D (mitochondrial)
chr8_+_43590248 3.78 ENSRNOT00000088053
olfactory receptor 1318
chr20_-_33323367 3.76 ENSRNOT00000080444
ROS proto-oncogene 1 , receptor tyrosine kinase
chr3_+_76790186 3.72 ENSRNOT00000084374
olfactory receptor 635
chr1_+_69615603 3.69 ENSRNOT00000084806
zinc finger protein 418
chr8_+_40410604 3.64 ENSRNOT00000049392
olfactory receptor 1202
chr10_+_94445877 3.64 ENSRNOT00000013997
proteasome 26S subunit, ATPase 5
chr3_+_2648885 3.60 ENSRNOT00000020339
ATP binding cassette subfamily A member 2
chr19_-_37250919 3.60 ENSRNOT00000021015
exocyst complex component 3-like 1
chr4_+_1363724 3.56 ENSRNOT00000072782
olfactory receptor 143-like
chr20_-_556982 3.55 ENSRNOT00000047478
olfactory receptor 1683
chr10_+_46906115 3.48 ENSRNOT00000034006
alkB homolog 5, RNA demethylase
chr19_-_26053762 3.47 ENSRNOT00000004646
microtubule associated serine/threonine kinase 1
chr20_-_3818045 3.46 ENSRNOT00000091622
hydroxysteroid (17-beta) dehydrogenase 8
chr8_-_62987182 3.45 ENSRNOT00000070885
immunoglobulin superfamily containing leucine-rich repeat 2
chr16_-_755990 3.44 ENSRNOT00000013501
RNA polymerase III subunit A
chr8_+_40524733 3.37 ENSRNOT00000076626
ENSRNOT00000074528
olfactory receptor 1206
chr7_-_63728988 3.37 ENSRNOT00000009645
exportin for tRNA
chr6_-_86822094 3.36 ENSRNOT00000006531
FK506 binding protein 3
chr3_+_1413671 3.33 ENSRNOT00000007675
interleukin 1 family member 10
chr2_+_188748359 3.31 ENSRNOT00000028038
SHC adaptor protein 1
chr1_-_175676699 3.31 ENSRNOT00000030474
lymphatic vessel endothelial hyaluronan receptor 1
chr2_-_61414038 3.30 ENSRNOT00000051910
ENSRNOT00000088202
threonyl-tRNA synthetase
chr8_+_41954140 3.25 ENSRNOT00000049709
olfactory receptor 1223
chr6_+_136330383 3.22 ENSRNOT00000093106
ENSRNOT00000092774
ENSRNOT00000065281
ENSRNOT00000015935
kinesin light chain 1
chr8_+_119228612 3.22 ENSRNOT00000078439
ENSRNOT00000043737
leucine rich repeat containing 2
chr1_-_78997869 3.22 ENSRNOT00000023490
hypoxia inducible factor 3, alpha subunit
chr11_-_83944763 3.20 ENSRNOT00000002358
proteasome 26S subunit, non-ATPase 2
chr8_+_43644822 3.18 ENSRNOT00000085286
olfactory receptor 1321
chr8_+_43675950 3.18 ENSRNOT00000079430
olfactory receptor 1323
chr3_-_2490392 3.12 ENSRNOT00000014993
SS nuclear autoantigen 1
chr20_-_35342 3.11 ENSRNOT00000048277
olfactory receptor 2B11-like
chr11_-_84037938 3.10 ENSRNOT00000002327
ATP binding cassette subfamily F member 3
chr4_+_167351697 3.07 ENSRNOT00000007659
ENSRNOT00000046622
glutamine/glutamic acid-rich protein B
chr9_-_82154266 3.05 ENSRNOT00000024283
crystallin, beta A2
chr4_+_113866804 3.03 ENSRNOT00000081196
lysyl oxidase-like 3
chr20_+_386421 3.02 ENSRNOT00000044420
olfactory receptor 1670
chr4_-_55740627 3.00 ENSRNOT00000010658
paired box 4
chr16_+_21050243 2.99 ENSRNOT00000064308
neurocan
chr3_-_158985814 2.97 ENSRNOT00000071070
olfactory receptor 150-like
chr15_+_35761388 2.96 ENSRNOT00000086118
olfactory receptor 1286
chr4_-_9881484 2.95 ENSRNOT00000016450
proteasome 26S subunit, ATPase 2
chr10_-_86393141 2.92 ENSRNOT00000009485
migration and invasion enhancer 1
chr4_+_24222500 2.89 ENSRNOT00000045346
zinc finger protein 804B
chr17_+_4165041 2.89 ENSRNOT00000061427
trophoblast specific protein alpha
chr8_+_40383918 2.87 ENSRNOT00000071422
olfactory receptor 1201
chr12_-_50404550 2.83 ENSRNOT00000073072
crystallin, beta B1
chr5_+_120340646 2.80 ENSRNOT00000086259
ENSRNOT00000086539
DnaJ heat shock protein family (Hsp40) member C6
chr10_+_95706685 2.73 ENSRNOT00000004283
proteasome 26S subunit, non-ATPase 12
chr1_-_225035687 2.68 ENSRNOT00000026539
G protein subunit gamma 3
chr2_+_46186105 2.62 ENSRNOT00000071256
olfactory receptor 145-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfe2_Bach1_Mafk

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
16.1 48.2 GO:0000053 argininosuccinate metabolic process(GO:0000053)
11.9 59.3 GO:0009115 xanthine catabolic process(GO:0009115)
9.4 28.3 GO:0046167 glycerol-3-phosphate biosynthetic process(GO:0046167)
7.7 23.0 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
6.2 24.7 GO:0097069 cellular response to thyroxine stimulus(GO:0097069)
5.8 29.0 GO:0097332 response to antipsychotic drug(GO:0097332)
5.7 22.8 GO:1901907 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
5.4 21.6 GO:0038128 ERBB2 signaling pathway(GO:0038128)
5.0 15.0 GO:0060974 cell migration involved in heart formation(GO:0060974)
4.5 49.7 GO:1902031 regulation of NADP metabolic process(GO:1902031)
4.5 58.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
4.3 12.8 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
4.0 12.1 GO:2000158 flavin-containing compound metabolic process(GO:0042726) positive regulation of ubiquitin-specific protease activity(GO:2000158)
3.2 12.9 GO:1904975 response to bleomycin(GO:1904975)
3.2 9.6 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
2.7 27.2 GO:0035754 B cell chemotaxis(GO:0035754)
2.6 10.2 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
2.5 7.5 GO:0033693 neurofilament bundle assembly(GO:0033693)
2.4 26.0 GO:0015747 urate transport(GO:0015747)
2.3 9.2 GO:0038086 cell migration involved in vasculogenesis(GO:0035441) VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
2.3 6.9 GO:0072162 regulation of metanephros size(GO:0035566) metanephric mesenchymal cell differentiation(GO:0072162)
2.2 6.6 GO:1903233 positive regulation of endoplasmic reticulum calcium ion concentration(GO:0032470) regulation of calcium ion-dependent exocytosis of neurotransmitter(GO:1903233) calcium ion import into sarcoplasmic reticulum(GO:1990036)
2.2 36.8 GO:0019532 oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
2.1 19.1 GO:0061635 regulation of protein complex stability(GO:0061635)
2.1 8.2 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
2.0 6.0 GO:1903860 negative regulation of dendrite extension(GO:1903860)
2.0 8.0 GO:0051684 maintenance of Golgi location(GO:0051684)
1.9 9.4 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
1.9 57.4 GO:0019430 removal of superoxide radicals(GO:0019430)
1.8 7.1 GO:1990375 baculum development(GO:1990375)
1.8 17.7 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
1.7 6.8 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
1.7 5.0 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
1.6 17.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
1.6 4.7 GO:1901143 insulin catabolic process(GO:1901143)
1.6 11.0 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
1.5 3.0 GO:2000328 regulation of T-helper 17 cell lineage commitment(GO:2000328)
1.5 5.9 GO:0042851 L-alanine metabolic process(GO:0042851)
1.4 10.1 GO:0002074 extraocular skeletal muscle development(GO:0002074)
1.4 15.5 GO:0051132 NK T cell activation(GO:0051132)
1.4 8.4 GO:0010966 regulation of phosphate transport(GO:0010966)
1.4 2.8 GO:0072318 clathrin coat disassembly(GO:0072318)
1.4 4.1 GO:0021898 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
1.3 4.0 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
1.3 3.8 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
1.3 3.8 GO:0070084 protein initiator methionine removal(GO:0070084)
1.2 3.6 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
1.2 14.1 GO:0042738 exogenous drug catabolic process(GO:0042738)
1.1 3.4 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
1.1 4.5 GO:0010999 regulation of eIF2 alpha phosphorylation by heme(GO:0010999)
1.1 4.4 GO:2000195 negative regulation of female gonad development(GO:2000195)
1.1 3.3 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
1.1 6.4 GO:0010992 ubiquitin homeostasis(GO:0010992)
1.0 4.0 GO:0070560 protein secretion by platelet(GO:0070560)
1.0 39.7 GO:0030224 monocyte differentiation(GO:0030224)
1.0 8.6 GO:0038161 prolactin signaling pathway(GO:0038161)
0.9 3.5 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.8 15.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.8 3.1 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.8 2.3 GO:0015820 leucine transport(GO:0015820)
0.8 3.8 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.7 1.5 GO:0048850 hypophysis morphogenesis(GO:0048850)
0.7 12.6 GO:0048484 enteric nervous system development(GO:0048484)
0.7 2.2 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.7 2.2 GO:1990091 sodium-dependent self proteolysis(GO:1990091)
0.7 2.2 GO:0042628 mating plug formation(GO:0042628) post-mating behavior(GO:0045297)
0.7 7.0 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.7 2.1 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.7 2.0 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
0.6 3.2 GO:0035617 stress granule disassembly(GO:0035617)
0.6 5.7 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.6 4.4 GO:0016259 selenocysteine metabolic process(GO:0016259)
0.6 4.4 GO:0060720 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) spongiotrophoblast cell proliferation(GO:0060720) cell proliferation involved in embryonic placenta development(GO:0060722)
0.6 8.7 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.6 22.0 GO:0047496 vesicle transport along microtubule(GO:0047496)
0.6 7.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.6 1.7 GO:1904178 sterol regulatory element binding protein import into nucleus(GO:0035105) negative regulation of adipose tissue development(GO:1904178)
0.6 3.9 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.5 2.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.5 103.2 GO:0030308 negative regulation of cell growth(GO:0030308)
0.5 2.1 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.5 7.7 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.5 1.5 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) embryonic genitalia morphogenesis(GO:0030538)
0.5 4.4 GO:1904116 response to vasopressin(GO:1904116)
0.5 1.9 GO:0070827 chromatin maintenance(GO:0070827)
0.4 6.7 GO:0043248 proteasome assembly(GO:0043248)
0.4 2.4 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.4 8.5 GO:0045760 positive regulation of action potential(GO:0045760)
0.4 3.9 GO:0060068 vagina development(GO:0060068)
0.4 3.5 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.4 43.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.4 20.3 GO:0001523 retinoid metabolic process(GO:0001523)
0.4 1.8 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.4 2.5 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
0.4 4.4 GO:0060430 lung saccule development(GO:0060430)
0.4 8.7 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.3 5.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.3 4.3 GO:0022038 corpus callosum development(GO:0022038)
0.3 9.5 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.3 3.8 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.3 1.5 GO:0090187 positive regulation of pancreatic juice secretion(GO:0090187)
0.3 7.9 GO:0060046 regulation of acrosome reaction(GO:0060046)
0.3 4.7 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.3 9.7 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.3 5.0 GO:2000505 regulation of energy homeostasis(GO:2000505)
0.3 1.9 GO:0006477 protein sulfation(GO:0006477)
0.3 3.6 GO:0051601 exocyst localization(GO:0051601)
0.2 3.0 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.2 2.4 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.2 7.0 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.2 0.9 GO:1905150 regulation of membrane depolarization during action potential(GO:0098902) regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825) regulation of voltage-gated sodium channel activity(GO:1905150)
0.2 2.2 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.2 1.0 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 3.9 GO:0070166 enamel mineralization(GO:0070166)
0.2 8.2 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.2 0.5 GO:0070649 formin-nucleated actin cable assembly(GO:0070649)
0.2 3.3 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.1 3.9 GO:0048745 smooth muscle tissue development(GO:0048745)
0.1 0.4 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.1 0.9 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 1.0 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.1 2.4 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.1 38.6 GO:0006914 autophagy(GO:0006914)
0.1 1.1 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.1 1.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 1.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 4.1 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1 7.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 0.3 GO:0042938 dipeptide transport(GO:0042938)
0.1 2.7 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 3.9 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 2.9 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.1 110.7 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 5.2 GO:0046785 microtubule polymerization(GO:0046785)
0.1 16.0 GO:0001889 liver development(GO:0001889)
0.1 5.0 GO:0071230 cellular response to amino acid stimulus(GO:0071230)
0.1 3.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.7 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 1.2 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 0.8 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 11.0 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.1 4.3 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.1 1.2 GO:0071577 cellular zinc ion homeostasis(GO:0006882) zinc II ion transmembrane transport(GO:0071577)
0.1 4.0 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 2.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.6 GO:0035404 histone-serine phosphorylation(GO:0035404)
0.0 23.0 GO:0030163 protein catabolic process(GO:0030163)
0.0 0.9 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.0 0.5 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.0 3.0 GO:0051591 response to cAMP(GO:0051591)
0.0 7.2 GO:0042692 muscle cell differentiation(GO:0042692)
0.0 2.6 GO:0006413 translational initiation(GO:0006413)
0.0 0.2 GO:0007097 nuclear migration(GO:0007097)
0.0 0.4 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.3 21.8 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
4.0 12.1 GO:1990730 VCP-NSFL1C complex(GO:1990730)
3.4 58.1 GO:0035686 sperm fibrous sheath(GO:0035686)
3.0 48.2 GO:0070852 cell body fiber(GO:0070852)
2.6 12.8 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
2.5 22.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
2.3 36.6 GO:0031045 dense core granule(GO:0031045)
2.2 11.0 GO:0005927 muscle tendon junction(GO:0005927)
2.2 6.6 GO:0090534 longitudinal sarcoplasmic reticulum(GO:0014801) calcium ion-transporting ATPase complex(GO:0090534)
1.5 30.3 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
1.5 1.5 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
1.5 7.3 GO:0089701 U2AF(GO:0089701)
1.4 38.8 GO:0022624 proteasome accessory complex(GO:0022624)
1.3 4.0 GO:0031095 platelet dense tubular network membrane(GO:0031095)
1.3 41.5 GO:0032839 dendrite cytoplasm(GO:0032839)
1.3 19.1 GO:0044754 autolysosome(GO:0044754)
1.2 4.7 GO:0097513 myosin II filament(GO:0097513)
1.0 18.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.9 17.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.8 9.2 GO:0043202 lysosomal lumen(GO:0043202)
0.8 3.8 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.7 9.7 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.7 13.4 GO:0005916 fascia adherens(GO:0005916)
0.7 7.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.7 5.0 GO:0071986 Ragulator complex(GO:0071986)
0.7 14.3 GO:0030056 hemidesmosome(GO:0030056)
0.7 7.5 GO:0097418 neurofibrillary tangle(GO:0097418)
0.5 27.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.5 15.0 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.5 8.7 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.4 10.1 GO:0031430 M band(GO:0031430)
0.3 9.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.3 3.2 GO:0035253 ciliary rootlet(GO:0035253)
0.3 4.0 GO:0030127 COPII vesicle coat(GO:0030127)
0.3 4.7 GO:0071437 invadopodium(GO:0071437)
0.3 11.7 GO:0000502 proteasome complex(GO:0000502)
0.2 6.8 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.2 4.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 3.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.2 9.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 11.0 GO:0014704 intercalated disc(GO:0014704)
0.2 28.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.2 6.9 GO:0034451 centriolar satellite(GO:0034451)
0.2 11.4 GO:0044438 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.2 1.7 GO:0005638 lamin filament(GO:0005638)
0.2 10.6 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 2.9 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 3.6 GO:0000145 exocyst(GO:0000145)
0.2 4.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 1.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.0 GO:0005915 zonula adherens(GO:0005915)
0.1 1.1 GO:0000815 ESCRT III complex(GO:0000815)
0.1 2.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 2.5 GO:0042734 presynaptic membrane(GO:0042734)
0.1 28.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 8.6 GO:0031526 brush border membrane(GO:0031526)
0.1 8.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 7.0 GO:0030667 secretory granule membrane(GO:0030667)
0.1 9.1 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 6.1 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 0.7 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 68.2 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 1.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.9 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 11.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 10.5 GO:0043197 dendritic spine(GO:0043197)
0.1 3.9 GO:0016459 myosin complex(GO:0016459)
0.1 37.8 GO:0043025 neuronal cell body(GO:0043025)
0.1 4.1 GO:0031901 early endosome membrane(GO:0031901)
0.1 111.8 GO:0005739 mitochondrion(GO:0005739)
0.1 2.2 GO:0030315 T-tubule(GO:0030315)
0.1 0.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 3.4 GO:0005643 nuclear pore(GO:0005643)
0.1 37.4 GO:0016604 nuclear body(GO:0016604)
0.0 2.4 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 7.0 GO:0016324 apical plasma membrane(GO:0016324)
0.0 4.2 GO:0005604 basement membrane(GO:0005604)
0.0 0.7 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 4.1 GO:0001650 fibrillar center(GO:0001650)
0.0 3.1 GO:0036064 ciliary basal body(GO:0036064)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.6 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.5 GO:0012506 vesicle membrane(GO:0012506)
0.0 0.9 GO:0042383 sarcolemma(GO:0042383)
0.0 0.3 GO:0005903 brush border(GO:0005903)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
16.6 49.7 GO:0008948 oxaloacetate decarboxylase activity(GO:0008948)
12.1 60.7 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
11.9 59.3 GO:0004854 aldehyde oxidase activity(GO:0004031) xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
9.4 28.3 GO:0004370 glycerol kinase activity(GO:0004370)
8.3 58.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
6.4 25.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
5.7 22.8 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
4.5 27.2 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
4.5 40.1 GO:0030957 Tat protein binding(GO:0030957)
4.3 12.8 GO:0002134 UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
4.0 12.1 GO:0035800 deubiquitinase activator activity(GO:0035800)
3.7 15.0 GO:0051870 methotrexate binding(GO:0051870)
3.2 16.0 GO:0004301 epoxide hydrolase activity(GO:0004301)
3.1 21.8 GO:0045503 dynein light chain binding(GO:0045503)
3.1 15.5 GO:0005534 galactose binding(GO:0005534)
3.1 55.7 GO:0015643 toxic substance binding(GO:0015643)
3.1 9.2 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
2.9 8.6 GO:0004925 prolactin receptor activity(GO:0004925)
2.6 26.0 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
2.5 36.8 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
2.0 5.9 GO:0047635 L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635)
1.5 12.3 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
1.5 8.7 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
1.5 4.4 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
1.4 7.1 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
1.4 39.3 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
1.3 10.3 GO:0047134 protein-disulfide reductase activity(GO:0047134)
1.3 3.8 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
1.2 17.7 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
1.2 24.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
1.2 3.5 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
1.1 4.5 GO:0030350 iron-responsive element binding(GO:0030350)
1.1 3.3 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
1.0 8.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
1.0 8.7 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
1.0 3.9 GO:0033149 FFAT motif binding(GO:0033149)
0.9 24.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.9 6.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.9 4.4 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.9 3.5 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.8 5.0 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.8 3.3 GO:0048408 epidermal growth factor binding(GO:0048408)
0.8 43.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.7 23.0 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.7 4.4 GO:0045340 mercury ion binding(GO:0045340)
0.7 7.3 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.7 18.7 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.7 7.0 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.7 19.1 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.6 24.0 GO:0030506 ankyrin binding(GO:0030506)
0.6 6.4 GO:0016004 phospholipase activator activity(GO:0016004)
0.6 7.7 GO:0042056 chemoattractant activity(GO:0042056)
0.6 3.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.6 4.1 GO:0071532 GKAP/Homer scaffold activity(GO:0030160) ankyrin repeat binding(GO:0071532)
0.6 100.1 GO:0008083 growth factor activity(GO:0008083)
0.6 4.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.5 14.1 GO:0070330 aromatase activity(GO:0070330)
0.5 4.7 GO:0043559 insulin binding(GO:0043559)
0.5 7.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.5 2.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.5 5.0 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.5 4.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.4 6.6 GO:0044548 S100 protein binding(GO:0044548)
0.4 3.8 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.4 3.8 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.4 1.1 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.4 10.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 11.0 GO:0043236 laminin binding(GO:0043236)
0.3 2.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.3 4.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.3 4.5 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.3 7.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.3 1.9 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.3 21.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.3 2.7 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.3 3.4 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 6.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 13.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.2 0.9 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558)
0.2 2.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.2 5.9 GO:0004707 MAP kinase activity(GO:0004707)
0.2 18.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 3.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 4.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2 3.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 2.2 GO:0031432 titin binding(GO:0031432)
0.2 4.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.2 2.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.2 64.3 GO:0005549 odorant binding(GO:0005549)
0.2 3.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.4 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.1 4.0 GO:0030507 spectrin binding(GO:0030507)
0.1 1.5 GO:0045295 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.1 2.4 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 0.3 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.1 9.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 15.0 GO:0008201 heparin binding(GO:0008201)
0.1 13.8 GO:0005262 calcium channel activity(GO:0005262)
0.1 1.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.3 GO:0015322 proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.1 1.9 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 1.0 GO:0070097 delta-catenin binding(GO:0070097)
0.1 3.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 2.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 13.2 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.1 9.7 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.1 9.9 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 2.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 4.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 2.2 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 4.0 GO:0002039 p53 binding(GO:0002039)
0.1 3.5 GO:0032947 protein complex scaffold(GO:0032947)
0.1 46.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.4 GO:0009881 photoreceptor activity(GO:0009881)
0.0 4.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.6 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 6.0 GO:0005179 hormone activity(GO:0005179)
0.0 1.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 2.0 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.0 2.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.2 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 7.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.4 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 3.6 GO:0000149 SNARE binding(GO:0000149)
0.0 5.8 GO:0003924 GTPase activity(GO:0003924)
0.0 2.3 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 1.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 7.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.2 GO:0005521 lamin binding(GO:0005521)
0.0 1.1 GO:0008565 protein transporter activity(GO:0008565)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 12.6 PID ALK2 PATHWAY ALK2 signaling events
0.8 62.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.8 40.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.5 9.6 ST G ALPHA S PATHWAY G alpha s Pathway
0.5 20.7 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.5 19.1 PID IL1 PATHWAY IL1-mediated signaling events
0.4 5.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.4 23.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.4 12.3 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.3 9.2 PID S1P S1P3 PATHWAY S1P3 pathway
0.3 13.0 PID AURORA B PATHWAY Aurora B signaling
0.3 24.7 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.3 3.2 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.3 8.6 PID ERBB4 PATHWAY ErbB4 signaling events
0.3 12.8 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.3 10.6 PID ARF6 PATHWAY Arf6 signaling events
0.2 3.0 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.2 4.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 3.9 PID FOXO PATHWAY FoxO family signaling
0.1 4.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.2 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 13.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 0.9 PID ARF 3PATHWAY Arf1 pathway
0.1 3.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.5 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.3 PID E2F PATHWAY E2F transcription factor network
0.0 0.3 PID REELIN PATHWAY Reelin signaling pathway
0.0 2.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 46.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
2.4 26.0 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
1.7 90.9 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
1.6 19.1 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
1.5 58.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
1.1 12.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.9 24.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.8 24.0 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6 28.3 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.5 7.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.5 9.6 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.5 12.3 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.5 23.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.5 9.8 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.5 8.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.4 54.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.4 54.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.4 9.7 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.4 5.3 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.3 6.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.3 10.5 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.3 33.2 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 25.1 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.3 4.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.3 3.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.3 3.3 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.2 7.1 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 4.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.2 2.8 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 3.6 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 3.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 4.7 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 3.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 2.7 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 7.0 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.1 0.7 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.1 7.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 4.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.9 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 0.7 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 2.2 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 3.4 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.1 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 2.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.4 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.5 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.2 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1