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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Jun

Z-value: 1.02

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Transcription factors associated with Jun

Gene Symbol Gene ID Gene Info
ENSRNOG00000026293 Jun proto-oncogene, AP-1 transcription factor subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Junrn6_v1_chr5_-_114014277_114014277-0.071.9e-01Click!

Activity profile of Jun motif

Sorted Z-values of Jun motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_199555722 73.26 ENSRNOT00000054983
integrin subunit alpha X
chr4_+_98457810 63.87 ENSRNOT00000074175

chr12_+_24761210 41.43 ENSRNOT00000002003
claudin 4
chr8_+_5606592 40.72 ENSRNOT00000011727
matrix metallopeptidase 12
chr13_+_27889345 37.67 ENSRNOT00000079134
ENSRNOT00000003274
serpin family B member 8
chr4_+_78694447 35.78 ENSRNOT00000011945
glycoprotein nmb
chr10_+_83655460 30.12 ENSRNOT00000008011
G protein subunit gamma transducin 2
chr15_-_35417273 28.38 ENSRNOT00000083961
ENSRNOT00000041430
granzyme B
chr8_+_55603968 28.27 ENSRNOT00000066848
POU class 2 associating factor 1
chr3_+_16753703 28.25 ENSRNOT00000077741

chr1_-_197770669 27.15 ENSRNOT00000023563
linker for activation of T cells
chr13_+_88606894 26.17 ENSRNOT00000048692
SH2 domain containing 1B
chr4_+_99239115 25.36 ENSRNOT00000009515
CD8a molecule
chr4_-_164049599 25.24 ENSRNOT00000078267

chr7_-_142300382 25.23 ENSRNOT00000048262
bridging integrator 2
chr20_+_295250 24.99 ENSRNOT00000000955
chloride intracellular channel 2
chr1_+_220992770 24.99 ENSRNOT00000045233
RELA proto-oncogene, NF-kB subunit
chr10_-_15125408 24.62 ENSRNOT00000026395
mesothelin
chr3_+_19274273 24.09 ENSRNOT00000040102

chr4_-_163445302 23.91 ENSRNOT00000087106
killer cell lectin-like receptor subfamily C, member 3
chr15_-_36472327 23.41 ENSRNOT00000032601
ENSRNOT00000059660
granzyme-like protein 1-like
chr13_+_92264231 22.81 ENSRNOT00000066509
ENSRNOT00000004716
spectrin, alpha, erythrocytic 1
chr3_+_19772056 22.66 ENSRNOT00000044455

chr3_+_18315320 22.61 ENSRNOT00000006954

chr1_+_81499821 22.41 ENSRNOT00000027100
Ly6/Plaur domain containing 3
chr13_+_89975267 21.50 ENSRNOT00000006266
ENSRNOT00000000053
CD244 molecule
chr4_-_163423628 21.31 ENSRNOT00000079526
killer cell lectin-like receptor subfamily C, member 3
chr1_-_89474252 21.10 ENSRNOT00000028597
FXYD domain-containing ion transport regulator 5
chr3_-_14019204 21.01 ENSRNOT00000072400
ENSRNOT00000092918
TNF receptor-associated factor 1
chr4_-_155401480 21.00 ENSRNOT00000020735
apolipoprotein B mRNA editing enzyme catalytic subunit 1
chr11_+_27364916 20.90 ENSRNOT00000002151
BTB domain and CNC homolog 1
chr1_-_99587205 20.89 ENSRNOT00000048947
sialic acid binding Ig-like lectin 8
chr18_-_28535828 20.72 ENSRNOT00000068386
transmembrane protein 173
chrX_+_28593405 19.78 ENSRNOT00000071708
thymosin beta 4, X-linked
chr9_+_67774150 18.91 ENSRNOT00000091060
inducible T-cell co-stimulator
chr18_-_28438654 18.85 ENSRNOT00000036301
marginal zone B and B1 cell-specific protein
chr1_-_89473904 18.55 ENSRNOT00000089474
FXYD domain-containing ion transport regulator 5
chr3_-_16753987 18.52 ENSRNOT00000091257

chr3_+_162346490 18.25 ENSRNOT00000087530
EYA transcriptional coactivator and phosphatase 2
chr20_+_5040337 17.96 ENSRNOT00000068435
chloride intracellular channel 1
chr3_+_16610086 17.77 ENSRNOT00000046231
rCG64257-like
chr1_+_140601791 17.33 ENSRNOT00000091588
interferon stimulated exonuclease gene 20
chr4_-_163261958 17.20 ENSRNOT00000086390
oxidized low density lipoprotein (lectin-like) receptor 1
chr2_+_248249468 16.96 ENSRNOT00000022648
guanylate binding protein 4
chr3_-_166994286 16.40 ENSRNOT00000081593
zinc finger protein 217
chr3_-_166993940 16.37 ENSRNOT00000034669
zinc finger protein 217
chr17_+_10138810 16.23 ENSRNOT00000079850
hexokinase 3
chr8_-_128665988 16.18 ENSRNOT00000050543
cysteine and serine rich nuclear protein 1
chr13_-_70626252 16.04 ENSRNOT00000036947
laminin subunit gamma 2
chr4_-_163445136 15.98 ENSRNOT00000080299
killer cell lectin-like receptor subfamily C, member 3
chr11_+_61970976 15.52 ENSRNOT00000078921
T cell immunoreceptor with Ig and ITIM domains
chr15_+_36897999 15.37 ENSRNOT00000076030
poly (ADP-ribose) polymerase family, member 4
chrX_+_134940615 15.20 ENSRNOT00000005604
X-prolyl aminopeptidase 2
chr16_+_9235888 15.06 ENSRNOT00000027204
leucine rich repeat containing 18
chr6_-_11298216 14.87 ENSRNOT00000021135
epithelial cell adhesion molecule
chr13_-_36101411 14.80 ENSRNOT00000074471
transmembrane protein 37
chr15_+_36898195 14.69 ENSRNOT00000076266
poly (ADP-ribose) polymerase family, member 4
chr3_+_151285249 14.43 ENSRNOT00000055254
protein C receptor
chr14_+_89314176 14.39 ENSRNOT00000006765
uridine phosphorylase 1
chr2_+_248276709 14.36 ENSRNOT00000068683
guanylate binding protein 2
chr2_-_26135340 14.27 ENSRNOT00000074626
coagulation factor II (thrombin) receptor
chr1_+_81230612 14.07 ENSRNOT00000026489
potassium calcium-activated channel subfamily N member 4
chr3_-_92749121 14.03 ENSRNOT00000008760
CD44 molecule (Indian blood group)
chr1_+_221236773 13.83 ENSRNOT00000051979
solute carrier family 25, member 45
chr4_+_71740532 13.72 ENSRNOT00000023537
zyxin
chr7_+_145068286 13.57 ENSRNOT00000088956
ENSRNOT00000065753
NCK associated protein 1 like
chr1_+_81230989 13.50 ENSRNOT00000077952
potassium calcium-activated channel subfamily N member 4
chr1_-_78180216 13.48 ENSRNOT00000071576
complement component 5a receptor 2
chr1_-_191007503 13.26 ENSRNOT00000023262
immunoglobulin superfamily, member 6
chr2_-_60657712 13.21 ENSRNOT00000040348
retinoic acid induced 14
chr20_+_3189473 13.17 ENSRNOT00000047439
RT1 class I, locus T24, gene 4
chr6_-_138852571 13.14 ENSRNOT00000081803

chr4_-_103761881 13.13 ENSRNOT00000084103

chr13_+_26903052 12.69 ENSRNOT00000003625
serpin family B member 5
chr5_-_159293673 12.63 ENSRNOT00000009081
peptidyl arginine deiminase 4
chr3_+_164665532 12.59 ENSRNOT00000014309
protein tyrosine phosphatase, non-receptor type 1
chr4_+_96449351 12.42 ENSRNOT00000091272
TNFAIP3 interacting protein 3
chr4_-_22307453 12.03 ENSRNOT00000047126
ATP binding cassette subfamily B member 1A
chr1_-_228194977 11.73 ENSRNOT00000028535
syntaxin 3
chr4_-_10329241 11.68 ENSRNOT00000017232
fibrinogen-like 2
chr18_+_56414488 11.62 ENSRNOT00000088988
colony stimulating factor 1 receptor
chr19_+_55381565 11.62 ENSRNOT00000018923
chromatin licensing and DNA replication factor 1
chr4_+_3043231 11.49 ENSRNOT00000013732
interleukin 6
chr3_+_16590244 11.18 ENSRNOT00000073229

chr10_-_88152064 10.66 ENSRNOT00000019477
keratin 16
chr5_-_151824633 10.30 ENSRNOT00000043959
stratifin
chr11_-_87628502 10.22 ENSRNOT00000002568
mediator complex subunit 15
chr10_+_105499569 10.01 ENSRNOT00000088457
sphingosine kinase 1
chr5_-_163167299 9.96 ENSRNOT00000022478
TNF receptor superfamily member 1B
chr8_+_117117430 9.87 ENSRNOT00000073247
glutathione peroxidase 1
chr13_-_70625842 9.69 ENSRNOT00000092499
laminin subunit gamma 2
chr7_-_11648322 9.62 ENSRNOT00000026871
growth arrest and DNA-damage-inducible, beta
chr3_+_161413298 9.53 ENSRNOT00000023965
ENSRNOT00000088776
matrix metallopeptidase 9
chr10_-_83655182 9.51 ENSRNOT00000007897
ABI family, member 3
chr10_+_47961056 9.46 ENSRNOT00000027312
family with sequence similarity 83, member G
chr3_+_55623634 9.34 ENSRNOT00000080525
dehydrogenase/reductase 9
chr10_-_88036040 9.28 ENSRNOT00000018851
keratin 13
chrX_+_43625169 9.20 ENSRNOT00000086311
spermidine/spermine N1-acetyl transferase 1
chr16_-_10706073 9.07 ENSRNOT00000089114
family with sequence similarity 25, member A
chr6_-_1454480 8.95 ENSRNOT00000072810
eukaryotic translation initiation factor 2-alpha kinase 2
chr3_+_1452644 8.89 ENSRNOT00000007949
interleukin 1 receptor antagonist
chr4_+_169147243 8.72 ENSRNOT00000011580
epithelial membrane protein 1
chr8_+_75687100 8.64 ENSRNOT00000038677
annexin A2
chrX_+_104734082 8.58 ENSRNOT00000005020
sushi-repeat-containing protein, X-linked 2
chr4_+_169161585 8.54 ENSRNOT00000079785
epithelial membrane protein 1
chr15_+_87704340 8.52 ENSRNOT00000034987
sciellin
chr4_-_131694755 8.46 ENSRNOT00000013271
forkhead box P1
chr3_-_119619865 8.38 ENSRNOT00000016172
inositol 1,4,5-trisphosphate receptor interacting protein-like 1
chr10_+_15485905 8.34 ENSRNOT00000027609
transmembrane protein 8A
chr18_+_3861539 8.32 ENSRNOT00000015363
laminin subunit alpha 3
chr20_+_10438444 8.28 ENSRNOT00000071248
ENSRNOT00000075545
crystallin, alpha A
chr12_-_51877624 8.18 ENSRNOT00000056800
checkpoint kinase 2
chr5_-_19559244 8.17 ENSRNOT00000014289
ENSRNOT00000089666
neutral sphingomyelinase activation associated factor
chr7_-_143863186 7.96 ENSRNOT00000017096
retinoic acid receptor, gamma
chr17_-_78812111 7.73 ENSRNOT00000021506
DNA cross-link repair 1C
chr8_+_5893249 7.70 ENSRNOT00000014041
matrix metallopeptidase 7
chr1_-_101514547 7.57 ENSRNOT00000079633
protein phosphatase 1, regulatory subunit 15A
chr17_-_84488480 7.49 ENSRNOT00000000158
ENSRNOT00000075983
nebulette
chr1_+_197999037 7.45 ENSRNOT00000091065
apolipoprotein B receptor
chr2_-_192671059 7.32 ENSRNOT00000012174
small proline-rich protein 1A
chr2_-_197860699 7.20 ENSRNOT00000028740
extracellular matrix protein 1
chr14_+_34727915 7.19 ENSRNOT00000085089
kinase insert domain receptor
chr8_-_82492243 7.04 ENSRNOT00000013852
tropomodulin 3
chr2_+_198040536 6.97 ENSRNOT00000028744
acidic nuclear phosphoprotein 32 family member E
chr7_+_54213319 6.94 ENSRNOT00000005286
nucleosome assembly protein 1-like 1
chrX_+_15679254 6.76 ENSRNOT00000045256
proteolipid protein 2
chr5_+_164796185 6.76 ENSRNOT00000010779
natriuretic peptide B
chr14_+_2050483 6.43 ENSRNOT00000000047
solute carrier family 26 member 1
chr20_-_30748784 6.39 ENSRNOT00000084391
sphingosine-1-phosphate lyase 1
chr19_+_37576075 6.38 ENSRNOT00000089022
family with sequence similarity 65, member A
chr8_+_80965255 6.29 ENSRNOT00000079508
WD repeat domain 72
chr6_+_93461713 6.13 ENSRNOT00000031595
AT-rich interaction domain 4A
chr1_-_88193346 5.99 ENSRNOT00000078600
immortalization up-regulated protein-like
chr1_-_42971208 5.93 ENSRNOT00000088535
predicted gene 5414
chr2_-_187863503 5.86 ENSRNOT00000093036
ENSRNOT00000026705
ENSRNOT00000082174
lamin A/C
chr13_+_88557860 5.85 ENSRNOT00000058547
SH2 domain containing 1B2
chr2_-_186480278 5.82 ENSRNOT00000031743
kin of IRRE like (Drosophila)
chr8_+_48571323 5.75 ENSRNOT00000059776
coiled-coil domain containing 153
chr2_+_2605996 5.69 ENSRNOT00000016372
glutaredoxin
chr7_+_13062196 5.66 ENSRNOT00000000193
phospholipid phosphatase 2
chr15_+_42653148 5.66 ENSRNOT00000022095
clusterin
chr9_-_119332967 5.58 ENSRNOT00000021048
myosin light chain 12A
chr2_-_29121104 5.20 ENSRNOT00000020543
transportin 1
chr4_-_157704596 5.18 ENSRNOT00000083016
non-SMC condensin I complex, subunit D2
chr1_-_228755866 5.17 ENSRNOT00000083283
deltex E3 ubiquitin ligase 4
chr3_-_121836086 5.15 ENSRNOT00000006113
interleukin 1 alpha
chr2_-_197814808 5.14 ENSRNOT00000074156
ADAMTS-like 4
chr14_+_17210733 5.09 ENSRNOT00000003075
C-X-C motif chemokine ligand 10
chr4_-_163649637 5.04 ENSRNOT00000080873
similar to killer cell lectin-like receptor, subfamily A, member 17
chr12_-_2568382 5.03 ENSRNOT00000035142
leucine rich repeat containing 8 family, member E
chr3_+_114900343 5.02 ENSRNOT00000068129
sulfide quinone reductase-like (yeast)
chr5_+_134691881 4.98 ENSRNOT00000091543
ENSRNOT00000067655
MAP kinase-interacting serine/threonine kinase 1
chr2_+_227455722 4.97 ENSRNOT00000064809
SEC24 homolog D, COPII coat complex component
chr1_+_197999336 4.92 ENSRNOT00000023555
apolipoprotein B receptor
chr9_+_95285592 4.83 ENSRNOT00000063853
UDP glucuronosyltransferase family 1 member A5
chr3_+_110442637 4.83 ENSRNOT00000010471
p21 (RAC1) activated kinase 6
chr1_+_91152635 4.82 ENSRNOT00000073438
dermokine-like
chr2_-_158156150 4.82 ENSRNOT00000016621
ventricular zone expressed PH domain-containing 1
chr2_-_158156444 4.71 ENSRNOT00000088559
ventricular zone expressed PH domain-containing 1
chr7_-_63687978 4.64 ENSRNOT00000009260
TANK-binding kinase 1
chr19_+_41631715 4.61 ENSRNOT00000022749
carbohydrate sulfotransferase 4
chr1_-_124803363 4.46 ENSRNOT00000066380
Kruppel-like factor 13
chr2_-_187863349 4.46 ENSRNOT00000084455
lamin A/C
chr9_+_16302578 4.44 ENSRNOT00000021762
GLTSCR1-like
chr1_-_165997751 4.39 ENSRNOT00000050227
pyrimidinergic receptor P2Y6
chr5_+_161889342 4.36 ENSRNOT00000040481
ribosomal protein S20-like
chr1_+_73837944 4.29 ENSRNOT00000036413
leukocyte-associated immunoglobulin-like receptor 1
chr13_-_100928811 4.19 ENSRNOT00000045326
calpain 2
chr7_-_14217778 4.15 ENSRNOT00000038961
epoxide hydrolase 3
chr16_+_50049828 4.12 ENSRNOT00000034448
family with sequence similarity 149, member A
chr6_-_71199110 4.12 ENSRNOT00000081883
protein kinase D1
chr18_-_28425944 4.08 ENSRNOT00000084372
solute carrier family 23 member 1
chr11_+_73015387 4.06 ENSRNOT00000090978
glycoprotein V (platelet)
chr9_+_81402124 3.92 ENSRNOT00000046019
RUN and FYVE domain containing 4
chr17_-_42276797 3.91 ENSRNOT00000083996
uncharacterized LOC100911664
chr3_-_3700200 3.75 ENSRNOT00000036231

chr1_-_142197182 3.68 ENSRNOT00000015521
furin (paired basic amino acid cleaving enzyme)
chr1_+_185356975 3.56 ENSRNOT00000086681
pleckstrin homology domain containing A7
chr20_-_10257044 3.49 ENSRNOT00000068289
WD repeat domain 4
chr4_+_44573264 3.49 ENSRNOT00000080271
caveolin 2
chr10_+_82032656 3.47 ENSRNOT00000067751
ankyrin repeat domain 40
chr3_+_22964230 3.46 ENSRNOT00000041813
ribosomal protein S20-like
chr20_-_3419831 3.45 ENSRNOT00000046798
mediator of DNA damage checkpoint 1
chr1_-_214263581 3.38 ENSRNOT00000044238
cadherin-related family member 5
chr13_+_51384389 3.34 ENSRNOT00000087025
lysine demethylase 5B
chr10_-_56491715 3.34 ENSRNOT00000020970
potassium channel tetramerization domain containing 11
chr4_-_155690869 3.32 ENSRNOT00000012216
complement C3a receptor 1
chr5_+_135687538 3.20 ENSRNOT00000091664

chr1_-_65681440 3.16 ENSRNOT00000026305
zinc finger protein 128
chr16_+_90325304 3.14 ENSRNOT00000057310
solute carrier family 10 member 2
chr1_-_80864846 3.13 ENSRNOT00000074412
immunoglobulin superfamily, member 23
chr10_+_35537977 3.13 ENSRNOT00000071917
ring finger protein 130
chr2_-_193136520 3.11 ENSRNOT00000042142
keratinocyte proline-rich protein
chr1_+_72636959 3.07 ENSRNOT00000023489
interleukin 11
chr3_-_81911197 3.04 ENSRNOT00000066526
PR/SET domain 11
chr15_-_61564695 2.98 ENSRNOT00000068216
regulator of cell cycle
chr18_-_29562153 2.97 ENSRNOT00000023977
CD14 molecule
chr18_+_56364620 2.97 ENSRNOT00000068535
ENSRNOT00000086033
platelet derived growth factor receptor beta
chr11_+_74014983 2.94 ENSRNOT00000040884
glycoprotein V platelet
chr9_+_94425252 2.92 ENSRNOT00000064965
ENSRNOT00000076099
GRB10 interacting GYF protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Jun

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.8 21.5 GO:0071613 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
10.2 40.7 GO:0072641 type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
9.5 28.4 GO:0060545 positive regulation of necroptotic process(GO:0060545)
8.5 25.4 GO:0045065 cytotoxic T cell differentiation(GO:0045065)
8.3 25.0 GO:0006117 acetaldehyde metabolic process(GO:0006117)
7.0 21.0 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
7.0 20.9 GO:0060101 negative regulation of phagocytosis, engulfment(GO:0060101)
6.8 20.4 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
5.8 17.3 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
4.8 14.3 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
4.7 18.8 GO:0002378 immunoglobulin biosynthetic process(GO:0002378) negative regulation of glucose import in response to insulin stimulus(GO:2001274)
4.5 13.6 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
4.5 13.5 GO:0090024 negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024)
4.5 17.8 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
4.3 12.8 GO:1904178 sterol regulatory element binding protein import into nucleus(GO:0035105) negative regulation of adipose tissue development(GO:1904178)
4.1 12.3 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
3.9 11.6 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163) regulation of DNA replication origin binding(GO:1902595)
3.6 25.0 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
3.5 14.0 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
3.4 13.5 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
3.3 3.3 GO:0002462 tolerance induction to nonself antigen(GO:0002462)
3.3 19.8 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
3.3 9.9 GO:0009609 response to symbiotic bacterium(GO:0009609)
3.2 9.5 GO:0009644 response to high light intensity(GO:0009644)
3.1 12.6 GO:1903898 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
3.0 12.0 GO:1905230 carbohydrate export(GO:0033231) daunorubicin transport(GO:0043215) response to borneol(GO:1905230) cellular response to borneol(GO:1905231) response to codeine(GO:1905233) response to quercetin(GO:1905235) drug transport across blood-brain barrier(GO:1990962) establishment of blood-retinal barrier(GO:1990963)
2.9 11.6 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
2.9 14.4 GO:0046133 pyrimidine ribonucleoside catabolic process(GO:0046133)
2.8 13.8 GO:0000066 mitochondrial ornithine transport(GO:0000066)
2.8 27.6 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
2.7 8.0 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
2.6 7.7 GO:0002780 antimicrobial peptide biosynthetic process(GO:0002777) antibacterial peptide biosynthetic process(GO:0002780)
2.5 12.6 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
2.5 7.6 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) response to methyl methanesulfonate(GO:0072702) cellular response to methyl methanesulfonate(GO:0072703) response to environmental enrichment(GO:0090648) positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
2.5 7.5 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
2.3 9.2 GO:0032919 spermine acetylation(GO:0032919)
2.2 56.5 GO:0061436 establishment of skin barrier(GO:0061436)
2.2 41.2 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
2.0 8.2 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
2.0 18.3 GO:0016576 histone dephosphorylation(GO:0016576)
2.0 10.0 GO:0019371 cyclooxygenase pathway(GO:0019371)
2.0 21.9 GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
1.9 5.7 GO:1902988 regulation of neuronal signal transduction(GO:1902847) regulation of tau-protein kinase activity(GO:1902947) positive regulation of tau-protein kinase activity(GO:1902949) neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996) positive regulation of neurofibrillary tangle assembly(GO:1902998)
1.9 11.3 GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033)
1.8 12.4 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
1.8 28.2 GO:0044406 adhesion of symbiont to host(GO:0044406)
1.7 3.5 GO:0075509 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
1.7 5.1 GO:1904444 regulation of establishment of Sertoli cell barrier(GO:1904444)
1.7 11.7 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
1.5 4.6 GO:0044565 dendritic cell proliferation(GO:0044565)
1.5 20.9 GO:0002517 T cell tolerance induction(GO:0002517)
1.5 3.0 GO:1900238 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
1.5 20.7 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
1.4 8.3 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
1.4 36.9 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
1.4 4.1 GO:0015882 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
1.2 6.1 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
1.2 25.7 GO:0070831 basement membrane assembly(GO:0070831)
1.2 73.3 GO:0050798 activated T cell proliferation(GO:0050798)
1.2 9.3 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
1.2 20.9 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
1.2 4.6 GO:0042339 keratan sulfate metabolic process(GO:0042339)
1.1 25.2 GO:0097320 membrane tubulation(GO:0097320)
1.1 8.6 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
1.0 4.2 GO:2000864 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
1.0 2.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
1.0 7.7 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
1.0 6.8 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
1.0 17.3 GO:0032060 bleb assembly(GO:0032060)
0.9 2.8 GO:0070946 neutrophil mediated killing of gram-positive bacterium(GO:0070946)
0.9 8.9 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.9 7.0 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.9 3.5 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.9 15.5 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.9 4.3 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
0.8 9.3 GO:0043587 tongue morphogenesis(GO:0043587)
0.8 49.5 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.7 3.0 GO:1903413 cellular response to bile acid(GO:1903413)
0.7 5.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.7 3.4 GO:1904970 brush border assembly(GO:1904970)
0.7 7.3 GO:0031424 keratinization(GO:0031424)
0.7 10.0 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.6 2.6 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.6 9.6 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.6 4.4 GO:0030321 transepithelial chloride transport(GO:0030321)
0.6 1.8 GO:0000053 argininosuccinate metabolic process(GO:0000053)
0.6 37.8 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.6 2.3 GO:1903575 cornified envelope assembly(GO:1903575)
0.6 2.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.6 22.6 GO:0060325 face morphogenesis(GO:0060325)
0.5 4.8 GO:0052697 xenobiotic glucuronidation(GO:0052697)
0.5 6.9 GO:0014010 Schwann cell proliferation(GO:0014010)
0.5 18.0 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.5 8.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.5 31.0 GO:0007004 RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004)
0.4 18.5 GO:0050819 negative regulation of coagulation(GO:0050819)
0.4 12.7 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.4 6.4 GO:1902358 oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
0.4 5.2 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.4 5.9 GO:0045953 negative regulation of leukocyte mediated cytotoxicity(GO:0001911) negative regulation of cell killing(GO:0031342) negative regulation of natural killer cell mediated cytotoxicity(GO:0045953)
0.4 2.7 GO:0042636 negative regulation of hair cycle(GO:0042636)
0.4 3.0 GO:0071724 response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.4 7.0 GO:0043486 histone exchange(GO:0043486)
0.4 2.2 GO:0038203 TORC2 signaling(GO:0038203)
0.4 7.2 GO:0002828 regulation of type 2 immune response(GO:0002828)
0.4 2.2 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.4 2.8 GO:0002827 positive regulation of T-helper 1 type immune response(GO:0002827)
0.3 6.3 GO:0070166 enamel mineralization(GO:0070166)
0.3 2.8 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.3 1.7 GO:0060510 Type II pneumocyte differentiation(GO:0060510)
0.3 1.0 GO:0071500 cellular response to nitrosative stress(GO:0071500) regulation of determination of dorsal identity(GO:2000015)
0.3 2.0 GO:0060721 regulation of spongiotrophoblast cell proliferation(GO:0060721) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.3 13.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.3 4.2 GO:0016540 protein autoprocessing(GO:0016540)
0.3 24.6 GO:0031016 pancreas development(GO:0031016)
0.3 3.3 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.3 2.6 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.3 4.9 GO:0008105 asymmetric protein localization(GO:0008105)
0.3 2.7 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.3 1.9 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.3 4.9 GO:0007567 parturition(GO:0007567)
0.3 0.8 GO:0072602 interleukin-4 secretion(GO:0072602)
0.2 1.9 GO:0051546 keratinocyte migration(GO:0051546)
0.2 2.8 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.2 2.3 GO:0070995 NADPH oxidation(GO:0070995)
0.2 1.6 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.2 2.5 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.2 1.3 GO:0010991 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.2 1.9 GO:0034312 diol biosynthetic process(GO:0034312)
0.2 19.1 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.2 0.6 GO:0051106 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106) protein localization to site of double-strand break(GO:1990166)
0.2 1.7 GO:0015747 urate transport(GO:0015747)
0.2 5.6 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.2 2.3 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.2 5.7 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 5.0 GO:0009651 response to salt stress(GO:0009651)
0.1 2.9 GO:0061157 mRNA destabilization(GO:0061157)
0.1 8.5 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 21.3 GO:0007160 cell-matrix adhesion(GO:0007160)
0.1 0.3 GO:1902534 single-organism membrane invagination(GO:1902534)
0.1 1.5 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.1 2.6 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.1 12.6 GO:0030509 BMP signaling pathway(GO:0030509)
0.1 1.2 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 0.8 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.1 0.4 GO:0009838 abscission(GO:0009838)
0.1 3.1 GO:0008206 bile acid metabolic process(GO:0008206)
0.1 2.6 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 1.7 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 8.2 GO:0006641 triglyceride metabolic process(GO:0006641)
0.1 10.2 GO:0019827 stem cell population maintenance(GO:0019827)
0.1 2.3 GO:0046326 positive regulation of glucose import(GO:0046326)
0.1 0.1 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.1 6.4 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.1 1.5 GO:0030224 monocyte differentiation(GO:0030224)
0.1 1.2 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.3 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
0.0 0.3 GO:0000103 sulfate assimilation(GO:0000103)
0.0 5.0 GO:0044070 regulation of anion transport(GO:0044070)
0.0 3.1 GO:0030838 positive regulation of actin filament polymerization(GO:0030838)
0.0 1.4 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 8.7 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 1.4 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 1.0 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.0 1.3 GO:0030330 DNA damage response, signal transduction by p53 class mediator(GO:0030330)
0.0 2.6 GO:0034968 histone lysine methylation(GO:0034968)
0.0 2.4 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.8 31.3 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
6.0 24.2 GO:0005607 laminin-2 complex(GO:0005607)
4.7 14.0 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
3.9 11.7 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
3.9 11.6 GO:1990682 CSF1-CSF1R complex(GO:1990682)
3.8 11.5 GO:0005896 interleukin-6 receptor complex(GO:0005896)
3.5 28.4 GO:0044194 cytolytic granule(GO:0044194)
2.9 14.3 GO:0031094 platelet dense tubular network(GO:0031094)
2.8 25.0 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
2.5 19.8 GO:0097443 sorting endosome(GO:0097443)
2.3 22.8 GO:0008091 spectrin(GO:0008091) spectrin-associated cytoskeleton(GO:0014731) cuticular plate(GO:0032437)
2.0 9.9 GO:0097413 Lewy body(GO:0097413)
1.8 64.6 GO:0008305 integrin complex(GO:0008305)
1.7 41.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
1.7 18.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
1.5 13.6 GO:0035749 myelin sheath adaxonal region(GO:0035749)
1.4 8.3 GO:0005610 laminin-5 complex(GO:0005610)
1.3 10.1 GO:0005638 lamin filament(GO:0005638)
1.2 10.9 GO:0031209 SCAR complex(GO:0031209)
1.1 3.4 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
1.0 27.6 GO:0042629 mast cell granule(GO:0042629)
0.9 25.2 GO:0001891 phagocytic cup(GO:0001891)
0.9 7.7 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.8 13.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.8 43.0 GO:0034707 chloride channel complex(GO:0034707)
0.7 30.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.7 3.5 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.6 5.2 GO:0000796 condensin complex(GO:0000796)
0.6 5.7 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.6 3.0 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.6 7.0 GO:0000812 Swr1 complex(GO:0000812)
0.5 7.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.5 5.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.4 39.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.4 26.6 GO:0005876 spindle microtubule(GO:0005876)
0.4 32.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.4 43.6 GO:0031225 anchored component of membrane(GO:0031225)
0.4 39.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.4 17.6 GO:0009925 basal plasma membrane(GO:0009925)
0.4 5.0 GO:0030127 COPII vesicle coat(GO:0030127)
0.4 91.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.3 1.0 GO:0036488 CHOP-C/EBP complex(GO:0036488) CHOP-ATF3 complex(GO:1990622)
0.3 17.3 GO:0015030 Cajal body(GO:0015030)
0.3 7.3 GO:0001533 cornified envelope(GO:0001533)
0.3 2.9 GO:1990635 proximal dendrite(GO:1990635)
0.3 2.8 GO:0043020 NADPH oxidase complex(GO:0043020)
0.3 3.0 GO:0043202 lysosomal lumen(GO:0043202)
0.3 5.1 GO:0005614 interstitial matrix(GO:0005614)
0.2 0.7 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.2 4.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 26.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 3.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.2 2.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 3.2 GO:0016460 myosin II complex(GO:0016460)
0.2 11.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 55.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 1.5 GO:0045179 apical cortex(GO:0045179)
0.2 6.6 GO:0016592 mediator complex(GO:0016592)
0.2 47.3 GO:0016324 apical plasma membrane(GO:0016324)
0.2 4.1 GO:0000421 autophagosome membrane(GO:0000421)
0.2 2.2 GO:0031932 TORC2 complex(GO:0031932)
0.1 1.8 GO:0070852 cell body fiber(GO:0070852)
0.1 1.1 GO:0005796 Golgi lumen(GO:0005796)
0.1 2.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 2.8 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 12.8 GO:0000776 kinetochore(GO:0000776)
0.1 6.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 2.6 GO:0098802 plasma membrane receptor complex(GO:0098802)
0.1 0.4 GO:0090543 Flemming body(GO:0090543)
0.1 2.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 5.3 GO:0045095 keratin filament(GO:0045095)
0.1 3.9 GO:0005882 intermediate filament(GO:0005882)
0.1 5.8 GO:0016605 PML body(GO:0016605)
0.1 9.5 GO:0001650 fibrillar center(GO:0001650)
0.1 1.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 9.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 1.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 5.2 GO:0034399 nuclear periphery(GO:0034399)
0.1 13.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 18.3 GO:0009986 cell surface(GO:0009986)
0.0 3.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 5.0 GO:0034702 ion channel complex(GO:0034702)
0.0 6.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 2.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 2.2 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.3 GO:0000407 pre-autophagosomal structure(GO:0000407)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.5 GO:0001847 opsonin receptor activity(GO:0001847)
4.5 35.8 GO:0045545 syndecan binding(GO:0045545)
4.2 16.9 GO:0015057 thrombin receptor activity(GO:0015057)
3.6 25.0 GO:0071532 ankyrin repeat binding(GO:0071532)
3.5 21.0 GO:0004126 cytidine deaminase activity(GO:0004126)
3.5 17.3 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
3.3 10.0 GO:0008481 sphinganine kinase activity(GO:0008481)
3.2 12.6 GO:0034618 arginine binding(GO:0034618)
3.1 9.2 GO:0019809 spermidine binding(GO:0019809)
2.9 20.3 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
2.7 8.2 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
2.7 16.2 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
2.5 12.4 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
2.4 12.0 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
1.7 13.8 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
1.7 8.6 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
1.6 11.5 GO:0005138 interleukin-6 receptor binding(GO:0005138)
1.5 34.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
1.5 20.9 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
1.5 20.9 GO:0033691 sialic acid binding(GO:0033691)
1.5 8.9 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
1.5 4.4 GO:0071553 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
1.4 7.2 GO:0005134 interleukin-2 receptor binding(GO:0005134)
1.4 17.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
1.4 14.0 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
1.4 4.1 GO:0015229 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
1.3 30.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
1.3 9.3 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
1.3 10.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
1.2 8.7 GO:0048019 receptor antagonist activity(GO:0048019)
1.2 11.7 GO:0050544 arachidonic acid binding(GO:0050544)
1.2 21.9 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
1.1 7.7 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
1.0 5.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
1.0 27.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.0 20.8 GO:0031996 thioesterase binding(GO:0031996)
0.9 18.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.9 21.5 GO:0042288 MHC class I protein binding(GO:0042288)
0.8 5.7 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.8 4.6 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.7 2.2 GO:0005135 erythropoietin receptor binding(GO:0005128) interleukin-3 receptor binding(GO:0005135)
0.7 2.8 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.7 4.2 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.7 15.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.7 19.8 GO:0003785 actin monomer binding(GO:0003785)
0.7 8.0 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.6 1.9 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.6 3.0 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.6 9.5 GO:0001968 fibronectin binding(GO:0001968)
0.6 2.8 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.5 5.7 GO:0042577 lipid phosphatase activity(GO:0042577)
0.5 24.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.5 7.5 GO:0005523 tropomyosin binding(GO:0005523)
0.5 11.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.5 10.0 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.5 5.0 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.5 1.4 GO:0017168 5-oxoprolinase (ATP-hydrolyzing) activity(GO:0017168)
0.4 30.1 GO:0005518 collagen binding(GO:0005518)
0.4 6.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.4 2.6 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.4 5.0 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.4 13.8 GO:0043236 laminin binding(GO:0043236)
0.4 2.6 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.4 3.3 GO:0004875 complement receptor activity(GO:0004875)
0.4 3.7 GO:0048406 nerve growth factor binding(GO:0048406)
0.4 20.7 GO:0030551 cyclic nucleotide binding(GO:0030551)
0.4 14.4 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.4 13.2 GO:0042605 peptide antigen binding(GO:0042605)
0.4 5.7 GO:0051787 misfolded protein binding(GO:0051787)
0.3 12.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.3 1.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 6.8 GO:0019956 chemokine binding(GO:0019956)
0.3 6.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.3 2.6 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.3 3.5 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.3 2.8 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.3 1.1 GO:0005163 nerve growth factor receptor binding(GO:0005163)
0.3 1.4 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.3 7.0 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.3 3.6 GO:0070097 delta-catenin binding(GO:0070097)
0.3 3.5 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.3 1.9 GO:0033592 RNA strand annealing activity(GO:0033592)
0.3 4.1 GO:0004697 protein kinase C activity(GO:0004697)
0.3 8.5 GO:0050681 androgen receptor binding(GO:0050681)
0.2 34.6 GO:0008201 heparin binding(GO:0008201)
0.2 32.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 11.6 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.2 2.0 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.2 10.0 GO:0031593 polyubiquitin binding(GO:0031593)
0.2 3.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 2.6 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.2 1.7 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2 4.1 GO:0070412 R-SMAD binding(GO:0070412)
0.2 0.7 GO:0016842 amidine-lyase activity(GO:0016842)
0.2 3.2 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 4.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 1.0 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.2 5.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 46.3 GO:0003924 GTPase activity(GO:0003924)
0.2 1.9 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.1 1.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 60.8 GO:0005216 ion channel activity(GO:0005216)
0.1 2.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 2.9 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.3 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.1 1.2 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 6.4 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.1 1.9 GO:0002162 dystroglycan binding(GO:0002162)
0.1 17.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 21.3 GO:0030246 carbohydrate binding(GO:0030246)
0.1 1.5 GO:0070034 telomerase RNA binding(GO:0070034)
0.1 7.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 14.2 GO:0000287 magnesium ion binding(GO:0000287)
0.1 5.1 GO:0002020 protease binding(GO:0002020)
0.1 4.9 GO:0019838 growth factor binding(GO:0019838)
0.1 3.4 GO:0008013 beta-catenin binding(GO:0008013)
0.0 4.8 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 4.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 1.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.6 GO:0017022 myosin binding(GO:0017022)
0.0 1.7 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.0 9.8 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 1.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.4 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 1.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 73.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
1.9 27.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
1.9 32.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
1.3 48.5 PID AVB3 OPN PATHWAY Osteopontin-mediated events
1.2 28.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
1.1 30.1 PID CONE PATHWAY Visual signal transduction: Cones
1.1 20.2 PID S1P S1P1 PATHWAY S1P1 pathway
1.0 21.0 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.9 10.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.9 11.5 ST STAT3 PATHWAY STAT3 Pathway
0.9 33.2 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.8 25.1 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.7 13.7 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.6 35.0 PID IL12 2PATHWAY IL12-mediated signaling events
0.6 50.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.6 5.1 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.5 15.4 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.5 9.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.5 6.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.5 8.0 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.5 19.4 PID ATM PATHWAY ATM pathway
0.4 4.1 PID IGF1 PATHWAY IGF1 pathway
0.4 8.5 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.4 12.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.4 8.2 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.3 13.7 PID ATF2 PATHWAY ATF-2 transcription factor network
0.3 12.5 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.2 2.8 PID IL23 PATHWAY IL23-mediated signaling events
0.2 3.5 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.2 4.6 PID IL1 PATHWAY IL1-mediated signaling events
0.2 3.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 7.6 PID BMP PATHWAY BMP receptor signaling
0.1 9.9 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 5.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 5.2 PID AURORA B PATHWAY Aurora B signaling
0.1 4.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 4.2 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 5.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.6 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.2 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 2.8 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 9.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 1.9 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 15.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.0 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.1 1.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 2.2 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 4.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 25.0 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
1.6 12.6 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
1.4 9.9 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
1.4 45.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
1.3 47.0 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
1.1 14.4 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
1.1 14.0 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
1.0 27.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
1.0 86.9 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.9 11.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.8 5.0 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.8 7.4 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.8 31.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.7 8.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.7 25.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.7 28.4 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.7 11.6 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.6 21.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.6 11.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.6 7.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.6 1.1 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.6 17.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.5 3.7 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.5 9.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.5 4.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.4 4.8 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.4 23.4 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.4 13.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.4 4.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.3 15.9 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.3 16.2 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.3 12.1 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.3 5.0 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 5.2 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3 7.6 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.3 5.2 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.3 4.8 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.3 25.6 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.2 8.9 REACTOME INTERFERON SIGNALING Genes involved in Interferon Signaling
0.2 5.0 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 9.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.2 9.5 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.2 2.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 2.6 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.2 3.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 1.7 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 21.0 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.1 9.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 10.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.0 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 5.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.6 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 3.0 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 1.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.7 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.1 2.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 2.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 2.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 1.5 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 1.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases