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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Mga

Z-value: 0.77

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Transcription factors associated with Mga

Gene Symbol Gene ID Gene Info
Mga
ENSRNOG00000006378 MGA, MAX dimerization protein

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mgarn6_v1_chr3_+_111699021_1116990870.211.2e-04Click!

Activity profile of Mga motif

Sorted Z-values of Mga motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_110232843 32.11 ENSRNOT00000054934
Cd7
Cd7 molecule
chr16_-_31301880 29.12 ENSRNOT00000084847
ENSRNOT00000083943
AABR07025272.1

chr3_+_19772056 29.04 ENSRNOT00000044455
AABR07051708.1

chr4_+_163162211 25.23 ENSRNOT00000082537
Clec1b
C-type lectin domain family 1, member B
chr5_-_138239306 22.60 ENSRNOT00000039305
Ermap
erythroblast membrane-associated protein
chr7_-_12635943 20.18 ENSRNOT00000015029
Cfd
complement factor D
chr14_-_5859581 18.38 ENSRNOT00000052308
AABR07014241.1

chr3_-_20695952 17.87 ENSRNOT00000072306
AABR07051746.1

chrX_+_122507374 16.57 ENSRNOT00000032275
ENSRNOT00000080517
Dock11
dedicator of cytokinesis 11
chr2_+_87418517 15.66 ENSRNOT00000048046
LOC100909879
tyrosine-protein phosphatase non-receptor type substrate 1-like
chr19_-_37952501 15.44 ENSRNOT00000026809
Dpep3
dipeptidase 3
chr7_+_119820537 15.26 ENSRNOT00000077256
ENSRNOT00000056221
Cyth4
cytohesin 4
chr15_-_28081465 15.02 ENSRNOT00000033739
Rnase6
ribonuclease, RNase A family, 6
chr8_-_50526843 14.96 ENSRNOT00000092188
AABR07070085.1

chr7_-_117680004 14.49 ENSRNOT00000040422
Slc39a4
solute carrier family 39 member 4
chr3_+_20007192 13.90 ENSRNOT00000075229
AABR07051716.1

chr7_+_140758615 13.41 ENSRNOT00000089448
Troap
trophinin associated protein
chr8_+_5768811 13.32 ENSRNOT00000013936
Mmp8
matrix metallopeptidase 8
chr3_-_46601409 13.04 ENSRNOT00000079261
Pla2r1
phospholipase A2 receptor 1
chr10_-_57837602 12.40 ENSRNOT00000075185
Nlrp1b
NLR family, pyrin domain containing 1B
chr8_-_114449956 12.36 ENSRNOT00000056414
Col6a6
collagen type VI alpha 6 chain
chr20_-_3401273 11.31 ENSRNOT00000089257
ENSRNOT00000078451
ENSRNOT00000001085
Nrm
nurim (nuclear envelope membrane protein)
chr14_-_84662143 10.84 ENSRNOT00000057529
ENSRNOT00000080078
Hormad2
HORMA domain containing 2
chr3_+_17180411 10.75 ENSRNOT00000058260
AABR07051565.1

chr10_+_105498728 10.53 ENSRNOT00000032163
Sphk1
sphingosine kinase 1
chr20_-_7219548 10.46 ENSRNOT00000033907
Rps10
ribosomal protein S10
chr1_+_252589785 10.34 ENSRNOT00000025928
Fas
Fas cell surface death receptor
chr4_-_78342863 10.25 ENSRNOT00000049038
Gimap6
GTPase, IMAP family member 6
chr1_-_101095594 10.25 ENSRNOT00000027944
Fcgrt
Fc fragment of IgG receptor and transporter
chrX_-_118513061 9.97 ENSRNOT00000043338
Il13ra2
interleukin 13 receptor subunit alpha 2
chr1_+_79754587 9.90 ENSRNOT00000083211
Micb
MHC class I polypeptide-related sequence B
chr9_+_82632230 9.84 ENSRNOT00000085165
Gmppa
GDP-mannose pyrophosphorylase A
chr2_+_186703541 9.83 ENSRNOT00000093342
Fcrl1
Fc receptor-like 1
chr1_+_213040024 9.66 ENSRNOT00000050237
Olr300
olfactory receptor 300
chr20_-_5618254 9.56 ENSRNOT00000092326
ENSRNOT00000000576
Bak1
BCL2-antagonist/killer 1
chr6_-_79306443 9.10 ENSRNOT00000030706
Clec14a
C-type lectin domain family 14, member A
chr17_+_43632397 8.86 ENSRNOT00000013790
Hist1h2ah
histone cluster 1, H2ah
chr4_+_154391647 8.84 ENSRNOT00000081488
ENSRNOT00000079192
Mug1
murinoglobulin 1
chr4_-_154855098 8.57 ENSRNOT00000041957
LOC297568
alpha-1-inhibitor III
chr6_-_127816055 8.54 ENSRNOT00000013175
Serpina3m
serine (or cysteine) proteinase inhibitor, clade A, member 3M
chr4_-_164306500 8.39 ENSRNOT00000080133
Ly49i5
Ly49 inhibitory receptor 5
chr7_-_65275408 8.08 ENSRNOT00000065137
Hmga2
high mobility group AT-hook 2
chr18_+_16590408 7.74 ENSRNOT00000093715
Mocos
molybdenum cofactor sulfurase
chr4_+_181481147 7.63 ENSRNOT00000002523
Klhl42
kelch-like family, member 42
chr10_+_105500290 7.41 ENSRNOT00000079080
ENSRNOT00000083593
Sphk1
sphingosine kinase 1
chr18_-_70924708 7.31 ENSRNOT00000025257
Lipg
lipase G, endothelial type
chr16_-_81434363 6.68 ENSRNOT00000080963
Rasa3
RAS p21 protein activator 3
chr20_+_20519031 6.65 ENSRNOT00000000780
AABR07044783.1

chr11_+_67555658 6.58 ENSRNOT00000039075
Csta
cystatin A (stefin A)
chr7_+_126096793 6.51 ENSRNOT00000047234
ENSRNOT00000088042
Fbln1
fibulin 1
chr9_+_69497121 6.37 ENSRNOT00000042562
Nrp2
neuropilin 2
chr7_+_120176530 6.29 ENSRNOT00000087548
Triobp
TRIO and F-actin binding protein
chr2_-_200762206 6.13 ENSRNOT00000068511
ENSRNOT00000086835
Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr12_-_6879154 5.89 ENSRNOT00000001207
Alox5ap
arachidonate 5-lipoxygenase activating protein
chr16_-_83132785 5.74 ENSRNOT00000043449
Arhgef7
Rho guanine nucleotide exchange factor 7
chr3_+_72540538 5.56 ENSRNOT00000012379
Aplnr
apelin receptor
chr8_-_119523716 5.45 ENSRNOT00000064581
Mlh1
mutL homolog 1
chr8_-_119523964 5.18 ENSRNOT00000081718
Mlh1
mutL homolog 1
chr8_-_132027006 5.17 ENSRNOT00000050963
LOC367195
similar to 60S RIBOSOMAL PROTEIN L7
chr5_+_69833225 5.09 ENSRNOT00000013759
Nipsnap3b
nipsnap homolog 3B
chrX_-_1786978 5.03 ENSRNOT00000011317
Rbm10
RNA binding motif protein 10
chr1_+_222250995 4.92 ENSRNOT00000031458
Trpt1
tRNA phosphotransferase 1
chr9_+_82632384 4.56 ENSRNOT00000027064
Gmppa
GDP-mannose pyrophosphorylase A
chr18_+_24540659 4.54 ENSRNOT00000061074
Ammecr1l
AMMECR1 like
chr6_+_106496992 4.49 ENSRNOT00000086136
ENSRNOT00000058181
Rgs6
regulator of G-protein signaling 6
chr8_-_22929294 4.30 ENSRNOT00000015609
Rab3d
RAB3D, member RAS oncogene family
chr13_-_61306939 4.30 ENSRNOT00000086610
Rgs21
regulator of G-protein signaling 21
chr20_-_14393793 4.29 ENSRNOT00000001764
Specc1l
sperm antigen with calponin homology and coiled-coil domains 1-like
chr9_+_15309127 4.24 ENSRNOT00000019177
Prickle4
prickle planar cell polarity protein 4
chr6_+_12253788 3.96 ENSRNOT00000061675
Ppp1r21
protein phosphatase 1, regulatory subunit 21
chrX_-_159206949 3.93 ENSRNOT00000071516
Map7d3
MAP7 domain containing 3
chr1_+_221409271 3.88 ENSRNOT00000028462
Syvn1
synoviolin 1
chr10_+_71008709 3.84 ENSRNOT00000055923
Wfdc18
WAP four-disulfide core domain 18
chr9_+_61738471 3.82 ENSRNOT00000090305
AABR07067762.1

chr7_+_141973553 3.81 ENSRNOT00000052075
Mettl7a
methyltransferase like 7A
chr7_+_61165640 3.76 ENSRNOT00000087955
Mdm1
Mdm1 nuclear protein
chr16_+_55834458 3.59 ENSRNOT00000086141
AABR07025928.1

chr5_+_159220979 3.44 ENSRNOT00000008940
Rcc2
regulator of chromosome condensation 2
chr5_-_57683932 3.44 ENSRNOT00000074796
Dcaf12
DDB1 and CUL4 associated factor 12
chr18_+_70248713 3.38 ENSRNOT00000032202
Mbd1
methyl-CpG binding domain protein 1
chr5_-_162602339 3.34 ENSRNOT00000071779
RGD1563334
similar to novel protein similar to esterases
chr5_-_160158386 3.04 ENSRNOT00000089345
Fblim1
filamin binding LIM protein 1
chr5_-_157820889 2.98 ENSRNOT00000024326
Mrto4
MRT4 homolog, ribosome maturation factor
chr11_+_67451549 2.95 ENSRNOT00000042777
Stfa2l2
stefin A2-like 2
chr19_-_25220010 2.93 ENSRNOT00000008786
Dcaf15
DDB1 and CUL4 associated factor 15
chr10_-_61045355 2.84 ENSRNOT00000048167
Olr1514
olfactory receptor 1514
chr7_+_23854846 2.59 ENSRNOT00000037290
Bpifc
BPI fold containing family C
chr1_-_90151405 2.42 ENSRNOT00000028688
RGD1308428
similar to RIKEN cDNA 4931406P16
chr7_+_58366192 2.37 ENSRNOT00000081891
Zfc3h1
zinc finger, C3H1-type containing
chr2_-_34923024 2.36 ENSRNOT00000090060
Cwc27
CWC27 spliceosome-associated protein homolog
chr9_+_20004280 2.33 ENSRNOT00000075670
Ankrd66
ankyrin repeat domain 66
chr1_-_80271001 2.31 ENSRNOT00000034266
Cd3eap
CD3e molecule associated protein
chr2_-_34419428 2.29 ENSRNOT00000048123
AABR07007905.1

chr3_-_111587151 2.15 ENSRNOT00000007299
Rpap1
RNA polymerase II associated protein 1
chr5_-_135859643 2.14 ENSRNOT00000024719
Urod
uroporphyrinogen decarboxylase
chr5_+_68717519 2.12 ENSRNOT00000066226
Smc2
structural maintenance of chromosomes 2
chr13_-_78851600 2.09 ENSRNOT00000076985
Zbtb37
zinc finger and BTB domain containing 37
chr4_+_106361762 1.92 ENSRNOT00000052417
AABR07061136.1

chr2_+_187512164 1.84 ENSRNOT00000051394
Mef2d
myocyte enhancer factor 2D
chr14_+_17123360 1.71 ENSRNOT00000003070
Nup54
nucleoporin 54
chrX_-_111102464 1.57 ENSRNOT00000084176
Ripply1
ripply transcriptional repressor 1
chr12_-_16310190 1.53 ENSRNOT00000060444
Eif3b
eukaryotic translation initiation factor 3, subunit B
chr4_-_167180656 1.46 ENSRNOT00000049487
Tas2r103
taste receptor, type 2, member 103
chr1_+_163797660 1.18 ENSRNOT00000021674
Wnt11
wingless-type MMTV integration site family, member 11
chr4_-_69149520 1.02 ENSRNOT00000017611
Prss58
protease, serine, 58
chr7_-_14369821 0.97 ENSRNOT00000008560
Akap8l
A-kinase anchoring protein 8 like
chr9_+_14951047 0.87 ENSRNOT00000074267
LOC100911489
uncharacterized LOC100911489
chr2_+_257295193 0.79 ENSRNOT00000052249
AABR07013798.1

chr3_+_75809445 0.70 ENSRNOT00000049950
Olr581
olfactory receptor 581
chr2_+_192553983 0.69 ENSRNOT00000085204
LOC102550416
small proline-rich protein 2I-like
chr5_+_157820908 0.55 ENSRNOT00000068168
Emc1
ER membrane protein complex subunit 1
chr4_+_152437966 0.49 ENSRNOT00000013070
Rad52
RAD52 homolog, DNA repair protein
chr7_-_143085833 0.48 ENSRNOT00000031257
ENSRNOT00000077286
Krt83
keratin 83
chr17_-_71897972 0.44 ENSRNOT00000065942
Sfmbt2
Scm-like with four mbt domains 2
chr1_+_63201271 0.42 ENSRNOT00000090830
LOC108348164
vomeronasal type-1 receptor 4-like
chr4_+_1535100 0.23 ENSRNOT00000074575
LOC100912488
olfactory receptor 147-like
chr9_-_44617210 0.23 ENSRNOT00000074343
Lyg1
lysozyme G1
chr3_+_147073160 0.15 ENSRNOT00000012690
Sdcbp2
syndecan binding protein 2
chr1_-_168869420 0.05 ENSRNOT00000021436
Olr125
olfactory receptor 125
chr1_+_207508414 0.01 ENSRNOT00000054896
Nps
neuropeptide S

Network of associatons between targets according to the STRING database.

First level regulatory network of Mga

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.5 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
3.6 17.9 GO:0019371 cyclooxygenase pathway(GO:0019371)
3.5 10.6 GO:0043060 meiotic metaphase I plate congression(GO:0043060)
2.9 14.4 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
2.4 7.3 GO:0010986 regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of lipoprotein particle clearance(GO:0010986)
2.2 6.5 GO:2001201 regulation of transforming growth factor-beta secretion(GO:2001201)
2.1 6.4 GO:1904835 vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
2.1 10.3 GO:0036337 ovarian follicle atresia(GO:0001552) Fas signaling pathway(GO:0036337)
2.0 8.1 GO:2001038 senescence-associated heterochromatin focus assembly(GO:0035986) histone H2A phosphorylation(GO:1990164) regulation of cellular response to drug(GO:2001038)
1.9 13.0 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238) oxidative stress-induced premature senescence(GO:0090403)
1.8 16.6 GO:0002315 marginal zone B cell differentiation(GO:0002315)
1.8 20.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.6 9.6 GO:0048597 B cell selection(GO:0002339) post-embryonic camera-type eye morphogenesis(GO:0048597)
1.5 5.9 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
1.1 10.8 GO:0045144 meiotic sister chromatid segregation(GO:0045144) meiotic sister chromatid cohesion(GO:0051177)
1.1 4.3 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
1.0 6.1 GO:0034757 negative regulation of iron ion transport(GO:0034757)
1.0 10.0 GO:0043305 negative regulation of mast cell degranulation(GO:0043305)
1.0 25.2 GO:0030220 platelet formation(GO:0030220)
0.7 7.7 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.7 32.1 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.7 10.2 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.6 5.7 GO:2000394 positive regulation of lamellipodium morphogenesis(GO:2000394)
0.6 15.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.6 1.2 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.6 3.4 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.6 5.0 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.5 12.4 GO:0050716 positive regulation of interleukin-1 secretion(GO:0050716) positive regulation of interleukin-1 beta secretion(GO:0050718)
0.5 3.8 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.5 2.1 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.4 4.9 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.4 8.7 GO:0030574 collagen catabolic process(GO:0030574)
0.3 10.5 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 15.4 GO:0007140 male meiosis(GO:0007140)
0.3 1.5 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.3 9.1 GO:0002042 cell migration involved in sprouting angiogenesis(GO:0002042)
0.2 3.0 GO:0033623 regulation of integrin activation(GO:0033623)
0.2 2.1 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.2 1.7 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.2 3.4 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.2 6.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.2 1.0 GO:0030397 membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.2 6.6 GO:0018149 peptide cross-linking(GO:0018149)
0.1 8.8 GO:0006953 acute-phase response(GO:0006953)
0.1 3.9 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 1.8 GO:0007512 adult heart development(GO:0007512)
0.1 6.7 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 3.0 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 1.6 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.1 4.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 15.0 GO:0090501 RNA phosphodiester bond hydrolysis(GO:0090501)
0.1 8.9 GO:0006342 chromatin silencing(GO:0006342)
0.1 9.9 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 2.3 GO:0009303 rRNA transcription(GO:0009303)
0.1 0.5 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.1 21.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 2.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 7.6 GO:0032886 regulation of microtubule-based process(GO:0032886)
0.1 3.9 GO:0046785 microtubule polymerization(GO:0046785)
0.1 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 2.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.5 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 5.6 GO:0007369 gastrulation(GO:0007369)
0.0 1.5 GO:0050909 sensory perception of taste(GO:0050909)
0.0 4.5 GO:0045666 positive regulation of neuron differentiation(GO:0045666)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.6 GO:0005712 chiasma(GO:0005712) recombination nodule(GO:0005713)
2.1 10.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
1.8 12.4 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
1.6 8.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
1.3 6.5 GO:0071953 elastic fiber(GO:0071953)
1.3 3.9 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.8 5.7 GO:0000322 storage vacuole(GO:0000322)
0.5 9.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.4 6.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.3 9.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.3 14.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.3 2.1 GO:0000796 condensin complex(GO:0000796)
0.2 6.6 GO:0001533 cornified envelope(GO:0001533)
0.2 3.4 GO:1990023 mitotic spindle midzone(GO:1990023)
0.2 10.8 GO:0000795 synaptonemal complex(GO:0000795)
0.2 11.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 2.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 1.5 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.2 1.7 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.2 4.3 GO:0042588 zymogen granule(GO:0042588)
0.1 10.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 4.3 GO:0005921 gap junction(GO:0005921)
0.1 3.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 3.0 GO:0045120 pronucleus(GO:0045120)
0.1 4.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 13.5 GO:0072562 blood microparticle(GO:0072562)
0.1 7.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 8.9 GO:0044815 DNA packaging complex(GO:0044815)
0.1 16.0 GO:0008021 synaptic vesicle(GO:0008021)
0.1 22.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 4.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 9.1 GO:0031012 extracellular matrix(GO:0031012)
0.1 3.8 GO:0005811 lipid particle(GO:0005811)
0.0 0.5 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 13.0 GO:0043235 receptor complex(GO:0043235)
0.0 3.4 GO:0000792 heterochromatin(GO:0000792)
0.0 3.8 GO:0005814 centriole(GO:0005814)
0.0 6.3 GO:0005925 focal adhesion(GO:0005925)
0.0 7.3 GO:0005769 early endosome(GO:0005769)
0.0 25.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 2.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 52.0 GO:0070062 extracellular exosome(GO:0070062)
0.0 6.4 GO:0016607 nuclear speck(GO:0016607)
0.0 2.9 GO:0031965 nuclear membrane(GO:0031965)
0.0 9.3 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.0 2.5 GO:0030424 axon(GO:0030424)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 17.9 GO:0008481 sphinganine kinase activity(GO:0008481)
3.6 14.4 GO:0070568 guanylyltransferase activity(GO:0070568)
2.1 10.6 GO:0032137 guanine/thymine mispair binding(GO:0032137)
2.1 10.3 GO:0043120 tumor necrosis factor binding(GO:0043120)
2.0 10.2 GO:0019770 IgG receptor activity(GO:0019770)
2.0 6.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
2.0 8.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
2.0 5.9 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051) leukotriene-C4 synthase activity(GO:0004464)
1.9 7.7 GO:0008265 Mo-molybdopterin cofactor sulfurase activity(GO:0008265)
1.5 15.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
1.2 7.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
1.1 9.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
1.1 6.5 GO:0070051 fibrinogen binding(GO:0070051)
1.0 12.4 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.8 6.4 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.6 9.6 GO:0051400 BH domain binding(GO:0051400)
0.6 15.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.6 13.0 GO:0043274 phospholipase binding(GO:0043274)
0.6 3.4 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.5 14.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.4 3.9 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.3 6.7 GO:0015278 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.3 3.0 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.2 25.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 19.2 GO:0017048 Rho GTPase binding(GO:0017048)
0.2 10.5 GO:0000049 tRNA binding(GO:0000049)
0.2 4.3 GO:0031489 myosin V binding(GO:0031489)
0.1 15.0 GO:0004540 ribonuclease activity(GO:0004540)
0.1 9.9 GO:0003823 antigen binding(GO:0003823)
0.1 6.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 10.0 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 2.1 GO:0008198 ferrous iron binding(GO:0008198)
0.1 1.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 3.8 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.1 1.0 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.1 25.2 GO:0030246 carbohydrate binding(GO:0030246)
0.1 15.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.1 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1 2.4 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 1.5 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 1.2 GO:0005109 frizzled binding(GO:0005109)
0.0 7.7 GO:0008017 microtubule binding(GO:0008017)
0.0 2.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 3.8 GO:0008168 methyltransferase activity(GO:0008168)
0.0 4.0 GO:0019902 phosphatase binding(GO:0019902)
0.0 6.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.2 GO:0003796 lysozyme activity(GO:0003796)
0.0 9.6 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 2.4 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 10.0 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.9 10.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.7 17.9 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.7 9.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.6 6.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.5 32.1 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.3 11.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.3 12.4 NABA COLLAGENS Genes encoding collagen proteins
0.2 29.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 10.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 2.1 PID AURORA B PATHWAY Aurora B signaling
0.0 6.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 6.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 20.2 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.9 14.4 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.8 14.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.7 10.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.6 17.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.5 6.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.5 6.1 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.3 8.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 9.6 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.2 12.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 10.6 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.2 3.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.1 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 7.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 14.2 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 1.7 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 0.5 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 2.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 3.4 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase