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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Mnx1_Lhx6_Lmx1a

Z-value: 0.52

Motif logo

Transcription factors associated with Mnx1_Lhx6_Lmx1a

Gene Symbol Gene ID Gene Info
ENSRNOG00000046959 motor neuron and pancreas homeobox 1
ENSRNOG00000005996 LIM homeobox 6
ENSRNOG00000004642 LIM homeobox transcription factor 1 alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Lhx6rn6_v1_chr3_-_15433252_15433252-0.422.8e-15Click!
Lmx1arn6_v1_chr13_+_85918252_85918252-0.392.2e-13Click!
Mnx1rn6_v1_chr4_-_2381271_2381271-0.132.3e-02Click!

Activity profile of Mnx1_Lhx6_Lmx1a motif

Sorted Z-values of Mnx1_Lhx6_Lmx1a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_54466280 25.42 ENSRNOT00000033112
complement C6
chr17_+_25082056 22.44 ENSRNOT00000037041

chr8_+_47674321 21.10 ENSRNOT00000026170
ENSRNOT00000078776
tripartite motif-containing 29
chr12_-_45801842 19.98 ENSRNOT00000078837

chr13_-_77821312 16.88 ENSRNOT00000082110

chr6_-_125723732 16.48 ENSRNOT00000084815
fibulin 5
chr6_+_2216623 16.02 ENSRNOT00000008045
regulator of microtubule dynamics 2
chr4_-_100252755 15.58 ENSRNOT00000017301
vesicle-associated membrane protein 8
chr3_-_14229067 15.11 ENSRNOT00000025534
ENSRNOT00000092865
complement C5
chr8_+_106449321 14.08 ENSRNOT00000018622
retinol binding protein 1
chr4_+_22898527 13.64 ENSRNOT00000072455
ENSRNOT00000076123
DBF4 zinc finger
chr8_+_71914867 13.57 ENSRNOT00000023372
death-associated protein kinase 2
chr1_+_279633671 13.00 ENSRNOT00000036012
ENSRNOT00000091669
coiled-coil domain containing 172
chr2_-_158156444 12.71 ENSRNOT00000088559
ventricular zone expressed PH domain-containing 1
chr4_+_172119331 11.69 ENSRNOT00000010579
microsomal glutathione S-transferase 1
chr1_-_166912524 11.43 ENSRNOT00000092952
inositol polyphosphate phosphatase-like 1
chr7_-_140291620 11.34 ENSRNOT00000088323
adenylate cyclase 6
chr2_-_138833933 11.17 ENSRNOT00000013343
protocadherin 18
chr16_+_2634603 11.17 ENSRNOT00000019113
HESX homeobox 1
chr7_-_73130740 10.61 ENSRNOT00000075584
RIKEN cDNA 9430069I07 gene
chr2_-_158156150 10.19 ENSRNOT00000016621
ventricular zone expressed PH domain-containing 1
chr7_-_71139267 9.73 ENSRNOT00000065232
similar to Retinol dehydrogenase type II (RODH II) (29 k-protein)
chr7_-_69982592 9.70 ENSRNOT00000040010
similar to developmental pluripotency associated 5
chr3_-_57607683 9.54 ENSRNOT00000093222
ENSRNOT00000058524
methyltransferase like 8
chr3_-_90751055 9.53 ENSRNOT00000040741
LRRGT00091
chr5_+_50381244 9.44 ENSRNOT00000012385
glycoprotein hormones, alpha polypeptide
chr1_-_101095594 9.43 ENSRNOT00000027944
Fc fragment of IgG receptor and transporter
chr14_+_76732650 9.23 ENSRNOT00000088197
cytokine-dependent hematopoietic cell linker
chr14_+_91782354 9.09 ENSRNOT00000005902
IKAROS family zinc finger 1
chrX_+_33443186 8.77 ENSRNOT00000005622
S100 calcium binding protein G
chr8_-_49109981 8.58 ENSRNOT00000019933
tetratricopeptide repeat domain 36
chr2_+_80269661 8.48 ENSRNOT00000015975

chr11_-_28478360 8.47 ENSRNOT00000032663
claudin 17
chr16_+_10267482 8.28 ENSRNOT00000085255
growth differentiation factor 2
chr4_-_172063391 8.27 ENSRNOT00000010158
solute carrier family 15, member 5
chr1_+_88955440 8.02 ENSRNOT00000091101
proline dehydrogenase 2
chr10_-_87468711 7.81 ENSRNOT00000039983
keratin associated protein 3-3
chr20_+_3176107 7.62 ENSRNOT00000001036
RT1 class Ib, locus S3
chr14_+_21177237 7.60 ENSRNOT00000004866
immunoglobulin joining chain
chrX_+_156463953 7.37 ENSRNOT00000079889
filamin A
chr13_-_83457888 7.33 ENSRNOT00000076289
ENSRNOT00000004065
SFT2 domain containing 2
chr4_-_88684415 7.31 ENSRNOT00000009001
similar to 40S ribosomal protein S7 (S8)
chr7_-_101138860 7.10 ENSRNOT00000077137

chr8_+_71514281 6.94 ENSRNOT00000022256
NS5A (hepatitis C virus) transactivated protein 9
chr7_-_101138373 6.83 ENSRNOT00000043257
Ab1-152
chr18_-_26656879 6.73 ENSRNOT00000086729
erythrocyte membrane protein band 4.1 like 4A
chr3_-_7498555 6.46 ENSRNOT00000017725
BarH-like homeobox 1
chr20_+_4357733 6.33 ENSRNOT00000000509
PBX homeobox 2
chr18_+_81694808 6.28 ENSRNOT00000020446
cytochrome b5 type A
chrM_+_7006 6.08 ENSRNOT00000043693
mitochondrially encoded cytochrome c oxidase II
chr11_-_79703736 6.05 ENSRNOT00000044279
LIM domain containing preferred translocation partner in lipoma
chr11_-_43022565 6.01 ENSRNOT00000002285
ribosomal oxygenase 2
chr7_-_143497108 6.01 ENSRNOT00000048613
keratin 76
chr8_+_99632803 5.93 ENSRNOT00000087190
phospholipid scramblase 1
chr1_-_19376301 5.75 ENSRNOT00000015547
Rho GTPase activating protein 18
chr1_-_104973648 5.63 ENSRNOT00000019739
developing brain homeobox 1
chr20_+_44680449 5.60 ENSRNOT00000000728
Traf3 interacting protein 2
chr1_+_88955135 5.42 ENSRNOT00000083550
proline dehydrogenase 2
chr5_-_115387377 5.41 ENSRNOT00000036030
ENSRNOT00000077492
similar to hypothetical protein MGC34837
chr10_+_95770154 5.40 ENSRNOT00000030300
helicase with zinc finger
chr4_+_68849033 5.31 ENSRNOT00000016912
maltase-glucoamylase
chr4_-_80395502 5.27 ENSRNOT00000014437
neuropeptide VF precursor
chr14_-_8600512 5.27 ENSRNOT00000092537
Rho GTPase activating protein 24
chr8_+_104106740 5.19 ENSRNOT00000015015
transcription factor Dp-2
chr10_+_61685645 5.15 ENSRNOT00000003933
MAX network transcriptional repressor
chr12_-_47142852 5.10 ENSRNOT00000001591
POP5 homolog, ribonuclease P/MRP subunit
chr17_-_39824299 4.95 ENSRNOT00000023412
prolactin
chr6_-_125723944 4.92 ENSRNOT00000007004
fibulin 5
chr1_-_6903486 4.90 ENSRNOT00000086574
utrophin
chr2_+_266315036 4.89 ENSRNOT00000055245
wntless Wnt ligand secretion mediator
chr11_-_62451149 4.85 ENSRNOT00000093686
ENSRNOT00000081443
zinc finger and BTB domain containing 20
chr3_-_165537940 4.77 ENSRNOT00000071119
ENSRNOT00000070964
spalt-like transcription factor 4
chr13_-_83425641 4.63 ENSRNOT00000063870
T-box 19
chr14_+_23405717 4.55 ENSRNOT00000029805
transmembrane protease, serine 11C
chr10_-_88172910 4.53 ENSRNOT00000046956
keratin 42
chr8_+_117117430 4.52 ENSRNOT00000073247
glutathione peroxidase 1
chr13_-_90405591 4.52 ENSRNOT00000006849
VANGL planar cell polarity protein 2
chr4_+_6827429 4.43 ENSRNOT00000071737
Ras homolog enriched in brain
chr7_+_121841855 4.37 ENSRNOT00000024673
GRB2-related adaptor protein 2
chr3_+_110855000 4.31 ENSRNOT00000081613
kinetochore scaffold 1
chr6_-_95934296 4.24 ENSRNOT00000034338
SIX homeobox 1
chr16_+_50049828 4.21 ENSRNOT00000034448
family with sequence similarity 149, member A
chr4_-_170740274 4.18 ENSRNOT00000012212
guanylate cyclase 2C
chr20_+_3155652 4.14 ENSRNOT00000042882
RT1 class Ib, locus S2
chr1_-_263762785 4.05 ENSRNOT00000018221
carboxypeptidase N subunit 1
chr1_+_253221812 4.04 ENSRNOT00000085880
ENSRNOT00000054753
kinesin family member 20B
chr9_-_79630452 4.00 ENSRNOT00000078125
ENSRNOT00000086044
ENSRNOT00000089283
peroxisomal trans-2-enoyl-CoA reductase
chr9_+_88918433 3.97 ENSRNOT00000021730
C-C motif chemokine ligand 20
chr8_+_22648323 3.95 ENSRNOT00000013165
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr6_-_128149220 3.93 ENSRNOT00000014204
goosecoid homeobox
chr7_-_126382449 3.91 ENSRNOT00000085540
RIKEN cDNA 7530416G11 gene
chrX_-_72034099 3.90 ENSRNOT00000004310
ERCC excision repair 6 like, spindle assembly checkpoint helicase
chr14_-_44078897 3.89 ENSRNOT00000031792
NEDD4 binding protein 2
chr7_-_2941122 3.88 ENSRNOT00000082107
extended synaptotagmin 1
chr18_-_12640716 3.76 ENSRNOT00000020697
kelch-like family member 14
chrX_-_32095867 3.72 ENSRNOT00000049947
ENSRNOT00000080730
angiotensin I converting enzyme 2
chr2_-_61692487 3.71 ENSRNOT00000078544
LRRGT00045
chr8_+_85259982 3.69 ENSRNOT00000010409
ELOVL fatty acid elongase 5
chr16_-_85306366 3.66 ENSRNOT00000089650
tumor necrosis factor superfamily member 13b
chr2_-_31753528 3.63 ENSRNOT00000075057
phosphoinositide-3-kinase regulatory subunit 1
chr17_-_80807181 3.60 ENSRNOT00000040052
ENSRNOT00000090064
cubilin
chr4_+_158088505 3.60 ENSRNOT00000026643
von Willebrand factor
chr1_+_22332090 3.58 ENSRNOT00000091252
trace amine-associated receptor 8c (Taar8c), mRNA
chr5_+_165724027 3.50 ENSRNOT00000018000
castor zinc finger 1
chr1_+_107344904 3.46 ENSRNOT00000082582
growth arrest-specific 2
chrM_+_2740 3.45 ENSRNOT00000047550
mitochondrially encoded NADH dehydrogenase 1
chr14_-_2032593 3.43 ENSRNOT00000000037
fibroblast growth factor receptor-like 1
chr11_+_45751812 3.43 ENSRNOT00000079336
similar to Dermal papilla derived protein 7
chr1_-_276228574 3.38 ENSRNOT00000021746
guanylate cyclase 2G
chr10_-_87521514 3.37 ENSRNOT00000084668
ENSRNOT00000071705
keratin associated protein 2-4-like
chr5_-_147412705 3.31 ENSRNOT00000010688
similar to mKIAA1522 protein
chr2_+_188478082 3.30 ENSRNOT00000085817
CDC-like kinase 2
chr4_+_82637411 3.29 ENSRNOT00000048225
LRRGT00062
chr2_-_60657712 3.21 ENSRNOT00000040348
retinoic acid induced 14
chr9_-_4978892 3.18 ENSRNOT00000015189
sulfotransferase family 1C member 3
chr2_+_208749996 3.16 ENSRNOT00000086321
chitinase, acidic
chr1_+_260093641 3.13 ENSRNOT00000019521
cyclin J
chr11_-_32550539 3.13 ENSRNOT00000002715
regulator of calcineurin 1
chr6_-_77421286 3.12 ENSRNOT00000011453
NK2 homeobox 1
chrX_+_43626480 3.09 ENSRNOT00000068078
spermidine/spermine N1-acetyl transferase 1
chr10_-_88000423 3.07 ENSRNOT00000076787
ENSRNOT00000046751
ENSRNOT00000091394
keratin 32
chr17_-_57394985 3.05 ENSRNOT00000019968
enhancer of polycomb homolog 1
chr9_-_14550625 3.04 ENSRNOT00000078227
O-acyl-ADP-ribose deacylase 1
chr11_-_70322690 3.03 ENSRNOT00000002443
heart development protein with EGF-like domains 1
chr5_-_102743417 3.02 ENSRNOT00000067389
basonuclin 2
chr4_-_103569159 2.93 ENSRNOT00000084036

chr13_+_92264231 2.91 ENSRNOT00000066509
ENSRNOT00000004716
spectrin, alpha, erythrocytic 1
chr4_-_21920651 2.91 ENSRNOT00000066211
transmembrane protein 243
chr1_+_13595295 2.88 ENSRNOT00000079250
NHS-like 1
chr4_+_31229913 2.87 ENSRNOT00000077134
ENSRNOT00000087897
sterile alpha motif domain containing 9-like
chr8_+_48718329 2.86 ENSRNOT00000089763
solute carrier family 37 member 4
chr2_-_88553086 2.83 ENSRNOT00000042494
similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chr10_-_65502936 2.83 ENSRNOT00000089615
SPT6 homolog, histone chaperone
chr2_+_243577082 2.79 ENSRNOT00000016556
alcohol dehydrogenase 6A (class V)
chr5_+_25253010 2.76 ENSRNOT00000061333
RNA binding motif protein 12B
chrM_+_9451 2.75 ENSRNOT00000041241
mitochondrially encoded NADH dehydrogenase 3
chrM_+_8599 2.74 ENSRNOT00000049683
mitochondrially encoded cytochrome C oxidase III
chr1_-_252461461 2.73 ENSRNOT00000026093
ankyrin repeat domain 22
chr11_-_71284939 2.68 ENSRNOT00000002421

chr3_+_73302571 2.68 ENSRNOT00000085420
olfactory receptor 468
chr2_-_238369692 2.68 ENSRNOT00000041583
Rho guanine nucleotide exchange factor 38
chr4_+_147832136 2.60 ENSRNOT00000064603
rhodopsin
chr17_+_9596957 2.58 ENSRNOT00000017349
family with sequence similarity 193, member B
chr14_+_23330933 2.54 ENSRNOT00000088552
transmembrane protease, serine 11d
chr5_+_25725683 2.54 ENSRNOT00000087602
similar to swan
chr8_+_57983556 2.45 ENSRNOT00000009562
similar to RIKEN cDNA 4930550C14
chr4_-_10995792 2.40 ENSRNOT00000078733

chrM_+_7919 2.39 ENSRNOT00000046108
mitochondrially encoded ATP synthase 6
chr19_+_53055745 2.36 ENSRNOT00000074430
forkhead box L1
chr6_-_108660063 2.35 ENSRNOT00000006240
apoptosis resistant E3 ubiquitin protein ligase 1
chr14_-_84189266 2.35 ENSRNOT00000005934
transcobalamin 2
chr1_-_220938814 2.34 ENSRNOT00000028081
ovo like transcriptional repressor 1
chr1_-_15374850 2.33 ENSRNOT00000016728
peroxisomal biogenesis factor 7
chr1_-_227932603 2.29 ENSRNOT00000033795
membrane spanning 4-domains A6A
chr2_-_236431596 2.26 ENSRNOT00000055570
ENSRNOT00000089674
cytochrome P450, family 2, subfamily u, polypeptide 1
chr1_+_185210922 2.24 ENSRNOT00000055120
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
chrM_+_11736 2.24 ENSRNOT00000048767
mitochondrially encoded NADH dehydrogenase 5
chr2_+_186776644 2.23 ENSRNOT00000046778
Fc receptor-like 3
chr1_-_101819478 2.23 ENSRNOT00000056181
glutamate-rich WD repeat containing 1
chr16_+_4469468 2.19 ENSRNOT00000021164
wingless-type MMTV integration site family, member 5A
chr8_-_53816447 2.19 ENSRNOT00000011454
tetratricopeptide repeat domain 12
chr16_+_29674793 2.19 ENSRNOT00000059724
annexin A10
chr2_+_208750356 2.18 ENSRNOT00000041562
chitinase, acidic
chr10_+_105630810 2.17 ENSRNOT00000064904
photoreceptor disc component
chr2_+_226563050 2.14 ENSRNOT00000065111
breast cancer anti-estrogen resistance 3
chr9_+_47536824 2.14 ENSRNOT00000049349
transmembrane protein 182
chr5_+_133819726 2.13 ENSRNOT00000081075
Scl/Tal1 interrupting locus
chrM_+_10160 2.12 ENSRNOT00000042928
mitochondrially encoded NADH dehydrogenase 4
chr17_-_78812111 2.11 ENSRNOT00000021506
DNA cross-link repair 1C
chr20_+_42966140 2.10 ENSRNOT00000000707
myristoylated alanine rich protein kinase C substrate
chr19_+_53044379 2.09 ENSRNOT00000072369
forkhead box C2
chr2_+_252090669 2.09 ENSRNOT00000020656
lysophosphatidic acid receptor 3
chr13_+_79378733 2.09 ENSRNOT00000039221
tumor necrosis factor superfamily member 18
chr14_-_43694584 2.08 ENSRNOT00000041866

chr9_-_117484262 2.04 ENSRNOT00000091931

chr1_+_280633938 2.01 ENSRNOT00000012564
empty spiracles homeobox 2
chrM_+_9870 2.00 ENSRNOT00000044582
mitochondrially encoded NADH 4L dehydrogenase
chr3_-_8659102 1.97 ENSRNOT00000050908
zinc finger, DHHC-type containing 12
chr7_+_38900593 1.95 ENSRNOT00000072166
epiphycan
chr5_+_6373583 1.95 ENSRNOT00000084749

chr1_+_101554642 1.94 ENSRNOT00000028474
branched chain amino acid transaminase 2
chr3_-_75576520 1.94 ENSRNOT00000083330
olfactory receptor 567
chr1_-_134871167 1.94 ENSRNOT00000076300
chromodomain helicase DNA binding protein 2
chr3_+_73366155 1.93 ENSRNOT00000044979
olfactory receptor 473
chr1_-_94404211 1.91 ENSRNOT00000019463
URI1, prefoldin-like chaperone
chr16_-_85305782 1.86 ENSRNOT00000067511
ENSRNOT00000076737
tumor necrosis factor superfamily member 13b
chr3_+_2591331 1.86 ENSRNOT00000017466
suppressor APC domain containing 2
chr1_+_128637049 1.85 ENSRNOT00000018639
tetratricopeptide repeat domain 23
chr6_+_8886591 1.79 ENSRNOT00000091510
ENSRNOT00000089174
SIX homeobox 3
chr14_-_45859908 1.77 ENSRNOT00000086994
phosphoglucomutase 2
chr2_-_33025271 1.73 ENSRNOT00000074941
microtubule associated serine/threonine kinase family member 4
chr11_+_47924970 1.69 ENSRNOT00000060577
zona pellucida-like domain containing 1
chr1_+_101599018 1.66 ENSRNOT00000028494
fucosyltransferase 1
chrX_+_105147534 1.66 ENSRNOT00000046288
centromere protein I
chr10_-_87564327 1.64 ENSRNOT00000064760
ENSRNOT00000068237
similar to keratin associated protein 4-7
chr3_-_76135475 1.60 ENSRNOT00000007712
olfactory receptor 604
chr5_+_33097654 1.57 ENSRNOT00000008087
cyclic nucleotide gated channel beta 3
chr3_+_5709236 1.55 ENSRNOT00000061201
ENSRNOT00000070887
dopamine beta-hydroxylase
chr12_+_47590154 1.55 ENSRNOT00000045946
GIT ArfGAP 2
chr7_+_133856101 1.55 ENSRNOT00000038686
PDZ domain containing RING finger 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Mnx1_Lhx6_Lmx1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.5 25.4 GO:0001969 activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
5.2 15.6 GO:0036395 pancreatic amylase secretion(GO:0036395) regulation of pancreatic amylase secretion(GO:1902276) positive regulation of histamine secretion by mast cell(GO:1903595)
4.5 13.6 GO:2000424 regulation of eosinophil chemotaxis(GO:2000422) positive regulation of eosinophil chemotaxis(GO:2000424)
4.5 13.4 GO:0010133 proline catabolic process to glutamate(GO:0010133)
2.5 7.6 GO:0032679 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) TRAIL production(GO:0032639) regulation of TRAIL production(GO:0032679) positive regulation of TRAIL production(GO:0032759)
2.5 15.1 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
2.3 9.1 GO:0045658 regulation of neutrophil differentiation(GO:0045658)
2.1 21.4 GO:0048251 elastic fiber assembly(GO:0048251)
2.0 5.9 GO:1903173 phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173)
1.9 11.3 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660)
1.8 14.1 GO:0006776 vitamin A metabolic process(GO:0006776)
1.6 4.9 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
1.6 11.2 GO:0030916 otic vesicle formation(GO:0030916)
1.5 4.5 GO:0009609 response to symbiotic bacterium(GO:0009609)
1.5 4.5 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
1.5 6.0 GO:0015889 cobalamin transport(GO:0015889)
1.5 7.4 GO:1905031 regulation of membrane repolarization during cardiac muscle cell action potential(GO:1905031)
1.4 4.2 GO:1905242 response to 3,3',5-triiodo-L-thyronine(GO:1905242) cellular response to 3,3',5-triiodo-L-thyronine(GO:1905243) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
1.4 5.5 GO:0031296 B cell costimulation(GO:0031296)
1.3 4.0 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
1.3 4.0 GO:0042222 interleukin-1 biosynthetic process(GO:0042222)
1.3 4.0 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
1.3 7.6 GO:0060267 positive regulation of respiratory burst(GO:0060267)
1.2 3.7 GO:0015827 angiotensin-mediated drinking behavior(GO:0003051) tryptophan transport(GO:0015827) positive regulation of gap junction assembly(GO:1903598)
1.2 3.5 GO:0042706 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) retinal rod cell differentiation(GO:0060221)
1.1 5.3 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
1.0 11.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
1.0 3.0 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.8 5.9 GO:2000371 phosphatidylserine exposure on apoptotic cell surface(GO:0070782) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.8 4.0 GO:0030070 insulin processing(GO:0030070)
0.8 2.4 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.8 3.1 GO:0032919 spermine acetylation(GO:0032919)
0.7 2.2 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.7 3.7 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.7 11.0 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.7 2.2 GO:0061346 serotonergic neuron axon guidance(GO:0036515) Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) melanocyte proliferation(GO:0097325)
0.7 14.8 GO:0033327 Leydig cell differentiation(GO:0033327)
0.7 2.1 GO:2000328 regulation of T-helper 17 cell lineage commitment(GO:2000328)
0.6 1.9 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.6 14.7 GO:0032274 gonadotropin secretion(GO:0032274)
0.6 5.0 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.6 6.0 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.6 1.8 GO:0014016 proximal/distal axis specification(GO:0009946) neuroblast differentiation(GO:0014016)
0.6 4.4 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.5 5.3 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.5 2.1 GO:0072011 apoptotic process involved in outflow tract morphogenesis(GO:0003275) positive regulation of vascular wound healing(GO:0035470) glomerular endothelium development(GO:0072011) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.5 1.5 GO:0046333 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
0.5 1.5 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.5 2.9 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.5 2.8 GO:0070827 chromatin maintenance(GO:0070827)
0.5 6.0 GO:0048733 sebaceous gland development(GO:0048733)
0.5 1.4 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.4 2.1 GO:1900019 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.4 8.3 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.4 3.6 GO:0070417 cellular response to cold(GO:0070417)
0.4 3.9 GO:0014029 neural crest formation(GO:0014029)
0.4 2.3 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.3 2.3 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.3 1.3 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.3 4.3 GO:0034501 protein localization to kinetochore(GO:0034501)
0.3 5.6 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.3 0.9 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.3 3.4 GO:0060539 diaphragm development(GO:0060539)
0.3 2.2 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.3 2.1 GO:0033504 floor plate development(GO:0033504)
0.3 2.1 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.3 3.1 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.3 2.6 GO:0018298 protein-chromophore linkage(GO:0018298)
0.3 3.6 GO:0001878 response to yeast(GO:0001878)
0.3 4.9 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.2 4.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 1.2 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.2 2.8 GO:0009642 response to light intensity(GO:0009642)
0.2 1.4 GO:0089700 protein kinase D signaling(GO:0089700)
0.2 21.7 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.2 4.0 GO:0043968 histone H2A acetylation(GO:0043968)
0.2 0.9 GO:0035582 growth plate cartilage chondrocyte proliferation(GO:0003419) sequestering of BMP in extracellular matrix(GO:0035582)
0.2 6.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 12.4 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.2 1.1 GO:0051081 membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.2 2.2 GO:0006337 nucleosome disassembly(GO:0006337)
0.2 1.1 GO:0042256 mature ribosome assembly(GO:0042256)
0.2 6.3 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.2 3.0 GO:0043586 tongue development(GO:0043586)
0.2 3.4 GO:0033194 response to hydroperoxide(GO:0033194)
0.2 1.1 GO:0007379 segment specification(GO:0007379)
0.2 0.8 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.2 2.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 0.6 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.2 1.7 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 1.0 GO:0000459 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.1 0.4 GO:0030824 negative regulation of cGMP metabolic process(GO:0030824)
0.1 0.9 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 1.7 GO:0036065 fucosylation(GO:0036065)
0.1 2.9 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.1 0.4 GO:0030242 pexophagy(GO:0030242)
0.1 1.2 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 2.0 GO:0021542 dentate gyrus development(GO:0021542)
0.1 1.1 GO:0051382 kinetochore assembly(GO:0051382)
0.1 2.1 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 0.5 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.1 6.3 GO:0046686 response to cadmium ion(GO:0046686)
0.1 9.5 GO:0006334 nucleosome assembly(GO:0006334)
0.1 2.4 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 1.3 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.1 0.5 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.1 0.5 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 5.1 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 0.9 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 1.4 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 9.6 GO:0016573 histone acetylation(GO:0016573)
0.1 1.2 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 1.5 GO:0048266 behavioral response to pain(GO:0048266)
0.1 0.9 GO:1902358 oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
0.0 0.7 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 1.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 4.1 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 0.0 GO:1903936 cellular response to sodium arsenite(GO:1903936)
0.0 0.4 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 2.9 GO:0030901 midbrain development(GO:0030901)
0.0 0.5 GO:0090520 sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.4 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 4.7 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.0 0.2 GO:0044206 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) UMP salvage(GO:0044206)
0.0 1.5 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 1.0 GO:0042990 regulation of transcription factor import into nucleus(GO:0042990)
0.0 2.1 GO:0007569 cell aging(GO:0007569)
0.0 0.1 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.0 1.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 3.9 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 0.3 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.5 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 0.5 GO:0048741 skeletal muscle fiber development(GO:0048741)
0.0 0.1 GO:0061727 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.5 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.3 GO:0007625 grooming behavior(GO:0007625)
0.0 0.5 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.4 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 3.1 GO:0042278 purine nucleoside metabolic process(GO:0042278)
0.0 0.0 GO:1990918 double-strand break repair involved in meiotic recombination(GO:1990918)
0.0 1.1 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 1.2 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 4.7 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway(GO:0007169)
0.0 0.4 GO:0014909 smooth muscle cell migration(GO:0014909)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 40.5 GO:0005579 membrane attack complex(GO:0005579)
5.2 15.6 GO:0035577 azurophil granule membrane(GO:0035577)
4.3 21.4 GO:0071953 elastic fiber(GO:0071953)
2.5 7.6 GO:0032398 MHC class Ib protein complex(GO:0032398)
1.9 7.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
1.5 4.5 GO:0060187 cell pole(GO:0060187)
1.2 3.6 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.9 4.5 GO:0097413 Lewy body(GO:0097413)
0.8 5.1 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.8 3.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.7 18.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.7 2.1 GO:0042585 germinal vesicle(GO:0042585)
0.7 4.0 GO:0005726 perichromatin fibrils(GO:0005726)
0.6 9.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.6 3.6 GO:0033093 Weibel-Palade body(GO:0033093)
0.5 8.6 GO:0070938 contractile ring(GO:0070938)
0.4 1.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.4 1.5 GO:0034774 secretory granule lumen(GO:0034774)
0.4 6.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 1.3 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.3 3.6 GO:0043202 lysosomal lumen(GO:0043202)
0.3 2.9 GO:0008091 spectrin(GO:0008091) spectrin-associated cytoskeleton(GO:0014731) cuticular plate(GO:0032437)
0.3 3.9 GO:0044232 organelle membrane contact site(GO:0044232)
0.3 12.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 2.1 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.2 16.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 1.4 GO:0035189 Rb-E2F complex(GO:0035189)
0.2 21.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 2.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.2 7.4 GO:0031941 filamentous actin(GO:0031941)
0.2 12.5 GO:0045095 keratin filament(GO:0045095)
0.2 2.4 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 4.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 2.3 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 0.4 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.1 2.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.0 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.1 2.8 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 1.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.9 GO:0000812 Swr1 complex(GO:0000812)
0.1 1.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 9.1 GO:0000922 spindle pole(GO:0000922)
0.1 0.2 GO:0045098 type III intermediate filament(GO:0045098)
0.1 1.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 3.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.1 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 3.4 GO:0044291 cell-cell contact zone(GO:0044291)
0.1 1.4 GO:0000421 autophagosome membrane(GO:0000421)
0.0 17.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 7.6 GO:0030027 lamellipodium(GO:0030027)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 4.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 7.9 GO:0005840 ribosome(GO:0005840)
0.0 10.4 GO:0005925 focal adhesion(GO:0005925)
0.0 1.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 4.5 GO:0005681 spliceosomal complex(GO:0005681)
0.0 2.1 GO:0005814 centriole(GO:0005814)
0.0 6.3 GO:0016607 nuclear speck(GO:0016607)
0.0 0.5 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.7 GO:0031201 SNARE complex(GO:0031201)
0.0 1.1 GO:0005882 intermediate filament(GO:0005882)
0.0 10.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 3.5 GO:0005911 cell-cell junction(GO:0005911)
0.0 0.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 15.1 GO:0031714 C5a anaphylatoxin chemotactic receptor binding(GO:0031714)
4.5 13.4 GO:0004657 proline dehydrogenase activity(GO:0004657)
2.4 17.1 GO:0030881 beta-2-microglobulin binding(GO:0030881)
1.9 11.3 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
1.8 12.3 GO:0031852 mu-type opioid receptor binding(GO:0031852)
1.5 7.6 GO:0019862 IgA binding(GO:0019862)
1.5 8.8 GO:0005499 vitamin D binding(GO:0005499)
1.3 5.3 GO:0016160 amylase activity(GO:0016160)
1.3 15.6 GO:0019869 chloride channel inhibitor activity(GO:0019869)
1.3 3.9 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
1.3 11.4 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445)
1.2 6.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
1.1 14.1 GO:0019841 retinol binding(GO:0019841)
1.0 3.1 GO:0019809 spermidine binding(GO:0019809)
1.0 21.1 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
1.0 4.0 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670) trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
1.0 4.0 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.9 2.8 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.9 3.7 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.9 5.3 GO:0004568 chitinase activity(GO:0004568)
0.8 5.0 GO:0005148 prolactin receptor binding(GO:0005148)
0.8 3.2 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.8 3.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.7 6.0 GO:0031419 cobalamin binding(GO:0031419)
0.7 2.2 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.7 16.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.6 1.9 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.6 2.6 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.6 3.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.6 1.7 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.5 1.5 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.5 5.1 GO:0004526 ribonuclease P activity(GO:0004526)
0.5 4.0 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.5 12.6 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 3.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.4 5.9 GO:0042609 CD4 receptor binding(GO:0042609)
0.4 2.9 GO:0015119 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.4 1.9 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.4 7.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.4 2.6 GO:0016918 retinal binding(GO:0016918)
0.4 3.7 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.4 1.8 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.3 2.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.3 1.3 GO:0019002 GMP binding(GO:0019002)
0.3 2.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.3 0.9 GO:0016015 morphogen activity(GO:0016015)
0.3 7.5 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.3 2.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.3 1.4 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.3 3.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.3 4.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 30.5 GO:0005178 integrin binding(GO:0005178)
0.2 13.7 GO:0009055 electron carrier activity(GO:0009055)
0.2 13.4 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.2 1.1 GO:0033592 RNA strand annealing activity(GO:0033592)
0.2 2.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 1.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.2 4.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 1.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 8.3 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 1.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 4.2 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.6 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.1 7.6 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.1 12.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 3.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 1.8 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 0.9 GO:1990405 protein antigen binding(GO:1990405)
0.1 0.4 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 11.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 3.0 GO:0019213 deacetylase activity(GO:0019213)
0.1 4.4 GO:0019003 GDP binding(GO:0019003)
0.1 2.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.4 GO:0004697 protein kinase C activity(GO:0004697)
0.1 0.9 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.9 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.1 GO:0005521 lamin binding(GO:0005521)
0.1 0.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 2.3 GO:0070330 aromatase activity(GO:0070330)
0.0 0.6 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.6 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 1.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 9.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.1 GO:0005080 protein kinase C binding(GO:0005080)
0.0 2.8 GO:0015297 antiporter activity(GO:0015297)
0.0 1.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 9.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.4 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 9.7 GO:0005549 odorant binding(GO:0005549)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 5.5 GO:0045296 cadherin binding(GO:0045296)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.3 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 1.9 GO:0004386 helicase activity(GO:0004386)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.4 GO:0004623 phospholipase A2 activity(GO:0004623)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 15.1 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.4 4.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.4 14.1 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.3 3.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.3 4.0 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.3 5.7 PID LPA4 PATHWAY LPA4-mediated signaling events
0.3 8.3 PID ALK1 PATHWAY ALK1 signaling events
0.2 9.6 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.2 11.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.2 9.1 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.1 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 5.9 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 24.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.1 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.6 PID CONE PATHWAY Visual signal transduction: Cones
0.1 5.2 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 2.4 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 3.4 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.1 2.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 4.4 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 3.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.2 PID PLK1 PATHWAY PLK1 signaling events
0.1 3.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 2.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 5.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 2.2 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 0.8 PID MYC PATHWAY C-MYC pathway
0.0 2.1 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.9 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.9 PID BMP PATHWAY BMP receptor signaling
0.0 0.8 PID E2F PATHWAY E2F transcription factor network
0.0 0.4 PID ATR PATHWAY ATR signaling pathway
0.0 0.2 PID FGF PATHWAY FGF signaling pathway
0.0 3.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 40.5 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
1.0 13.6 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.9 9.4 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.6 15.6 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.5 11.3 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.5 4.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.5 17.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.5 4.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.4 14.1 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.4 11.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.4 3.7 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.3 2.6 REACTOME OPSINS Genes involved in Opsins
0.3 8.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.2 3.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 5.0 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.2 2.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2 3.6 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 3.1 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 4.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 1.4 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 3.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 0.7 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.9 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 6.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.2 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 1.8 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 4.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.9 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 1.0 REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.1 1.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 5.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 9.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.3 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.9 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.5 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 1.5 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 2.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.6 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism