ISMARA results: Max

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Max_Mycn

Z-value: 1.74

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Transcription factors associated with Max_Mycn

Gene Symbol	Gene ID	Gene Info
Max NCBI RGD Ensembl	ENSRNOG00000008049	MYC associated factor X
Mycn NCBI RGD Ensembl	ENSRNOG00000051372	v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Max	rn6_v1_chr6_-_100011388_100011388	-0.36	3.3e-11	Click!
Mycn	rn6_v1_chr6_-_38228379_38228379	-0.02	6.7e-01	Click!

Activity profile of Max_Mycn motif

Sorted Z-values of Max_Mycn motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_78879294 Show fit	59.90	ENSRNOT00000084543	Igf2bp3 NCBI RGD Ensembl Show fit	insulin-like growth factor 2 mRNA binding protein 3
chr9_+_12633990 Show fit	47.64	ENSRNOT00000066517 ENSRNOT00000077532	Dazl NCBI RGD Ensembl Show fit	deleted in azoospermia-like
chr1_+_193424812 Show fit	46.52	ENSRNOT00000019939	Aqp8 NCBI RGD Ensembl Show fit	aquaporin 8
chr3_+_152909189 Show fit	39.72	ENSRNOT00000066341	Tgif2 NCBI RGD Ensembl Show fit	TGFB-induced factor homeobox 2
chr8_+_62779875 Show fit	37.26	ENSRNOT00000010831	Cyp11a1 NCBI RGD Ensembl Show fit	cytochrome P450, family 11, subfamily a, polypeptide 1
chr2_-_187668677 Show fit	36.39	ENSRNOT00000056898 ENSRNOT00000092563	Tsacc NCBI RGD Ensembl Show fit	TSSK6 activating co-chaperone
chr9_+_80118029 Show fit	36.36	ENSRNOT00000023068	Igfbp2 NCBI RGD Ensembl Show fit	insulin-like growth factor binding protein 2
chr16_-_36373546 Show fit	35.51	ENSRNOT00000079552	Hand2 NCBI RGD Ensembl Show fit	heart and neural crest derivatives expressed transcript 2
chr10_-_35058870 Show fit	33.63	ENSRNOT00000079481	AABR07029573.3 NCBI RGD Ensembl Show fit
chr18_-_786674 Show fit	33.42	ENSRNOT00000021955	Cetn1 NCBI RGD Ensembl Show fit	centrin 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Max_Mycn

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	209.8	GO:0048232	male gamete generation(GO:0048232)
10.0	170.8	GO:0034587	piRNA metabolic process(GO:0034587)
2.0	100.0	GO:0007129	synapsis(GO:0007129)
5.9	70.3	GO:0007135	meiosis II(GO:0007135)
8.2	57.4	GO:0015722	canalicular bile acid transport(GO:0015722)
2.6	48.9	GO:0038092	nodal signaling pathway(GO:0038092)
4.2	46.0	GO:1902570	protein localization to nucleolus(GO:1902570)
1.6	40.7	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
13.4	40.1	GO:0006059	hexitol metabolic process(GO:0006059)
4.3	38.6	GO:0075522	IRES-dependent viral translational initiation(GO:0075522)

Showing 1 to 10 of 638 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	132.6	GO:0005667	transcription factor complex(GO:0005667)
1.9	87.1	GO:0005844	polysome(GO:0005844)
2.5	86.2	GO:0000795	synaptonemal complex(GO:0000795)
11.2	67.3	GO:0071547	piP-body(GO:0071547)
0.2	57.1	GO:0005743	mitochondrial inner membrane(GO:0005743)
2.8	55.7	GO:0034364	high-density lipoprotein particle(GO:0034364)
15.5	46.5	GO:0046691	intracellular canaliculus(GO:0046691)
4.8	43.3	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.4	42.4	GO:0001669	acrosomal vesicle(GO:0001669)
0.4	42.4	GO:0031514	motile cilium(GO:0031514)

Showing 1 to 10 of 269 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	200.9	GO:0003677	DNA binding(GO:0003677)
4.2	117.5	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
9.0	81.4	GO:0008494	translation activator activity(GO:0008494)
1.1	70.5	GO:0004004	RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.4	69.6	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
3.1	55.5	GO:0043295	glutathione binding(GO:0043295)
2.4	54.9	GO:0015288	porin activity(GO:0015288)
5.1	51.1	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.4	47.0	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.4	46.9	GO:0003714	transcription corepressor activity(GO:0003714)

Showing 1 to 10 of 415 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	100.5	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.7	51.4	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
2.8	47.3	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.9	46.4	PID AR TF PATHWAY	Regulation of Androgen receptor activity
1.5	39.0	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.7	36.3	PID PLK1 PATHWAY	PLK1 signaling events
1.0	32.5	PID BARD1 PATHWAY	BARD1 signaling events
0.7	30.0	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.7	24.5	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.5	23.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks

Showing 1 to 10 of 80 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	98.3	REACTOME DIABETES PATHWAYS	Genes involved in Diabetes pathways
1.4	74.5	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.6	64.1	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.8	62.0	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
2.0	56.5	REACTOME RNA POL I TRANSCRIPTION INITIATION	Genes involved in RNA Polymerase I Transcription Initiation
1.1	55.6	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
2.1	53.5	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.3	48.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.9	40.6	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.5	39.4	REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	Genes involved in Glycerophospholipid biosynthesis

Showing 1 to 10 of 146 entries

Results for Max_Mycn

Z-value: 1.74

Motif logo

Transcription factors associated with Max_Mycn

Activity-expression correlation:

Activity profile of Max_Mycn motif

Sorted Z-values of Max_Mycn motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Max_Mycn

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: