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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Isl1

Z-value: 0.34

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Transcription factors associated with Isl1

Gene Symbol Gene ID Gene Info
Isl1
ENSRNOG00000012556 ISL LIM homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Isl1rn6_v1_chr2_-_48501436_485014360.045.0e-01Click!

Activity profile of Isl1 motif

Sorted Z-values of Isl1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_12820466 13.00 ENSRNOT00000001699
Ftcd
formimidoyltransferase cyclodeaminase
chr9_-_26707571 11.14 ENSRNOT00000080948
AABR07067023.1

chrX_-_32153794 9.71 ENSRNOT00000005348
Tmem27
transmembrane protein 27
chrX_+_23081125 8.91 ENSRNOT00000071639
AABR07037520.1

chr14_-_64476796 7.78 ENSRNOT00000029104
Gba3
glucosidase, beta, acid 3
chr14_-_19191863 6.04 ENSRNOT00000003921
Alb
albumin
chr10_-_31359699 6.01 ENSRNOT00000081280
Cyfip2
cytoplasmic FMR1 interacting protein 2
chr14_+_20266891 5.16 ENSRNOT00000004174
Gc
group specific component
chr9_-_82336806 5.03 ENSRNOT00000024667
Slc23a3
solute carrier family 23, member 3
chrX_-_32095867 4.82 ENSRNOT00000049947
ENSRNOT00000080730
Ace2
angiotensin I converting enzyme 2
chr8_+_57936650 4.67 ENSRNOT00000089686
Exph5
exophilin 5
chr4_+_157836912 4.58 ENSRNOT00000067271
Scnn1a
sodium channel epithelial 1 alpha subunit
chr1_-_102826965 4.50 ENSRNOT00000078692
Saa4
serum amyloid A4
chr3_+_54253949 4.48 ENSRNOT00000010018
B3galt1
Beta-1,3-galactosyltransferase 1
chr1_-_43638161 4.41 ENSRNOT00000024460
Ipcef1
interaction protein for cytohesin exchange factors 1
chr3_+_117421604 4.38 ENSRNOT00000008860
ENSRNOT00000008857
Slc12a1
solute carrier family 12 member 1
chr15_-_52320385 4.09 ENSRNOT00000067776
Dmtn
dematin actin binding protein
chr2_-_100372252 3.84 ENSRNOT00000011890
Hnf4g
hepatocyte nuclear factor 4, gamma
chr6_-_46631983 3.73 ENSRNOT00000045963
Sox11
SRY box 11
chr18_-_4294136 3.39 ENSRNOT00000091909
Osbpl1a
oxysterol binding protein-like 1A
chr9_-_71900044 3.27 ENSRNOT00000020322
Idh1
isocitrate dehydrogenase (NADP(+)) 1, cytosolic
chr14_-_5101177 3.15 ENSRNOT00000002888
Lrrc8d
leucine rich repeat containing 8 family, member D
chr2_+_83393282 2.69 ENSRNOT00000044871
Ctnnd2
catenin delta 2
chr11_-_27971359 2.39 ENSRNOT00000085629
ENSRNOT00000051060
ENSRNOT00000042581
ENSRNOT00000050073
ENSRNOT00000081066
Grik1
glutamate ionotropic receptor kainate type subunit 1
chr7_+_28654733 2.30 ENSRNOT00000006174
Pmch
pro-melanin-concentrating hormone
chr18_-_28017925 1.97 ENSRNOT00000075420
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr7_+_83113672 1.78 ENSRNOT00000006783
Trhr
thyrotropin releasing hormone receptor
chr15_+_62406873 1.68 ENSRNOT00000047572
Olfm4
olfactomedin 4
chr19_-_58735173 1.66 ENSRNOT00000030077
Pcnx2
pecanex homolog 2 (Drosophila)
chr15_+_12827707 1.63 ENSRNOT00000012452
Fezf2
Fez family zinc finger 2
chr17_-_77527894 1.57 ENSRNOT00000032173
Bend7
BEN domain containing 7
chr15_-_29761117 1.50 ENSRNOT00000075194
AABR07017658.2

chr3_-_44177689 1.36 ENSRNOT00000006387
Cytip
cytohesin 1 interacting protein
chr15_+_31417147 1.34 ENSRNOT00000092182
AABR07017824.2

chr14_-_3288017 1.33 ENSRNOT00000080452
LOC689986
hypothetical protein LOC689986
chr3_-_25212049 1.26 ENSRNOT00000040023
Lrp1b
LDL receptor related protein 1B
chr4_+_88119838 1.25 ENSRNOT00000073173
Vom1r82
vomeronasal 1 receptor 82
chr15_+_28023018 1.21 ENSRNOT00000090272
Rnase4
ribonuclease A family member 4
chr20_-_48503898 1.20 ENSRNOT00000073091
Wasf1
WAS protein family, member 1
chr3_-_71798531 1.19 ENSRNOT00000088170
Calcrl
calcitonin receptor like receptor
chr14_+_69800156 1.08 ENSRNOT00000072746
Lcorl
ligand dependent nuclear receptor corepressor-like
chr15_+_31395772 1.06 ENSRNOT00000075087
AABR07017824.1

chrX_-_128268285 1.00 ENSRNOT00000009755
ENSRNOT00000081880
Thoc2
THO complex 2
chr2_+_66940057 1.00 ENSRNOT00000043050
Cdh9
cadherin 9
chr5_+_126698582 0.96 ENSRNOT00000012427
Cdcp2
CUB domain containing protein 2
chr13_-_102942863 0.94 ENSRNOT00000003198
Mark1
microtubule affinity regulating kinase 1
chr10_-_21265026 0.89 ENSRNOT00000011922
Tenm2
teneurin transmembrane protein 2
chr5_-_128446725 0.83 ENSRNOT00000011272
Btf3l4
basic transcription factor 3-like 4
chr2_-_157759819 0.81 ENSRNOT00000015763
ENSRNOT00000016016
LOC100909712
cyclin-L1-like
chr18_-_26656879 0.80 ENSRNOT00000086729
Epb41l4a
erythrocyte membrane protein band 4.1 like 4A
chr13_-_89242443 0.72 ENSRNOT00000029202
Atf6
activating transcription factor 6
chrX_+_153677811 0.72 ENSRNOT00000072808
AABR07042361.1

chr19_-_37528011 0.72 ENSRNOT00000059628
Agrp
agouti related neuropeptide
chr15_-_29903755 0.71 ENSRNOT00000066802
AABR07017669.1

chr15_+_30750093 0.69 ENSRNOT00000071830
AABR07017763.1

chr5_+_172364421 0.63 ENSRNOT00000018769
Hes5
hes family bHLH transcription factor 5
chr4_-_167089055 0.62 ENSRNOT00000050409
Tas2r113
taste receptor, type 2, member 113
chr15_+_108318664 0.61 ENSRNOT00000057469
Ubac2
UBA domain containing 2
chr20_+_9948908 0.56 ENSRNOT00000001541
Ubash3a
ubiquitin associated and SH3 domain containing, A
chr5_-_28130803 0.51 ENSRNOT00000093186
Slc26a7
solute carrier family 26 member 7
chr2_+_34312766 0.50 ENSRNOT00000060962
Cenpk
centromere protein K
chr10_-_64657089 0.49 ENSRNOT00000080703
Abr
active BCR-related
chr5_-_28131133 0.48 ENSRNOT00000067331
Slc26a7
solute carrier family 26 member 7
chr10_-_87286387 0.48 ENSRNOT00000044206
Krt28
keratin 28
chr20_+_48503973 0.45 ENSRNOT00000064081
Cdc40
cell division cycle 40
chr4_-_7885301 0.45 ENSRNOT00000035034
Rint1
RAD50 interactor 1
chr3_+_21114856 0.44 ENSRNOT00000044947
Olr423
olfactory receptor 423
chr1_+_168519499 0.38 ENSRNOT00000045286
Olr98
olfactory receptor 98
chr20_+_48504264 0.37 ENSRNOT00000087740
Cdc40
cell division cycle 40
chr3_-_76187045 0.36 ENSRNOT00000075650
LOC686683
similar to olfactory receptor 73
chr3_-_161819029 0.34 ENSRNOT00000091834
LOC102555457
engulfment and cell motility protein 2-like
chr6_-_117972898 0.34 ENSRNOT00000032968
AABR07065265.1

chr15_-_45927804 0.28 ENSRNOT00000086271
Ints6
integrator complex subunit 6
chr15_+_56666012 0.27 ENSRNOT00000013408
Htr2a
5-hydroxytryptamine receptor 2A
chr3_-_76085971 0.26 ENSRNOT00000007679
Olr601
olfactory receptor 601
chr15_-_28786094 0.25 ENSRNOT00000044250
Olr1639
olfactory receptor 1639
chr4_+_57883849 0.17 ENSRNOT00000013880
Cpa4
carboxypeptidase A4
chr5_+_145311375 0.14 ENSRNOT00000019224
Smim12
small integral membrane protein 12
chr10_-_34333305 0.14 ENSRNOT00000071365
Olr1384
olfactory receptor gene Olr1384
chr1_+_168575090 0.13 ENSRNOT00000048299
Olr103
olfactory receptor 103
chr2_+_4989295 0.11 ENSRNOT00000041541
Fam172a
family with sequence similarity 172, member A
chr16_-_8685529 0.09 ENSRNOT00000092751
Slc18a3
solute carrier family 18 member A3
chr13_+_56513286 0.09 ENSRNOT00000015596
Zbtb41
zinc finger and BTB domain containing 41
chr1_+_85213652 0.08 ENSRNOT00000092044
Nccrp1
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
chrX_-_63182385 0.04 ENSRNOT00000076613
Zfx
zinc finger protein X-linked
chr14_+_22192970 0.03 ENSRNOT00000041514
ENSRNOT00000002704
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1

Network of associatons between targets according to the STRING database.

First level regulatory network of Isl1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 13.0 GO:0043606 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) formamide metabolic process(GO:0043606)
1.9 7.8 GO:0051692 cellular oligosaccharide catabolic process(GO:0051692) regulation of exo-alpha-sialidase activity(GO:1903015)
1.6 4.8 GO:0015827 angiotensin-mediated drinking behavior(GO:0003051) tryptophan transport(GO:0015827) positive regulation of gap junction assembly(GO:1903598)
1.5 4.4 GO:0032978 protein insertion into membrane from inner side(GO:0032978)
1.1 9.7 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
1.0 4.1 GO:0070560 protein secretion by platelet(GO:0070560)
1.0 6.0 GO:0001907 killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004) response to platinum ion(GO:0070541)
0.9 3.7 GO:0003357 noradrenergic neuron differentiation(GO:0003357)
0.9 7.2 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.5 3.3 GO:0006102 isocitrate metabolic process(GO:0006102) glyoxylate metabolic process(GO:0046487)
0.5 4.7 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.5 2.3 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.4 1.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 4.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.3 0.3 GO:0007208 phospholipase C-activating serotonin receptor signaling pathway(GO:0007208)
0.3 5.2 GO:0042359 vitamin D metabolic process(GO:0042359)
0.2 2.0 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.2 2.4 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
0.2 0.6 GO:2000974 auditory receptor cell fate determination(GO:0042668) negative regulation of pro-B cell differentiation(GO:2000974) negative regulation of forebrain neuron differentiation(GO:2000978)
0.2 1.7 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.2 0.5 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.2 1.8 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.1 0.4 GO:0072434 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.1 4.6 GO:0055078 sodium ion homeostasis(GO:0055078)
0.1 1.2 GO:0009744 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 1.0 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.1 0.7 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.9 GO:0097264 self proteolysis(GO:0097264)
0.1 4.5 GO:0006953 acute-phase response(GO:0006953)
0.1 0.8 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 1.0 GO:0019532 oxalate transport(GO:0019532)
0.1 0.6 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.7 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 2.7 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 0.6 GO:0038065 collagen-activated signaling pathway(GO:0038065)
0.0 3.1 GO:0044070 regulation of anion transport(GO:0044070)
0.0 0.1 GO:1901374 acetate ester transport(GO:1901374)
0.0 3.8 GO:0030522 intracellular receptor signaling pathway(GO:0030522)
0.0 0.3 GO:0016180 snRNA processing(GO:0016180)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 13.0 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
1.4 4.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.4 2.4 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.2 4.6 GO:0034706 sodium channel complex(GO:0034706)
0.2 4.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 0.4 GO:0070939 Dsl1p complex(GO:0070939)
0.1 1.2 GO:0031209 SCAR complex(GO:0031209)
0.1 1.0 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 1.7 GO:0042581 specific granule(GO:0042581)
0.1 11.2 GO:0072562 blood microparticle(GO:0072562)
0.1 0.7 GO:0005796 Golgi lumen(GO:0005796)
0.1 5.4 GO:0031526 brush border membrane(GO:0031526)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 3.3 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.3 GO:0070852 cell body fiber(GO:0070852)
0.0 0.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 3.1 GO:0034702 ion channel complex(GO:0034702)
0.0 2.7 GO:0043204 perikaryon(GO:0043204)
0.0 2.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 7.8 GO:0005768 endosome(GO:0005768)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 14.5 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
2.6 13.0 GO:0016841 ammonia-lyase activity(GO:0016841)
2.6 7.8 GO:0017042 glycosylceramidase activity(GO:0017042)
1.5 4.4 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
1.1 3.3 GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990)
0.9 4.5 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.9 5.2 GO:0005499 vitamin D binding(GO:0005499)
0.5 4.6 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.4 1.2 GO:0001605 adrenomedullin receptor activity(GO:0001605)
0.3 2.4 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.3 6.0 GO:0015643 toxic substance binding(GO:0015643)
0.2 3.1 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 2.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.3 GO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding(GO:0071886)
0.1 4.1 GO:0030507 spectrin binding(GO:0030507)
0.1 3.4 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.9 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 1.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 3.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 2.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 3.8 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.7 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 2.7 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.1 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
0.0 1.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.2 GO:0004540 ribonuclease activity(GO:0004540)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 6.0 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 6.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.7 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.6 PID CDC42 PATHWAY CDC42 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 6.0 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.2 7.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.2 5.2 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 2.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 3.3 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 3.8 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 0.7 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 13.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 5.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.1 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 4.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.3 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.5 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription