ISMARA results: Klf16

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Klf16_Sp8

Z-value: 2.51

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Transcription factors associated with Klf16_Sp8

Gene Symbol	Gene ID	Gene Info
Klf16 NCBI RGD Ensembl	ENSRNOG00000033694	Kruppel-like factor 16
Sp8 NCBI RGD Ensembl	ENSRNOG00000005943	Sp8 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Klf16	rn6_v1_chr7_+_12006710_12006710	-0.44	6.7e-17	Click!
Sp8	rn6_v1_chr6_+_146784915_146784915	-0.22	6.7e-05	Click!

Activity profile of Klf16_Sp8 motif

Sorted Z-values of Klf16_Sp8 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_36320461 Show fit	185.52	ENSRNOT00000023659	Srd5a1 NCBI RGD Ensembl Show fit	steroid 5 alpha-reductase 1
chr13_-_50499060 Show fit	156.41	ENSRNOT00000065347 ENSRNOT00000076924	Etnk2 NCBI RGD Ensembl Show fit	ethanolamine kinase 2
chr8_-_22937909 Show fit	131.40	ENSRNOT00000015684	Tmem205 NCBI RGD Ensembl Show fit	transmembrane protein 205
chr7_-_12246729 Show fit	130.00	ENSRNOT00000044030	Reep6 NCBI RGD Ensembl Show fit	receptor accessory protein 6
chrX_-_54303729 Show fit	115.47	ENSRNOT00000087919 ENSRNOT00000064340 ENSRNOT00000051249 ENSRNOT00000087547	Gk NCBI RGD Ensembl Show fit	glycerol kinase
chr16_-_32868680 Show fit	113.82	ENSRNOT00000015974 ENSRNOT00000082392	Aadat NCBI RGD Ensembl Show fit	aminoadipate aminotransferase
chr6_-_108167185 Show fit	110.45	ENSRNOT00000015545	Aldh6a1 NCBI RGD Ensembl Show fit	aldehyde dehydrogenase 6 family, member A1
chr1_-_80666566 Show fit	107.61	ENSRNOT00000082125 ENSRNOT00000025388	Nectin2 NCBI RGD Ensembl Show fit	nectin cell adhesion molecule 2
chr3_-_176144531 Show fit	102.70	ENSRNOT00000082266	Tcfl5 NCBI RGD Ensembl Show fit	transcription factor like 5
chr1_-_80599572 Show fit	99.23	ENSRNOT00000024832	Apoc4 NCBI RGD Ensembl Show fit	apolipoprotein C4

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf16_Sp8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
9.4	328.2	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
9.0	324.0	GO:0006695	cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
1.0	320.6	GO:0007283	spermatogenesis(GO:0007283)
5.5	283.8	GO:0006635	fatty acid beta-oxidation(GO:0006635)
34.6	276.8	GO:0006559	L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
14.6	218.9	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646)
13.4	215.1	GO:0042448	progesterone metabolic process(GO:0042448)
4.2	191.7	GO:0008203	cholesterol metabolic process(GO:0008203)
23.1	185.1	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.1	164.2	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)

Showing 1 to 10 of 1,034 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	2067.1	GO:0005739	mitochondrion(GO:0005739)
3.5	1061.2	GO:0005759	mitochondrial matrix(GO:0005759)
1.3	699.8	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
4.2	611.2	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
3.2	419.8	GO:0001669	acrosomal vesicle(GO:0001669)
19.9	317.7	GO:0070852	cell body fiber(GO:0070852)
18.2	236.1	GO:0034385	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
3.4	224.1	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
8.9	187.9	GO:0060293	P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
1.7	166.4	GO:0072562	blood microparticle(GO:0072562)

Showing 1 to 10 of 294 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.9	427.0	GO:0004364	glutathione transferase activity(GO:0004364)
1.9	412.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
11.4	297.2	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
11.0	241.9	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
15.1	226.6	GO:0004029	aldehyde dehydrogenase (NAD) activity(GO:0004029)
44.6	223.2	GO:0004103	choline kinase activity(GO:0004103)
5.5	215.3	GO:0070330	aromatase activity(GO:0070330)
1.7	193.4	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
47.1	188.5	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
21.2	169.5	GO:0008172	S-methyltransferase activity(GO:0008172)

Showing 1 to 10 of 605 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.1	280.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.6	145.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
2.0	90.1	PID HNF3A PATHWAY	FOXA1 transcription factor network
2.0	89.8	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
3.4	72.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
1.3	67.2	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
2.3	66.9	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.2	64.8	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
2.1	60.4	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
2.6	55.3	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Showing 1 to 10 of 61 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.9	1038.4	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
13.8	398.8	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
11.2	258.4	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
14.1	254.6	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
17.8	248.7	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
13.0	221.5	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
5.5	219.0	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
23.4	210.7	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
15.9	190.3	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
6.4	173.2	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation

Showing 1 to 10 of 145 entries

Results for Klf16_Sp8

Z-value: 2.51

Motif logo

Transcription factors associated with Klf16_Sp8

Activity-expression correlation:

Activity profile of Klf16_Sp8 motif

Sorted Z-values of Klf16_Sp8 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf16_Sp8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: