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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Mtf1

Z-value: 0.66

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Transcription factors associated with Mtf1

Gene Symbol Gene ID Gene Info
Mtf1
ENSRNOG00000025724 metal-regulatory transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mtf1rn6_v1_chr5_+_142797366_1427973660.131.7e-02Click!

Activity profile of Mtf1 motif

Sorted Z-values of Mtf1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_11302938 46.34 ENSRNOT00000038212
AC128848.1

chr19_-_11308740 46.16 ENSRNOT00000067391
Mt2A
metallothionein 2A
chr17_+_43423111 18.37 ENSRNOT00000022630
Hist1h2ba
histone cluster 1 H2B family member a
chr9_+_93030714 17.71 ENSRNOT00000023581
Spata3
spermatogenesis associated 3
chrX_+_74497262 14.35 ENSRNOT00000003899
Zcchc13
zinc finger CCHC-type containing 13
chr7_-_117679219 12.99 ENSRNOT00000071522
Slc39a4
solute carrier family 39 member 4
chr8_+_49342067 12.65 ENSRNOT00000021693
Mpzl2
myelin protein zero-like 2
chr7_-_117680004 11.82 ENSRNOT00000040422
Slc39a4
solute carrier family 39 member 4
chr1_-_81377976 11.74 ENSRNOT00000075189
Srrm5
serine/arginine repetitive matrix 5
chr1_+_189549960 10.82 ENSRNOT00000019654
Exnef
exonuclease NEF-sp
chr13_+_110677810 10.73 ENSRNOT00000006340
Slc30a1
solute carrier family 30 member 1
chr1_+_217018916 10.67 ENSRNOT00000028195
ENSRNOT00000078979
Dhcr7
7-dehydrocholesterol reductase
chr20_-_5806097 10.50 ENSRNOT00000000611
Clps
colipase
chr1_-_213921208 10.37 ENSRNOT00000044393
Ano9
anoctamin 9
chr1_+_72882806 10.33 ENSRNOT00000024640
Tnni3
troponin I3, cardiac type
chr13_+_75059927 10.12 ENSRNOT00000080801
LOC680254
hypothetical protein LOC680254
chr9_-_119871382 9.25 ENSRNOT00000018644
Ndc80
NDC80 kinetochore complex component
chr16_+_47368768 8.91 ENSRNOT00000017966
Wwc2
WW and C2 domain containing 2
chr16_-_21348391 8.88 ENSRNOT00000083537
Lpar2
lysophosphatidic acid receptor 2
chr6_+_127400585 8.70 ENSRNOT00000087429
Ppp4r4
protein phosphatase 4, regulatory subunit 4
chr6_-_47811853 8.65 ENSRNOT00000010942
Allc
allantoicase
chrX_+_29157470 8.35 ENSRNOT00000081986
LOC100910245
ribose-phosphate pyrophosphokinase 2-like
chr19_+_25983169 8.24 ENSRNOT00000004404
Syce2
synaptonemal complex central element protein 2
chr5_+_152559577 8.22 ENSRNOT00000082245
Slc30a2
solute carrier family 30 member 2
chr13_-_84217332 8.14 ENSRNOT00000047488
ENSRNOT00000087096
Pou2f1
POU class 2 homeobox 1
chr1_-_219853329 8.08 ENSRNOT00000026169
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr19_+_10142496 7.97 ENSRNOT00000088645
ENSRNOT00000060351
Cngb1
cyclic nucleotide gated channel beta 1
chr1_-_81127059 6.46 ENSRNOT00000026252
Zfp94
zinc finger protein 94
chr4_+_78458625 6.42 ENSRNOT00000049891
Tmem176a
transmembrane protein 176A
chr4_+_170149029 6.36 ENSRNOT00000073287
LOC103690002
histone H2A.J
chrX_+_28435507 6.31 ENSRNOT00000005615
Prps2
phosphoribosyl pyrophosphate synthetase 2
chr4_-_66899914 6.30 ENSRNOT00000011481
Parp12
poly (ADP-ribose) polymerase family, member 12
chr5_-_147743723 6.26 ENSRNOT00000012854
Hdac1
histone deacetylase 1
chr2_-_45077219 6.23 ENSRNOT00000014319
Gzmk
granzyme K
chr6_-_26875376 6.22 ENSRNOT00000011838
Tmem214
transmembrane protein 214
chr3_-_171166454 6.22 ENSRNOT00000034131
Ctcfl
CCCTC-binding factor like
chr2_-_27364906 6.19 ENSRNOT00000078639
Polk
DNA polymerase kappa
chr20_-_5805627 5.99 ENSRNOT00000085996
Clps
colipase
chr9_-_84894599 5.94 ENSRNOT00000018423
Hdac1l
histone deacetylase 1-like
chr3_+_152143811 5.94 ENSRNOT00000026578
LOC100911109
sperm-associated antigen 4 protein-like
chr7_-_141307233 5.76 ENSRNOT00000071885
Racgap1
Rac GTPase-activating protein 1
chr1_-_220096319 5.68 ENSRNOT00000091787
ENSRNOT00000073983
Ccs
copper chaperone for superoxide dismutase
chr8_-_71784551 5.66 ENSRNOT00000022960
Snx1
sorting nexin 1
chr3_+_151609602 5.62 ENSRNOT00000065052
Spag4
sperm associated antigen 4
chr11_-_90406797 5.01 ENSRNOT00000073049
Snai2
snail family transcriptional repressor 2
chr10_-_78219793 4.95 ENSRNOT00000003369
Tom1l1
target of myb1 like 1 membrane trafficking protein
chr11_+_67757928 4.85 ENSRNOT00000039215
Dtx3l
deltex E3 ubiquitin ligase 3L
chr4_+_7355574 4.84 ENSRNOT00000013800
Kcnh2
potassium voltage-gated channel subfamily H member 2
chr1_-_89042176 4.72 ENSRNOT00000080842
Kmt2b
lysine methyltransferase 2B
chr4_-_115453659 4.59 ENSRNOT00000065847
Tex261
testis expressed 261
chr8_+_60117729 4.53 ENSRNOT00000021074
Isl2
ISL LIM homeobox 2
chr19_+_55300395 4.52 ENSRNOT00000092169
Ctu2
cytosolic thiouridylase subunit 2
chr16_-_40555576 4.46 ENSRNOT00000015529
Vegfc
vascular endothelial growth factor C
chr7_-_116963281 4.21 ENSRNOT00000082058
ENSRNOT00000012306
Tsta3
tissue specific transplantation antigen P35B
chr2_+_27365148 4.12 ENSRNOT00000021549
Col4a3bp
collagen type IV alpha 3 binding protein
chr2_+_198359754 3.82 ENSRNOT00000048582
Hist2h2ab
histone cluster 2 H2A family member b
chr5_-_74190991 3.74 ENSRNOT00000090366
Epb41l4b
erythrocyte membrane protein band 4.1 like 4B
chr12_+_7454884 3.47 ENSRNOT00000077328
LOC100910196
katanin p60 ATPase-containing subunit A-like 1-like
chr20_-_35450513 3.45 ENSRNOT00000087342
Man1a1
mannosidase, alpha, class 1A, member 1
chr19_-_55300403 3.09 ENSRNOT00000018591
Rnf166
ring finger protein 166
chr11_+_81757983 3.01 ENSRNOT00000088503
Tbccd1
TBCC domain containing 1
chr1_-_189549891 2.91 ENSRNOT00000019747
Eri2
ERI1 exoribonuclease family member 2
chr12_-_2545740 2.90 ENSRNOT00000075527
Tgfbr3l
transforming growth factor beta receptor 3 like
chr16_+_7035068 2.66 ENSRNOT00000024296
Nek4
NIMA-related kinase 4
chr8_-_114892910 2.09 ENSRNOT00000074934
Ppm1m
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr5_-_58484900 2.09 ENSRNOT00000012386
Fam214b
family with sequence similarity 214, member B
chr3_+_175548174 2.07 ENSRNOT00000091941
Adrm1
adhesion regulating molecule 1
chr12_-_11265865 1.99 ENSRNOT00000001315
Arpc1b
actin related protein 2/3 complex, subunit 1B
chr12_+_52359310 1.95 ENSRNOT00000071857
ENSRNOT00000065893
Fbrsl1
fibrosin-like 1
chr5_+_164950917 1.73 ENSRNOT00000083678
Mad2l2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr9_+_16543688 1.71 ENSRNOT00000021868
Cnpy3
canopy FGF signaling regulator 3
chr16_+_71629525 1.67 ENSRNOT00000035347
ENSRNOT00000088462
Tacc1
transforming, acidic coiled-coil containing protein 1
chr5_+_164951789 1.52 ENSRNOT00000055658
ENSRNOT00000012193
Mad2l2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr16_+_20109200 1.48 ENSRNOT00000079784
Jak3
Janus kinase 3
chr11_-_81757813 1.48 ENSRNOT00000002462
Dnajb11
DnaJ heat shock protein family (Hsp40) member B11
chr13_+_97702097 1.27 ENSRNOT00000057787
LOC103689999
saccharopine dehydrogenase-like oxidoreductase
chr8_-_62948720 1.21 ENSRNOT00000075476
Islr
immunoglobulin superfamily containing leucine-rich repeat
chr3_-_9448167 1.16 ENSRNOT00000012617
Abl1
ABL proto-oncogene 1, non-receptor tyrosine kinase
chr3_-_13978224 1.11 ENSRNOT00000025528
Phf19
PHD finger protein 19
chr10_-_18574909 1.09 ENSRNOT00000083090
Kcnip1
potassium voltage-gated channel interacting protein 1
chrX_-_16526028 0.96 ENSRNOT00000093647
Dgkk
diacylglycerol kinase kappa
chr2_-_225389120 0.89 ENSRNOT00000016739
Abcd3
ATP binding cassette subfamily D member 3
chr20_-_422464 0.79 ENSRNOT00000051646
Olr1673
olfactory receptor 1673
chr1_+_29432152 0.76 ENSRNOT00000019436
ENSRNOT00000083276
Trmt11
tRNA methyltransferase 11 homolog
chr3_-_9447813 0.69 ENSRNOT00000043661
Abl1
ABL proto-oncogene 1, non-receptor tyrosine kinase
chr4_+_144916789 0.55 ENSRNOT00000083660
AABR07061801.2

chr4_-_123494742 0.50 ENSRNOT00000073268
Slc41a3
solute carrier family 41, member 3
chr20_-_529024 0.44 ENSRNOT00000075114
Olr1675
olfactory receptor 1675
chr5_-_106758032 0.41 ENSRNOT00000033651
Hacd4
3-hydroxyacyl-CoA dehydratase 4
chr19_-_52282877 0.36 ENSRNOT00000021271
Kcng4
potassium voltage-gated channel modifier subfamily G member 4
chr16_+_7035241 0.24 ENSRNOT00000084977
Nek4
NIMA-related kinase 4
chr4_+_175431904 0.03 ENSRNOT00000032843
Pde3a
phosphodiesterase 3A
chr20_-_11737050 0.03 ENSRNOT00000001637
Sumo3
small ubiquitin-like modifier 3
chrX_+_10964067 0.03 ENSRNOT00000093181
ENSRNOT00000066480
Med14
mediator complex subunit 14

Network of associatons between targets according to the STRING database.

First level regulatory network of Mtf1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.3 24.8 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
6.6 46.2 GO:0048143 response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016) astrocyte activation(GO:0048143)
3.6 10.7 GO:0071579 regulation of zinc ion transport(GO:0071579)
3.6 10.7 GO:0016128 phytosteroid metabolic process(GO:0016128) phytosteroid biosynthetic process(GO:0016129)
3.5 10.4 GO:2001226 negative regulation of inorganic anion transmembrane transport(GO:1903796) negative regulation of chloride transport(GO:2001226)
3.1 18.4 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
2.9 8.6 GO:0043605 cellular amide catabolic process(GO:0043605)
2.0 8.1 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
1.9 5.8 GO:0000912 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
1.7 5.0 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
1.6 4.8 GO:1902303 negative regulation of potassium ion export(GO:1902303)
1.6 6.4 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.6 6.3 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
1.6 6.3 GO:0061197 fungiform papilla morphogenesis(GO:0061197) fungiform papilla formation(GO:0061198)
1.5 4.5 GO:0021524 visceral motor neuron differentiation(GO:0021524)
1.5 4.5 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
1.5 4.5 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
1.5 8.9 GO:0035331 negative regulation of hippo signaling(GO:0035331)
1.4 4.2 GO:0042350 GDP-L-fucose biosynthetic process(GO:0042350)
1.2 9.2 GO:0090267 positive regulation of spindle checkpoint(GO:0090232) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
1.0 2.1 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.9 8.2 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.9 6.2 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.8 4.1 GO:0035627 ceramide transport(GO:0035627)
0.8 3.3 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.8 3.0 GO:0051684 maintenance of Golgi location(GO:0051684)
0.7 8.0 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.7 5.6 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.6 10.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.6 1.8 GO:0002332 transitional stage B cell differentiation(GO:0002332) transitional one stage B cell differentiation(GO:0002333) positive regulation of actin filament binding(GO:1904531) positive regulation of actin binding(GO:1904618)
0.5 1.5 GO:0045210 negative regulation of dendritic cell cytokine production(GO:0002731) FasL biosynthetic process(GO:0045210)
0.4 2.9 GO:0000467 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.4 3.7 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.4 5.7 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.4 8.7 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.3 10.9 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.3 8.2 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.3 8.9 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.3 3.5 GO:0051013 microtubule severing(GO:0051013)
0.2 5.9 GO:0070932 histone H3 deacetylation(GO:0070932)
0.2 2.9 GO:0001302 replicative cell aging(GO:0001302)
0.2 16.5 GO:0032094 response to food(GO:0032094)
0.2 5.7 GO:0019430 removal of superoxide radicals(GO:0019430)
0.2 4.8 GO:0010390 histone monoubiquitination(GO:0010390)
0.2 5.0 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.2 3.5 GO:0006491 N-glycan processing(GO:0006491)
0.1 1.1 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.1 11.7 GO:0033077 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.1 0.9 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.1 1.7 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 8.4 GO:0009156 ribonucleoside monophosphate biosynthetic process(GO:0009156)
0.1 6.8 GO:0006342 chromatin silencing(GO:0006342)
0.1 1.5 GO:0016556 mRNA modification(GO:0016556)
0.1 1.0 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 2.0 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 1.1 GO:0045760 positive regulation of action potential(GO:0045760)
0.0 10.8 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 3.1 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 0.4 GO:0030497 fatty acid elongation(GO:0030497)
0.0 2.4 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.0 GO:0060282 positive regulation of oocyte development(GO:0060282)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 10.3 GO:1990584 cardiac Troponin complex(GO:1990584)
1.8 9.2 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942) Ndc80 complex(GO:0031262)
1.4 5.8 GO:0097149 centralspindlin complex(GO:0097149)
1.3 6.3 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.7 8.0 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.7 3.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.6 8.2 GO:0000801 central element(GO:0000801)
0.5 24.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.4 10.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.4 6.3 GO:0016580 Sin3 complex(GO:0016580)
0.3 25.1 GO:0000786 nucleosome(GO:0000786)
0.2 2.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.2 3.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 5.7 GO:0030904 retromer complex(GO:0030904)
0.2 2.0 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 1.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 8.7 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287)
0.1 10.7 GO:0030315 T-tubule(GO:0030315)
0.1 5.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 4.6 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 6.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 5.8 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 8.9 GO:0030139 endocytic vesicle(GO:0030139)
0.1 8.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 47.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.9 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 5.0 GO:0005795 Golgi stack(GO:0005795)
0.0 3.7 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 6.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 3.5 GO:0005874 microtubule(GO:0005874)
0.0 2.7 GO:0000790 nuclear chromatin(GO:0000790)
0.0 10.8 GO:0005730 nucleolus(GO:0005730)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 46.2 GO:0046870 cadmium ion binding(GO:0046870)
2.6 10.3 GO:0030172 troponin C binding(GO:0030172)
2.1 6.3 GO:0035851 Krueppel-associated box domain binding(GO:0035851)
1.9 5.7 GO:1990460 leptin receptor binding(GO:1990460)
1.8 14.7 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
1.7 43.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.1 5.7 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.8 8.0 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.7 4.8 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.7 4.1 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.7 8.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.5 5.9 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.5 10.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.4 4.5 GO:0016783 sulfurtransferase activity(GO:0016783)
0.4 10.7 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.4 4.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.3 2.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.3 8.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.3 3.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.3 2.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.3 6.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 3.3 GO:0008432 JUN kinase binding(GO:0008432)
0.3 0.8 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.2 3.5 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 5.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 6.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 4.7 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.2 0.9 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 1.8 GO:0070097 delta-catenin binding(GO:0070097)
0.1 15.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.4 GO:0102344 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.1 10.8 GO:0004527 exonuclease activity(GO:0004527)
0.1 8.9 GO:0032947 protein complex scaffold(GO:0032947)
0.1 8.7 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 3.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.0 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 2.9 GO:0030145 manganese ion binding(GO:0030145)
0.1 5.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 10.3 GO:0042393 histone binding(GO:0042393)
0.0 26.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 5.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 4.2 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 1.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 5.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 6.4 GO:0008047 enzyme activator activity(GO:0008047)
0.0 1.6 GO:0030165 PDZ domain binding(GO:0030165)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 18.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.5 46.2 PID AP1 PATHWAY AP-1 transcription factor network
0.5 6.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.4 4.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.4 16.7 PID AURORA B PATHWAY Aurora B signaling
0.3 8.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.3 8.0 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.2 8.9 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.1 1.5 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 5.5 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.1 5.0 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 1.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.0 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 2.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 43.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.8 45.2 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.7 18.4 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.5 10.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.4 16.5 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.4 4.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.3 8.1 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.3 10.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.3 6.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 5.8 REACTOME KINESINS Genes involved in Kinesins
0.1 1.7 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 4.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 5.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 9.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 3.5 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 9.8 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.1 1.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.9 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 3.3 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 6.3 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.0 4.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation