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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Nfat5

Z-value: 1.22

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Transcription factors associated with Nfat5

Gene Symbol Gene ID Gene Info
Nfat5
ENSRNOG00000011879 nuclear factor of activated T-cells 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfat5rn6_v1_chr19_-_38533735_385337350.071.9e-01Click!

Activity profile of Nfat5 motif

Sorted Z-values of Nfat5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_141237768 54.29 ENSRNOT00000091717
Aqp2
aquaporin 2
chr2_+_68821004 50.46 ENSRNOT00000083713
Egf
epidermal growth factor
chr2_+_68820615 48.75 ENSRNOT00000087007
ENSRNOT00000089504
Egf
epidermal growth factor
chr2_-_235177275 47.62 ENSRNOT00000093153
LOC103691699
uncharacterized LOC103691699
chr8_+_49713190 42.36 ENSRNOT00000022074
Fxyd2
FXYD domain-containing ion transport regulator 2
chr9_+_95501778 42.28 ENSRNOT00000086805
Spp2
secreted phosphoprotein 2
chr18_-_69944632 39.40 ENSRNOT00000047271
Mapk4
mitogen-activated protein kinase 4
chr10_+_71159869 35.72 ENSRNOT00000075977
ENSRNOT00000047427
Hnf1b
HNF1 homeobox B
chr9_+_95161157 30.91 ENSRNOT00000071200
Ugt1a5
UDP glucuronosyltransferase family 1 member A5
chr4_-_177196180 28.99 ENSRNOT00000018999
St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr3_-_94808861 28.89 ENSRNOT00000038464
Prrg4
proline rich and Gla domain 4
chr6_+_8284878 24.85 ENSRNOT00000009581
Slc3a1
solute carrier family 3 member 1
chr5_-_146795866 24.63 ENSRNOT00000065640
Tlr12
toll-like receptor 12
chr10_+_109665682 22.34 ENSRNOT00000054963
Slc25a10
solute carrier family 25 member 10
chr12_-_29743705 21.93 ENSRNOT00000001185
Caln1
calneuron 1
chr7_-_68549763 21.82 ENSRNOT00000078014
Slc16a7
solute carrier family 16 member 7
chr7_-_97071968 21.33 ENSRNOT00000006596
Slc22a22
solute carrier family 22 (organic cation transporter), member 22
chr9_-_60255746 17.15 ENSRNOT00000093710
Dnah7
dynein, axonemal, heavy chain 7
chr4_+_98337367 16.94 ENSRNOT00000042165
AABR07060872.1

chr5_-_160620334 16.93 ENSRNOT00000019171
Tmem51
transmembrane protein 51
chr15_+_39779648 16.80 ENSRNOT00000084505
Cab39l
calcium binding protein 39-like
chr1_+_256382791 15.89 ENSRNOT00000022549
Cyp26a1
cytochrome P450, family 26, subfamily a, polypeptide 1
chr1_+_213886775 15.75 ENSRNOT00000020864
Pkp3
plakophilin 3
chr6_-_42616548 15.26 ENSRNOT00000081433
Atp6v1c2
ATPase H+ transporting V1 subunit C2
chr3_-_148057523 14.68 ENSRNOT00000055408
Defb24
defensin beta 24
chr7_-_27552078 13.72 ENSRNOT00000059538
Stab2
stabilin 2
chr6_-_107080524 13.51 ENSRNOT00000011662
Zfyve1
zinc finger FYVE-type containing 1
chr3_-_153321352 13.38 ENSRNOT00000064824
Rbl1
RB transcriptional corepressor like 1
chr9_-_60330086 12.83 ENSRNOT00000092162
ENSRNOT00000093630
Dnah7
dynein, axonemal, heavy chain 7
chr9_+_30939555 12.66 ENSRNOT00000016887
Lmbrd1
LMBR1 domain containing 1
chr4_-_123713319 12.56 ENSRNOT00000012875
ENSRNOT00000086982
Slc6a6
solute carrier family 6 member 6
chr16_+_54765325 12.41 ENSRNOT00000065327
ENSRNOT00000086899
Mtmr7
myotubularin related protein 7
chrX_+_43626480 12.31 ENSRNOT00000068078
Sat1
spermidine/spermine N1-acetyl transferase 1
chr5_+_135351816 12.30 ENSRNOT00000082602
Ipp
intracisternal A particle-promoted polypeptide
chr1_-_24190896 12.22 ENSRNOT00000016121
Sgk1
serum/glucocorticoid regulated kinase 1
chr6_-_143195445 11.87 ENSRNOT00000078672
AABR07065837.1

chr14_+_48726045 11.70 ENSRNOT00000086646
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_+_5967463 11.01 ENSRNOT00000086251
Tmem123
transmembrane protein 123
chr8_-_128672284 11.00 ENSRNOT00000083004
Csrnp1
cysteine and serine rich nuclear protein 1
chr11_-_11585765 10.80 ENSRNOT00000066439
Robo2
roundabout guidance receptor 2
chr1_+_41192824 10.53 ENSRNOT00000082133
Esr1
estrogen receptor 1
chr2_-_28801223 10.46 ENSRNOT00000020726
Tmem171
transmembrane protein 171
chr11_+_32211115 10.41 ENSRNOT00000087452
Mrps6
mitochondrial ribosomal protein S6
chr2_-_112802073 10.26 ENSRNOT00000093081
Ect2
epithelial cell transforming 2
chr6_-_143195143 9.98 ENSRNOT00000081337
AABR07065837.1

chr2_+_185590986 9.78 ENSRNOT00000088807
ENSRNOT00000088188
Lrba
LPS responsive beige-like anchor protein
chr16_+_49350884 9.44 ENSRNOT00000014828
Snx25
sorting nexin 25
chrX_+_110894845 9.41 ENSRNOT00000080072
Tbc1d8b
TBC1 domain family member 8B
chr5_-_100970043 9.20 ENSRNOT00000013950
Zdhhc21
zinc finger, DHHC-type containing 21
chr16_+_74534130 8.88 ENSRNOT00000050637
Slc25a15
solute carrier family 25 member 15
chr1_-_194769524 8.78 ENSRNOT00000025988
Nupr1
nuclear protein 1, transcriptional regulator
chrX_-_82699487 8.60 ENSRNOT00000081625
Rps6ka6
ribosomal protein S6 kinase A6
chr1_-_198045154 7.99 ENSRNOT00000072875
Nupr1l1
nuclear protein, transcriptional regulator, 1-like 1
chr2_+_165601007 7.66 ENSRNOT00000013931
Smc4
structural maintenance of chromosomes 4
chr18_+_25749098 7.66 ENSRNOT00000027771
Camk4
calcium/calmodulin-dependent protein kinase IV
chr4_-_178441547 7.66 ENSRNOT00000087434
ENSRNOT00000055542
Sox5
SRY box 5
chr3_-_2490392 7.44 ENSRNOT00000014993
Ssna1
SS nuclear autoantigen 1
chr10_+_108132105 7.34 ENSRNOT00000072534
Cbx2
chromobox 2
chr16_-_82288022 7.34 ENSRNOT00000078609
Spaca7
sperm acrosome associated 7
chr13_-_78521911 6.82 ENSRNOT00000087506
Rabgap1l
RAB GTPase activating protein 1-like
chr7_+_74350479 6.75 ENSRNOT00000089034
AABR07057495.1

chr17_+_24242642 6.65 ENSRNOT00000024323
Rnf182
ring finger protein 182
chr6_+_126766967 6.42 ENSRNOT00000052296
Cox8c
cytochrome c oxidase subunit 8C
chr12_+_37702404 6.29 ENSRNOT00000049985
Mphosph9
M-phase phosphoprotein 9
chr15_+_10120206 6.08 ENSRNOT00000033048
Rarb
retinoic acid receptor, beta
chr2_+_180012414 5.90 ENSRNOT00000082273
Pdgfc
platelet derived growth factor C
chr5_-_153924896 5.80 ENSRNOT00000065247
Grhl3
grainyhead-like transcription factor 3
chr3_-_77483322 5.50 ENSRNOT00000008077
Olr661
olfactory receptor 661
chr15_+_5904569 5.41 ENSRNOT00000072599
LOC102546376
disks large homolog 5-like
chr7_+_20262680 4.98 ENSRNOT00000046378
LOC300308
similar to hypothetical protein 4930509O22
chr16_-_81693000 4.92 ENSRNOT00000092353
Lamp1
lysosomal-associated membrane protein 1
chr13_+_49003803 4.81 ENSRNOT00000080556
Lemd1
LEM domain containing 1
chr12_+_21767606 4.79 ENSRNOT00000059602
LOC103691013
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1-like
chr8_-_6305033 4.66 ENSRNOT00000029887
Cep126
centrosomal protein 126
chr18_+_29386809 4.36 ENSRNOT00000082079
ENSRNOT00000024825
Eif4ebp3
eukaryotic translation initiation factor 4E binding protein 3
chr11_+_47243342 4.31 ENSRNOT00000041116
Nfkbiz
NFKB inhibitor zeta
chr14_+_81819799 4.22 ENSRNOT00000076840
Mxd4
Max dimerization protein 4
chr1_-_211196868 4.19 ENSRNOT00000022714
Mapk1ip1
mitogen-activated protein kinase 1 interacting protein 1
chr10_-_73629581 4.11 ENSRNOT00000091172
Brip1
BRCA1 interacting protein C-terminal helicase 1
chr16_-_75107931 3.88 ENSRNOT00000058066
Defb15
defensin beta 15
chr1_+_199655660 3.78 ENSRNOT00000027032
Armc5
armadillo repeat containing 5
chr7_-_140556639 3.70 ENSRNOT00000089523
Rhebl1
Ras homolog enriched in brain like 1
chr12_+_23544287 3.59 ENSRNOT00000001938
Orai2
ORAI calcium release-activated calcium modulator 2
chr20_-_3372070 3.40 ENSRNOT00000080770
Dhx16
DEAH-box helicase 16
chr5_+_64566804 3.34 ENSRNOT00000073192
LOC103690035
TGF-beta receptor type-1-like
chr16_+_75122996 3.23 ENSRNOT00000018375
Defb15
defensin beta 15
chr16_-_75518336 2.95 ENSRNOT00000058037
Defa11
defensin alpha 11
chr5_-_24926904 2.95 ENSRNOT00000075288
AABR07047232.1

chr12_-_41590244 2.86 ENSRNOT00000038736
Slc8b1
solute carrier family 8 member B1
chr12_-_18227991 2.82 ENSRNOT00000072986
AABR07035501.1

chr2_+_87418517 2.74 ENSRNOT00000048046
LOC100909879
tyrosine-protein phosphatase non-receptor type substrate 1-like
chr19_-_52424318 2.49 ENSRNOT00000021743
Tldc1
TBC/LysM-associated domain containing 1
chr5_+_130286393 2.48 ENSRNOT00000044795
Ccp6l1
cytosolic carboxypeptidase 6-like 1
chr1_-_274107138 2.43 ENSRNOT00000078670
Smndc1
survival motor neuron domain containing 1
chr13_-_27653839 2.23 ENSRNOT00000071638
LOC100360575
signal-regulatory protein alpha-like
chr7_+_23012070 2.03 ENSRNOT00000042460
LOC300308
similar to hypothetical protein 4930509O22
chr9_+_37462693 1.99 ENSRNOT00000016316
Lgsn
lengsin, lens protein with glutamine synthetase domain
chr10_-_87407634 1.93 ENSRNOT00000016657
Krt23
keratin 23
chr6_-_98566523 1.90 ENSRNOT00000077715
Ppp2r5e
protein phosphatase 2 regulatory subunit B', epsilon
chr10_+_83081168 1.89 ENSRNOT00000035023
Tac4
tachykinin 4 (hemokinin)
chr7_-_15821927 1.85 ENSRNOT00000050658
LOC691422
similar to zinc finger protein 101
chr14_-_78902063 1.77 ENSRNOT00000088469
Ppp2r2c
protein phosphatase 2, regulatory subunit B, gamma
chr20_+_1936438 1.69 ENSRNOT00000073981
Olr1749
olfactory receptor 1749
chr1_+_57345577 1.53 ENSRNOT00000082790
ENSRNOT00000084017
Fam120b
family with sequence similarity 120B
chr15_-_61648267 1.45 ENSRNOT00000071805
Naa16
N(alpha)-acetyltransferase 16, NatA auxiliary subunit
chr11_+_43340505 1.02 ENSRNOT00000043299
Olr1541
olfactory receptor 1541
chr8_+_132120452 1.00 ENSRNOT00000055822
Tgm4
transglutaminase 4
chr6_+_73358112 0.79 ENSRNOT00000041373
Arhgap5
Rho GTPase activating protein 5
chr15_+_70790125 0.75 ENSRNOT00000012440
Tdrd3
tudor domain containing 3
chr8_+_22423467 0.69 ENSRNOT00000085320
Ilf3
interleukin enhancer binding factor 3
chr19_-_59894937 0.39 ENSRNOT00000027145
Rbm34
RNA binding motif protein 34
chr18_+_60745035 0.37 ENSRNOT00000045098
LOC502176
hypothetical protein LOC502176
chr3_+_2490518 0.35 ENSRNOT00000015099
Anapc2
anaphase promoting complex subunit 2
chr7_-_134495835 0.26 ENSRNOT00000058349
Gxylt1
glucoside xylosyltransferase 1
chr7_-_15723127 0.13 ENSRNOT00000071599
LOC100909683
olfactory receptor 63-like
chr8_-_76940094 0.11 ENSRNOT00000082709
ENSRNOT00000084313
Rnf111
ring finger protein 111
chr10_-_25847994 0.11 ENSRNOT00000082076
Mat2b
methionine adenosyltransferase 2B
chrX_-_118459355 0.03 ENSRNOT00000084465
Il13ra2
interleukin 13 receptor subunit alpha 2
chr8_-_42944070 0.01 ENSRNOT00000075290
LOC100910409
olfactory receptor 146-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfat5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
18.1 54.3 GO:0042631 cellular response to water deprivation(GO:0042631)
12.4 99.2 GO:0007262 STAT protein import into nucleus(GO:0007262)
11.9 35.7 GO:0061228 mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
7.4 22.3 GO:0071422 succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422)
5.3 21.3 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
4.4 21.8 GO:1901475 pyruvate transmembrane transport(GO:1901475)
4.0 15.9 GO:0034653 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
3.4 30.9 GO:0052697 xenobiotic glucuronidation(GO:0052697)
3.1 15.7 GO:0002159 desmosome assembly(GO:0002159)
3.1 12.3 GO:0032919 spermine acetylation(GO:0032919)
2.6 10.5 GO:1990375 baculum development(GO:1990375)
2.5 42.4 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
2.2 10.8 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
1.9 7.4 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
1.8 8.9 GO:0000066 mitochondrial ornithine transport(GO:0000066)
1.8 30.0 GO:0036159 inner dynein arm assembly(GO:0036159)
1.6 4.9 GO:0043323 positive regulation of natural killer cell degranulation(GO:0043323)
1.5 7.7 GO:0010032 meiotic chromosome condensation(GO:0010032)
1.5 7.7 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
1.4 12.2 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
1.3 29.0 GO:0097503 sialylation(GO:0097503)
1.1 9.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.9 24.6 GO:0042832 defense response to protozoan(GO:0042832)
0.8 12.4 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
0.8 4.1 GO:1990918 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.8 6.1 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.7 12.7 GO:0046325 negative regulation of glucose import(GO:0046325)
0.7 9.4 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.7 8.6 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.6 10.3 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.6 7.7 GO:0002371 dendritic cell cytokine production(GO:0002371)
0.6 8.8 GO:2000194 regulation of female gonad development(GO:2000194)
0.5 6.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5 5.9 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.4 11.0 GO:0045793 positive regulation of cell size(GO:0045793)
0.4 42.3 GO:0046849 bone remodeling(GO:0046849)
0.4 5.8 GO:0061029 eyelid development in camera-type eye(GO:0061029) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.4 1.9 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.3 12.6 GO:0072348 sulfur compound transport(GO:0072348)
0.3 8.2 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
0.3 13.4 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.3 12.9 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.2 1.4 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.2 16.2 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.2 4.4 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.2 3.3 GO:0042118 endothelial cell activation(GO:0042118)
0.2 1.0 GO:0042628 mating plug formation(GO:0042628) post-mating behavior(GO:0045297)
0.2 11.0 GO:0048008 platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.2 13.7 GO:1900046 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.2 3.6 GO:0002115 store-operated calcium entry(GO:0002115)
0.2 13.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 21.9 GO:0006865 amino acid transport(GO:0006865)
0.1 1.8 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 2.5 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
0.1 2.0 GO:0009084 glutamine family amino acid biosynthetic process(GO:0009084)
0.1 1.5 GO:0035357 peroxisome proliferator activated receptor signaling pathway(GO:0035357)
0.1 4.7 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.1 39.4 GO:0000165 MAPK cascade(GO:0000165)
0.1 7.3 GO:0007338 single fertilization(GO:0007338)
0.0 3.7 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.0 0.8 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.0 0.4 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.3 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 13.0 GO:0016567 protein ubiquitination(GO:0016567)
0.0 4.4 GO:0045137 development of primary sexual characteristics(GO:0045137)
0.0 2.9 GO:0050796 regulation of insulin secretion(GO:0050796)
0.0 0.0 GO:0043305 negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of mast cell activation involved in immune response(GO:0033007) negative regulation of leukocyte degranulation(GO:0043301) negative regulation of mast cell degranulation(GO:0043305)
0.0 4.3 GO:0006954 inflammatory response(GO:0006954)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.5 30.0 GO:0036156 inner dynein arm(GO:0036156)
4.5 13.5 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
3.5 42.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
3.1 15.3 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
2.6 10.3 GO:0097149 centralspindlin complex(GO:0097149)
1.5 54.3 GO:0046930 pore complex(GO:0046930)
1.2 4.9 GO:0061474 phagolysosome membrane(GO:0061474)
1.1 10.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
1.0 7.7 GO:0000796 condensin complex(GO:0000796)
0.8 21.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.7 15.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.5 25.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.5 7.3 GO:0035102 PRC1 complex(GO:0035102)
0.4 6.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.4 12.7 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.4 10.4 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.3 24.9 GO:0031526 brush border membrane(GO:0031526)
0.3 99.2 GO:0043235 receptor complex(GO:0043235)
0.2 1.4 GO:0031415 NatA complex(GO:0031415)
0.2 2.9 GO:0030061 mitochondrial crista(GO:0030061)
0.2 12.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 4.7 GO:0097546 ciliary base(GO:0097546)
0.1 53.5 GO:0005667 transcription factor complex(GO:0005667)
0.1 3.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 16.3 GO:0001650 fibrillar center(GO:0001650)
0.1 3.3 GO:0030673 axolemma(GO:0030673)
0.1 24.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 21.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 6.3 GO:0005814 centriole(GO:0005814)
0.1 1.9 GO:0042629 mast cell granule(GO:0042629)
0.1 7.4 GO:0036064 ciliary basal body(GO:0036064)
0.1 7.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 9.8 GO:0005802 trans-Golgi network(GO:0005802)
0.1 2.4 GO:0015030 Cajal body(GO:0015030)
0.0 8.8 GO:0032993 protein-DNA complex(GO:0032993)
0.0 4.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.8 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 6.8 GO:0005769 early endosome(GO:0005769)
0.0 21.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 9.4 GO:0005768 endosome(GO:0005768)
0.0 2.5 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 12.2 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 5.9 GO:0009986 cell surface(GO:0009986)
0.0 1.9 GO:0005882 intermediate filament(GO:0005882)
0.0 3.8 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
10.9 54.3 GO:0015168 polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
7.4 22.3 GO:0015141 succinate transmembrane transporter activity(GO:0015141)
5.8 99.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
5.3 15.9 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
4.4 21.8 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
4.2 12.6 GO:0030977 taurine binding(GO:0030977)
4.1 12.3 GO:0019809 spermidine binding(GO:0019809)
3.0 42.4 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
2.1 10.5 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
1.8 21.3 GO:0004955 prostaglandin receptor activity(GO:0004955)
1.7 12.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
1.7 15.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
1.6 12.7 GO:0031419 cobalamin binding(GO:0031419)
1.4 39.4 GO:0004707 MAP kinase activity(GO:0004707)
1.3 29.0 GO:0008373 sialyltransferase activity(GO:0008373)
1.2 13.7 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
1.2 15.7 GO:0045294 alpha-catenin binding(GO:0045294)
1.1 8.9 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
1.0 30.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.9 10.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.8 9.4 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.6 7.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.5 13.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545) phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.5 6.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.4 12.4 GO:0052866 phosphatidylinositol phosphate phosphatase activity(GO:0052866)
0.4 3.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.4 13.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.4 4.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.4 11.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.3 30.0 GO:0003777 microtubule motor activity(GO:0003777)
0.3 9.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 34.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.3 5.9 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.2 6.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 3.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 4.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 10.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 1.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 60.2 GO:0005509 calcium ion binding(GO:0005509)
0.1 40.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 4.3 GO:0035064 methylated histone binding(GO:0035064)
0.1 5.8 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 3.7 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.3 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 19.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 8.6 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.0 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0 8.1 GO:0003682 chromatin binding(GO:0003682)
0.0 1.5 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 6.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.8 GO:0042169 SH2 domain binding(GO:0042169)
0.0 7.0 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 2.7 GO:0003712 transcription cofactor activity(GO:0003712)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 99.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.6 35.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.5 18.2 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.4 12.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.3 11.7 PID ARF6 PATHWAY Arf6 signaling events
0.2 12.2 PID FOXO PATHWAY FoxO family signaling
0.2 17.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.2 6.1 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.2 7.7 PID AURORA B PATHWAY Aurora B signaling
0.2 9.4 PID PLK1 PATHWAY PLK1 signaling events
0.1 4.1 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 1.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 5.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.8 PID RAC1 PATHWAY RAC1 signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 99.2 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
4.5 54.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
1.6 30.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
1.6 21.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
1.1 12.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
1.1 13.7 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
1.1 16.8 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
1.0 59.8 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.9 35.7 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.9 42.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.7 12.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.6 15.3 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.5 9.2 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.5 13.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.5 15.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.5 5.9 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.5 16.3 REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS Genes involved in Post NMDA receptor activation events
0.2 10.8 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.2 10.5 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 10.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.2 4.1 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 9.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.9 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 11.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 7.4 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.4 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C