ISMARA results: Jun

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Jun

Z-value: 1.02

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Transcription factors associated with Jun

Gene Symbol	Gene ID	Gene Info
Jun NCBI RGD Ensembl	ENSRNOG00000026293	Jun proto-oncogene, AP-1 transcription factor subunit

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Jun	rn6_v1_chr5_-_114014277_114014277	-0.07	1.9e-01	Click!

Activity profile of Jun motif

Sorted Z-values of Jun motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_199555722 Show fit	73.26	ENSRNOT00000054983	Itgax NCBI RGD Ensembl Show fit	integrin subunit alpha X
chr4_+_98457810 Show fit	63.87	ENSRNOT00000074175	AABR07060872.1 NCBI RGD Ensembl Show fit
chr12_+_24761210 Show fit	41.43	ENSRNOT00000002003	Cldn4 NCBI RGD Ensembl Show fit	claudin 4
chr8_+_5606592 Show fit	40.72	ENSRNOT00000011727	Mmp12 NCBI RGD Ensembl Show fit	matrix metallopeptidase 12
chr13_+_27889345 Show fit	37.67	ENSRNOT00000079134 ENSRNOT00000003274	Serpinb8 NCBI RGD Ensembl Show fit	serpin family B member 8
chr4_+_78694447 Show fit	35.78	ENSRNOT00000011945	Gpnmb NCBI RGD Ensembl Show fit	glycoprotein nmb
chr10_+_83655460 Show fit	30.12	ENSRNOT00000008011	Gngt2 NCBI RGD Ensembl Show fit	G protein subunit gamma transducin 2
chr15_-_35417273 Show fit	28.38	ENSRNOT00000083961 ENSRNOT00000041430	Gzmb NCBI RGD Ensembl Show fit	granzyme B
chr8_+_55603968 Show fit	28.27	ENSRNOT00000066848	Pou2af1 NCBI RGD Ensembl Show fit	POU class 2 associating factor 1
chr3_+_16753703 Show fit	28.25	ENSRNOT00000077741	AABR07051548.2 NCBI RGD Ensembl Show fit

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Jun

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	73.3	GO:0050798	activated T cell proliferation(GO:0050798)
2.2	56.5	GO:0061436	establishment of skin barrier(GO:0061436)
0.8	49.5	GO:0002260	lymphocyte homeostasis(GO:0002260)
2.2	41.2	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
10.2	40.7	GO:0072641	type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.6	37.8	GO:2000649	regulation of sodium ion transmembrane transporter activity(GO:2000649)
1.4	36.9	GO:0031954	positive regulation of protein autophosphorylation(GO:0031954)
0.5	31.0	GO:0007004	RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004)
9.5	28.4	GO:0060545	positive regulation of necroptotic process(GO:0060545)
1.8	28.2	GO:0044406	adhesion of symbiont to host(GO:0044406)

Showing 1 to 10 of 167 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	91.8	GO:0009897	external side of plasma membrane(GO:0009897)
1.8	64.6	GO:0008305	integrin complex(GO:0008305)
0.2	55.4	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.2	47.3	GO:0016324	apical plasma membrane(GO:0016324)
0.4	43.6	GO:0031225	anchored component of membrane(GO:0031225)
0.8	43.0	GO:0034707	chloride channel complex(GO:0034707)
1.7	41.4	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.4	39.8	GO:0005913	cell-cell adherens junction(GO:0005913)
0.4	39.1	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
0.4	32.8	GO:0000118	histone deacetylase complex(GO:0000118)

Showing 1 to 10 of 89 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	60.8	GO:0005216	ion channel activity(GO:0005216)
0.2	46.3	GO:0003924	GTPase activity(GO:0003924)
4.5	35.8	GO:0045545	syndecan binding(GO:0045545)
1.5	34.9	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.2	34.6	GO:0008201	heparin binding(GO:0008201)
0.2	32.8	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.3	30.7	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4	30.1	GO:0005518	collagen binding(GO:0005518)
1.0	27.2	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
3.6	25.0	GO:0071532	ankyrin repeat binding(GO:0071532)

Showing 1 to 10 of 129 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	73.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.6	50.3	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
1.3	48.5	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.6	35.0	PID IL12 2PATHWAY	IL12-mediated signaling events
0.9	33.2	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
1.9	32.5	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
1.1	30.1	PID CONE PATHWAY	Visual signal transduction: Cones
1.2	28.4	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
1.9	27.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.8	25.1	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Showing 1 to 10 of 50 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	86.9	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
1.3	47.0	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
1.4	45.7	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.8	31.3	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.7	28.4	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
1.0	27.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.3	25.6	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.7	25.4	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
2.5	25.0	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.4	23.4	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization

Showing 1 to 10 of 64 entries

Results for Jun

Z-value: 1.02

Motif logo

Transcription factors associated with Jun

Activity-expression correlation:

Activity profile of Jun motif

Sorted Z-values of Jun motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Jun

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: