ISMARA results: Mybl2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Mybl2

Z-value: 1.40

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Transcription factors associated with Mybl2

Gene Symbol	Gene ID	Gene Info
Mybl2 NCBI RGD Ensembl	ENSRNOG00000007805	myeloblastosis oncogene-like 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Mybl2	rn6_v1_chr3_+_159421671_159421671	0.38	3.8e-12	Click!

Activity profile of Mybl2 motif

Sorted Z-values of Mybl2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_102915191 Show fit	72.89	ENSRNOT00000017851	Ldhc NCBI RGD Ensembl Show fit	lactate dehydrogenase C
chr6_+_54417903 Show fit	70.63	ENSRNOT00000052356	Prps1l1 NCBI RGD Ensembl Show fit	phosphoribosyl pyrophosphate synthetase 1-like 1
chr5_-_135472116 Show fit	59.73	ENSRNOT00000022170	Nasp NCBI RGD Ensembl Show fit	nuclear autoantigenic sperm protein
chr7_-_26144466 Show fit	58.52	ENSRNOT00000009162	Fhl4 NCBI RGD Ensembl Show fit	four and a half LIM domains 4
chr13_-_87847263 Show fit	58.32	ENSRNOT00000003650	Nuf2 NCBI RGD Ensembl Show fit	NUF2, NDC80 kinetochore complex component
chr15_-_44411004 Show fit	55.09	ENSRNOT00000031163	Cdca2 NCBI RGD Ensembl Show fit	cell division cycle associated 2
chr2_+_78825074 Show fit	54.05	ENSRNOT00000032027	March11 NCBI RGD Ensembl Show fit	membrane associated ring-CH-type finger 11
chr3_-_118427851 Show fit	53.94	ENSRNOT00000055995	Fam227b NCBI RGD Ensembl Show fit	family with sequence similarity 227, member B
chr3_+_110367939 Show fit	49.28	ENSRNOT00000010406	Bub1b NCBI RGD Ensembl Show fit	BUB1 mitotic checkpoint serine/threonine kinase B
chr2_+_197682000 Show fit	46.25	ENSRNOT00000066821	Hormad1 NCBI RGD Ensembl Show fit	HORMA domain containing 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Mybl2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
38.4	115.2	GO:0019244	lactate biosynthetic process from pyruvate(GO:0019244)
17.8	89.2	GO:0051754	meiotic sister chromatid cohesion, centromeric(GO:0051754)
3.3	60.3	GO:0043486	histone exchange(GO:0043486)
11.8	59.2	GO:0051177	meiotic sister chromatid segregation(GO:0045144) meiotic sister chromatid cohesion(GO:0051177)
1.0	55.8	GO:0035307	positive regulation of protein dephosphorylation(GO:0035307)
1.2	54.3	GO:0051310	metaphase plate congression(GO:0051310)
2.9	49.8	GO:0034587	piRNA metabolic process(GO:0034587)
1.6	48.7	GO:0021591	ventricular system development(GO:0021591)
1.2	44.3	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.1	41.8	GO:0051301	cell division(GO:0051301)

Showing 1 to 10 of 193 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	161.4	GO:0031514	motile cilium(GO:0031514)
2.0	93.0	GO:0000777	condensed chromosome kinetochore(GO:0000777)
0.1	72.5	GO:0005694	chromosome(GO:0005694)
2.7	70.5	GO:0097225	sperm midpiece(GO:0097225)
5.8	69.9	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
2.0	59.2	GO:0000795	synaptonemal complex(GO:0000795)
11.7	58.3	GO:0031262	Ndc80 complex(GO:0031262)
3.4	58.2	GO:0035686	sperm fibrous sheath(GO:0035686)
0.1	47.2	GO:0005929	cilium(GO:0005929)
0.9	44.3	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Showing 1 to 10 of 106 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
28.8	115.2	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.4	74.4	GO:0042393	histone binding(GO:0042393)
0.1	73.0	GO:0003700	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
2.2	70.8	GO:0008139	nuclear localization sequence binding(GO:0008139)
8.8	70.6	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.8	69.3	GO:0003777	microtubule motor activity(GO:0003777)
0.1	57.0	GO:0008270	zinc ion binding(GO:0008270)
0.8	50.3	GO:0003743	translation initiation factor activity(GO:0003743)
11.1	44.3	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.8	42.5	GO:0019894	kinesin binding(GO:0019894)

Showing 1 to 10 of 135 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	82.1	PID PLK1 PATHWAY	PLK1 signaling events
1.3	67.7	PID FANCONI PATHWAY	Fanconi anemia pathway
1.8	65.9	PID AURORA B PATHWAY	Aurora B signaling
2.6	34.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.6	27.2	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.3	22.5	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
0.6	20.9	PID ATM PATHWAY	ATM pathway
0.6	20.6	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.3	13.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.3	12.9	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling

Showing 1 to 10 of 31 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	93.1	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
2.8	87.0	REACTOME KINESINS	Genes involved in Kinesins
0.3	61.0	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.0	49.7	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
2.5	48.1	REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.9	28.4	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.4	24.8	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
2.2	22.5	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
1.2	21.2	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.8	20.8	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules

Showing 1 to 10 of 53 entries

Results for Mybl2

Z-value: 1.40

Motif logo

Transcription factors associated with Mybl2

Activity-expression correlation:

Activity profile of Mybl2 motif

Sorted Z-values of Mybl2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Mybl2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: