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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Lhx8

Z-value: 0.73

Motif logo

Transcription factors associated with Lhx8

Gene Symbol Gene ID Gene Info
ENSRNOG00000028348 LIM homeobox 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Lhx8rn6_v1_chr2_-_260596777_2605967770.351.8e-10Click!

Activity profile of Lhx8 motif

Sorted Z-values of Lhx8 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_48106099 38.59 ENSRNOT00000007218
solute carrier family 4 member 10
chr14_+_99529284 28.72 ENSRNOT00000006897
ENSRNOT00000067134
V-set and transmembrane domain containing 2A
chr3_+_51687809 27.52 ENSRNOT00000087242
sodium voltage-gated channel alpha subunit 2
chrX_-_56765893 27.17 ENSRNOT00000076283
interleukin 1 receptor accessory protein-like 1
chr3_-_38090526 25.65 ENSRNOT00000059430
calcium voltage-gated channel auxiliary subunit beta 4
chr4_-_159192526 24.58 ENSRNOT00000026731
potassium voltage-gated channel subfamily A member 1
chr6_-_14523961 24.42 ENSRNOT00000071402
neurexin 1
chr8_-_59226597 21.10 ENSRNOT00000088208
acyl-CoA synthetase bubblegum family member 1
chr2_-_57935334 20.33 ENSRNOT00000022319
ENSRNOT00000085599
ENSRNOT00000077790
ENSRNOT00000035821
solute carrier family 1 member 3
chr2_-_170460754 20.32 ENSRNOT00000013009
SLIT and NTRK-like family, member 3
chr1_+_37507276 20.14 ENSRNOT00000047627
adenylate cyclase 2
chr18_+_30515962 19.93 ENSRNOT00000027172
protocadherin beta-6-like
chr18_+_30474947 19.18 ENSRNOT00000027188
protocadherin beta 9
chr4_+_70252366 18.83 ENSRNOT00000073039
cell adhesion molecule L1-like
chr2_-_181531978 18.48 ENSRNOT00000072029
neuropeptide Y receptor Y2
chr5_-_16140896 17.75 ENSRNOT00000029503
XK related 4
chr6_-_99870024 17.27 ENSRNOT00000010043
RAB15, member RAS oncogene family
chr11_+_74834050 16.88 ENSRNOT00000002333
ATPase 13A4
chr18_+_27047382 16.06 ENSRNOT00000027691
ENSRNOT00000090264
APC, WNT signaling pathway regulator
chr13_+_82072497 15.24 ENSRNOT00000063810
ENSRNOT00000085135
kinesin-associated protein 3
chr12_-_10335499 13.50 ENSRNOT00000071567
WAS protein family, member 3
chr6_+_9790422 13.27 ENSRNOT00000020959
protein kinase C, epsilon
chr19_+_320906 12.84 ENSRNOT00000041664

chr7_-_82059247 12.72 ENSRNOT00000087177
R-spondin 2
chr18_+_63203063 12.55 ENSRNOT00000024144
PRELI domain containing 3A
chr10_-_51576376 12.24 ENSRNOT00000004829
Rho GTPase activating protein 44
chr2_-_18531210 12.19 ENSRNOT00000088313
versican
chr6_+_28515025 12.15 ENSRNOT00000088033
ENSRNOT00000005317
ENSRNOT00000081141
DnaJ heat shock protein family (Hsp40) member C27
chr18_+_29951094 11.10 ENSRNOT00000027402
protocadherin alpha-1-like
chr8_-_65587658 11.07 ENSRNOT00000091982
leucine rich repeat containing 49
chr13_+_24823488 10.93 ENSRNOT00000019907
cadherin 20
chr18_+_30424814 10.63 ENSRNOT00000073425
protocadherin beta 7
chr12_-_5773036 10.04 ENSRNOT00000041365
FRY microtubule binding protein
chr9_-_63641400 9.95 ENSRNOT00000087684
SATB homeobox 2
chr2_-_173563273 9.94 ENSRNOT00000081423
zinc finger, B-box domain containing
chr20_+_1749716 9.71 ENSRNOT00000048856
olfactory receptor 1735
chr20_+_1764794 9.65 ENSRNOT00000075084
olfactory receptor 1736
chr6_+_95323579 9.46 ENSRNOT00000007369
pecanex homolog 4 (Drosophila)
chr3_-_105470475 9.41 ENSRNOT00000011078
gap junction protein, delta 2
chr2_-_147819335 9.38 ENSRNOT00000057909
ankyrin repeat and ubiquitin domain containing 1
chr1_+_42169501 8.98 ENSRNOT00000025477
ENSRNOT00000092791
vasoactive intestinal peptide
chr9_-_52401660 8.83 ENSRNOT00000049387
vomeronasal 1 receptor 50
chr9_-_65442257 8.67 ENSRNOT00000037660
family with sequence similarity 126, member B
chr18_+_30909490 8.11 ENSRNOT00000026967
protocadherin gamma subfamily B, 8
chr16_+_39909270 8.03 ENSRNOT00000081994
WD repeat domain 17
chr8_+_52127632 7.75 ENSRNOT00000079797
cell adhesion molecule 1
chr1_-_67094567 7.66 ENSRNOT00000073583

chr3_+_80362858 7.38 ENSRNOT00000021353
ENSRNOT00000086242
LDL receptor related protein 4
chr6_+_43234526 7.17 ENSRNOT00000086808
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr12_+_2140203 6.63 ENSRNOT00000084906
calmodulin regulated spectrin-associated protein family, member 3
chr4_-_150506557 6.58 ENSRNOT00000076927
zinc finger protein 248
chr16_-_75637789 6.39 ENSRNOT00000058029
defensin beta 4
chr2_+_72006099 6.29 ENSRNOT00000034044
cadherin 12
chr7_-_40316532 6.08 ENSRNOT00000083347
similar to RIKEN cDNA C430008C19
chr16_-_3765917 6.02 ENSRNOT00000088284
double homeobox B-like 1
chr1_+_204959174 5.91 ENSRNOT00000023257
zinc finger RANBP2-type containing 1
chr3_-_77227036 5.85 ENSRNOT00000072638
olfactory receptor 4P4-like
chr10_+_90230711 5.82 ENSRNOT00000055185
transmembrane and ubiquitin-like domain containing 2
chrX_-_2657155 5.70 ENSRNOT00000005630
carbohydrate sulfotransferase 7
chr7_+_2831004 5.60 ENSRNOT00000029778
ring finger protein 41
chr6_-_76608864 5.56 ENSRNOT00000010824
Ral GTPase activating protein catalytic alpha subunit 1
chr3_-_80000091 5.55 ENSRNOT00000079394
MAP-kinase activating death domain
chr1_-_79899648 5.42 ENSRNOT00000057960

chrX_-_138112408 5.41 ENSRNOT00000077028
FERM domain containing 7
chr10_-_45297385 5.28 ENSRNOT00000041187
histone cluster 3 H2B family member b
chr10_-_52290657 5.07 ENSRNOT00000005293
mitogen activated protein kinase kinase 4
chr7_-_15301382 4.99 ENSRNOT00000081512
zinc finger protein 763
chr15_-_11812485 4.88 ENSRNOT00000030991
ENSRNOT00000007795
NIMA-related kinase 10
chr4_+_160020472 4.88 ENSRNOT00000078802
poly (ADP-ribose) polymerase family, member 11
chr3_-_101547478 4.80 ENSRNOT00000006203
fin bud initiation factor homolog (zebrafish)
chr15_-_93868292 4.67 ENSRNOT00000093546
ENSRNOT00000014583
MYC binding protein 2, E3 ubiquitin protein ligase
chr9_+_16702460 4.58 ENSRNOT00000061432
protein tyrosine kinase 7
chr2_+_196145384 4.43 ENSRNOT00000080966
phosphatidylinositol 4-kinase beta
chr7_-_9465527 4.42 ENSRNOT00000044882
olfactory receptor 1069
chr16_-_49820235 4.42 ENSRNOT00000029628
sorbin and SH3 domain containing 2
chr10_-_13996565 4.37 ENSRNOT00000016221
ENSRNOT00000052138
tuberous sclerosis 2
chr1_-_49844547 4.24 ENSRNOT00000086127
ENSRNOT00000077423
ENSRNOT00000089439
ENSRNOT00000090521

chr11_-_82810014 4.21 ENSRNOT00000083539
mitogen-activated protein kinase kinase kinase 13
chrX_-_77559348 4.03 ENSRNOT00000047823
fibronectin type III domain containing 3C1
chr4_-_150506406 4.02 ENSRNOT00000076307
zinc finger protein 248
chr1_-_103426467 3.84 ENSRNOT00000045792
MAS-related GPR, member B4
chr1_+_218466289 3.75 ENSRNOT00000017948
MAS related GPR family member F
chr2_-_38110567 3.71 ENSRNOT00000072212
importin 11
chr5_+_144581427 3.69 ENSRNOT00000015227
claspin
chr3_-_9936352 3.59 ENSRNOT00000011224
ENSRNOT00000042798
formin binding protein 1
chr5_-_137617258 3.58 ENSRNOT00000071641
olfactory receptor 1330, pseudogene 1
chr6_+_55374984 3.32 ENSRNOT00000091682
anterior gradient 3, protein disulphide isomerase family member
chrX_+_32495809 3.31 ENSRNOT00000020999
similar to RIKEN cDNA 1700045I19
chr1_-_48891130 3.28 ENSRNOT00000083884

chr13_+_82355886 3.18 ENSRNOT00000076757
selectin E
chr1_-_62114672 3.14 ENSRNOT00000072607

chr1_+_168489077 3.02 ENSRNOT00000021191
olfactory receptor 96
chr11_-_71136673 3.02 ENSRNOT00000042240
forty-two-three domain containing 1
chr7_-_15852930 3.01 ENSRNOT00000009270
similar to zinc finger protein 101
chr1_-_242441247 2.98 ENSRNOT00000068645
phosphatidylinositol-4-phosphate 5-kinase type 1 beta
chrX_-_119162518 2.88 ENSRNOT00000073176
ubiquitin-conjugating enzyme E2 W
chrX_+_71540895 2.86 ENSRNOT00000004692
ENSRNOT00000082967
O-linked N-acetylglucosamine (GlcNAc) transferase
chrX_-_29825439 2.86 ENSRNOT00000048155
gem (nuclear organelle) associated protein 8
chr1_+_219250265 2.84 ENSRNOT00000024353
double C2-like domains, gamma
chr16_+_32457521 2.81 ENSRNOT00000083579
chloride voltage-gated channel 3
chr20_+_1736377 2.77 ENSRNOT00000047035
olfactory receptor 1734
chr2_-_258997138 2.74 ENSRNOT00000045020
ENSRNOT00000042256
adhesion G protein-coupled receptor L2
chr13_+_82355471 2.71 ENSRNOT00000030677
selectin E
chr7_-_140342727 2.71 ENSRNOT00000089612
DEAD-box helicase 23
chr8_+_41336340 2.64 ENSRNOT00000072049
olfactory receptor 1225
chr1_-_261371508 2.62 ENSRNOT00000019978
arginine vasopressin-induced 1
chr2_+_189857587 2.54 ENSRNOT00000048214
interleukin enhancer binding factor 2
chr4_+_2593876 2.51 ENSRNOT00000092992
ubiquitin protein ligase E3C
chr10_-_45812641 2.46 ENSRNOT00000038951
zinc finger protein 867
chr9_-_38495126 2.44 ENSRNOT00000016933
ENSRNOT00000090385
RAB23, member RAS oncogene family
chr1_+_70454322 2.42 ENSRNOT00000072272
olfactory receptor 4
chr11_+_88424414 2.40 ENSRNOT00000022328
sperm associated antigen 6-like
chr5_-_78183122 2.39 ENSRNOT00000002083
ENSRNOT00000067076
FK506 binding protein 15
chr16_+_6609668 2.34 ENSRNOT00000021862
transketolase
chr1_-_23556241 2.34 ENSRNOT00000072943
syntaxin-7-like
chr18_+_1866080 2.31 ENSRNOT00000018646
small nuclear ribonucleoprotein D1
chr10_-_64341066 2.30 ENSRNOT00000082825
ENSRNOT00000010010
VPS53 GARP complex subunit
chr3_+_15038267 2.27 ENSRNOT00000083134
DAB2 interacting protein
chr4_-_165828814 2.27 ENSRNOT00000007481
taste receptor, type 2, member 105
chr1_-_168611670 2.24 ENSRNOT00000021273
olfactory receptor 106
chr5_+_139385429 2.23 ENSRNOT00000078622
sex comb on midleg homolog 1 (Drosophila)
chr13_-_89433815 2.20 ENSRNOT00000091541
Fc fragment of IgG receptor IIb
chr11_+_38727048 2.18 ENSRNOT00000081537
zinc finger protein 260-like
chr7_+_35773928 2.17 ENSRNOT00000034639
centrosomal protein 83
chr1_+_79899155 2.13 ENSRNOT00000078503
Myb-related transcription factor, partner of profilin
chr3_-_74590459 2.08 ENSRNOT00000065152
olfactory receptor 535
chr7_+_14643704 2.04 ENSRNOT00000044642

chr2_+_62150251 2.00 ENSRNOT00000016196
zinc finger RNA binding protein
chr1_+_221710670 1.99 ENSRNOT00000064798
mitogen activated protein kinase kinase kinase kinase 2
chr2_-_86475096 1.99 ENSRNOT00000075247
ENSRNOT00000075062
zinc finger protein 43-like
chr1_+_169616178 1.97 ENSRNOT00000023170
olfactory receptor 157
chr4_+_123760743 1.96 ENSRNOT00000013498
coiled-coil domain containing 174
chr11_-_70207361 1.94 ENSRNOT00000002444
mucin 13, cell surface associated
chr13_-_31753800 1.90 ENSRNOT00000050715

chr2_+_200076054 1.87 ENSRNOT00000025327
SEC22 homolog B, vesicle trafficking protein
chr5_-_168123030 1.84 ENSRNOT00000092747
period circadian clock 3
chr2_-_205212681 1.83 ENSRNOT00000022575
thyroid stimulating hormone, beta
chrX_+_31054394 1.83 ENSRNOT00000037439
similar to ribonucleic acid binding protein S1
chr17_-_42422053 1.81 ENSRNOT00000048298
family with sequence similarity 65, member B
chr7_+_121361415 1.79 ENSRNOT00000067904
TGF-beta activated kinase 1/MAP3K7 binding protein 1
chr3_-_10694649 1.76 ENSRNOT00000037742
G protein-coupled receptor 107
chrX_-_115426083 1.72 ENSRNOT00000014756

chr8_+_13862651 1.71 ENSRNOT00000014605
TATA-box binding protein associated factor, RNA polymerase I subunit D
chr5_-_137846436 1.70 ENSRNOT00000046941
olfactory receptor 866
chr4_-_72020642 1.70 ENSRNOT00000075946
family with sequence similarity 115, member E
chr1_+_107262659 1.68 ENSRNOT00000022499
growth arrest-specific 2
chr9_+_99720856 1.66 ENSRNOT00000047487
olfactory receptor 1346
chr17_-_23792353 1.55 ENSRNOT00000019089
TBC1 domain family, member 7
chr17_+_16333415 1.50 ENSRNOT00000060550
protein tyrosine phosphatase domain containing 1
chr11_+_45751812 1.47 ENSRNOT00000079336
similar to Dermal papilla derived protein 7
chr1_+_1771710 1.44 ENSRNOT00000080138
ENSRNOT00000073528
nucleoporin 43
chrX_-_915953 1.39 ENSRNOT00000075264
sperm acrosome associated 5
chr14_+_22597103 1.29 ENSRNOT00000048482
UDP glucuronosyltransferase 2 family, polypeptide A1
chr7_-_20118466 1.28 ENSRNOT00000080523
similar to hypothetical protein 4930509O22
chr10_+_44228800 1.24 ENSRNOT00000046817
olfactory receptor 1431
chr7_-_114590119 1.23 ENSRNOT00000079599
protein tyrosine kinase 2
chr7_-_9630611 1.21 ENSRNOT00000011176
olfactory receptor 1072
chr3_-_76696107 1.20 ENSRNOT00000044692
olfactory receptor 629
chr7_+_23854846 1.19 ENSRNOT00000037290
BPI fold containing family C
chr7_+_14743008 1.17 ENSRNOT00000055284

chr1_+_229889771 1.15 ENSRNOT00000085941
olfactory receptor 348
chr20_+_4824226 1.11 ENSRNOT00000001113
NFKB inhibitor like 1
chr4_+_1591444 1.04 ENSRNOT00000078277
olfactory receptor 1245
chr9_-_23454316 1.00 ENSRNOT00000072826
cytochrome P450, family 2, subfamily ac, polypeptide 1
chr12_-_12782139 0.99 ENSRNOT00000001392
ENSRNOT00000079836
eukaryotic translation initiation factor 2 alpha kinase 1
chr12_+_16899025 0.97 ENSRNOT00000001716
proteasome assembly chaperone 3
chr7_-_143793774 0.90 ENSRNOT00000079678
cysteine sulfinic acid decarboxylase
chr1_-_71373605 0.90 ENSRNOT00000034854
galanin-like peptide
chr7_+_132378273 0.87 ENSRNOT00000010990
hypothetical protein LOC690142
chr2_-_198834925 0.87 ENSRNOT00000089831
nudix hydrolase 17
chr3_-_74906989 0.86 ENSRNOT00000071001
olfactory receptor 545
chr17_-_2705123 0.84 ENSRNOT00000024940
olfactory receptor 1652
chr1_-_171045419 0.79 ENSRNOT00000047239
olfactory receptor 224
chr1_+_86103298 0.74 ENSRNOT00000014883
vomeronasal 2 receptor, 10
chr7_-_130408187 0.74 ENSRNOT00000015374
choline kinase beta
chr5_-_164648328 0.73 ENSRNOT00000090811
zinc finger protein 933
chr5_-_157059508 0.72 ENSRNOT00000022282
von Willebrand factor A domain containing 5B1
chr3_-_103140972 0.70 ENSRNOT00000052368
olfactory receptor 780
chr10_-_44750464 0.66 ENSRNOT00000042919
olfactory receptor 1457
chr10_-_60573129 0.65 ENSRNOT00000083428
olfactory receptor 1499
chr10_+_29033989 0.65 ENSRNOT00000088322
SLU7 homolog, splicing factor
chr18_-_71614980 0.64 ENSRNOT00000032563
peroxisomal biogenesis factor 19-like
chr17_+_78915604 0.63 ENSRNOT00000057855
ribonuclease P/MRP 38 subunit
chr9_-_88534710 0.60 ENSRNOT00000020880
transmembrane 4 L six family member 20
chr3_-_75733970 0.58 ENSRNOT00000033519
olfactory receptor 577
chr20_+_4823662 0.57 ENSRNOT00000090028
NFKB inhibitor like 1
chr4_+_88026033 0.55 ENSRNOT00000074905
vomeronasal 1 receptor 80
chr10_+_60974225 0.54 ENSRNOT00000042349
olfactory receptor 1511
chr1_-_169892850 0.51 ENSRNOT00000037868
olfactory receptor 183
chr9_+_79659251 0.50 ENSRNOT00000021656
X-ray repair cross complementing 5
chr2_+_235738416 0.50 ENSRNOT00000074209
ethanolamine-phosphate phospho-lyase
chr3_-_77365887 0.49 ENSRNOT00000090742
similar to olfactory receptor 1198
chrX_+_32232142 0.49 ENSRNOT00000047354
carbonic anhydrase 5B
chr1_+_65906344 0.48 ENSRNOT00000068611
vomeronasal 2 receptor, 34
chr3_+_78086943 0.44 ENSRNOT00000047425
olfactory receptor 691
chr1_+_230217215 0.44 ENSRNOT00000072772
similar to olfactory receptor 1467
chr8_-_87419564 0.43 ENSRNOT00000015365
filamin A interacting protein 1
chr3_+_102859815 0.43 ENSRNOT00000037906
olfactory receptor 771
chr14_-_87701884 0.41 ENSRNOT00000079338
motile sperm domain containing 1
chr1_-_66321642 0.40 ENSRNOT00000074234

Network of associatons between targets according to the STRING database.

First level regulatory network of Lhx8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 59.0 GO:0097105 presynaptic membrane assembly(GO:0097105)
5.7 28.7 GO:0070346 white fat cell proliferation(GO:0070343) positive regulation of fat cell proliferation(GO:0070346) regulation of white fat cell proliferation(GO:0070350)
5.1 20.3 GO:0043490 malate-aspartate shuttle(GO:0043490)
4.9 24.6 GO:0050975 sensory perception of touch(GO:0050975)
4.8 28.8 GO:0042483 negative regulation of odontogenesis(GO:0042483)
4.2 21.1 GO:0001552 ovarian follicle atresia(GO:0001552)
3.4 27.5 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
3.3 13.3 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
3.1 18.5 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
3.1 12.2 GO:0098886 modification of dendritic spine(GO:0098886)
2.5 10.0 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
2.0 38.6 GO:0021860 pyramidal neuron development(GO:0021860)
2.0 25.7 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
2.0 5.9 GO:1990168 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) protein K33-linked deubiquitination(GO:1990168)
1.8 5.5 GO:0036395 pancreatic amylase secretion(GO:0036395) regulation of pancreatic amylase secretion(GO:1902276)
1.5 7.7 GO:0009826 unidimensional cell growth(GO:0009826)
1.4 20.1 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
1.3 6.6 GO:0045218 zonula adherens maintenance(GO:0045218)
1.3 5.1 GO:0072709 cellular response to sorbitol(GO:0072709)
1.0 15.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
1.0 9.0 GO:0070459 prolactin secretion(GO:0070459)
0.9 10.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.9 4.4 GO:0044861 protein transport into plasma membrane raft(GO:0044861) negative regulation of pinocytosis(GO:0048550)
0.8 8.3 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.7 2.9 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.7 13.5 GO:0031643 positive regulation of myelination(GO:0031643)
0.7 2.8 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.6 5.6 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.6 81.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.6 2.2 GO:0002884 immune complex clearance(GO:0002434) negative regulation of hypersensitivity(GO:0002884)
0.5 3.7 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.5 5.7 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.5 2.3 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.4 3.7 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.4 4.7 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.4 4.6 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.3 17.6 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.3 1.2 GO:0007172 signal complex assembly(GO:0007172)
0.3 0.9 GO:0042412 taurine biosynthetic process(GO:0042412)
0.3 23.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.3 2.2 GO:0051660 establishment of centrosome localization(GO:0051660)
0.3 3.8 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.3 12.1 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.3 5.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 1.0 GO:0010999 regulation of eIF2 alpha phosphorylation by heme(GO:0010999)
0.2 12.2 GO:0008347 glial cell migration(GO:0008347)
0.2 2.4 GO:0006968 cellular defense response(GO:0006968)
0.2 5.4 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.2 1.9 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.2 1.7 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.2 4.9 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.2 12.6 GO:0015914 phospholipid transport(GO:0015914)
0.2 7.4 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.2 0.7 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.2 2.4 GO:0007288 sperm axoneme assembly(GO:0007288)
0.1 1.9 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 5.2 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 0.3 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350) spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.1 2.3 GO:0048278 vesicle docking(GO:0048278)
0.1 1.6 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.1 4.4 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.5 GO:1904430 negative regulation of t-circle formation(GO:1904430)
0.1 2.9 GO:0071218 cellular response to misfolded protein(GO:0071218)
0.1 1.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 4.9 GO:0006998 nuclear envelope organization(GO:0006998)
0.1 5.0 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 0.7 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 9.4 GO:0007601 visual perception(GO:0007601)
0.1 2.3 GO:0050913 sensory perception of bitter taste(GO:0050913)
0.1 0.2 GO:0046127 thymidine catabolic process(GO:0006214) pyrimidine deoxyribonucleoside catabolic process(GO:0046127)
0.1 4.2 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 5.6 GO:0090630 activation of GTPase activity(GO:0090630)
0.1 2.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 1.3 GO:0035404 histone-serine phosphorylation(GO:0035404)
0.1 1.8 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.1 2.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 2.3 GO:0032456 endocytic recycling(GO:0032456)
0.1 16.9 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 2.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 3.0 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 5.3 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.8 GO:0033189 response to vitamin A(GO:0033189)
0.0 0.3 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.9 GO:0032098 regulation of appetite(GO:0032098)
0.0 1.8 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 0.2 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 2.2 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 1.8 GO:0007224 smoothened signaling pathway(GO:0007224)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 38.6 GO:0097441 basilar dendrite(GO:0097441)
5.4 16.1 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
3.0 15.2 GO:0016939 kinesin II complex(GO:0016939)
1.9 52.1 GO:0033270 paranode region of axon(GO:0033270)
1.5 4.4 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.9 6.6 GO:0036449 microtubule minus-end(GO:0036449)
0.8 20.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.8 2.3 GO:1990032 parallel fiber(GO:1990032)
0.7 7.4 GO:0016600 flotillin complex(GO:0016600)
0.6 2.3 GO:0000938 GARP complex(GO:0000938) EARP complex(GO:1990745)
0.6 1.7 GO:0005668 RNA polymerase transcription factor SL1 complex(GO:0005668)
0.6 25.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.6 24.4 GO:0044295 axonal growth cone(GO:0044295)
0.6 7.7 GO:0070852 cell body fiber(GO:0070852)
0.5 2.4 GO:1990716 axonemal central apparatus(GO:1990716)
0.4 9.4 GO:0005922 connexon complex(GO:0005922)
0.4 2.3 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.2 2.9 GO:0032797 SMN complex(GO:0032797)
0.2 3.0 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.2 2.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 12.2 GO:0048786 presynaptic active zone(GO:0048786)
0.2 5.6 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.2 2.2 GO:0097539 ciliary transition fiber(GO:0097539)
0.2 4.4 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.2 2.8 GO:0042581 specific granule(GO:0042581)
0.2 2.7 GO:0005682 U5 snRNP(GO:0005682)
0.1 5.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 24.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 9.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 1.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.5 GO:0043564 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) Ku70:Ku80 complex(GO:0043564)
0.1 2.2 GO:0010369 chromocenter(GO:0010369)
0.1 9.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 24.9 GO:0098793 presynapse(GO:0098793)
0.1 17.8 GO:0030427 site of polarized growth(GO:0030427)
0.1 17.9 GO:0030027 lamellipodium(GO:0030027)
0.1 21.6 GO:0043197 dendritic spine(GO:0043197)
0.1 2.9 GO:0042588 zymogen granule(GO:0042588)
0.1 4.2 GO:0031201 SNARE complex(GO:0031201)
0.1 43.5 GO:0030425 dendrite(GO:0030425)
0.1 74.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 1.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 5.2 GO:1902911 protein kinase complex(GO:1902911)
0.1 5.3 GO:0000786 nucleosome(GO:0000786)
0.0 1.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 4.7 GO:0030424 axon(GO:0030424)
0.0 2.4 GO:0005776 autophagosome(GO:0005776)
0.0 7.6 GO:0043025 neuronal cell body(GO:0043025)
0.0 2.2 GO:0055037 recycling endosome(GO:0055037)
0.0 4.3 GO:0001650 fibrillar center(GO:0001650)
0.0 10.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 12.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 2.7 GO:0043005 neuron projection(GO:0043005)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.3 GO:0000145 exocyst(GO:0000145)
0.0 5.5 GO:0016607 nuclear speck(GO:0016607)
0.0 1.6 GO:0036064 ciliary basal body(GO:0036064)
0.0 1.0 GO:0000502 proteasome complex(GO:0000502)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.6 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
4.1 20.3 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
3.7 18.5 GO:0001601 peptide YY receptor activity(GO:0001601)
3.5 24.4 GO:0097109 neuroligin family protein binding(GO:0097109)
3.3 13.3 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
2.3 27.2 GO:0019966 interleukin-1 binding(GO:0019966)
2.1 21.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.9 5.6 GO:0005135 erythropoietin receptor binding(GO:0005128) interleukin-3 receptor binding(GO:0005135)
1.8 27.5 GO:0043522 leucine zipper domain binding(GO:0043522)
1.4 38.6 GO:0005452 inorganic anion exchanger activity(GO:0005452)
1.4 25.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.3 5.3 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
1.1 4.6 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
1.1 16.1 GO:0045295 gamma-catenin binding(GO:0045295)
1.1 24.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.1 20.1 GO:0008179 adenylate cyclase binding(GO:0008179)
1.0 2.9 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
0.9 5.7 GO:0034481 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) chondroitin sulfotransferase activity(GO:0034481)
0.9 2.8 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.9 4.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.8 16.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.7 3.7 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.6 6.6 GO:0051011 microtubule minus-end binding(GO:0051011)
0.6 12.2 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.5 7.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.4 5.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.4 5.9 GO:0033691 sialic acid binding(GO:0033691)
0.4 2.3 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.4 2.3 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.4 3.0 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.3 2.0 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.3 15.2 GO:0019894 kinesin binding(GO:0019894)
0.3 2.3 GO:1990446 U1 snRNP binding(GO:1990446)
0.3 1.8 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.2 12.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.2 5.9 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.2 4.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 0.7 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.2 1.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 4.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.2 2.2 GO:0019864 IgG binding(GO:0019864)
0.2 4.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 1.0 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.2 3.3 GO:0002162 dystroglycan binding(GO:0002162)
0.2 1.2 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.7 GO:0004103 choline kinase activity(GO:0004103)
0.1 18.8 GO:0002020 protease binding(GO:0002020)
0.1 5.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.4 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.5 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.1 4.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 2.3 GO:0008527 taste receptor activity(GO:0008527)
0.1 12.7 GO:0008201 heparin binding(GO:0008201)
0.1 1.3 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 59.0 GO:0005509 calcium ion binding(GO:0005509)
0.1 7.4 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 0.5 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.1 0.2 GO:0017113 dihydrouracil dehydrogenase (NAD+) activity(GO:0004159) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
0.1 7.7 GO:0030165 PDZ domain binding(GO:0030165)
0.1 2.4 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 1.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 8.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 2.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 5.2 GO:0003924 GTPase activity(GO:0003924)
0.0 5.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 3.0 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 6.1 GO:0000976 transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.0 4.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 33.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.8 19.0 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.4 10.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.4 5.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 4.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 9.3 PID TNF PATHWAY TNF receptor signaling pathway
0.1 7.5 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 1.7 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 4.2 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.1 5.6 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 5.9 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 2.3 PID RAS PATHWAY Regulation of Ras family activation
0.1 3.7 PID ATR PATHWAY ATR signaling pathway
0.1 5.7 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 1.8 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 2.4 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.2 PID BCR 5PATHWAY BCR signaling pathway
0.0 10.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 20.1 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
1.0 16.1 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.9 12.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.8 27.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.6 25.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.5 13.3 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.5 9.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.5 14.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.5 24.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.5 15.2 REACTOME KINESINS Genes involved in Kinesins
0.5 4.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.4 5.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.4 20.3 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.3 5.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.3 6.9 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.2 4.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.2 9.0 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.2 5.3 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 1.8 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 1.9 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 5.0 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 17.7 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.0 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 1.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.7 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 9.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 0.7 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 0.5 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 1.4 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 2.3 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 0.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.2 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)