ISMARA results: Maf

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Maf_Nrl

Z-value: 1.12

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Transcription factors associated with Maf_Nrl

Gene Symbol	Gene ID	Gene Info
Maf NCBI RGD Ensembl	ENSRNOG00000012428	MAF bZIP transcription factor
Nrl NCBI RGD Ensembl	ENSRNOG00000018528	neural retina leucine zipper

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Maf	rn6_v1_chr19_-_48196748_48196748	0.28	2.9e-07	Click!
Nrl	rn6_v1_chr15_-_34198921_34198921	-0.05	3.6e-01	Click!

Activity profile of Maf_Nrl motif

Sorted Z-values of Maf_Nrl motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_73948583 Show fit	71.69	ENSRNOT00000018097	Myl1 NCBI RGD Ensembl Show fit	myosin, light chain 1
chr10_+_53818818 Show fit	46.43	ENSRNOT00000057260	Myh8 NCBI RGD Ensembl Show fit	myosin heavy chain 8
chr9_-_73958480 Show fit	45.41	ENSRNOT00000017838	Myl1 NCBI RGD Ensembl Show fit	myosin, light chain 1
chr11_-_28527890 Show fit	41.30	ENSRNOT00000002138	Cldn8 NCBI RGD Ensembl Show fit	claudin 8
chr4_-_41212072 Show fit	26.53	ENSRNOT00000085596	Ppp1r3a NCBI RGD Ensembl Show fit	protein phosphatase 1, regulatory subunit 3A
chr2_-_28799266 Show fit	25.58	ENSRNOT00000089293	Tmem171 NCBI RGD Ensembl Show fit	transmembrane protein 171
chr16_+_26906716 Show fit	22.48	ENSRNOT00000064297	Cpe NCBI RGD Ensembl Show fit	carboxypeptidase E
chr1_+_238222521 Show fit	19.56	ENSRNOT00000024000	Aldh1a1 NCBI RGD Ensembl Show fit	aldehyde dehydrogenase 1 family, member A1
chr3_+_112242270 Show fit	19.35	ENSRNOT00000080533 ENSRNOT00000082876	Capn3 NCBI RGD Ensembl Show fit	calpain 3
chr7_+_38858062 Show fit	18.96	ENSRNOT00000006234	Kera NCBI RGD Ensembl Show fit	keratocan

Showing 1 to 10 of 196 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Maf_Nrl

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	117.1	GO:0060048	cardiac muscle contraction(GO:0060048)
4.2	46.4	GO:0030049	muscle filament sliding(GO:0030049)
4.5	22.5	GO:2000173	insulin processing(GO:0030070) negative regulation of branching morphogenesis of a nerve(GO:2000173)
3.3	19.6	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	19.5	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
6.4	19.3	GO:1990091	sodium-dependent self proteolysis(GO:1990091)
2.7	19.0	GO:0061303	cornea development in camera-type eye(GO:0061303)
4.5	18.0	GO:0046351	disaccharide biosynthetic process(GO:0046351)
0.4	17.9	GO:0015804	neutral amino acid transport(GO:0015804)
3.5	17.6	GO:0035106	operant conditioning(GO:0035106)

Showing 1 to 10 of 100 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	120.3	GO:0016459	myosin complex(GO:0016459)
2.2	52.5	GO:0016327	apicolateral plasma membrane(GO:0016327)
3.1	46.4	GO:0032982	myosin filament(GO:0032982)
0.3	37.3	GO:0030018	Z disc(GO:0030018)
0.4	33.0	GO:0031526	brush border membrane(GO:0031526)
0.1	28.6	GO:0016607	nuclear speck(GO:0016607)
1.4	22.5	GO:0031045	dense core granule(GO:0031045)
0.0	20.9	GO:0005615	extracellular space(GO:0005615)
0.1	17.4	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
2.6	15.9	GO:0032280	symmetric synapse(GO:0032280)

Showing 1 to 10 of 50 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	78.2	GO:0005509	calcium ion binding(GO:0005509)
2.1	46.4	GO:0000146	microfilament motor activity(GO:0000146)
12.4	37.2	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	28.4	GO:0005198	structural molecule activity(GO:0005198)
1.5	27.0	GO:0050308	sugar-phosphatase activity(GO:0050308)
1.6	22.5	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	19.5	GO:0004984	olfactory receptor activity(GO:0004984)
1.4	19.3	GO:0031432	titin binding(GO:0031432)
0.7	17.9	GO:0005328	neurotransmitter:sodium symporter activity(GO:0005328)
3.4	17.0	GO:0022841	potassium ion leak channel activity(GO:0022841)

Showing 1 to 10 of 80 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	40.8	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.9	28.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	23.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.5	20.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.3	19.4	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.5	16.2	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.3	13.9	PID BMP PATHWAY	BMP receptor signaling
0.3	13.3	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.3	12.5	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.2	10.3	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.3	167.0	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
1.3	41.3	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.7	27.0	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.8	21.7	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
2.4	19.6	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.5	19.3	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
1.4	19.0	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.8	17.9	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
1.3	17.0	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.4	13.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis

Showing 1 to 10 of 33 entries

Results for Maf_Nrl

Z-value: 1.12

Motif logo

Transcription factors associated with Maf_Nrl

Activity-expression correlation:

Activity profile of Maf_Nrl motif

Sorted Z-values of Maf_Nrl motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Maf_Nrl

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: