ISMARA results: Mef2b

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Mef2b

Z-value: 1.96

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Transcription factors associated with Mef2b

Gene Symbol	Gene ID	Gene Info
Mef2b NCBI RGD Ensembl	ENSRNOG00000020400	myocyte enhancer factor 2B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Mef2b	rn6_v1_chr16_-_21017163_21017163	-0.49	3.7e-21	Click!

Activity profile of Mef2b motif

Sorted Z-values of Mef2b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_227207584 Show fit	117.86	ENSRNOT00000065361 ENSRNOT00000080215	Myoz2 NCBI RGD Ensembl Show fit	myozenin 2
chr9_+_37727942 Show fit	111.61	ENSRNOT00000016511 ENSRNOT00000074276	LOC100912306 NCBI RGD Ensembl Show fit	myotilin-like
chr1_+_199449973 Show fit	107.89	ENSRNOT00000029994	Trim72 NCBI RGD Ensembl Show fit	tripartite motif containing 72
chr10_+_54352270 Show fit	103.08	ENSRNOT00000036752	Dhrs7c NCBI RGD Ensembl Show fit	dehydrogenase/reductase 7C
chr18_+_35574002 Show fit	98.96	ENSRNOT00000093442 ENSRNOT00000070817 ENSRNOT00000093356	Myot NCBI RGD Ensembl Show fit	myotilin
chr6_-_60124274 Show fit	98.16	ENSRNOT00000059823	Lsmem1 NCBI RGD Ensembl Show fit	leucine-rich single-pass membrane protein 1
chr1_-_199624783 Show fit	91.41	ENSRNOT00000026908	Cox6a2 NCBI RGD Ensembl Show fit	cytochrome c oxidase subunit 6A2
chr1_-_104166367 Show fit	90.92	ENSRNOT00000092211	Csrp3 NCBI RGD Ensembl Show fit	cysteine and glycine rich protein 3
chr3_+_55910177 Show fit	88.49	ENSRNOT00000009969	Klhl41 NCBI RGD Ensembl Show fit	kelch-like family member 41
chr9_-_73948583 Show fit	88.09	ENSRNOT00000018097	Myl1 NCBI RGD Ensembl Show fit	myosin, light chain 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Mef2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	251.1	GO:0016567	protein ubiquitination(GO:0016567)
3.3	193.5	GO:0030239	myofibril assembly(GO:0030239)
14.1	182.8	GO:0001778	plasma membrane repair(GO:0001778)
1.5	178.0	GO:0006941	striated muscle contraction(GO:0006941)
0.1	176.2	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
3.3	148.1	GO:0003009	skeletal muscle contraction(GO:0003009)
5.0	94.1	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
7.6	91.4	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
30.3	90.9	GO:1903918	regulation of actin filament severing(GO:1903918) negative regulation of actin filament severing(GO:1903919)
6.3	88.5	GO:2001014	regulation of skeletal muscle cell differentiation(GO:2001014)

Showing 1 to 10 of 107 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.2	1002.0	GO:0030018	Z disc(GO:0030018)
12.3	148.1	GO:0005861	troponin complex(GO:0005861)
26.3	105.1	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
34.4	103.1	GO:0014801	longitudinal sarcoplasmic reticulum(GO:0014801)
5.7	91.4	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.5	90.5	GO:0005741	mitochondrial outer membrane(GO:0005741)
1.2	88.9	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
6.8	88.5	GO:0031143	pseudopodium(GO:0031143)
15.5	77.7	GO:0005927	muscle tendon junction(GO:0005927)
8.3	74.9	GO:0005826	actomyosin contractile ring(GO:0005826)

Showing 1 to 10 of 60 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	286.7	GO:0005509	calcium ion binding(GO:0005509)
39.2	274.3	GO:0031433	telethonin binding(GO:0031433)
0.6	269.9	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
4.5	203.9	GO:0051393	alpha-actinin binding(GO:0051393)
0.1	176.2	GO:0004984	olfactory receptor activity(GO:0004984)
21.2	148.1	GO:0031014	troponin T binding(GO:0031014)
9.1	127.6	GO:0031432	titin binding(GO:0031432)
4.7	103.1	GO:0004745	retinol dehydrogenase activity(GO:0004745)
3.0	91.4	GO:0016676	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
2.1	83.5	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)

Showing 1 to 10 of 85 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	82.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.4	64.0	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.7	40.0	PID BMP PATHWAY	BMP receptor signaling
0.6	36.0	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.4	31.8	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
1.0	31.2	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.6	25.9	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.9	18.5	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
1.0	17.6	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.5	9.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Showing 1 to 10 of 19 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.7	300.1	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.8	196.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.6	54.9	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
1.4	54.2	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
6.6	39.8	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
2.0	36.3	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
1.7	36.0	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
2.0	35.6	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
2.0	32.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
1.5	31.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Showing 1 to 10 of 33 entries

Results for Mef2b

Z-value: 1.96

Motif logo

Transcription factors associated with Mef2b

Activity-expression correlation:

Activity profile of Mef2b motif

Sorted Z-values of Mef2b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Mef2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: