ISMARA results: Mafb

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Mafb

Z-value: 1.01

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Transcription factors associated with Mafb

Gene Symbol	Gene ID	Gene Info
Mafb NCBI RGD Ensembl	ENSRNOG00000016037	MAF bZIP transcription factor B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Mafb	rn6_v1_chr3_-_156340913_156340913	0.01	8.3e-01	Click!

Activity profile of Mafb motif

Sorted Z-values of Mafb motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_+_38828444 Show fit	36.02	ENSRNOT00000001809	Hpd NCBI RGD Ensembl Show fit	4-hydroxyphenylpyruvate dioxygenase
chr17_+_21382455 Show fit	32.37	ENSRNOT00000019756	Elovl2 NCBI RGD Ensembl Show fit	ELOVL fatty acid elongase 2
chr11_-_81444375 Show fit	30.63	ENSRNOT00000058479 ENSRNOT00000078131 ENSRNOT00000080949 ENSRNOT00000080562 ENSRNOT00000084867	Kng1 NCBI RGD Ensembl Show fit	kininogen 1
chr13_+_89597138 Show fit	30.34	ENSRNOT00000004662	Apoa2 NCBI RGD Ensembl Show fit	apolipoprotein A2
chr7_+_28066635 Show fit	28.92	ENSRNOT00000005844	Pah NCBI RGD Ensembl Show fit	phenylalanine hydroxylase
chr14_-_19072677 Show fit	25.35	ENSRNOT00000060548	LOC360919 NCBI RGD Ensembl Show fit	similar to alpha-fetoprotein
chr1_-_240601744 Show fit	23.57	ENSRNOT00000024093	Aldh1a7 NCBI RGD Ensembl Show fit	aldehyde dehydrogenase family 1, subfamily A7
chr1_-_224698514 Show fit	23.55	ENSRNOT00000024234	Slc22a25 NCBI RGD Ensembl Show fit	solute carrier family 22, member 25
chr14_+_22553650 Show fit	22.21	ENSRNOT00000092201 ENSRNOT00000002712	Ugt2b35 NCBI RGD Ensembl Show fit	UDP glucuronosyltransferase 2 family, polypeptide B35
chr1_+_238222521 Show fit	21.65	ENSRNOT00000024000	Aldh1a1 NCBI RGD Ensembl Show fit	aldehyde dehydrogenase 1 family, member A1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Mafb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	101.9	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
9.1	72.9	GO:1902222	L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.2	52.7	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
3.2	34.8	GO:0015747	urate transport(GO:0015747)
0.6	34.7	GO:0030239	myofibril assembly(GO:0030239)
6.5	32.4	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.7	30.6	GO:0042311	vasodilation(GO:0042311)
10.1	30.3	GO:0046340	negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) diacylglycerol catabolic process(GO:0046340)
3.4	27.1	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
5.2	25.8	GO:0072240	DCT cell differentiation(GO:0072069) metanephric DCT cell differentiation(GO:0072240)

Showing 1 to 10 of 196 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	116.4	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.0	97.5	GO:1903561	extracellular vesicle(GO:1903561)
0.0	55.5	GO:0016021	integral component of membrane(GO:0016021)
0.6	52.5	GO:0031526	brush border membrane(GO:0031526)
0.1	49.6	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.3	44.0	GO:0030018	Z disc(GO:0030018)
0.3	38.0	GO:0072562	blood microparticle(GO:0072562)
3.4	30.3	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.2	29.8	GO:0031227	intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.3	27.7	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)

Showing 1 to 10 of 76 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	61.1	GO:0004984	olfactory receptor activity(GO:0004984)
0.5	54.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.7	49.5	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1	46.5	GO:0005549	odorant binding(GO:0005549)
14.4	43.3	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
3.9	38.7	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
7.5	37.3	GO:0051373	FATZ binding(GO:0051373)
3.2	32.4	GO:0009922	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.9	32.4	GO:0004364	glutathione transferase activity(GO:0004364)
0.2	31.9	GO:0004252	serine-type endopeptidase activity(GO:0004252)

Showing 1 to 10 of 143 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	75.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.1	35.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.4	17.9	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.3	8.0	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.2	7.5	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.2	7.5	PID CD40 PATHWAY	CD40/CD40L signaling
0.2	5.7	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.2	5.3	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.1	4.8	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.2	3.2	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes

Showing 1 to 10 of 19 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	78.9	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
4.7	46.8	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
5.1	40.8	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
1.5	30.6	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
1.8	30.3	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.6	23.8	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.5	19.9	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
1.2	15.3	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.3	14.3	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.5	11.6	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation

Showing 1 to 10 of 54 entries

Results for Mafb

Z-value: 1.01

Motif logo

Transcription factors associated with Mafb

Activity-expression correlation:

Activity profile of Mafb motif

Sorted Z-values of Mafb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Mafb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: