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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Klf1
Z-value: 1.74
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Transcription factors associated with Klf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Klf1 | rn6_v1_chr19_+_26016382_26016382 | 0.35 | 7.3e-11 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_10417185 Show fit | 49.54 |
ENSRNOT00000082186
|
annexin A8 |
|
| chr7_+_11077411 Show fit | 44.40 |
ENSRNOT00000007117
|
sphingosine-1-phosphate receptor 4 |
|
| chr10_-_104628676 Show fit | 43.97 |
ENSRNOT00000010466
|
unc-13 homolog D |
|
| chr19_-_37427989 Show fit | 40.66 |
ENSRNOT00000022863
|
tubulin polymerization-promoting protein family member 3 |
|
| chr10_-_56506446 Show fit | 36.18 |
ENSRNOT00000021357
|
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 |
|
| chr1_-_142615673 Show fit | 34.33 |
ENSRNOT00000018021
|
IQ motif containing GTPase activating protein 1 |
|
| chr4_-_100883038 Show fit | 33.62 |
ENSRNOT00000041880
|
thymosin, beta 10-like |
|
| chr4_-_100883275 Show fit | 31.83 |
ENSRNOT00000022846
|
thymosin, beta 10-like |
|
| chr13_+_89774764 Show fit | 31.79 |
ENSRNOT00000005619
|
Rho GTPase activating protein 30 |
|
| chr6_-_1942972 Show fit | 31.60 |
ENSRNOT00000048711
|
CDC42 effector protein 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Klf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 168.5 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 7.0 | 105.0 | GO:0015671 | oxygen transport(GO:0015671) |
| 3.3 | 65.6 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 2.7 | 60.3 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 7.1 | 49.5 | GO:0032429 | regulation of phospholipase A2 activity(GO:0032429) |
| 4.0 | 48.5 | GO:0045820 | negative regulation of glycolytic process(GO:0045820) |
| 1.1 | 45.8 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 7.5 | 45.2 | GO:1902966 | regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966) |
| 14.7 | 44.0 | GO:0002432 | granuloma formation(GO:0002432) |
| 3.4 | 43.7 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 125.0 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 9.5 | 105.0 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.3 | 80.1 | GO:0005874 | microtubule(GO:0005874) |
| 1.1 | 79.0 | GO:0031902 | late endosome membrane(GO:0031902) |
| 1.0 | 75.0 | GO:0032432 | actin filament bundle(GO:0032432) |
| 0.3 | 66.3 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 65.2 | GO:0016604 | nuclear body(GO:0016604) |
| 0.3 | 63.3 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 1.4 | 53.4 | GO:0001772 | immunological synapse(GO:0001772) |
| 3.6 | 47.2 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 126.9 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.5 | 121.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.4 | 103.9 | GO:0015631 | tubulin binding(GO:0015631) |
| 6.7 | 80.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.9 | 77.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 3.0 | 76.2 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 5.6 | 67.3 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.5 | 53.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.9 | 45.8 | GO:0005112 | Notch binding(GO:0005112) |
| 2.3 | 45.2 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 169.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 127.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 1.4 | 109.4 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.4 | 91.2 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 4.9 | 73.9 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 3.8 | 64.9 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 1.3 | 59.8 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 2.2 | 57.5 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 1.2 | 56.2 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 1.0 | 47.0 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 102.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 2.4 | 92.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 1.1 | 55.2 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 1.5 | 52.9 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 1.9 | 52.6 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.5 | 51.5 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.9 | 43.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.9 | 43.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.4 | 42.8 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 1.4 | 41.8 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |