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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Klf3

Z-value: 0.19

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Transcription factors associated with Klf3

Gene Symbol Gene ID Gene Info
ENSRNOG00000002163 Kruppel like factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Klf3rn6_v1_chr14_-_45165207_451652070.211.8e-04Click!

Activity profile of Klf3 motif

Sorted Z-values of Klf3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_7064870 4.03 ENSRNOT00000019983
syntaxin 11
chr1_+_226091774 2.67 ENSRNOT00000027693
fatty acid desaturase 3
chr4_+_100407658 1.89 ENSRNOT00000018562
capping actin protein, gelsolin like
chr8_-_94563760 1.69 ENSRNOT00000032792
synaptosomal-associated protein 91
chr19_-_1074333 1.68 ENSRNOT00000017983
ENSRNOT00000086995
cadherin 5
chrX_-_72133692 1.32 ENSRNOT00000004263
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr10_-_56465393 1.16 ENSRNOT00000056860
tyrosine kinase, non-receptor, 1
chr8_-_117082162 1.03 ENSRNOT00000075241
T-cell leukemia translocation altered
chr2_+_206314213 0.94 ENSRNOT00000056068
BCL2-like 15
chr7_-_144322240 0.79 ENSRNOT00000089290
calcium-binding and coiled-coil domain-containing protein 1-like
chr7_-_145450233 0.74 ENSRNOT00000092974
ENSRNOT00000021523
calcium binding and coiled coil domain 1
chr7_-_75597087 0.61 ENSRNOT00000080676
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr13_+_27449934 0.51 ENSRNOT00000003409
serpin family B member 2
chr1_-_78968329 0.47 ENSRNOT00000023078
protein phosphatase 5, catalytic subunit
chr8_-_55171718 0.46 ENSRNOT00000080736
hypothetical protein LOC689959
chr8_+_118013612 0.20 ENSRNOT00000056166
microtubule-associated protein 4
chr1_-_274106502 0.17 ENSRNOT00000020539
survival motor neuron domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0043316 cytotoxic T cell degranulation(GO:0043316)
0.3 1.7 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.3 1.3 GO:0071104 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003340) response to interleukin-9(GO:0071104)
0.2 1.7 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 0.6 GO:0090168 Golgi reassembly(GO:0090168)
0.1 1.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.2 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.5 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 2.7 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 1.2 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0098830 presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.3 1.9 GO:0090543 Flemming body(GO:0090543)
0.1 4.0 GO:0031201 SNARE complex(GO:0031201)
0.0 0.5 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.6 GO:0042629 mast cell granule(GO:0042629)
0.0 1.7 GO:0005913 cell-cell adherens junction(GO:0005913)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 1.3 GO:0050693 LBD domain binding(GO:0050693)
0.1 4.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 1.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.7 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.5 GO:0051879 Hsp90 protein binding(GO:0051879)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.0 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling