ISMARA results: Mecp2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Mecp2

Z-value: 2.56

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Transcription factors associated with Mecp2

Gene Symbol	Gene ID	Gene Info
Mecp2 NCBI RGD Ensembl	ENSRNOG00000056659	methyl CpG binding protein 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Mecp2	rn6_v1_chrX_+_156655960_156655960	0.38	1.8e-12	Click!

Activity profile of Mecp2 motif

Sorted Z-values of Mecp2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_127271289 Show fit	71.62	ENSRNOT00000015113	Itga9 NCBI RGD Ensembl Show fit	integrin subunit alpha 9
chr10_-_11174861 Show fit	56.57	ENSRNOT00000006680	Glis2 NCBI RGD Ensembl Show fit	GLIS family zinc finger 2
chr7_-_142260896 Show fit	54.15	ENSRNOT00000073536	Smagp NCBI RGD Ensembl Show fit	small cell adhesion glycoprotein
chr18_-_48384645 Show fit	52.82	ENSRNOT00000023485	Ppic NCBI RGD Ensembl Show fit	peptidylprolyl isomerase C
chr9_-_81400987 Show fit	52.78	ENSRNOT00000035277	Tns1 NCBI RGD Ensembl Show fit	tensin 1
chr3_-_51297852 Show fit	51.52	ENSRNOT00000001607	Cobll1 NCBI RGD Ensembl Show fit	cordon-bleu WH2 repeat protein-like 1
chr7_+_130474508 Show fit	51.32	ENSRNOT00000085191	Shank3 NCBI RGD Ensembl Show fit	SH3 and multiple ankyrin repeat domains 3
chr11_+_82466071 Show fit	50.30	ENSRNOT00000036958	Igf2bp2 NCBI RGD Ensembl Show fit	insulin-like growth factor 2 mRNA binding protein 2
chrX_-_157139291 Show fit	49.66	ENSRNOT00000092123	Slc6a8 NCBI RGD Ensembl Show fit	solute carrier family 6 member 8
chr10_+_84182118 Show fit	49.61	ENSRNOT00000011027	Hoxb3 NCBI RGD Ensembl Show fit	homeo box B3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Mecp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	126.2	GO:0007229	integrin-mediated signaling pathway(GO:0007229)
24.7	123.4	GO:1904717	regulation of AMPA glutamate receptor clustering(GO:1904717)
1.9	104.4	GO:0006635	fatty acid beta-oxidation(GO:0006635)
1.3	95.0	GO:0090630	activation of GTPase activity(GO:0090630)
15.5	93.0	GO:1904426	positive regulation of GTP binding(GO:1904426)
8.1	89.4	GO:0060242	contact inhibition(GO:0060242)
10.3	82.3	GO:0010668	ectodermal cell differentiation(GO:0010668)
3.5	77.2	GO:0042744	hydrogen peroxide catabolic process(GO:0042744)
3.1	76.6	GO:0042554	superoxide anion generation(GO:0042554)
9.1	72.5	GO:0015871	choline transport(GO:0015871)

Showing 1 to 10 of 1,128 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	1152.1	GO:0070062	extracellular exosome(GO:0070062)
1.8	724.5	GO:0005924	cell-substrate adherens junction(GO:0005924)
1.2	416.9	GO:0031012	extracellular matrix(GO:0031012)
1.1	370.9	GO:0005667	transcription factor complex(GO:0005667)
3.3	286.5	GO:0032432	actin filament bundle(GO:0032432)
1.1	262.7	GO:0005759	mitochondrial matrix(GO:0005759)
1.2	244.1	GO:0098852	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.9	229.2	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.7	213.1	GO:0016607	nuclear speck(GO:0016607)
6.4	199.0	GO:0008305	integrin complex(GO:0008305)

Showing 1 to 10 of 335 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	306.4	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.8	252.4	GO:0050839	cell adhesion molecule binding(GO:0050839)
12.0	155.9	GO:0048407	platelet-derived growth factor binding(GO:0048407)
8.5	144.7	GO:0042813	Wnt-activated receptor activity(GO:0042813)
4.0	138.6	GO:0043236	laminin binding(GO:0043236)
5.7	137.0	GO:0050431	transforming growth factor beta binding(GO:0050431)
1.7	133.8	GO:0005178	integrin binding(GO:0005178)
1.3	128.2	GO:0017124	SH3 domain binding(GO:0017124)
1.0	119.8	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
16.9	118.3	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)

Showing 1 to 10 of 647 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	380.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.9	313.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
8.3	241.0	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
3.8	229.7	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
3.9	207.7	PID BMP PATHWAY	BMP receptor signaling
4.3	163.8	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
6.6	158.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
5.1	148.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
3.0	142.1	PID CERAMIDE PATHWAY	Ceramide signaling pathway
2.9	126.5	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor

Showing 1 to 10 of 133 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.7	405.9	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
4.1	202.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
2.2	185.4	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
1.6	162.1	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
2.1	144.7	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
10.8	129.4	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
3.8	107.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
1.7	106.8	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
2.6	102.8	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
1.7	102.2	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport

Showing 1 to 10 of 201 entries

Results for Mecp2

Z-value: 2.56

Motif logo

Transcription factors associated with Mecp2

Activity-expression correlation:

Activity profile of Mecp2 motif

Sorted Z-values of Mecp2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Mecp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: