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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Lhx5_Lmx1b_Lhx1

Z-value: 0.85

Motif logo

Transcription factors associated with Lhx5_Lmx1b_Lhx1

Gene Symbol Gene ID Gene Info
ENSRNOG00000001392 LIM homeobox 5
ENSRNOG00000017019 LIM homeobox transcription factor 1 beta
ENSRNOG00000002812 LIM homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Lhx1rn6_v1_chr10_-_71849293_71849293-0.516.6e-23Click!
Lhx5rn6_v1_chr12_-_41671437_41671437-0.462.3e-18Click!
Lmx1brn6_v1_chr3_-_12686869_12686869-0.202.3e-04Click!

Activity profile of Lhx5_Lmx1b_Lhx1 motif

Sorted Z-values of Lhx5_Lmx1b_Lhx1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_54352270 46.38 ENSRNOT00000036752
dehydrogenase/reductase 7C
chr4_+_29535852 41.84 ENSRNOT00000087619
collagen, type I, alpha 2
chrX_-_40086870 38.01 ENSRNOT00000010027
small muscle protein, X-linked
chr4_-_41212072 30.54 ENSRNOT00000085596
protein phosphatase 1, regulatory subunit 3A
chr4_+_180291389 29.17 ENSRNOT00000002465
sarcospan
chr3_-_37854561 27.77 ENSRNOT00000076095
nebulin
chr17_+_25082056 26.52 ENSRNOT00000037041

chr13_-_90074952 24.18 ENSRNOT00000038006
SLAM family member 7
chr4_+_163349125 23.46 ENSRNOT00000084823
killer cell lectin-like receptor, family E, member 1
chr5_+_165724027 20.87 ENSRNOT00000018000
castor zinc finger 1
chr9_+_53013413 17.77 ENSRNOT00000005313
ankyrin and armadillo repeat containing
chrX_+_71342775 17.44 ENSRNOT00000004888
integrin subunit beta 1 binding protein 2
chr19_+_27404712 17.11 ENSRNOT00000023657
myosin light chain kinase 3
chr20_+_42966140 16.70 ENSRNOT00000000707
myristoylated alanine rich protein kinase C substrate
chr16_+_29674793 16.50 ENSRNOT00000059724
annexin A10
chr1_-_101095594 15.65 ENSRNOT00000027944
Fc fragment of IgG receptor and transporter
chr6_-_142353308 15.31 ENSRNOT00000066416

chr18_+_32336102 14.83 ENSRNOT00000018577
fibroblast growth factor 1
chr9_-_53315915 14.65 ENSRNOT00000038093
myostatin
chr4_+_101882994 13.30 ENSRNOT00000087773

chr2_-_54777729 13.23 ENSRNOT00000082548
complement C7
chr20_-_5166448 12.61 ENSRNOT00000076331
allograft inflammatory factor 1
chr4_+_101687327 12.22 ENSRNOT00000082501

chr4_+_169147243 12.09 ENSRNOT00000011580
epithelial membrane protein 1
chr17_-_18592750 11.96 ENSRNOT00000065742
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr20_+_3176107 11.90 ENSRNOT00000001036
RT1 class Ib, locus S3
chr1_+_101603222 11.63 ENSRNOT00000033278
izumo sperm-egg fusion 1
chr6_+_49825469 11.61 ENSRNOT00000006921
family with sequence similarity 150, member B
chr4_+_169161585 11.55 ENSRNOT00000079785
epithelial membrane protein 1
chr8_+_104106740 11.48 ENSRNOT00000015015
transcription factor Dp-2
chr18_+_79773608 11.45 ENSRNOT00000088484
zinc finger protein 516
chr10_+_53740841 11.45 ENSRNOT00000004295
myosin heavy chain 2
chr4_-_163762434 11.25 ENSRNOT00000081854
immunoreceptor Ly49si1
chr2_-_123972356 10.92 ENSRNOT00000023348
interleukin 21
chr20_-_4132604 10.90 ENSRNOT00000077630
ENSRNOT00000048332
RT1 class II, locus Da
chr11_-_60547201 10.32 ENSRNOT00000093151
B and T lymphocyte associated
chr16_-_29936307 10.28 ENSRNOT00000088707
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr7_-_69982592 10.26 ENSRNOT00000040010
similar to developmental pluripotency associated 5
chr19_-_29968424 10.05 ENSRNOT00000024981
inositol polyphosphate-4-phosphatase type II B
chr17_-_14679409 10.01 ENSRNOT00000020704
asporin
chr17_+_32082937 10.01 ENSRNOT00000074775
myosin light chain kinase family, member 4
chr6_-_21112734 9.65 ENSRNOT00000079819
RAS guanyl releasing protein 3
chr18_+_55666027 9.27 ENSRNOT00000045950
similar to CDNA sequence BC023105
chr3_-_118635268 9.26 ENSRNOT00000086357
ATPase phospholipid transporting 8B4 (putative)
chr7_-_29233392 9.16 ENSRNOT00000064241
Spi-C transcription factor
chr13_+_49005405 9.14 ENSRNOT00000092560
ENSRNOT00000076457
LEM domain containing 1
chr4_+_93959152 9.07 ENSRNOT00000058437

chr2_+_248398917 9.05 ENSRNOT00000045855
guanylate binding protein 1
chr1_+_255040426 9.02 ENSRNOT00000092151
polycomb group ring finger 5
chr8_+_71914867 8.89 ENSRNOT00000023372
death-associated protein kinase 2
chr13_-_77821312 8.76 ENSRNOT00000082110

chr11_-_60546997 8.76 ENSRNOT00000083124
ENSRNOT00000050092
B and T lymphocyte associated
chr19_-_10513349 8.69 ENSRNOT00000061270
adhesion G protein-coupled receptor G5
chr4_+_98481520 8.66 ENSRNOT00000078381
ENSRNOT00000048493

chr8_+_5790034 8.63 ENSRNOT00000061887
matrix metallopeptidase 27
chr6_-_143195445 8.62 ENSRNOT00000078672

chr8_-_39551700 8.44 ENSRNOT00000091894
ENSRNOT00000076025
PBX/knotted 1 homeobox 2
chr3_+_20303979 8.38 ENSRNOT00000058331

chr2_+_186776644 8.34 ENSRNOT00000046778
Fc receptor-like 3
chr4_+_93791054 8.34 ENSRNOT00000042300

chr4_+_155321553 8.15 ENSRNOT00000089614
microfibrillar associated protein 5
chr17_-_15519282 7.97 ENSRNOT00000093577
asporin-like 1
chr2_-_170301348 7.88 ENSRNOT00000088131
sucrase-isomaltase
chr17_-_15519060 7.82 ENSRNOT00000093624
asporin-like 1
chr20_-_13994794 7.63 ENSRNOT00000093466
gamma-glutamyltransferase 5
chr7_+_2459141 7.63 ENSRNOT00000075681
nascent polypeptide-associated complex alpha subunit
chr2_+_219598162 7.58 ENSRNOT00000020297
leucine rich repeat containing 39
chr14_-_77810147 7.47 ENSRNOT00000035427
cytokine like 1
chrX_+_131381134 7.45 ENSRNOT00000007474

chr10_-_896938 7.42 ENSRNOT00000086392
nudE neurodevelopment protein 1
chr8_+_22559098 7.41 ENSRNOT00000041091
hypothetical protein LOC691141
chr13_-_52413681 7.36 ENSRNOT00000037100
ENSRNOT00000011801
neuron navigator 1
chr6_-_140880070 7.20 ENSRNOT00000073779
uncharacterized LOC691828
chr2_+_240642847 7.07 ENSRNOT00000079694
ubiquitin-conjugating enzyme E2D 3
chr6_-_51498337 7.06 ENSRNOT00000012487
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr10_+_106812739 7.06 ENSRNOT00000074225
synaptogyrin 2
chr11_+_15081774 7.05 ENSRNOT00000009911
ubiquitin carboxyl-terminal hydrolase 25-like
chr3_+_16846412 7.02 ENSRNOT00000074266

chr10_+_69423086 6.99 ENSRNOT00000000256
C-C motif chemokine ligand 7
chr15_-_95514259 6.91 ENSRNOT00000038433
SLIT and NTRK-like family, member 6
chr9_+_8054466 6.81 ENSRNOT00000081513
adhesion G protein-coupled receptor E4
chr10_-_86930947 6.76 ENSRNOT00000081440
topoisomerase (DNA) II alpha
chrX_+_109996163 6.71 ENSRNOT00000093349
Nik related kinase
chr11_-_28900376 6.70 ENSRNOT00000061606
keratin associated protein 16-5
chrX_-_77675487 6.70 ENSRNOT00000042799
cysteinyl leukotriene receptor 1
chr3_-_16441030 6.63 ENSRNOT00000047784

chr17_-_43776460 6.62 ENSRNOT00000089055
histone cluster 2, H3c2
chr7_-_140291620 6.61 ENSRNOT00000088323
adenylate cyclase 6
chr14_+_7949239 6.57 ENSRNOT00000044617
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4-like 1
chr16_+_2537248 6.53 ENSRNOT00000017995
ankyrin repeat and SOCS box-containing 14
chr12_+_41316764 6.45 ENSRNOT00000090867
2'-5'-oligoadenylate synthetase 3
chr14_-_34561696 6.43 ENSRNOT00000059763
steroid 5 alpha-reductase 3
chr3_+_3389612 6.39 ENSRNOT00000041984
ribosomal protein L8
chr14_+_21177237 6.18 ENSRNOT00000004866
immunoglobulin joining chain
chr1_+_185863043 6.04 ENSRNOT00000079072
SRY box 6
chr13_-_83457888 5.94 ENSRNOT00000076289
ENSRNOT00000004065
SFT2 domain containing 2
chr16_+_72010106 5.92 ENSRNOT00000058330
ADAM metallopeptidase domain 5
chr13_-_50916982 5.84 ENSRNOT00000004408
BTG anti-proliferation factor 2
chrX_+_110014252 5.82 ENSRNOT00000093611
Nik related kinase
chrX_+_96863891 5.76 ENSRNOT00000085665

chr10_-_51778939 5.74 ENSRNOT00000078675
ENSRNOT00000057562
myocardin
chr10_-_85725429 5.73 ENSRNOT00000005471
ribosomal protein L23
chr4_+_103495993 5.73 ENSRNOT00000072325

chr1_+_260093641 5.70 ENSRNOT00000019521
cyclin J
chr10_-_29026002 5.58 ENSRNOT00000005070
pituitary tumor-transforming 1
chr1_+_22332090 5.55 ENSRNOT00000091252
trace amine-associated receptor 8c (Taar8c), mRNA
chr2_+_187447501 5.47 ENSRNOT00000038589
IQ motif containing GTPase activating protein 3
chr6_-_140485913 5.46 ENSRNOT00000048463

chr1_+_253221812 5.32 ENSRNOT00000085880
ENSRNOT00000054753
kinesin family member 20B
chr4_+_101531378 5.30 ENSRNOT00000087546

chr7_-_123088279 5.28 ENSRNOT00000071998
transducer of ERBB2, 2
chr3_-_165537940 5.23 ENSRNOT00000071119
ENSRNOT00000070964
spalt-like transcription factor 4
chr15_+_32828165 5.21 ENSRNOT00000060253

chr8_-_43304560 5.21 ENSRNOT00000060092
olfactory receptor 1307
chr1_-_78180216 5.19 ENSRNOT00000071576
complement component 5a receptor 2
chr6_+_138432550 5.18 ENSRNOT00000056829
a disintegrin and metallopeptidase domain 6
chr5_-_162751128 5.10 ENSRNOT00000068281
similar to novel protein similar to esterases
chr13_-_30800451 5.08 ENSRNOT00000046791
ribosomal protein L21
chr4_+_102262007 4.99 ENSRNOT00000079328

chr13_-_61306939 4.92 ENSRNOT00000086610
regulator of G-protein signaling 21
chr11_+_54619129 4.83 ENSRNOT00000059924
T cell receptor associated transmembrane adaptor 1
chr4_+_156253079 4.81 ENSRNOT00000013536
C-type lectin domain family 4, member D
chr7_+_16404755 4.79 ENSRNOT00000044977
olfactory receptor 6C70-like
chr4_+_101949285 4.79 ENSRNOT00000058446

chr11_-_62451149 4.76 ENSRNOT00000093686
ENSRNOT00000081443
zinc finger and BTB domain containing 20
chr6_+_126766967 4.75 ENSRNOT00000052296
cytochrome c oxidase subunit 8C
chr1_-_3849080 4.72 ENSRNOT00000045301
similar to ribosomal protein L27a
chr3_+_8430829 4.71 ENSRNOT00000090440
ENSRNOT00000060969
cerebral endothelial cell adhesion molecule
chr3_+_148327965 4.71 ENSRNOT00000010851
ENSRNOT00000088481
TPX2, microtubule nucleation factor
chr1_-_166919302 4.70 ENSRNOT00000026925
folate receptor beta
chrX_+_1543244 4.66 ENSRNOT00000071634

chr11_-_82366505 4.66 ENSRNOT00000041326
similar to ribosomal protein L27a
chr14_-_24123253 4.62 ENSRNOT00000002743
transmembrane protease, serine 11B
chrX_+_1600790 4.62 ENSRNOT00000072444

chr8_+_107859366 4.51 ENSRNOT00000039690
alpha-1,4-N-acetylglucosaminyltransferase
chr20_-_5020150 4.30 ENSRNOT00000001146
suppressor APC domain containing 1
chr4_-_66955732 4.28 ENSRNOT00000084282
lysine (K)-specific demethylase 7A
chr1_+_101397828 4.28 ENSRNOT00000028189
potassium voltage-gated channel subfamily A member 7
chr17_+_52755621 4.22 ENSRNOT00000089943
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha), pseudogene 1
chr7_-_139649286 4.21 ENSRNOT00000080056
SUMO1/sentrin specific peptidase 1
chr14_-_46524476 4.18 ENSRNOT00000079005
rRNA promoter binding protein
chr10_+_61685645 4.18 ENSRNOT00000003933
MAX network transcriptional repressor
chrX_-_106607352 4.11 ENSRNOT00000082858

chr2_-_147392062 4.11 ENSRNOT00000021535
transmembrane 4 L six family member 1
chr4_+_22898527 4.08 ENSRNOT00000072455
ENSRNOT00000076123
DBF4 zinc finger
chr12_-_5685448 4.07 ENSRNOT00000077167
FRY microtubule binding protein
chr3_-_94808861 4.05 ENSRNOT00000038464
proline rich and Gla domain 4
chr1_-_63684189 4.03 ENSRNOT00000085651
leukocyte immunoglobulin-like receptor, subfamily C, member 2
chr17_-_46115004 4.02 ENSRNOT00000087838
acyloxyacyl hydrolase
chr5_-_154438361 4.00 ENSRNOT00000085003

chr1_+_128637049 3.92 ENSRNOT00000018639
tetratricopeptide repeat domain 23
chr9_-_80295446 3.92 ENSRNOT00000023769
transition protein 1
chr20_+_3155652 3.84 ENSRNOT00000042882
RT1 class Ib, locus S2
chr11_-_62067655 3.79 ENSRNOT00000093382
zinc finger and BTB domain containing 20
chr4_-_119327822 3.78 ENSRNOT00000012645
Rho GTPase activating protein 25
chr14_+_82603671 3.78 ENSRNOT00000073177
NK1 homeobox 1
chr6_+_139428999 3.78 ENSRNOT00000084482

chr14_-_44375804 3.75 ENSRNOT00000042825
ribosomal protein P2-like
chr3_+_112346627 3.73 ENSRNOT00000074392
synaptosomal-associated protein 23
chr10_+_107502695 3.65 ENSRNOT00000038088
endo-beta-N-acetylglucosaminidase
chr15_+_108318664 3.64 ENSRNOT00000057469
UBA domain containing 2
chr4_-_167202106 3.61 ENSRNOT00000038581
taste receptor, type 2, member 140
chr4_+_162292305 3.57 ENSRNOT00000010098
C-type lectin domain family 2, member D
chr7_-_139542461 3.56 ENSRNOT00000089425
SUMO1/sentrin specific peptidase 1
chr8_+_117117430 3.56 ENSRNOT00000073247
glutathione peroxidase 1
chr20_+_4357733 3.49 ENSRNOT00000000509
PBX homeobox 2
chr10_-_74679858 3.45 ENSRNOT00000003859
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr5_+_36566783 3.41 ENSRNOT00000077650
F-box and leucine-rich repeat protein 4
chr7_+_42304534 3.41 ENSRNOT00000085097
KIT ligand
chr16_+_2634603 3.33 ENSRNOT00000019113
HESX homeobox 1
chr1_-_278042312 3.32 ENSRNOT00000018693
actin-binding LIM protein 1
chr12_-_40590361 3.30 ENSRNOT00000067503
transmembrane protein 116
chr4_-_103761881 3.30 ENSRNOT00000084103

chr1_-_80835701 3.29 ENSRNOT00000064305
poliovirus receptor
chr13_-_91735361 3.25 ENSRNOT00000058090
Fc fragment of IgE receptor Ia
chr8_-_39460844 3.16 ENSRNOT00000048875
PBX/knotted 1 homeobox 2
chr11_-_43022565 3.15 ENSRNOT00000002285
ribosomal oxygenase 2
chr1_-_88162583 3.12 ENSRNOT00000087411
cation channel sperm associated auxiliary subunit gamma
chr14_+_23405717 3.10 ENSRNOT00000029805
transmembrane protease, serine 11C
chr18_-_55891710 3.09 ENSRNOT00000064686
synaptopodin
chr11_+_34865532 2.99 ENSRNOT00000050342
dual specificity tyrosine phosphorylation regulated kinase 1A
chr10_-_87564327 2.96 ENSRNOT00000064760
ENSRNOT00000068237
similar to keratin associated protein 4-7
chr8_+_100260049 2.95 ENSRNOT00000011090

chr4_+_31229913 2.95 ENSRNOT00000077134
ENSRNOT00000087897
sterile alpha motif domain containing 9-like
chr1_+_279633671 2.93 ENSRNOT00000036012
ENSRNOT00000091669
coiled-coil domain containing 172
chr7_+_40318490 2.92 ENSRNOT00000081374
similar to hypothetical protein FLJ35821
chr2_-_60657712 2.91 ENSRNOT00000040348
retinoic acid induced 14
chr7_-_134482607 2.90 ENSRNOT00000081104
glucoside xylosyltransferase 1
chr3_-_4341771 2.85 ENSRNOT00000034694
similar to ribosomal protein S13
chr4_+_101909389 2.82 ENSRNOT00000086458

chrX_-_124252447 2.78 ENSRNOT00000061546
reproductive homeobox 12
chr4_-_169036950 2.78 ENSRNOT00000011295
germ cell associated 1
chr1_+_21613148 2.76 ENSRNOT00000018695
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr15_-_57651041 2.76 ENSRNOT00000072138
spermatid associated
chr5_+_33097654 2.69 ENSRNOT00000008087
cyclic nucleotide gated channel beta 3
chr16_+_71629525 2.67 ENSRNOT00000035347
ENSRNOT00000088462
transforming, acidic coiled-coil containing protein 1
chr18_+_30869628 2.67 ENSRNOT00000060470
protocadherin gamma subfamily B, 4
chr1_+_93242050 2.67 ENSRNOT00000013741
similar to 60S ribosomal protein L27a
chr16_-_75518336 2.63 ENSRNOT00000058037
defensin alpha 11
chr3_+_38367556 2.60 ENSRNOT00000049144
similar to developmental pluripotency associated 5

Network of associatons between targets according to the STRING database.

First level regulatory network of Lhx5_Lmx1b_Lhx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.8 23.5 GO:0002838 stimulatory C-type lectin receptor signaling pathway(GO:0002223) negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859)
7.0 20.9 GO:0042706 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
4.2 12.6 GO:0014739 positive regulation of muscle hyperplasia(GO:0014739)
4.0 11.9 GO:0032639 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) TRAIL production(GO:0032639) regulation of TRAIL production(GO:0032679) positive regulation of TRAIL production(GO:0032759)
3.4 17.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
3.3 16.5 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
3.0 9.1 GO:1901227 negative regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901227)
3.0 8.9 GO:2000422 regulation of eosinophil chemotaxis(GO:2000422) positive regulation of eosinophil chemotaxis(GO:2000424)
2.9 20.4 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
2.4 16.7 GO:1900020 activation of phospholipase D activity(GO:0031584) regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
2.1 12.5 GO:0060723 regulation of spongiotrophoblast cell proliferation(GO:0060721) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
1.8 10.9 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
1.8 10.9 GO:0002399 MHC class II protein complex assembly(GO:0002399) peptide antigen assembly with MHC class II protein complex(GO:0002503)
1.8 5.3 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
1.8 7.1 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
1.7 7.0 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
1.7 19.1 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
1.7 10.0 GO:0042483 negative regulation of odontogenesis(GO:0042483)
1.7 46.4 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
1.6 3.3 GO:0045425 regulation of interleukin-3 production(GO:0032672) positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
1.5 9.0 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
1.5 7.4 GO:2000574 regulation of microtubule motor activity(GO:2000574)
1.4 25.0 GO:0032060 bleb assembly(GO:0032060)
1.4 6.9 GO:0060005 vestibular reflex(GO:0060005)
1.4 20.5 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
1.3 6.4 GO:0016095 polyprenol catabolic process(GO:0016095)
1.2 3.6 GO:0009609 response to symbiotic bacterium(GO:0009609)
1.1 6.8 GO:0030263 apoptotic chromosome condensation(GO:0030263)
1.1 6.7 GO:0061737 leukotriene signaling pathway(GO:0061737)
1.1 7.8 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
1.1 6.6 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660)
1.1 3.3 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
1.1 13.8 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
1.0 8.3 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
1.0 6.2 GO:0060267 positive regulation of respiratory burst(GO:0060267)
1.0 4.1 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
1.0 6.0 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
1.0 7.6 GO:0006751 glutathione catabolic process(GO:0006751)
0.9 2.8 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.9 11.4 GO:0001778 plasma membrane repair(GO:0001778)
0.9 4.3 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.9 3.4 GO:0033026 negative regulation of mast cell apoptotic process(GO:0033026)
0.8 5.7 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.8 13.2 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.8 3.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.6 5.2 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
0.6 6.4 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.6 1.9 GO:1902211 regulation of prolactin signaling pathway(GO:1902211)
0.6 23.5 GO:0032814 regulation of natural killer cell activation(GO:0032814)
0.6 1.8 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.6 10.0 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.6 4.7 GO:0015884 folic acid transport(GO:0015884)
0.6 2.3 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
0.6 7.9 GO:0009744 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.6 3.9 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.6 3.3 GO:0030916 otic vesicle formation(GO:0030916)
0.5 3.7 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.5 1.5 GO:0034034 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.5 2.0 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.5 5.8 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.5 1.4 GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902167)
0.5 1.4 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.5 1.8 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.5 2.3 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.5 5.5 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.4 4.8 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.4 4.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.4 3.2 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.4 1.2 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.4 2.6 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.4 1.1 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.4 7.5 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.4 1.4 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.4 8.2 GO:0060216 definitive hemopoiesis(GO:0060216)
0.4 3.2 GO:0000733 DNA strand renaturation(GO:0000733)
0.3 1.4 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.3 1.7 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.3 15.8 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.3 1.6 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.3 2.5 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.3 0.9 GO:0021558 trochlear nerve development(GO:0021558)
0.3 2.9 GO:0016266 O-glycan processing(GO:0016266)
0.3 7.5 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 5.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.3 1.4 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.3 1.3 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.3 0.8 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.3 7.1 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.3 7.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.3 2.0 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.2 3.7 GO:0006517 protein deglycosylation(GO:0006517)
0.2 5.3 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.2 1.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.2 11.5 GO:0050873 brown fat cell differentiation(GO:0050873)
0.2 0.9 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.2 3.0 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.2 3.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 0.9 GO:1904925 positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.2 1.6 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.2 5.6 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.2 21.8 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.2 12.0 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.2 1.2 GO:2000394 positive regulation of lamellipodium morphogenesis(GO:2000394)
0.2 34.5 GO:0006941 striated muscle contraction(GO:0006941)
0.2 2.7 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.2 2.2 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.2 10.1 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 0.5 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.2 3.4 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.2 2.6 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.2 0.8 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 4.2 GO:0009303 rRNA transcription(GO:0009303)
0.1 1.7 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.3 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
0.1 9.2 GO:0001824 blastocyst development(GO:0001824)
0.1 0.6 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 1.4 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 0.7 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 1.9 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.6 GO:0002225 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803)
0.1 2.0 GO:0003283 atrial septum development(GO:0003283)
0.1 0.3 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.1 1.1 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.1 4.6 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 2.9 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.1 1.6 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 3.5 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 0.4 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 1.4 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.1 1.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 0.4 GO:0035627 ceramide transport(GO:0035627)
0.1 0.4 GO:0052055 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422) regulation of exo-alpha-sialidase activity(GO:1903015)
0.1 1.4 GO:0032288 myelin assembly(GO:0032288)
0.1 1.1 GO:0015816 glycine transport(GO:0015816)
0.1 3.8 GO:0043467 regulation of generation of precursor metabolites and energy(GO:0043467)
0.1 1.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.8 GO:1904894 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.1 4.6 GO:0006334 nucleosome assembly(GO:0006334)
0.1 0.6 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 1.2 GO:0035404 histone-serine phosphorylation(GO:0035404)
0.1 1.9 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.1 0.9 GO:0090520 sphingolipid mediated signaling pathway(GO:0090520)
0.1 0.6 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.1 1.8 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.1 2.3 GO:0009060 aerobic respiration(GO:0009060)
0.1 4.4 GO:0050909 sensory perception of taste(GO:0050909)
0.1 1.9 GO:0042755 eating behavior(GO:0042755)
0.1 4.4 GO:0044264 cellular polysaccharide metabolic process(GO:0044264)
0.1 4.2 GO:0007569 cell aging(GO:0007569)
0.0 2.2 GO:0007566 embryo implantation(GO:0007566)
0.0 0.1 GO:0006288 base-excision repair, DNA ligation(GO:0006288)
0.0 1.9 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.2 GO:0034475 U4 snRNA 3'-end processing(GO:0034475) DNA deamination(GO:0045006) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 2.4 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.5 GO:0001696 gastric acid secretion(GO:0001696)
0.0 0.4 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.0 2.5 GO:0030216 keratinocyte differentiation(GO:0030216)
0.0 1.2 GO:0006611 protein export from nucleus(GO:0006611)
0.0 2.4 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 2.4 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 1.4 GO:0051225 spindle assembly(GO:0051225)
0.0 0.5 GO:0007602 phototransduction(GO:0007602)
0.0 0.1 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.0 23.3 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.2 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.2 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.7 GO:0001658 branching involved in ureteric bud morphogenesis(GO:0001658)
0.0 0.1 GO:0072347 response to anesthetic(GO:0072347)
0.0 0.2 GO:0034587 piRNA metabolic process(GO:0034587)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
15.5 46.4 GO:0014801 longitudinal sarcoplasmic reticulum(GO:0014801)
7.6 38.0 GO:0005927 muscle tendon junction(GO:0005927)
4.2 16.7 GO:0042585 germinal vesicle(GO:0042585) dendritic branch(GO:0044307)
4.0 11.9 GO:0032398 MHC class Ib protein complex(GO:0032398)
2.4 7.1 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
2.3 9.0 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
1.7 6.8 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
1.5 6.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
1.5 29.2 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
1.3 11.4 GO:0005826 actomyosin contractile ring(GO:0005826)
1.2 8.6 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
1.1 5.3 GO:0070938 contractile ring(GO:0070938)
1.0 3.1 GO:0097444 spine apparatus(GO:0097444)
0.9 6.3 GO:0005579 membrane attack complex(GO:0005579)
0.9 25.8 GO:0046930 pore complex(GO:0046930)
0.7 8.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.7 3.6 GO:0097413 Lewy body(GO:0097413)
0.7 10.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.7 10.8 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.7 4.7 GO:0043203 axon hillock(GO:0043203)
0.6 7.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.5 2.3 GO:0098536 deuterosome(GO:0098536)
0.5 12.6 GO:0001891 phagocytic cup(GO:0001891)
0.4 3.1 GO:0036128 CatSper complex(GO:0036128)
0.4 11.6 GO:0002080 acrosomal membrane(GO:0002080)
0.4 9.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.3 2.0 GO:0005663 DNA replication factor C complex(GO:0005663)
0.3 29.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 4.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 4.8 GO:0042581 specific granule(GO:0042581)
0.3 43.5 GO:0030018 Z disc(GO:0030018)
0.3 4.8 GO:0042101 T cell receptor complex(GO:0042101)
0.2 4.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.2 11.6 GO:0045171 intercellular bridge(GO:0045171)
0.2 6.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 1.4 GO:0005608 laminin-3 complex(GO:0005608)
0.2 1.2 GO:0000322 storage vacuole(GO:0000322)
0.2 2.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 1.9 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.2 12.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.2 1.4 GO:0030870 Mre11 complex(GO:0030870)
0.2 2.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.2 1.4 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.2 1.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.2 2.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 1.0 GO:0097209 epidermal lamellar body(GO:0097209)
0.2 0.5 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.2 49.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 3.1 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 5.2 GO:0009925 basal plasma membrane(GO:0009925)
0.1 7.0 GO:0031519 PcG protein complex(GO:0031519)
0.1 2.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 7.1 GO:0031594 neuromuscular junction(GO:0031594)
0.1 5.3 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.7 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 1.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.2 GO:0005796 Golgi lumen(GO:0005796)
0.1 31.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 1.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.6 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 4.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.4 GO:0097255 R2TP complex(GO:0097255)
0.1 0.4 GO:0070847 core mediator complex(GO:0070847)
0.1 5.2 GO:0000792 heterochromatin(GO:0000792)
0.1 0.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 1.0 GO:0001520 outer dense fiber(GO:0001520)
0.1 7.9 GO:0005903 brush border(GO:0005903)
0.1 2.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.3 GO:0000243 commitment complex(GO:0000243)
0.0 3.4 GO:0031970 organelle envelope lumen(GO:0031970)
0.0 0.1 GO:0070421 DNA ligase III-XRCC1 complex(GO:0070421)
0.0 0.5 GO:0017119 Golgi transport complex(GO:0017119)
0.0 3.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 20.5 GO:0009986 cell surface(GO:0009986)
0.0 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 10.4 GO:0031965 nuclear membrane(GO:0031965)
0.0 9.9 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 4.6 GO:0005938 cell cortex(GO:0005938)
0.0 1.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.5 GO:0015934 large ribosomal subunit(GO:0015934)
0.0 0.1 GO:0000791 euchromatin(GO:0000791)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.1 GO:0071546 pi-body(GO:0071546)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 17.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
3.9 27.5 GO:0030881 beta-2-microglobulin binding(GO:0030881)
3.3 10.0 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
2.6 7.9 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
2.3 9.0 GO:0019002 GMP binding(GO:0019002)
2.2 10.9 GO:0005134 interleukin-2 receptor binding(GO:0005134)
1.7 5.2 GO:0001847 opsonin receptor activity(GO:0001847)
1.7 6.8 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
1.6 6.4 GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
1.6 7.8 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
1.5 7.4 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
1.3 6.7 GO:0004974 leukotriene receptor activity(GO:0004974)
1.3 6.4 GO:1990932 5.8S rRNA binding(GO:1990932)
1.3 7.6 GO:0036374 gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
1.2 6.2 GO:0019862 IgA binding(GO:0019862)
1.2 26.1 GO:0004745 retinol dehydrogenase activity(GO:0004745)
1.2 4.7 GO:0051870 methotrexate binding(GO:0051870)
1.2 7.0 GO:0031727 CCR1 chemokine receptor binding(GO:0031726) CCR2 chemokine receptor binding(GO:0031727)
1.1 5.7 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
1.1 25.8 GO:0015288 porin activity(GO:0015288)
1.1 6.6 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
1.1 5.5 GO:0032027 myosin light chain binding(GO:0032027)
0.9 4.7 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.9 2.8 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.9 2.6 GO:0032551 UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551)
0.8 14.8 GO:0044548 S100 protein binding(GO:0044548)
0.8 2.4 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.8 2.3 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.7 6.4 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.7 12.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.6 41.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.6 10.9 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.5 3.3 GO:0019767 IgE receptor activity(GO:0019767)
0.5 3.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.5 3.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.5 7.1 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.5 3.3 GO:0045503 dynein light chain binding(GO:0045503)
0.5 1.4 GO:0001069 regulatory region RNA binding(GO:0001069)
0.4 5.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.4 4.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.4 2.9 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.4 2.9 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.4 11.6 GO:0003785 actin monomer binding(GO:0003785)
0.4 1.5 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.4 1.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.3 5.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3 3.1 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.3 0.9 GO:0016882 cyclo-ligase activity(GO:0016882)
0.3 9.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.3 17.0 GO:0005080 protein kinase C binding(GO:0005080)
0.3 1.3 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.3 0.8 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.3 9.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.2 0.9 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.2 2.7 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.2 2.0 GO:0035497 cAMP response element binding(GO:0035497)
0.2 2.0 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 1.4 GO:0004065 arylsulfatase activity(GO:0004065)
0.2 4.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 1.5 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.2 2.0 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.2 1.4 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.2 5.7 GO:0070412 R-SMAD binding(GO:0070412)
0.2 1.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.2 11.5 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 24.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 3.0 GO:0048156 tau protein binding(GO:0048156)
0.2 1.7 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 0.7 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 16.7 GO:0005178 integrin binding(GO:0005178)
0.1 2.6 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 1.7 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 3.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 16.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.5 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 0.4 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 1.8 GO:0005523 tropomyosin binding(GO:0005523)
0.1 4.6 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 0.6 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 4.5 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 1.1 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 20.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.2 GO:0019961 interferon binding(GO:0019961)
0.1 0.3 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 5.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 1.8 GO:0019843 rRNA binding(GO:0019843)
0.1 1.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 23.3 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.4 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
0.1 9.6 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 1.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 3.1 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 1.7 GO:0050681 androgen receptor binding(GO:0050681)
0.1 2.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 1.9 GO:0008009 chemokine activity(GO:0008009)
0.1 10.2 GO:0051015 actin filament binding(GO:0051015)
0.1 0.9 GO:0071837 HMG box domain binding(GO:0071837)
0.1 2.8 GO:0070063 RNA polymerase binding(GO:0070063)
0.1 4.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 3.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 2.2 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 1.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 8.4 GO:0042393 histone binding(GO:0042393)
0.0 3.7 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.4 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 9.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 6.7 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 16.9 GO:0008134 transcription factor binding(GO:0008134)
0.0 1.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 4.7 GO:0005179 hormone activity(GO:0005179)
0.0 0.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 5.5 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 2.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 6.4 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 1.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.2 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 23.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.1 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 1.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.0 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 3.2 GO:0003779 actin binding(GO:0003779)
0.0 0.3 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.4 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 0.3 GO:0017069 snRNA binding(GO:0017069)
0.0 0.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 3.7 GO:0005525 GTP binding(GO:0005525)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 30.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.3 6.6 PID LPA4 PATHWAY LPA4-mediated signaling events
0.3 1.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.3 10.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.3 12.2 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.3 7.1 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.3 7.1 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.3 8.5 PID AURORA A PATHWAY Aurora A signaling
0.2 12.5 PID TNF PATHWAY TNF receptor signaling pathway
0.2 14.8 PID FGF PATHWAY FGF signaling pathway
0.2 11.5 PID NOTCH PATHWAY Notch signaling pathway
0.2 11.5 PID E2F PATHWAY E2F transcription factor network
0.2 6.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.3 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 7.8 PID P53 REGULATION PATHWAY p53 pathway
0.1 5.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 6.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 3.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 5.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 3.1 PID ENDOTHELIN PATHWAY Endothelins
0.1 3.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 4.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 1.9 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 5.2 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.4 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.1 0.7 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 6.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.5 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.4 PID MYC PATHWAY C-MYC pathway
0.0 0.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.8 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.4 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 3.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 16.7 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
1.3 7.9 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
1.1 14.8 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.8 11.5 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.7 27.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.6 6.7 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.5 6.7 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.4 9.0 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.4 6.6 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.4 3.4 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.4 3.6 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.3 4.8 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.3 3.9 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.3 5.6 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.3 15.5 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.3 19.1 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.3 7.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.3 7.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 9.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 18.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.2 2.6 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.2 9.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 3.0 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 12.7 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.1 1.4 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 5.3 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.1 1.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 3.0 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 3.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 2.9 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 3.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.2 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.1 1.8 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 4.3 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 3.7 REACTOME TRANS GOLGI NETWORK VESICLE BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.0 0.5 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.1 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.4 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.2 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.4 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.4 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.9 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase