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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Mef2d_Mef2a

Z-value: 6.11

Motif logo

Transcription factors associated with Mef2d_Mef2a

Gene Symbol Gene ID Gene Info
ENSRNOG00000031778 myocyte enhancer factor 2D
ENSRNOG00000047756 myocyte enhancer factor 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mef2arn6_v1_chr1_-_128287151_1282871510.553.7e-27Click!
Mef2drn6_v1_chr2_+_187512164_1875121640.412.1e-14Click!

Activity profile of Mef2d_Mef2a motif

Sorted Z-values of Mef2d_Mef2a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_41212072 744.73 ENSRNOT00000085596
protein phosphatase 1, regulatory subunit 3A
chr1_-_199624783 743.53 ENSRNOT00000026908
cytochrome c oxidase subunit 6A2
chr3_+_53563194 694.18 ENSRNOT00000048300
xin actin-binding repeat containing 2
chr1_-_25839198 642.18 ENSRNOT00000090388
ENSRNOT00000092757
ENSRNOT00000042072
triadin
chr1_-_277181345 562.02 ENSRNOT00000038017
ENSRNOT00000038038
nebulin-related anchoring protein
chr10_+_86337728 562.02 ENSRNOT00000085408
titin-cap
chr9_-_73948583 547.50 ENSRNOT00000018097
myosin, light chain 1
chr10_+_54352270 524.23 ENSRNOT00000036752
dehydrogenase/reductase 7C
chr2_-_45518502 472.78 ENSRNOT00000014627
heat shock protein family B (small) member 3
chr9_+_47536824 462.07 ENSRNOT00000049349
transmembrane protein 182
chr1_-_104166367 452.35 ENSRNOT00000092211
cysteine and glycine rich protein 3
chr2_+_205568935 445.78 ENSRNOT00000025248
adenosine monophosphate deaminase 1
chr11_+_66713888 445.69 ENSRNOT00000003340
F-box protein 40
chr15_+_4064706 416.93 ENSRNOT00000011956
synaptopodin 2-like
chrX_-_40086870 416.06 ENSRNOT00000010027
small muscle protein, X-linked
chr1_+_215609036 398.66 ENSRNOT00000076187
troponin I2, fast skeletal type
chr1_-_143398093 374.57 ENSRNOT00000078916
fibronectin type III and SPRY domain containing 2
chr16_-_10941414 371.74 ENSRNOT00000086627
ENSRNOT00000085414
ENSRNOT00000081631
ENSRNOT00000087521
ENSRNOT00000083623
LIM domain binding 3
chr8_+_110982777 370.21 ENSRNOT00000010992
kyphoscoliosis peptidase
chr10_-_56558487 369.95 ENSRNOT00000023256
solute carrier family 2 member 4
chr7_-_118108864 369.94 ENSRNOT00000006184
myoglobin
chr3_+_55910177 360.68 ENSRNOT00000009969
kelch-like family member 41
chr2_-_227207584 347.06 ENSRNOT00000065361
ENSRNOT00000080215
myozenin 2
chr2_+_204512302 344.54 ENSRNOT00000021846
calsequestrin 2
chr10_+_70262361 343.45 ENSRNOT00000064625
ENSRNOT00000076973
unc-45 myosin chaperone B
chr2_+_219598162 335.29 ENSRNOT00000020297
leucine rich repeat containing 39
chr10_+_53740841 329.48 ENSRNOT00000004295
myosin heavy chain 2
chr5_-_22769907 323.28 ENSRNOT00000047805
ENSRNOT00000076167
ENSRNOT00000076507
ENSRNOT00000076113
ENSRNOT00000083779
aspartate-beta-hydroxylase
chrX_-_64726210 319.01 ENSRNOT00000076012
ENSRNOT00000086265
ankyrin repeat and SOCS box-containing 12
chr1_+_142883040 315.29 ENSRNOT00000015898
alpha-kinase 3
chr10_-_32471454 312.12 ENSRNOT00000003224
sarcoglycan, delta
chr7_-_98197087 310.23 ENSRNOT00000010484
ENSRNOT00000079961
kelch-like family member 38
chr1_+_199449973 309.38 ENSRNOT00000029994
tripartite motif containing 72
chr6_+_73553210 302.80 ENSRNOT00000006562
A-kinase anchoring protein 6
chr10_+_53818818 287.71 ENSRNOT00000057260
myosin heavy chain 8
chr4_+_71675383 285.29 ENSRNOT00000051265
chloride voltage-gated channel 1
chr10_+_53778662 282.31 ENSRNOT00000045718
myosin heavy chain 2
chr3_+_112228919 273.35 ENSRNOT00000011761
calpain 3
chr1_-_198233588 270.40 ENSRNOT00000088473
aldolase, fructose-bisphosphate A
chr1_+_215609645 262.96 ENSRNOT00000076140
ENSRNOT00000027487
troponin I2, fast skeletal type
chr12_+_49761120 256.19 ENSRNOT00000070961
myosin XVIIIb
chr13_-_90602365 256.07 ENSRNOT00000009344
calsequestrin 1
chr5_+_90338795 251.60 ENSRNOT00000077864
ENSRNOT00000058882
similar to RIKEN cDNA 2310003M01
chr1_-_198233215 245.39 ENSRNOT00000087928
aldolase, fructose-bisphosphate A
chr8_+_119030875 240.31 ENSRNOT00000028458
myosin light chain 3
chr1_+_31531143 235.91 ENSRNOT00000034704
leucine rich repeat containing 14B
chr3_+_112228720 232.01 ENSRNOT00000079079
calpain 3
chr4_+_7158448 230.15 ENSRNOT00000076953
ankyrin repeat and SOCS box-containing 10
chr3_+_79940561 225.19 ENSRNOT00000016652
myosin binding protein C, cardiac
chr1_+_221756286 221.27 ENSRNOT00000028636
glycogen phosphorylase, muscle associated
chr10_+_11240138 214.06 ENSRNOT00000048687
sarcalumenin
chr5_+_152533349 213.82 ENSRNOT00000067524
tripartite motif containing 63
chr13_+_52624878 207.21 ENSRNOT00000076054
ENSRNOT00000076299
troponin I1, slow skeletal type
chr16_+_49266903 206.55 ENSRNOT00000014704
solute carrier family 25 member 4
chrX_-_31780425 205.14 ENSRNOT00000004693
ankyrin repeat and SOCS box-containing 9
chr1_+_167197549 200.85 ENSRNOT00000027427
ADP-ribosyltransferase 1
chr15_-_27819376 198.41 ENSRNOT00000067400
RIKEN cDNA A930018M24 gene
chr10_-_8654892 196.46 ENSRNOT00000066534
RNA binding protein, fox-1 homolog 1
chr16_+_2537248 194.62 ENSRNOT00000017995
ankyrin repeat and SOCS box-containing 14
chr9_+_82571269 190.45 ENSRNOT00000026941
SPEG complex locus
chr5_+_173640780 190.20 ENSRNOT00000027476
PPARGC1 and ESRR induced regulator, muscle 1
chr9_-_97151832 189.12 ENSRNOT00000040169
ankyrin repeat and SOCS box-containing 18
chr2_+_119197239 189.05 ENSRNOT00000048030
ubiquitin specific peptidase 13
chr17_-_78735324 178.11 ENSRNOT00000036299
cerebral dopamine neurotrophic factor
chrX_+_71342775 175.98 ENSRNOT00000004888
integrin subunit beta 1 binding protein 2
chr8_+_55178289 174.46 ENSRNOT00000059127
crystallin, alpha B
chr15_+_2766710 172.40 ENSRNOT00000017483
dual specificity phosphatase and pro isomerase domain containing 1
chr8_-_33017854 172.11 ENSRNOT00000011386
BARX homeobox 2
chr10_-_82785142 171.95 ENSRNOT00000005381
sarcoglycan, alpha
chr2_-_172361779 171.94 ENSRNOT00000085876
schwannomin interacting protein 1
chr17_+_32973695 170.74 ENSRNOT00000065674
similar to OTTMUSP00000000621
chr2_+_198655437 168.15 ENSRNOT00000028781
hemochromatosis type 2 (juvenile)
chr16_-_73827488 167.18 ENSRNOT00000064070
ankyrin 1
chrX_-_157013443 161.04 ENSRNOT00000082711
SRSF protein kinase 3
chr18_+_32273770 160.41 ENSRNOT00000087408
fibroblast growth factor 1
chr2_+_104416972 158.97 ENSRNOT00000017125
tripartite motif-containing 55
chr8_+_130416355 157.32 ENSRNOT00000026234
kelch-like family member 40
chr9_+_82556573 157.29 ENSRNOT00000026860
desmin
chr13_-_90676629 154.79 ENSRNOT00000058143
ATPase Na+/K+ transporting subunit alpha 2
chr3_+_58965552 152.36 ENSRNOT00000002068
mitogen-activated protein kinase kinase kinase 20
chr8_-_55177818 151.99 ENSRNOT00000013960
heat shock protein family B (small) member 2
chr6_+_56625650 149.19 ENSRNOT00000008803
mesenchyme homeobox 2
chr9_+_98490608 146.17 ENSRNOT00000027232
kelch-like family member 30
chr2_-_104958034 144.69 ENSRNOT00000080699
glycogenin 1
chr14_-_17171580 144.58 ENSRNOT00000085525
ADP-ribosyltransferase 3
chr7_+_70807867 135.97 ENSRNOT00000010639
SH3 and cysteine rich domain 3
chr4_-_99125111 132.41 ENSRNOT00000009184
SET and MYND domain containing 1
chr2_-_247988462 131.47 ENSRNOT00000022387
PDZ and LIM domain 5
chr2_-_227411964 125.51 ENSRNOT00000019931
synaptopodin 2
chr12_-_23841049 124.83 ENSRNOT00000031555
heat shock protein family B (small) member 1
chr1_+_101397828 124.17 ENSRNOT00000028189
potassium voltage-gated channel subfamily A member 7
chr15_-_28314459 119.77 ENSRNOT00000042055
ENSRNOT00000040540
NDRG family member 2
chr2_+_196334626 112.03 ENSRNOT00000050914
ENSRNOT00000028645
ENSRNOT00000090729
semaphorin 6C
chr7_-_49741540 110.27 ENSRNOT00000006523
myogenic factor 6
chr1_-_264975132 110.01 ENSRNOT00000021748
ladybird homeobox 1
chr15_+_86243148 109.59 ENSRNOT00000084471
ENSRNOT00000090727
LIM domain 7
chr4_-_61720956 109.12 ENSRNOT00000012879
aldo-keto reductase family 1 member B
chr15_-_37325178 107.23 ENSRNOT00000011699
gap junction protein, alpha 3
chr13_+_51034256 106.65 ENSRNOT00000004528
ENSRNOT00000046854
ENSRNOT00000087320
myosin binding protein H
chr1_-_89488223 101.81 ENSRNOT00000028624
FXYD domain-containing ion transport regulator 1
chr10_+_39655455 96.30 ENSRNOT00000058817
acyl-CoA synthetase long-chain family member 6
chr14_-_43072843 92.82 ENSRNOT00000064263
LIM and calponin homology domains 1
chr13_+_52662996 91.18 ENSRNOT00000047682
troponin T2, cardiac type
chr4_+_85551502 90.49 ENSRNOT00000087191
ENSRNOT00000015692
aquaporin 1
chr8_-_109560747 89.89 ENSRNOT00000087334
protein phosphatase 2, regulatory subunit B'', alpha
chr10_-_89338739 80.98 ENSRNOT00000073923
prostaglandin E synthase 3 like
chr5_+_154598758 79.54 ENSRNOT00000015776
transcription elongation factor A3
chr2_-_198016898 74.55 ENSRNOT00000025523
carbonic anhydrase 14
chr9_-_19372673 71.11 ENSRNOT00000073667
ENSRNOT00000079517
chloride intracellular channel 5
chr9_-_50762082 68.39 ENSRNOT00000015492
methyltransferase like 21C
chr6_-_137733026 67.97 ENSRNOT00000019213
jagged 2
chr4_+_144192989 65.17 ENSRNOT00000007523
LIM and cysteine-rich domains 1
chr17_+_72218769 64.88 ENSRNOT00000041346
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
chr19_+_52313795 64.87 ENSRNOT00000021630
WAP four-disulfide core domain 1
chr2_-_261337163 63.73 ENSRNOT00000030341
TNNI3 interacting kinase
chr2_+_93792601 63.70 ENSRNOT00000014701
ENSRNOT00000077311
fatty acid binding protein 4
chr9_-_9702306 63.18 ENSRNOT00000082341
thyroid hormone receptor interactor 10
chr6_-_136550371 60.24 ENSRNOT00000065971
retinal degeneration 3-like
chr5_-_144274981 57.03 ENSRNOT00000065871
MAP7 domain containing 1
chr13_-_81214494 56.62 ENSRNOT00000004950
ENSRNOT00000082385
paired related homeobox 1
chr20_+_3830164 56.32 ENSRNOT00000045533
ENSRNOT00000084117
collagen type XI alpha 2 chain
chr14_+_63095720 55.16 ENSRNOT00000006071
PPARG coactivator 1 alpha
chr1_-_24056373 52.91 ENSRNOT00000015566
solute carrier family 2 member 12
chr1_-_56683731 45.14 ENSRNOT00000014552
thrombospondin 2
chr4_+_148782479 42.96 ENSRNOT00000018133
similar to hypothetical protein MGC6835
chr11_+_42945084 41.88 ENSRNOT00000002292
crystallin beta-gamma domain containing 3
chr12_+_17734133 41.16 ENSRNOT00000042117
platelet derived growth factor subunit A
chr2_+_189997129 39.97 ENSRNOT00000015958
S100 calcium-binding protein A4
chr3_-_64024205 38.69 ENSRNOT00000037015
coiled-coil domain containing 141
chr1_-_142164263 38.32 ENSRNOT00000016281
mannosidase, alpha, class 2A, member 2
chr8_-_127782070 38.32 ENSRNOT00000045493
phospholipase C, delta 1
chrM_+_7006 37.61 ENSRNOT00000043693
mitochondrially encoded cytochrome c oxidase II
chr1_-_142164007 36.30 ENSRNOT00000078982
mannosidase, alpha, class 2A, member 2
chr2_-_197991198 34.18 ENSRNOT00000056322
circadian associated repressor of transcription
chr3_+_63353178 34.17 ENSRNOT00000091211
oxysterol binding protein-like 6
chr3_-_161299024 33.66 ENSRNOT00000021216
neuralized E3 ubiquitin protein ligase 2
chr3_+_151126591 32.26 ENSRNOT00000025859
myosin heavy chain 7B
chr7_+_142905758 28.17 ENSRNOT00000078663
nuclear receptor subfamily 4, group A, member 1
chr4_+_159563798 26.74 ENSRNOT00000081426
fibroblast growth factor 6
chr9_-_52238564 26.40 ENSRNOT00000005073
collagen type V alpha 2 chain
chr4_+_89079014 26.18 ENSRNOT00000087451
HECT and RLD domain containing E3 ubiquitin protein ligase 3
chr2_-_197991574 25.17 ENSRNOT00000085632
circadian associated repressor of transcription
chr1_+_238222521 23.70 ENSRNOT00000024000
aldehyde dehydrogenase 1 family, member A1
chr10_-_86688730 22.79 ENSRNOT00000055333
nuclear receptor subfamily 1, group D, member 1
chr13_-_1946508 18.77 ENSRNOT00000043890
dermatan sulfate epimerase-like
chr11_-_60679555 15.43 ENSRNOT00000059735
coiled-coil domain containing 80
chr8_-_120446455 14.50 ENSRNOT00000085161
ENSRNOT00000042854
ENSRNOT00000037199
cAMP regulated phosphoprotein 21
chr20_+_20236151 13.64 ENSRNOT00000079630
ankyrin 3
chr9_+_47134034 13.31 ENSRNOT00000020108
interleukin 1 receptor-like 1
chr7_+_132857628 13.19 ENSRNOT00000005438
leucine-rich repeat kinase 2
chr2_+_84645084 12.71 ENSRNOT00000015448
carboxymethylenebutenolidase homolog
chr6_+_8284878 11.41 ENSRNOT00000009581
solute carrier family 3 member 1
chr4_-_85329362 11.11 ENSRNOT00000014925
corticotropin releasing hormone receptor 2
chr3_+_65816569 10.81 ENSRNOT00000079672
ubiquitin-conjugating enzyme E2E 3
chr5_-_107039925 8.39 ENSRNOT00000049705
interferon, alpha 5
chr11_-_28777603 7.11 ENSRNOT00000002132
keratin associated protein 14
chr3_+_60026747 6.76 ENSRNOT00000081881
secernin 3
chr2_+_189993262 6.52 ENSRNOT00000016034
S100 calcium binding protein A3
chr10_+_55687050 5.20 ENSRNOT00000057136
period circadian clock 1
chr7_-_60743328 4.72 ENSRNOT00000066767
MDM2 proto-oncogene
chr6_-_33691301 4.53 ENSRNOT00000008008
ras homolog family member B
chrX_-_112473822 3.92 ENSRNOT00000079180
collagen type IV alpha 6 chain
chr2_-_187854363 3.89 ENSRNOT00000092993
lamin A/C
chr2_+_203200427 3.26 ENSRNOT00000020566
V-set domain containing T cell activation inhibitor 1
chr1_+_78800754 1.31 ENSRNOT00000084601
dishevelled-binding antagonist of beta-catenin 3
chr13_-_70174565 1.16 ENSRNOT00000067135
ral guanine nucleotide dissociation stimulator,-like 1
chr2_+_184230459 1.06 ENSRNOT00000074187

chr7_-_132143470 1.03 ENSRNOT00000038946
ENSRNOT00000044092
ENSRNOT00000066528
ENSRNOT00000045553
ENSRNOT00000046744
ENSRNOT00000055742
kinesin family member 21A
chr3_-_2689084 0.54 ENSRNOT00000020926
prostaglandin D2 synthase
chr1_+_190671696 0.51 ENSRNOT00000084934

chr16_-_20994379 0.30 ENSRNOT00000027639
transmembrane protein 161A

Network of associatons between targets according to the STRING database.

First level regulatory network of Mef2d_Mef2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
253.6 1014.4 GO:0035995 detection of muscle stretch(GO:0035995)
214.1 642.2 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
168.5 505.4 GO:1990091 sodium-dependent self proteolysis(GO:1990091)
123.3 369.9 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
76.8 921.2 GO:0001778 plasma membrane repair(GO:0001778)
75.7 302.8 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
74.3 445.8 GO:0032264 IMP salvage(GO:0032264)
71.4 214.1 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
71.3 213.8 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
64.7 323.3 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
64.0 256.1 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
62.0 743.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
60.5 241.9 GO:0007525 somatic muscle development(GO:0007525)
57.1 399.7 GO:0071313 cellular response to caffeine(GO:0071313)
51.6 206.5 GO:2000277 positive regulation of oxidative phosphorylation uncoupler activity(GO:2000277)
47.3 189.0 GO:0044313 protein K29-linked deubiquitination(GO:0035523) maintenance of unfolded protein(GO:0036506) protein K6-linked deubiquitination(GO:0044313) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
41.6 124.8 GO:0071348 cellular response to interleukin-11(GO:0071348) response to butyrate(GO:1903544)
38.7 154.8 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
37.9 378.9 GO:0030049 muscle filament sliding(GO:0030049)
36.9 331.8 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
36.8 515.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
36.4 109.1 GO:0006059 hexitol metabolic process(GO:0006059)
33.9 101.8 GO:1903278 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
32.8 557.1 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
32.1 96.3 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
32.1 160.4 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
31.5 157.3 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
30.2 90.5 GO:0072237 metanephric proximal tubule development(GO:0072237)
29.9 119.8 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
29.8 149.2 GO:0001757 somite specification(GO:0001757)
27.6 524.2 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
25.8 1004.8 GO:0003009 skeletal muscle contraction(GO:0003009)
25.6 256.2 GO:0048739 cardiac muscle fiber development(GO:0048739)
23.8 285.3 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
21.8 174.5 GO:0007021 tubulin complex assembly(GO:0007021)
18.5 166.6 GO:0048664 neuron fate determination(GO:0048664)
18.4 110.3 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
17.4 715.4 GO:0030239 myofibril assembly(GO:0030239)
17.0 68.0 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
15.6 171.9 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
15.6 934.5 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
14.2 370.0 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
14.1 704.3 GO:0055013 cardiac muscle cell development(GO:0055013)
13.7 41.2 GO:1990401 regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling(GO:0060683) embryonic lung development(GO:1990401)
13.3 345.4 GO:0006471 protein ADP-ribosylation(GO:0006471)
12.8 38.3 GO:0034696 response to prostaglandin F(GO:0034696)
11.6 221.3 GO:0005980 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
11.3 56.3 GO:0060023 soft palate development(GO:0060023)
11.2 168.2 GO:0016540 protein autoprocessing(GO:0016540)
9.5 190.2 GO:0014850 response to muscle activity(GO:0014850)
9.5 198.8 GO:0001502 cartilage condensation(GO:0001502)
9.4 958.8 GO:0006941 striated muscle contraction(GO:0006941)
9.3 65.2 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
8.6 171.9 GO:0008210 estrogen metabolic process(GO:0008210)
8.3 396.2 GO:0007528 neuromuscular junction development(GO:0007528)
8.1 515.3 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
7.6 22.8 GO:0060086 circadian temperature homeostasis(GO:0060086) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
7.4 132.4 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
7.1 312.1 GO:0055001 muscle cell development(GO:0055001)
6.8 74.6 GO:0006013 mannose metabolic process(GO:0006013)
6.6 26.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
6.3 157.3 GO:0045109 intermediate filament organization(GO:0045109)
5.5 71.1 GO:0002024 diet induced thermogenesis(GO:0002024)
5.4 178.1 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
5.4 167.2 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
5.2 343.5 GO:0061077 chaperone-mediated protein folding(GO:0061077)
4.6 63.7 GO:0071285 cellular response to lithium ion(GO:0071285)
4.4 13.3 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
4.2 152.4 GO:0007257 activation of JUN kinase activity(GO:0007257)
3.8 18.8 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
3.4 23.7 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
3.4 161.0 GO:0000245 spliceosomal complex assembly(GO:0000245)
2.8 11.1 GO:2000292 gastric motility(GO:0035482) regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
2.7 59.4 GO:0045475 locomotor rhythm(GO:0045475)
2.7 239.5 GO:0031032 actomyosin structure organization(GO:0031032)
2.6 1935.4 GO:0016567 protein ubiquitination(GO:0016567)
2.3 107.2 GO:0009268 response to pH(GO:0009268)
2.3 64.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
1.7 5.2 GO:0097167 circadian regulation of translation(GO:0097167)
1.5 49.0 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
1.5 172.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.3 38.7 GO:0051642 centrosome localization(GO:0051642)
1.3 79.5 GO:0006414 translational elongation(GO:0006414)
1.2 64.9 GO:0061045 negative regulation of wound healing(GO:0061045)
1.2 36.3 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
1.1 3.3 GO:0072602 interleukin-4 secretion(GO:0072602)
0.8 37.6 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.8 8.4 GO:0033139 regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033139) positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) serine phosphorylation of STAT protein(GO:0042501)
0.5 4.5 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.3 57.9 GO:0007411 axon guidance(GO:0007411)
0.3 3.9 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.2 15.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 0.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 57.0 GO:0000226 microtubule cytoskeleton organization(GO:0000226)
0.1 1.3 GO:0010719 negative regulation of epithelial to mesenchymal transition(GO:0010719)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
315.0 945.0 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
202.3 1011.7 GO:0005927 muscle tendon junction(GO:0005927)
174.7 524.2 GO:0014801 longitudinal sarcoplasmic reticulum(GO:0014801)
150.2 600.6 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
96.5 868.8 GO:0005861 troponin complex(GO:0005861)
89.5 805.2 GO:0097512 cardiac myofibril(GO:0097512)
80.7 484.1 GO:0016012 sarcoglycan complex(GO:0016012)
68.0 611.8 GO:0005826 actomyosin contractile ring(GO:0005826)
48.8 781.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
47.3 1324.8 GO:0031430 M band(GO:0031430)
36.0 287.7 GO:0032982 myosin filament(GO:0032982)
32.1 4820.2 GO:0031674 I band(GO:0031674)
29.4 323.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
28.5 370.0 GO:0032593 insulin-responsive compartment(GO:0032593)
28.0 168.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
22.6 90.5 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
21.8 109.1 GO:0097454 Schwann cell microvillus(GO:0097454)
18.8 56.3 GO:0005592 collagen type XI trimer(GO:0005592)
13.0 508.6 GO:0016459 myosin complex(GO:0016459)
12.9 154.8 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
8.1 64.9 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
8.0 458.2 GO:0034707 chloride channel complex(GO:0034707)
6.6 26.4 GO:0005588 collagen type V trimer(GO:0005588)
6.1 456.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
5.8 221.3 GO:0016529 sarcoplasmic reticulum(GO:0016529)
5.1 107.2 GO:0005922 connexon complex(GO:0005922)
3.5 89.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
3.3 13.2 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
2.4 336.1 GO:0042383 sarcolemma(GO:0042383)
2.4 63.2 GO:0001891 phagocytic cup(GO:0001891)
2.0 34.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
2.0 45.1 GO:0031091 platelet alpha granule(GO:0031091)
1.9 204.1 GO:0031225 anchored component of membrane(GO:0031225)
1.9 302.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
1.3 331.9 GO:0000151 ubiquitin ligase complex(GO:0000151)
1.3 124.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
1.1 109.6 GO:0005913 cell-cell adherens junction(GO:0005913)
1.0 11.1 GO:0070852 cell body fiber(GO:0070852)
1.0 63.7 GO:0005811 lipid particle(GO:0005811)
0.9 177.5 GO:0005802 trans-Golgi network(GO:0005802)
0.9 336.8 GO:0016607 nuclear speck(GO:0016607)
0.9 15.4 GO:0005614 interstitial matrix(GO:0005614)
0.8 81.9 GO:0030426 growth cone(GO:0030426)
0.5 37.5 GO:0005902 microvillus(GO:0005902)
0.5 3.9 GO:0098645 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.5 3.9 GO:0005638 lamin filament(GO:0005638)
0.4 39.4 GO:0016605 PML body(GO:0016605)
0.4 117.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.4 65.2 GO:0031012 extracellular matrix(GO:0031012)
0.1 4.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 26.6 GO:0000139 Golgi membrane(GO:0000139)
0.1 22.6 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 69.3 GO:0005856 cytoskeleton(GO:0005856)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
181.8 909.1 GO:0051373 FATZ binding(GO:0051373)
113.1 452.3 GO:0061629 telethonin binding(GO:0031433) RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
111.4 445.8 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
94.5 661.6 GO:0031014 troponin T binding(GO:0031014)
86.9 1391.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
73.8 221.3 GO:0008184 glycogen phosphorylase activity(GO:0008184)
73.7 515.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
65.4 719.2 GO:0031432 titin binding(GO:0031432)
47.3 189.0 GO:1904288 BAT3 complex binding(GO:1904288)
45.6 91.2 GO:0030172 troponin C binding(GO:0030172)
43.2 345.4 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
41.1 370.0 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
33.6 302.8 GO:0043495 protein anchor(GO:0043495)
33.4 167.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
31.9 63.7 GO:0031013 troponin I binding(GO:0031013)
28.0 168.2 GO:0098821 BMP receptor activity(GO:0098821)
26.0 781.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
24.7 369.9 GO:0005344 oxygen transporter activity(GO:0005344)
23.9 694.2 GO:0051393 alpha-actinin binding(GO:0051393)
22.9 206.5 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
20.7 144.7 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
20.4 448.4 GO:0004745 retinol dehydrogenase activity(GO:0004745)
18.1 90.5 GO:0015166 polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
16.1 241.1 GO:0042805 actinin binding(GO:0042805)
15.5 154.8 GO:1990239 steroid hormone binding(GO:1990239)
15.0 285.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
14.8 326.4 GO:0005212 structural constituent of eye lens(GO:0005212)
13.6 109.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
12.4 248.8 GO:0000146 microfilament motor activity(GO:0000146)
8.9 160.4 GO:0044548 S100 protein binding(GO:0044548)
8.8 343.5 GO:0051879 Hsp90 protein binding(GO:0051879)
8.6 112.0 GO:0030215 semaphorin receptor binding(GO:0030215)
8.3 240.3 GO:0003785 actin monomer binding(GO:0003785)
8.0 96.3 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
7.9 23.7 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
7.7 107.2 GO:0005243 gap junction channel activity(GO:0005243)
6.6 262.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
6.3 18.8 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
6.2 390.4 GO:0005080 protein kinase C binding(GO:0005080)
5.9 152.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
5.7 74.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
5.0 40.0 GO:0050786 RAGE receptor binding(GO:0050786)
4.5 251.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
4.4 13.3 GO:0002114 interleukin-33 receptor activity(GO:0002114)
4.4 13.2 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
3.9 1852.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
3.8 101.8 GO:0017080 sodium channel regulator activity(GO:0017080)
3.7 74.6 GO:0004559 alpha-mannosidase activity(GO:0004559)
3.6 79.5 GO:0003746 translation elongation factor activity(GO:0003746)
3.6 1282.8 GO:0003779 actin binding(GO:0003779)
3.5 38.3 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
3.3 172.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
3.3 515.5 GO:0044325 ion channel binding(GO:0044325)
3.2 64.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
2.8 11.1 GO:0043404 corticotrophin-releasing factor receptor activity(GO:0015056) corticotropin-releasing hormone receptor activity(GO:0043404)
2.7 37.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
2.6 55.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
2.6 36.3 GO:0005351 sugar:proton symporter activity(GO:0005351)
2.4 257.2 GO:0003774 motor activity(GO:0003774)
2.0 1375.9 GO:0005509 calcium ion binding(GO:0005509)
2.0 86.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
1.7 66.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
1.5 64.6 GO:0070888 E-box binding(GO:0070888)
1.5 22.8 GO:0001222 transcription corepressor binding(GO:0001222)
1.4 64.2 GO:0005504 fatty acid binding(GO:0005504)
1.1 179.9 GO:0003714 transcription corepressor activity(GO:0003714)
1.1 19.9 GO:0071837 HMG box domain binding(GO:0071837)
1.1 68.4 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
1.0 26.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.9 116.1 GO:0008083 growth factor activity(GO:0008083)
0.9 406.2 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.9 156.8 GO:0008022 protein C-terminus binding(GO:0008022)
0.8 8.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.8 63.0 GO:0005254 chloride channel activity(GO:0005254)
0.7 15.4 GO:0001968 fibronectin binding(GO:0001968)
0.6 31.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.5 6.8 GO:0016805 dipeptidase activity(GO:0016805)
0.5 54.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 191.1 GO:0005198 structural molecule activity(GO:0005198)
0.3 116.8 GO:0005525 GTP binding(GO:0005525)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
33.5 1037.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
13.3 570.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
6.9 124.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
6.5 494.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
3.6 157.3 PID AURORA B PATHWAY Aurora B signaling
3.4 168.2 PID BMP PATHWAY BMP receptor signaling
3.4 63.7 PID AP1 PATHWAY AP-1 transcription factor network
2.8 187.1 PID FGF PATHWAY FGF signaling pathway
1.8 55.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
1.6 28.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
1.2 76.9 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
1.2 277.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.2 84.7 PID CMYB PATHWAY C-MYB transcription factor network
1.0 68.0 PID NOTCH PATHWAY Notch signaling pathway
0.8 41.2 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.6 37.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.5 74.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.5 4.7 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 8.4 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 3.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 4.5 PID P75 NTR PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
70.6 2754.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
27.9 445.8 REACTOME PURINE SALVAGE Genes involved in Purine salvage
23.9 406.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
22.3 200.8 REACTOME DEFENSINS Genes involved in Defensins
18.3 366.0 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
15.6 124.8 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
14.4 187.1 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
13.2 515.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
7.5 90.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
6.1 206.5 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
6.0 107.2 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
5.7 68.0 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
5.3 96.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
5.2 180.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
4.2 63.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
4.1 64.9 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
3.3 109.1 REACTOME STEROID HORMONES Genes involved in Steroid hormones
3.2 154.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
3.0 23.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
3.0 168.2 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
2.9 681.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
2.9 77.9 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
2.8 41.5 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
2.5 124.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
2.3 76.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.6 26.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.4 8.4 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.4 41.2 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.4 5.2 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.4 11.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 4.7 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 3.9 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)