ISMARA results: Maz

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Maz_Zfp281

Z-value: 2.14

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Transcription factors associated with Maz_Zfp281

Gene Symbol	Gene ID	Gene Info
Maz NCBI RGD Ensembl	ENSRNOG00000055082	MYC associated zinc finger protein
Zfp281 NCBI RGD Ensembl	ENSRNOG00000058643	zinc finger protein 281

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Maz	rn6_v1_chr1_-_198460126_198460126	0.10	8.1e-02	Click!
Zfp281	rn6_v1_chr13_+_53506925_53506925	0.04	4.9e-01	Click!

Activity profile of Maz_Zfp281 motif

Sorted Z-values of Maz_Zfp281 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chrX_-_152641679 Show fit	143.87	ENSRNOT00000080277	Gabra3 NCBI RGD Ensembl Show fit	gamma-aminobutyric acid type A receptor alpha3 subunit
chr1_-_215834704 Show fit	79.99	ENSRNOT00000073850	Igf2 NCBI RGD Ensembl Show fit	insulin-like growth factor 2
chr3_+_41019898 Show fit	78.08	ENSRNOT00000007335	Kcnj3 NCBI RGD Ensembl Show fit	potassium voltage-gated channel subfamily J member 3
chr4_-_71713063 Show fit	78.05	ENSRNOT00000059447	Fam131b NCBI RGD Ensembl Show fit	family with sequence similarity 131, member B
chr4_-_169999873 Show fit	71.34	ENSRNOT00000011697	Grin2b NCBI RGD Ensembl Show fit	glutamate ionotropic receptor NMDA type subunit 2B
chrX_-_15707436 Show fit	70.33	ENSRNOT00000085907	Syp NCBI RGD Ensembl Show fit	synaptophysin
chr3_-_176666282 Show fit	66.01	ENSRNOT00000016947	Eef1a2 NCBI RGD Ensembl Show fit	eukaryotic translation elongation factor 1 alpha 2
chr4_+_30807879 Show fit	61.48	ENSRNOT00000013184	Dync1i1 NCBI RGD Ensembl Show fit	dynein cytoplasmic 1 intermediate chain 1
chr1_-_42587666 Show fit	60.96	ENSRNOT00000083225 ENSRNOT00000025355	Rgs17 NCBI RGD Ensembl Show fit	regulator of G-protein signaling 17
chr1_-_72727112 Show fit	58.32	ENSRNOT00000031172	Brsk1 NCBI RGD Ensembl Show fit	BR serine/threonine kinase 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Maz_Zfp281

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
12.5	525.0	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
18.0	215.5	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371)
5.0	188.4	GO:0003009	skeletal muscle contraction(GO:0003009)
3.3	186.7	GO:0051965	positive regulation of synapse assembly(GO:0051965)
3.1	180.0	GO:1901379	regulation of potassium ion transmembrane transport(GO:1901379)
5.9	178.0	GO:1903831	acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
3.2	167.7	GO:0048168	regulation of neuronal synaptic plasticity(GO:0048168)
2.6	161.7	GO:0099643	neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
16.0	144.4	GO:0030007	cellular potassium ion homeostasis(GO:0030007)
6.3	131.5	GO:1900449	regulation of glutamate receptor signaling pathway(GO:1900449)

Showing 1 to 10 of 998 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.2	686.8	GO:0034705	potassium channel complex(GO:0034705)
3.0	456.9	GO:0030427	site of polarized growth(GO:0030427)
2.2	404.1	GO:0099572	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
15.2	349.8	GO:1902711	GABA-A receptor complex(GO:1902711)
3.0	340.3	GO:0030017	sarcomere(GO:0030017)
0.9	278.0	GO:0043025	neuronal cell body(GO:0043025)
6.4	275.2	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
1.6	268.7	GO:0098793	presynapse(GO:0098793)
12.2	255.7	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
16.7	250.8	GO:0099634	postsynaptic specialization membrane(GO:0099634)

Showing 1 to 10 of 311 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	411.6	GO:0015631	tubulin binding(GO:0015631)
13.6	354.5	GO:0004890	GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
2.7	269.1	GO:0005267	potassium channel activity(GO:0005267)
2.2	190.1	GO:0044325	ion channel binding(GO:0044325)
2.1	187.5	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
6.1	182.0	GO:0017075	syntaxin-1 binding(GO:0017075)
0.7	171.4	GO:0005096	GTPase activator activity(GO:0005096)
21.2	169.9	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.4	159.6	GO:0005509	calcium ion binding(GO:0005509)
4.7	158.7	GO:0008307	structural constituent of muscle(GO:0008307)

Showing 1 to 10 of 533 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	327.5	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
4.3	178.2	PID REELIN PATHWAY	Reelin signaling pathway
4.3	177.5	PID NCADHERIN PATHWAY	N-cadherin signaling events
1.2	173.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
3.1	172.0	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
4.6	159.3	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.5	120.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
2.8	119.3	NABA PROTEOGLYCANS	Genes encoding proteoglycans
2.2	93.3	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
2.2	68.0	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1

Showing 1 to 10 of 91 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
11.1	421.9	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
20.4	347.4	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
6.9	338.8	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
7.0	302.2	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
7.4	259.7	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
6.8	250.2	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
11.4	215.8	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
2.9	213.8	REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	Genes involved in Transmission across Chemical Synapses
4.6	178.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
6.3	157.0	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis

Showing 1 to 10 of 145 entries

Results for Maz_Zfp281

Z-value: 2.14

Motif logo

Transcription factors associated with Maz_Zfp281

Activity-expression correlation:

Activity profile of Maz_Zfp281 motif

Sorted Z-values of Maz_Zfp281 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Maz_Zfp281

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: