ISMARA results: Nfat5

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nfat5

Z-value: 1.22

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Transcription factors associated with Nfat5

Gene Symbol	Gene ID	Gene Info
Nfat5 NCBI RGD Ensembl	ENSRNOG00000011879	nuclear factor of activated T-cells 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nfat5	rn6_v1_chr19_-_38533735_38533735	0.07	1.9e-01	Click!

Activity profile of Nfat5 motif

Sorted Z-values of Nfat5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_+_141237768 Show fit	54.29	ENSRNOT00000091717	Aqp2 NCBI RGD Ensembl Show fit	aquaporin 2
chr2_+_68821004 Show fit	50.46	ENSRNOT00000083713	Egf NCBI RGD Ensembl Show fit	epidermal growth factor
chr2_+_68820615 Show fit	48.75	ENSRNOT00000087007 ENSRNOT00000089504	Egf NCBI RGD Ensembl Show fit	epidermal growth factor
chr2_-_235177275 Show fit	47.62	ENSRNOT00000093153	LOC103691699 NCBI RGD Ensembl Show fit	uncharacterized LOC103691699
chr8_+_49713190 Show fit	42.36	ENSRNOT00000022074	Fxyd2 NCBI RGD Ensembl Show fit	FXYD domain-containing ion transport regulator 2
chr9_+_95501778 Show fit	42.28	ENSRNOT00000086805	Spp2 NCBI RGD Ensembl Show fit	secreted phosphoprotein 2
chr18_-_69944632 Show fit	39.40	ENSRNOT00000047271	Mapk4 NCBI RGD Ensembl Show fit	mitogen-activated protein kinase 4
chr10_+_71159869 Show fit	35.72	ENSRNOT00000075977 ENSRNOT00000047427	Hnf1b NCBI RGD Ensembl Show fit	HNF1 homeobox B
chr9_+_95161157 Show fit	30.91	ENSRNOT00000071200	Ugt1a5 NCBI RGD Ensembl Show fit	UDP glucuronosyltransferase family 1 member A5
chr4_-_177196180 Show fit	28.99	ENSRNOT00000018999	St8sia1 NCBI RGD Ensembl Show fit	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

Showing 1 to 10 of 119 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfat5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
12.4	99.2	GO:0007262	STAT protein import into nucleus(GO:0007262)
18.1	54.3	GO:0042631	cellular response to water deprivation(GO:0042631)
2.5	42.4	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.4	42.3	GO:0046849	bone remodeling(GO:0046849)
0.1	39.4	GO:0000165	MAPK cascade(GO:0000165)
11.9	35.7	GO:0061228	mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
3.4	30.9	GO:0052697	xenobiotic glucuronidation(GO:0052697)
1.8	30.0	GO:0036159	inner dynein arm assembly(GO:0036159)
1.3	29.0	GO:0097503	sialylation(GO:0097503)
0.9	24.6	GO:0042832	defense response to protozoan(GO:0042832)

Showing 1 to 10 of 69 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	99.2	GO:0043235	receptor complex(GO:0043235)
1.5	54.3	GO:0046930	pore complex(GO:0046930)
0.1	53.5	GO:0005667	transcription factor complex(GO:0005667)
3.5	42.4	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
7.5	30.0	GO:0036156	inner dynein arm(GO:0036156)
0.5	25.8	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.3	24.9	GO:0031526	brush border membrane(GO:0031526)
0.1	24.7	GO:0009897	external side of plasma membrane(GO:0009897)
0.8	21.9	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	21.3	GO:0005887	integral component of plasma membrane(GO:0005887)

Showing 1 to 10 of 47 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.8	99.2	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.1	60.2	GO:0005509	calcium ion binding(GO:0005509)
10.9	54.3	GO:0015168	polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
3.0	42.4	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1	40.2	GO:0046982	protein heterodimerization activity(GO:0046982)
1.4	39.4	GO:0004707	MAP kinase activity(GO:0004707)
0.3	34.0	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.0	30.9	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.3	30.0	GO:0003777	microtubule motor activity(GO:0003777)
1.3	29.0	GO:0008373	sialyltransferase activity(GO:0008373)

Showing 1 to 10 of 54 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.2	99.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.6	35.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.5	18.2	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.2	17.6	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.4	12.3	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.2	12.2	PID FOXO PATHWAY	FoxO family signaling
0.3	11.7	PID ARF6 PATHWAY	Arf6 signaling events
0.2	9.4	PID PLK1 PATHWAY	PLK1 signaling events
0.2	7.7	PID AURORA B PATHWAY	Aurora B signaling
0.2	6.1	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.0	99.2	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
1.0	59.8	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
4.5	54.3	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.9	42.4	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.9	35.7	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
1.6	30.9	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
1.6	21.8	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
1.1	16.8	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.5	16.3	REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	Genes involved in Post NMDA receptor activation events
0.5	15.9	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type

Showing 1 to 10 of 26 entries

Results for Nfat5

Z-value: 1.22

Motif logo

Transcription factors associated with Nfat5

Activity-expression correlation:

Activity profile of Nfat5 motif

Sorted Z-values of Nfat5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfat5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: