ISMARA results: Mef2d

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Mef2d_Mef2a

Z-value: 6.11

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Transcription factors associated with Mef2d_Mef2a

Gene Symbol	Gene ID	Gene Info
Mef2d NCBI RGD Ensembl	ENSRNOG00000031778	myocyte enhancer factor 2D
Mef2a NCBI RGD Ensembl	ENSRNOG00000047756	myocyte enhancer factor 2a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Mef2a	rn6_v1_chr1_-_128287151_128287151	0.55	3.7e-27	Click!
Mef2d	rn6_v1_chr2_+_187512164_187512164	0.41	2.1e-14	Click!

Activity profile of Mef2d_Mef2a motif

Sorted Z-values of Mef2d_Mef2a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_41212072 Show fit	744.73	ENSRNOT00000085596	Ppp1r3a NCBI RGD Ensembl Show fit	protein phosphatase 1, regulatory subunit 3A
chr1_-_199624783 Show fit	743.53	ENSRNOT00000026908	Cox6a2 NCBI RGD Ensembl Show fit	cytochrome c oxidase subunit 6A2
chr3_+_53563194 Show fit	694.18	ENSRNOT00000048300	Xirp2 NCBI RGD Ensembl Show fit	xin actin-binding repeat containing 2
chr1_-_25839198 Show fit	642.18	ENSRNOT00000090388 ENSRNOT00000092757 ENSRNOT00000042072	Trdn NCBI RGD Ensembl Show fit	triadin
chr1_-_277181345 Show fit	562.02	ENSRNOT00000038017 ENSRNOT00000038038	Nrap NCBI RGD Ensembl Show fit	nebulin-related anchoring protein
chr10_+_86337728 Show fit	562.02	ENSRNOT00000085408	Tcap NCBI RGD Ensembl Show fit	titin-cap
chr9_-_73948583 Show fit	547.50	ENSRNOT00000018097	Myl1 NCBI RGD Ensembl Show fit	myosin, light chain 1
chr10_+_54352270 Show fit	524.23	ENSRNOT00000036752	Dhrs7c NCBI RGD Ensembl Show fit	dehydrogenase/reductase 7C
chr2_-_45518502 Show fit	472.78	ENSRNOT00000014627	Hspb3 NCBI RGD Ensembl Show fit	heat shock protein family B (small) member 3
chr9_+_47536824 Show fit	462.07	ENSRNOT00000049349	Tmem182 NCBI RGD Ensembl Show fit	transmembrane protein 182

Showing 1 to 10 of 171 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Mef2d_Mef2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	1935.4	GO:0016567	protein ubiquitination(GO:0016567)
253.6	1014.4	GO:0035995	detection of muscle stretch(GO:0035995)
25.8	1004.8	GO:0003009	skeletal muscle contraction(GO:0003009)
9.4	958.8	GO:0006941	striated muscle contraction(GO:0006941)
15.6	934.5	GO:0055008	cardiac muscle tissue morphogenesis(GO:0055008)
76.8	921.2	GO:0001778	plasma membrane repair(GO:0001778)
62.0	743.5	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
17.4	715.4	GO:0030239	myofibril assembly(GO:0030239)
14.1	704.3	GO:0055013	cardiac muscle cell development(GO:0055013)
214.1	642.2	GO:0090158	endoplasmic reticulum membrane organization(GO:0090158)

Showing 1 to 10 of 95 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
32.1	4820.2	GO:0031674	I band(GO:0031674)
47.3	1324.8	GO:0031430	M band(GO:0031430)
202.3	1011.7	GO:0005927	muscle tendon junction(GO:0005927)
315.0	945.0	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
96.5	868.8	GO:0005861	troponin complex(GO:0005861)
89.5	805.2	GO:0097512	cardiac myofibril(GO:0097512)
48.8	781.1	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
68.0	611.8	GO:0005826	actomyosin contractile ring(GO:0005826)
150.2	600.6	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
174.7	524.2	GO:0014801	longitudinal sarcoplasmic reticulum(GO:0014801)

Showing 1 to 10 of 53 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.9	1852.2	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
86.9	1391.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
2.0	1375.9	GO:0005509	calcium ion binding(GO:0005509)
3.6	1282.8	GO:0003779	actin binding(GO:0003779)
181.8	909.1	GO:0051373	FATZ binding(GO:0051373)
26.0	781.1	GO:0016676	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
65.4	719.2	GO:0031432	titin binding(GO:0031432)
23.9	694.2	GO:0051393	alpha-actinin binding(GO:0051393)
94.5	661.6	GO:0031014	troponin T binding(GO:0031014)
73.7	515.8	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)

Showing 1 to 10 of 80 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
33.5	1037.5	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
13.3	570.6	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
6.5	494.6	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
1.2	277.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
2.8	187.1	PID FGF PATHWAY	FGF signaling pathway
3.4	168.2	PID BMP PATHWAY	BMP receptor signaling
3.6	157.3	PID AURORA B PATHWAY	Aurora B signaling
6.9	124.8	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
1.2	84.7	PID CMYB PATHWAY	C-MYB transcription factor network
1.2	76.9	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
70.6	2754.8	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
2.9	681.7	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
13.2	515.8	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
27.9	445.8	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
23.9	406.3	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
18.3	366.0	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
6.1	206.5	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
22.3	200.8	REACTOME DEFENSINS	Genes involved in Defensins
14.4	187.1	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
5.2	180.8	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins

Showing 1 to 10 of 32 entries

Results for Mef2d_Mef2a

Z-value: 6.11

Motif logo

Transcription factors associated with Mef2d_Mef2a

Activity-expression correlation:

Activity profile of Mef2d_Mef2a motif

Sorted Z-values of Mef2d_Mef2a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Mef2d_Mef2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: