ISMARA results: Klf6

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Klf6_Patz1

Z-value: 1.62

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Transcription factors associated with Klf6_Patz1

Gene Symbol	Gene ID	Gene Info
Klf6 NCBI RGD Ensembl	ENSRNOG00000016885	Kruppel-like factor 6
Patz1 NCBI RGD Ensembl	ENSRNOG00000018709	POZ (BTB) and AT hook containing zinc finger 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Klf6	rn6_v1_chr17_-_67904674_67904674	-0.27	1.3e-06	Click!
Patz1	rn6_v1_chr14_+_83510640_83510640	-0.05	3.4e-01	Click!

Activity profile of Klf6_Patz1 motif

Sorted Z-values of Klf6_Patz1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_+_20607507 Show fit	78.84	ENSRNOT00000000011	Cbln1 NCBI RGD Ensembl Show fit	cerebellin 1 precursor
chr1_-_198454914 Show fit	65.59	ENSRNOT00000049044	Prrt2 NCBI RGD Ensembl Show fit	proline-rich transmembrane protein 2
chr15_+_3936786 Show fit	59.84	ENSRNOT00000066163	Camk2g NCBI RGD Ensembl Show fit	calcium/calmodulin-dependent protein kinase II gamma
chr20_-_48503898 Show fit	53.92	ENSRNOT00000073091	Wasf1 NCBI RGD Ensembl Show fit	WAS protein family, member 1
chr7_-_116607674 Show fit	52.64	ENSRNOT00000076014	Ly6h NCBI RGD Ensembl Show fit	lymphocyte antigen 6 complex, locus H
chr5_+_139783951 Show fit	52.17	ENSRNOT00000081333	Rims3 NCBI RGD Ensembl Show fit	regulating synaptic membrane exocytosis 3
chr10_-_85974644 Show fit	49.24	ENSRNOT00000006098 ENSRNOT00000082974	Cacnb1 NCBI RGD Ensembl Show fit	calcium voltage-gated channel auxiliary subunit beta 1
chr8_-_94564525 Show fit	47.29	ENSRNOT00000084437	Snap91 NCBI RGD Ensembl Show fit	synaptosomal-associated protein 91
chr9_+_73493027 Show fit	45.91	ENSRNOT00000074427 ENSRNOT00000089478	Unc80 NCBI RGD Ensembl Show fit	unc-80 homolog, NALCN activator
chr9_+_9961021 Show fit	45.03	ENSRNOT00000075767	Tubb4a NCBI RGD Ensembl Show fit	tubulin, beta 4A class IVa

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf6_Patz1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.5	157.7	GO:2000300	regulation of synaptic vesicle exocytosis(GO:2000300)
3.9	109.4	GO:1903831	acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
15.4	92.6	GO:0097116	gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
1.8	86.0	GO:0021762	substantia nigra development(GO:0021762)
7.1	85.5	GO:0021684	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
4.7	85.4	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.7	84.4	GO:0048167	regulation of synaptic plasticity(GO:0048167)
9.0	71.9	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
6.3	69.4	GO:1901897	regulation of relaxation of cardiac muscle(GO:1901897)
11.0	65.7	GO:1902513	regulation of organelle transport along microtubule(GO:1902513)

Showing 1 to 10 of 564 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	290.0	GO:0098793	presynapse(GO:0098793)
4.9	217.6	GO:0048786	presynaptic active zone(GO:0048786)
2.5	206.7	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
3.5	148.4	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
5.0	124.5	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
3.8	114.3	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
3.1	108.4	GO:0032590	dendrite membrane(GO:0032590)
0.8	101.3	GO:0045211	postsynaptic membrane(GO:0045211)
9.7	97.1	GO:0044300	cerebellar mossy fiber(GO:0044300)
1.3	95.2	GO:0008076	voltage-gated potassium channel complex(GO:0008076)

Showing 1 to 10 of 227 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	270.9	GO:0044325	ion channel binding(GO:0044325)
1.9	140.2	GO:0030276	clathrin binding(GO:0030276)
3.5	118.7	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
16.8	117.6	GO:0097109	neuroligin family protein binding(GO:0097109)
1.6	95.4	GO:0005080	protein kinase C binding(GO:0005080)
6.6	92.4	GO:0030550	acetylcholine receptor inhibitor activity(GO:0030550)
0.2	85.4	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
1.2	78.1	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.4	77.4	GO:0008017	microtubule binding(GO:0008017)
4.5	75.9	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)

Showing 1 to 10 of 324 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	107.7	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
4.0	102.9	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
2.4	81.9	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
2.6	70.9	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
2.5	43.3	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.9	40.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.9	38.6	PID TNF PATHWAY	TNF receptor signaling pathway
1.0	37.0	PID RAS PATHWAY	Regulation of Ras family activation
3.0	36.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
1.3	34.1	PID NETRIN PATHWAY	Netrin-mediated signaling events

Showing 1 to 10 of 51 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	132.7	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
3.3	73.3	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
4.0	72.8	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
5.0	70.4	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
3.7	66.4	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
1.4	59.8	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.7	59.5	REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	Genes involved in Transmission across Chemical Synapses
1.8	57.9	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	52.3	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
2.2	51.7	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription

Showing 1 to 10 of 116 entries

Results for Klf6_Patz1

Z-value: 1.62

Motif logo

Transcription factors associated with Klf6_Patz1

Activity-expression correlation:

Activity profile of Klf6_Patz1 motif

Sorted Z-values of Klf6_Patz1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf6_Patz1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: