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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Irx6_Irx2_Irx3

Z-value: 0.68

Motif logo

Transcription factors associated with Irx6_Irx2_Irx3

Gene Symbol Gene ID Gene Info
ENSRNOG00000011037 iroquois homeobox 6
ENSRNOG00000012742 iroquois homeobox 2
ENSRNOG00000011533 iroquois homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irx6rn6_v1_chr19_-_15733412_15733412-0.392.5e-13Click!
Irx3rn6_v1_chr19_-_15840990_15840990-0.263.2e-06Click!
Irx2rn6_v1_chr1_-_33275540_33275540-0.149.4e-03Click!

Activity profile of Irx6_Irx2_Irx3 motif

Sorted Z-values of Irx6_Irx2_Irx3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_14157141 25.94 ENSRNOT00000079034
deuterosome assembly protein 1
chr1_+_83103925 21.88 ENSRNOT00000047540
ENSRNOT00000028196
cytochrome P450, family 2, subfamily b, polypeptide 2
chr1_+_53531076 14.77 ENSRNOT00000018015
t-complex protein 10b
chr13_+_89597138 14.60 ENSRNOT00000004662
apolipoprotein A2
chr1_-_258766881 14.50 ENSRNOT00000015801
cytochrome P450, family 2, subfamily c, polypeptide 12
chr4_+_14109864 13.83 ENSRNOT00000076349
similar to fatty acid translocase/CD36
chr2_+_193724248 13.44 ENSRNOT00000025249
repetin
chr7_-_2431197 12.81 ENSRNOT00000003498
hydroxysteroid (17-beta) dehydrogenase 6
chr7_+_99142450 11.55 ENSRNOT00000079036
ENSRNOT00000091923
cytochrome P450 2B1
chr16_-_82288022 10.97 ENSRNOT00000078609
sperm acrosome associated 7
chr2_-_173563273 10.38 ENSRNOT00000081423
zinc finger, B-box domain containing
chr18_+_35574002 10.29 ENSRNOT00000093442
ENSRNOT00000070817
ENSRNOT00000093356
myotilin
chr18_+_35121967 10.19 ENSRNOT00000017522
serine peptidase inhibitor, Kazal type 5
chr16_+_72086878 9.69 ENSRNOT00000023756
ENSRNOT00000078085
ADAM metallopeptidase domain 3A
chr3_-_46601409 9.63 ENSRNOT00000079261
phospholipase A2 receptor 1
chr13_-_56958549 9.42 ENSRNOT00000017293
ENSRNOT00000083912
similar to complement factor H-related protein
chrX_+_105011489 9.14 ENSRNOT00000085068
ADP ribosylation factor like GTPase 13A
chr2_+_35935670 9.08 ENSRNOT00000076875
ENSRNOT00000075753
serine protease inhibitor Kazal-type 5-like
chr9_+_24066303 8.96 ENSRNOT00000018163
cysteine-rich secretory protein 3
chr1_-_164142206 8.88 ENSRNOT00000081669
diacylglycerol O-acyltransferase 2
chr9_+_37727942 8.87 ENSRNOT00000016511
ENSRNOT00000074276
myotilin-like
chr10_-_107114271 8.87 ENSRNOT00000004035
dynein, axonemal, heavy chain 17
chr4_+_14039977 8.62 ENSRNOT00000091249
ENSRNOT00000075878
CD36 molecule
chr5_-_39611053 8.55 ENSRNOT00000046595
four and a half LIM domains 5
chr15_-_49505553 8.51 ENSRNOT00000028974
ADAM-like, decysin 1
chr14_+_22375955 8.50 ENSRNOT00000063915
ENSRNOT00000034784
UDP-glucuronosyltransferase 2 family, member 37
chr1_-_219312240 8.34 ENSRNOT00000066691
similar to hypothetical protein MGC37914
chr2_+_104744461 8.05 ENSRNOT00000016083
ENSRNOT00000082627
ceruloplasmin
chr16_+_50179458 8.00 ENSRNOT00000041946
coagulation factor XI
chr9_+_16139101 7.99 ENSRNOT00000070803
uncharacterized LOC100910668
chr9_+_14951047 7.73 ENSRNOT00000074267
uncharacterized LOC100911489
chr7_+_40318490 7.38 ENSRNOT00000081374
similar to hypothetical protein FLJ35821
chr3_+_1385654 7.21 ENSRNOT00000091805
ENSRNOT00000007593
interleukin 36 receptor antagonist
chr18_+_3861539 7.05 ENSRNOT00000015363
laminin subunit alpha 3
chr17_+_57033573 6.88 ENSRNOT00000020160
cAMP responsive element modulator
chr1_+_229267916 6.75 ENSRNOT00000073717
ENSRNOT00000082670
ENSRNOT00000076941
serine protease inhibitor Kazal-type 5-like
chr8_-_111761871 6.74 ENSRNOT00000056483
similar to RIKEN cDNA 1300017J02
chr17_-_69711689 6.57 ENSRNOT00000041925
aldo-keto reductase family 1, member C12
chr3_-_134462653 6.37 ENSRNOT00000033562
SEL1L2 ERAD E3 ligase adaptor subunit
chr18_-_399242 6.28 ENSRNOT00000045926
coagulation factor VIII
chr13_-_102721218 6.22 ENSRNOT00000005459
mitochondrial amidoxime reducing component 1
chr11_+_52828116 6.11 ENSRNOT00000035340
coiled-coil domain containing 54
chr1_+_147713892 5.96 ENSRNOT00000092985
ENSRNOT00000054742
ENSRNOT00000074103
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
chr18_+_35384743 5.90 ENSRNOT00000076143
ENSRNOT00000074593
serine protease inhibitor Kazal-type 5-like
chr14_+_22806132 5.86 ENSRNOT00000002728
UDP glucuronosyltransferase 2 family, polypeptide B10
chr16_+_9074033 5.82 ENSRNOT00000027193
family with sequence similarity 170, member B
chr2_+_205568935 5.73 ENSRNOT00000025248
adenosine monophosphate deaminase 1
chrX_+_96667863 5.72 ENSRNOT00000042552
similar to hypothetical protein 4932411N23
chr1_+_83163079 5.72 ENSRNOT00000077725
ENSRNOT00000034845
cytochrome P450, family 2, subfamily b, polypeptide 3
chr19_+_85606 5.66 ENSRNOT00000015724
carboxylesterase 2E
chr4_+_98337367 5.64 ENSRNOT00000042165

chr3_-_134340801 5.56 ENSRNOT00000085149
SEL1L2 ERAD E3 ligase adaptor subunit
chr2_-_192288568 5.54 ENSRNOT00000067346

chr1_+_83933942 5.54 ENSRNOT00000068690
cytochrome P450, family 2, subfamily f, polypeptide 4
chr1_-_227441442 5.52 ENSRNOT00000028433
membrane spanning 4-domains A1
chr16_-_6404957 5.40 ENSRNOT00000048459
calcium voltage-gated channel subunit alpha1 D
chr2_+_54466280 5.40 ENSRNOT00000033112
complement C6
chr13_-_53870428 5.33 ENSRNOT00000000812
nuclear receptor subfamily 5, group A, member 2
chr7_+_129595192 5.31 ENSRNOT00000071151
zinc finger, DHHC-type containing 25
chr14_-_1505085 5.29 ENSRNOT00000090361
uncharacterized LOC102554799
chr5_-_163167299 5.22 ENSRNOT00000022478
TNF receptor superfamily member 1B
chr3_+_55461420 5.22 ENSRNOT00000073549
glucose-6-phosphatase catalytic subunit 2
chr2_-_180914940 5.10 ENSRNOT00000015732
tryptophan 2,3-dioxygenase
chrX_+_43293551 5.09 ENSRNOT00000084562
hypothetical protein LOC680190
chr2_-_132301073 5.05 ENSRNOT00000058288
similar to GTPase activating protein testicular GAP1
chr7_-_54823956 5.00 ENSRNOT00000073180
GLI pathogenesis-related 1 like 2
chr1_-_116919269 4.95 ENSRNOT00000035149

chr8_-_38549268 4.95 ENSRNOT00000088001
urinary protein 3-like
chr2_-_208623314 4.92 ENSRNOT00000022731
primary cilia formation
chr13_+_89919667 4.91 ENSRNOT00000006196
intelectin 1
chr4_-_162649618 4.89 ENSRNOT00000050861
killer cell lectin-like receptor, subfamily A, member 5
chr3_-_153246433 4.78 ENSRNOT00000067748
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
chrX_+_122313470 4.77 ENSRNOT00000018322
similar to hypothetical protein
chr1_-_222118459 4.73 ENSRNOT00000067217
coiled-coil domain containing 88B
chr1_-_201702963 4.72 ENSRNOT00000031258
similar to RIKEN cDNA 1700022C21
chr4_-_163849618 4.67 ENSRNOT00000086363
ENSRNOT00000077637
immunoreceptor Ly49si1
chr4_+_155009479 4.52 ENSRNOT00000070906

chr17_-_57394985 4.50 ENSRNOT00000019968
enhancer of polycomb homolog 1
chr4_+_96562725 4.49 ENSRNOT00000009094
neuron-derived neurotrophic factor
chr16_-_6405117 4.48 ENSRNOT00000047737
calcium voltage-gated channel subunit alpha1 D
chr2_-_192381716 4.46 ENSRNOT00000064950

chr10_-_17415251 4.40 ENSRNOT00000005509
EF-hand calcium binding domain 9
chr1_+_48039909 4.38 ENSRNOT00000060412
ENSRNOT00000076338
PARN like, ribonuclease domain containing 1
chr4_+_165732643 4.26 ENSRNOT00000034403
hypothetical protein LOC690326
chr4_-_164051812 4.26 ENSRNOT00000085719

chr9_-_105282292 4.24 ENSRNOT00000071358
solute carrier organic anion transporter family member 6A1-like
chr1_-_169005190 4.22 ENSRNOT00000043719
hemoglobin subunit epsilon 1
chr2_+_252452269 4.16 ENSRNOT00000021970
urate oxidase
chr1_+_201672528 4.04 ENSRNOT00000093490
deleted in malignant brain tumors 1
chr6_-_86223052 4.03 ENSRNOT00000046828
fibrous sheath CABYR binding protein
chr3_-_110021149 4.02 ENSRNOT00000007808
fibrous sheath interacting protein 1
chr1_+_55219773 4.01 ENSRNOT00000041610
similar to putative protein kinase
chr5_+_117586103 4.00 ENSRNOT00000084640
ubiquitin specific peptidase 1
chr17_+_57676569 3.97 ENSRNOT00000072747
similar to isopentenyl diphosphate delta-isomerase type 2
chr2_+_127538659 3.96 ENSRNOT00000093483
ENSRNOT00000058476
solute carrier family 25 member 31
chr17_-_42639922 3.91 ENSRNOT00000081105
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr1_+_214183724 3.90 ENSRNOT00000091150
leucine rich repeat containing 56
chr1_+_77967755 3.87 ENSRNOT00000058241
zinc finger protein 541
chr10_-_64550145 3.87 ENSRNOT00000050232
nucleoredoxin
chr13_+_75177965 3.83 ENSRNOT00000007321
SEC16 homolog B, endoplasmic reticulum export factor
chrX_+_18163358 3.81 ENSRNOT00000045517
similar to Spindlin-like protein 2 (SPIN-2)
chr2_+_147496229 3.78 ENSRNOT00000022105
transmembrane 4 L six family member 4
chr1_-_220136470 3.70 ENSRNOT00000026812
actinin alpha 3
chr19_+_37090056 3.68 ENSRNOT00000019169
carboxylesterase 4A
chrX_+_97074710 3.68 ENSRNOT00000044379
similar to RIKEN cDNA 4921511C20 gene
chr4_+_70572942 3.67 ENSRNOT00000051964

chr4_-_163445302 3.64 ENSRNOT00000087106
killer cell lectin-like receptor subfamily C, member 3
chrX_-_63999622 3.64 ENSRNOT00000090902
protein gar2-like
chr11_-_14304603 3.63 ENSRNOT00000040202
ENSRNOT00000082143
SAM domain, SH3 domain and nuclear localization signals, 1
chr13_-_80819218 3.62 ENSRNOT00000072922
flavin containing monooxygenase 6
chr19_+_15081590 3.60 ENSRNOT00000024187
carboxylesterase 1F
chr12_+_13284532 3.59 ENSRNOT00000084045
zinc finger, DHHC-type containing 4
chr19_-_22632071 3.59 ENSRNOT00000077275
glutamic--pyruvic transaminase 2
chr7_-_107223047 3.53 ENSRNOT00000007250
ENSRNOT00000084875
leucine rich repeat containing 6
chr3_+_73335149 3.49 ENSRNOT00000042537
olfactory receptor 470
chr14_+_84282073 3.44 ENSRNOT00000078271
SEC14-like lipid binding 4
chr11_+_86094567 3.44 ENSRNOT00000086514
lambda-chain C1-region-like
chr6_-_141472746 3.41 ENSRNOT00000048010

chr6_+_127743971 3.37 ENSRNOT00000013045
serpin family A member 4
chr9_+_77320726 3.36 ENSRNOT00000068450
sperm associated antigen 16
chr11_+_45751812 3.35 ENSRNOT00000079336
similar to Dermal papilla derived protein 7
chr12_+_30606161 3.35 ENSRNOT00000093601
septin 14
chr1_-_201894775 3.33 ENSRNOT00000050519
CUB and zona pellucida-like domains 1
chrY_+_184603 3.31 ENSRNOT00000077708
zinc finger Y-chromosomal protein 2
chr14_+_97686121 3.31 ENSRNOT00000074877
POM121 transmembrane nucleoporin-like 12
chr1_-_227506822 3.26 ENSRNOT00000091506
membrane spanning 4-domains A7
chr2_+_154921999 3.25 ENSRNOT00000057620
similar to GTPase activating protein testicular GAP1
chrX_-_51792597 3.25 ENSRNOT00000072727
titin-like
chr16_-_31301880 3.24 ENSRNOT00000084847
ENSRNOT00000083943

chr8_+_106503504 3.22 ENSRNOT00000018755
retinol binding protein 2
chr11_+_85561460 3.22 ENSRNOT00000075455

chr19_-_49623758 3.21 ENSRNOT00000071130
polycystic kidney disease 1-like 2
chr5_+_117698764 3.18 ENSRNOT00000011486
angiopoietin-like 3
chr7_+_49385705 3.17 ENSRNOT00000006083
lin-7 homolog A, crumbs cell polarity complex component
chr14_+_22517774 3.15 ENSRNOT00000047655
UDP-glucuronosyltransferase 2 family, member 37
chrX_+_57866406 3.12 ENSRNOT00000076221
protein phosphatase 4 regulatory subunit 3C
chrX_+_57870445 3.11 ENSRNOT00000065038
protein phosphatase 4 regulatory subunit 3C
chr13_-_27192592 3.11 ENSRNOT00000040021
serpin family B member 3
chr18_-_15688117 3.10 ENSRNOT00000022584
desmoglein 3
chr4_-_176026133 3.07 ENSRNOT00000043374
ENSRNOT00000046598
solute carrier organic anion transporter family, member 1a4
chr15_+_31164401 3.02 ENSRNOT00000084286

chr15_-_38709984 2.98 ENSRNOT00000074738
PHD finger protein 11B
chr20_-_5166252 2.97 ENSRNOT00000001138
allograft inflammatory factor 1
chr1_-_73682247 2.97 ENSRNOT00000079498
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
chr4_-_78759408 2.95 ENSRNOT00000050994
insulin-like growth factor 2 mRNA binding protein 3
chr16_+_72010106 2.95 ENSRNOT00000058330
ADAM metallopeptidase domain 5
chr1_-_227457629 2.95 ENSRNOT00000035910
ENSRNOT00000073770
membrane spanning 4-domains A5
chr8_-_61917125 2.92 ENSRNOT00000085049
similar to human chromosome 15 open reading frame 39
chr17_-_32076181 2.92 ENSRNOT00000074842
leukocyte elastase inhibitor A-like
chr15_+_61826937 2.91 ENSRNOT00000084005
ENSRNOT00000079417
E74-like factor 1
chr4_-_50693869 2.89 ENSRNOT00000064228
ring finger protein 148
chr2_-_29248174 2.89 ENSRNOT00000071167
similar to HIStone family member (his-41)
chr2_+_192463203 2.88 ENSRNOT00000081253
small proline-rich protein 2H-like
chr19_+_487723 2.86 ENSRNOT00000061734
carboxylesterase 2J
chr1_+_256786124 2.85 ENSRNOT00000034563
free fatty acid receptor 4
chr19_+_26022849 2.85 ENSRNOT00000014887
deoxyribonuclease 2, lysosomal
chrX_-_24120987 2.85 ENSRNOT00000030377
hypothetical protein LOC685762
chr15_+_34328851 2.84 ENSRNOT00000026819
testis-specific serine kinase 4
chr10_+_59566223 2.84 ENSRNOT00000024068
ENSRNOT00000088245
purinergic receptor P2X 1
chr2_+_166856784 2.84 ENSRNOT00000035765
otolin 1
chr4_-_164899041 2.83 ENSRNOT00000090316
Ly49 inhibitory receptor 2
chr12_-_46889082 2.81 ENSRNOT00000001525
phospholipase A2 group IB
chr10_-_88122233 2.81 ENSRNOT00000083895
ENSRNOT00000005285
keratin 14
chr3_-_78790691 2.80 ENSRNOT00000008750
olfactory receptor 724
chr8_-_85720790 2.80 ENSRNOT00000071049
oocyte expressed protein
chr1_-_54854353 2.79 ENSRNOT00000072895
sperm motility kinase 2A
chr14_+_1318157 2.77 ENSRNOT00000061889
vomeronasal 2 receptor, 67
chr7_-_9174330 2.73 ENSRNOT00000051063
olfactory receptor 1060
chr11_-_79703736 2.71 ENSRNOT00000044279
LIM domain containing preferred translocation partner in lipoma
chr14_+_39368530 2.71 ENSRNOT00000084367
cytochrome c oxidase subunit 7B2
chr2_-_192481273 2.70 ENSRNOT00000012135
small proline-rich protein 2D
chr1_+_169951913 2.70 ENSRNOT00000040861
olfactory receptor 189
chr1_-_150101177 2.70 ENSRNOT00000042931
olfactory receptor 24
chr10_-_109840047 2.69 ENSRNOT00000054947
NOTUM, palmitoleoyl-protein carboxylesterase
chr2_-_192780631 2.69 ENSRNOT00000012371
sperm mitochondria-associated cysteine-rich protein
chr10_+_53781239 2.66 ENSRNOT00000082871
myosin heavy chain 2
chr20_-_1109027 2.64 ENSRNOT00000051315
olfactory receptor 1696
chr3_+_1413671 2.63 ENSRNOT00000007675
interleukin 1 family member 10
chr20_-_5166448 2.62 ENSRNOT00000076331
allograft inflammatory factor 1
chr11_-_87921679 2.62 ENSRNOT00000084973
serpin family D member 1
chr20_-_10013559 2.62 ENSRNOT00000091623
radial spoke head 1 homolog
chr17_-_51912496 2.58 ENSRNOT00000019272
inhibin beta A subunit
chr1_+_148240504 2.57 ENSRNOT00000085373
Cytochrome P450, family 2, subfamily c, polypeptide 7-like
chr1_+_169919411 2.57 ENSRNOT00000050034
olfactory receptor 186
chr9_-_54484533 2.56 ENSRNOT00000083514
signal transducer and activator of transcription 1
chr16_+_69022792 2.55 ENSRNOT00000035985
glutamic-oxaloacetic transaminase 1-like 1
chr17_+_43661222 2.53 ENSRNOT00000022881
ENSRNOT00000022809
ENSRNOT00000022810
hemochromatosis
chr9_-_32868371 2.52 ENSRNOT00000038369
similar to chromosome 9 open reading frame 79
chrX_+_118742313 2.52 ENSRNOT00000045110

chr13_-_91776397 2.49 ENSRNOT00000073147
mucosal pentraxin 1
chr9_+_93030714 2.45 ENSRNOT00000023581
spermatogenesis associated 3
chr1_-_48559162 2.44 ENSRNOT00000080352
plasminogen
chr16_-_6404578 2.43 ENSRNOT00000051371
calcium voltage-gated channel subunit alpha1 D
chr14_+_85871597 2.43 ENSRNOT00000079671
ankyrin repeat domain 36
chr17_+_84881414 2.43 ENSRNOT00000034157
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
chr11_-_29638922 2.42 ENSRNOT00000048888
ribosomal protein L29-like
chr1_-_13341952 2.41 ENSRNOT00000079531
epithelial cell transforming 2 like
chr6_+_36941596 2.41 ENSRNOT00000083383
structural maintenance of chromosomes 6
chr1_-_149859479 2.39 ENSRNOT00000052199
olfactory receptor 14A2-like
chr4_+_78382287 2.38 ENSRNOT00000084927
GTPase, IMAP family member 5

Network of associatons between targets according to the STRING database.

First level regulatory network of Irx6_Irx2_Irx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 25.9 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
4.9 14.6 GO:0046340 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) diacylglycerol catabolic process(GO:0046340)
2.1 57.6 GO:0019373 epoxygenase P450 pathway(GO:0019373)
1.9 5.6 GO:0014739 positive regulation of muscle hyperplasia(GO:0014739)
1.9 3.7 GO:1904023 regulation of fermentation(GO:0043465) regulation of NAD metabolic process(GO:1902688) regulation of glucose catabolic process to lactate via pyruvate(GO:1904023)
1.8 5.4 GO:0001969 activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
1.8 8.9 GO:0071400 cellular response to oleic acid(GO:0071400)
1.7 10.2 GO:0072564 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
1.7 10.2 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
1.6 6.3 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
1.6 6.2 GO:0042126 nitrate metabolic process(GO:0042126)
1.5 10.4 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
1.4 9.6 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238) oxidative stress-induced premature senescence(GO:0090403)
1.4 12.3 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
1.2 7.2 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
1.2 4.8 GO:0046061 dATP catabolic process(GO:0046061)
1.1 3.4 GO:0051012 microtubule sliding(GO:0051012)
1.1 5.3 GO:0061113 pancreas morphogenesis(GO:0061113)
1.0 3.1 GO:0035425 autocrine signaling(GO:0035425)
1.0 8.1 GO:0015679 plasma membrane copper ion transport(GO:0015679)
1.0 5.7 GO:0032264 IMP salvage(GO:0032264)
0.9 2.8 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.9 2.8 GO:0002554 serotonin secretion by platelet(GO:0002554)
0.9 2.7 GO:2000502 stimulatory C-type lectin receptor signaling pathway(GO:0002223) negative regulation of natural killer cell chemotaxis(GO:2000502)
0.9 5.2 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.9 2.6 GO:0006532 aspartate biosynthetic process(GO:0006532)
0.8 2.5 GO:0034759 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) regulation of iron ion transmembrane transport(GO:0034759)
0.8 1.7 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.8 3.3 GO:0034240 negative regulation of macrophage fusion(GO:0034240)
0.8 3.2 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.8 2.3 GO:0046167 glycerol-3-phosphate biosynthetic process(GO:0046167)
0.7 2.2 GO:0032290 peripheral nervous system myelin formation(GO:0032290)
0.7 5.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.7 1.4 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.7 7.0 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.7 4.9 GO:0009624 response to nematode(GO:0009624)
0.7 3.9 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.6 2.6 GO:0060279 positive regulation of ovulation(GO:0060279)
0.6 1.9 GO:1990743 protein sialylation(GO:1990743)
0.6 3.5 GO:0042851 L-alanine metabolic process(GO:0042851)
0.6 1.7 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
0.5 1.6 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.5 2.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.5 3.2 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.5 1.6 GO:0071226 cellular response to molecule of fungal origin(GO:0071226)
0.5 10.0 GO:0035404 histone-serine phosphorylation(GO:0035404)
0.5 1.4 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.5 2.8 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.5 1.4 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.5 16.2 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.4 1.3 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.4 3.8 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.4 4.5 GO:0061042 vascular wound healing(GO:0061042)
0.4 3.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.4 2.3 GO:0090598 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.4 1.5 GO:1990402 embryonic liver development(GO:1990402)
0.4 1.1 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
0.4 1.5 GO:0060460 left lung development(GO:0060459) left lung morphogenesis(GO:0060460)
0.4 0.7 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.4 1.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.4 7.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.4 1.1 GO:0072566 chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.4 1.5 GO:1903964 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.4 1.4 GO:0035697 CD8-positive, alpha-beta T cell extravasation(GO:0035697) regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531) diapedesis(GO:0050904) cellular response to vitamin K(GO:0071307)
0.4 1.1 GO:1902226 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.3 1.0 GO:0055073 cadmium ion homeostasis(GO:0055073)
0.3 4.0 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.3 5.2 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.3 2.9 GO:0052697 xenobiotic glucuronidation(GO:0052697)
0.3 4.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.3 12.4 GO:0008209 androgen metabolic process(GO:0008209)
0.3 2.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.3 5.2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.3 1.8 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.3 1.8 GO:0006069 ethanol oxidation(GO:0006069)
0.3 0.6 GO:0030186 melatonin metabolic process(GO:0030186)
0.3 2.6 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.3 4.2 GO:0015671 oxygen transport(GO:0015671)
0.3 1.1 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.3 2.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.3 2.2 GO:0006067 ethanol metabolic process(GO:0006067)
0.3 0.8 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.3 2.2 GO:0001865 NK T cell differentiation(GO:0001865)
0.3 4.9 GO:0043968 histone H2A acetylation(GO:0043968)
0.3 1.1 GO:0035519 protein K29-linked ubiquitination(GO:0035519)
0.3 0.8 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.3 2.4 GO:0070417 cellular response to cold(GO:0070417)
0.3 2.4 GO:0042159 lipoprotein catabolic process(GO:0042159)
0.3 1.0 GO:0060331 negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336)
0.3 1.3 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.2 1.0 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.2 1.2 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.2 0.9 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.2 1.4 GO:2001184 toll-like receptor 7 signaling pathway(GO:0034154) positive regulation of interleukin-12 secretion(GO:2001184)
0.2 0.9 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.2 0.7 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.2 1.3 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.2 1.3 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
0.2 1.3 GO:0002399 MHC class II protein complex assembly(GO:0002399) peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.2 1.7 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.2 4.7 GO:0042832 defense response to protozoan(GO:0042832)
0.2 8.2 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.2 2.7 GO:0001778 plasma membrane repair(GO:0001778)
0.2 0.6 GO:0006574 valine catabolic process(GO:0006574)
0.2 4.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 2.2 GO:0019321 pentose metabolic process(GO:0019321)
0.2 1.2 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.2 5.3 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2 1.0 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.2 2.8 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.2 0.6 GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033)
0.2 0.9 GO:0032917 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.2 0.6 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.2 1.1 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.2 0.9 GO:0090306 spindle assembly involved in meiosis(GO:0090306)
0.2 1.7 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.2 1.3 GO:0051026 chiasma assembly(GO:0051026)
0.2 0.5 GO:1901367 response to L-cysteine(GO:1901367)
0.2 0.6 GO:0015747 urate transport(GO:0015747)
0.2 1.0 GO:0006572 tyrosine catabolic process(GO:0006572)
0.2 0.5 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.2 0.9 GO:0070269 pyroptosis(GO:0070269)
0.1 0.4 GO:0002638 negative regulation of immunoglobulin production(GO:0002638)
0.1 0.3 GO:0032701 negative regulation of interleukin-18 production(GO:0032701)
0.1 0.4 GO:1903116 gastrin-induced gastric acid secretion(GO:0001698) positive regulation of actin filament-based movement(GO:1903116) negative regulation of forebrain neuron differentiation(GO:2000978)
0.1 1.0 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.1 1.1 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.1 1.1 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.4 GO:1904098 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.1 0.9 GO:0090232 positive regulation of spindle checkpoint(GO:0090232) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.1 0.6 GO:0002329 pre-B cell differentiation(GO:0002329)
0.1 3.2 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 1.3 GO:0045059 positive thymic T cell selection(GO:0045059)
0.1 0.8 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.1 3.8 GO:0002820 negative regulation of adaptive immune response(GO:0002820)
0.1 1.0 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.1 1.1 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.1 2.0 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 0.6 GO:1904970 brush border assembly(GO:1904970)
0.1 1.3 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.1 1.1 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.1 0.7 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.1 0.3 GO:0018094 protein polyglycylation(GO:0018094)
0.1 0.6 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.1 2.9 GO:0019835 cytolysis(GO:0019835)
0.1 0.8 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 0.4 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 6.4 GO:0035082 axoneme assembly(GO:0035082)
0.1 0.7 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.8 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 1.5 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 0.3 GO:0034769 basement membrane disassembly(GO:0034769)
0.1 0.3 GO:0018343 protein farnesylation(GO:0018343)
0.1 0.3 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.1 0.5 GO:0014732 skeletal muscle atrophy(GO:0014732)
0.1 0.6 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 1.4 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.1 2.9 GO:0050710 negative regulation of cytokine secretion(GO:0050710)
0.1 1.6 GO:0002360 T cell lineage commitment(GO:0002360)
0.1 0.9 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.1 1.9 GO:0048240 sperm capacitation(GO:0048240)
0.1 1.6 GO:0061050 regulation of cell growth involved in cardiac muscle cell development(GO:0061050)
0.1 9.9 GO:0007338 single fertilization(GO:0007338)
0.1 1.8 GO:0070166 enamel mineralization(GO:0070166)
0.1 1.0 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 1.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 1.3 GO:0036315 cellular response to sterol(GO:0036315)
0.1 0.8 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.1 0.3 GO:1902304 positive regulation of potassium ion export(GO:1902304)
0.1 0.2 GO:0033123 positive regulation of purine nucleotide catabolic process(GO:0033123)
0.1 1.1 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 0.7 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.1 3.5 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.1 0.7 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.2 GO:0070055 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054) mRNA endonucleolytic cleavage involved in unfolded protein response(GO:0070055)
0.1 1.0 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.1 0.6 GO:0071373 cellular response to luteinizing hormone stimulus(GO:0071373)
0.1 1.0 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.1 0.6 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 2.2 GO:0010447 response to acidic pH(GO:0010447)
0.1 2.1 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.1 0.2 GO:0035509 negative regulation of myosin-light-chain-phosphatase activity(GO:0035509)
0.1 0.5 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.1 0.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 2.3 GO:0009225 nucleotide-sugar metabolic process(GO:0009225)
0.1 0.3 GO:0070560 protein secretion by platelet(GO:0070560)
0.1 0.6 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.1 0.7 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.1 1.1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736)
0.1 3.5 GO:0006405 RNA export from nucleus(GO:0006405)
0.1 2.5 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.1 6.8 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 1.0 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.1 0.2 GO:0007308 oocyte construction(GO:0007308) oocyte axis specification(GO:0007309) oocyte anterior/posterior axis specification(GO:0007314) pole plasm assembly(GO:0007315) maternal determination of anterior/posterior axis, embryo(GO:0008358) P granule organization(GO:0030719)
0.1 3.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 3.6 GO:0042246 tissue regeneration(GO:0042246)
0.1 0.9 GO:0018149 peptide cross-linking(GO:0018149)
0.1 0.4 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.1 0.5 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 3.0 GO:0007566 embryo implantation(GO:0007566)
0.1 1.2 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 0.4 GO:0001302 replicative cell aging(GO:0001302)
0.1 1.5 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 2.2 GO:0030317 sperm motility(GO:0030317)
0.0 1.0 GO:0045116 protein neddylation(GO:0045116)
0.0 0.6 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.2 GO:0015811 L-cystine transport(GO:0015811)
0.0 9.0 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 2.6 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 0.5 GO:0044458 motile cilium assembly(GO:0044458)
0.0 4.9 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.5 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.1 GO:0071639 positive regulation of monocyte chemotactic protein-1 production(GO:0071639)
0.0 0.9 GO:0002292 T cell differentiation involved in immune response(GO:0002292)
0.0 0.3 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.3 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 1.1 GO:0042108 positive regulation of cytokine biosynthetic process(GO:0042108)
0.0 1.3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.9 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 2.0 GO:0030101 natural killer cell activation(GO:0030101)
0.0 0.1 GO:1904178 sterol regulatory element binding protein import into nucleus(GO:0035105) negative regulation of adipose tissue development(GO:1904178)
0.0 0.3 GO:0000479 endonucleolytic cleavage involved in rRNA processing(GO:0000478) endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479)
0.0 2.8 GO:0031638 zymogen activation(GO:0031638)
0.0 0.2 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 0.8 GO:0033344 cholesterol efflux(GO:0033344)
0.0 0.8 GO:0010596 negative regulation of endothelial cell migration(GO:0010596)
0.0 0.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 1.0 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 0.9 GO:0042100 B cell proliferation(GO:0042100)
0.0 0.2 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.2 GO:1901739 regulation of myoblast fusion(GO:1901739)
0.0 0.2 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.0 0.5 GO:0017144 drug metabolic process(GO:0017144)
0.0 0.0 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.0 0.2 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 0.6 GO:0033189 response to vitamin A(GO:0033189)
0.0 0.2 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.3 GO:0045760 positive regulation of action potential(GO:0045760)
0.0 0.6 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.1 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 1.4 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.1 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.3 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.5 GO:0001825 blastocyst formation(GO:0001825)
0.0 0.3 GO:0031572 mitotic G2 DNA damage checkpoint(GO:0007095) G2 DNA damage checkpoint(GO:0031572)
0.0 0.1 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 1.6 GO:0007286 spermatid development(GO:0007286)
0.0 1.6 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.1 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0 0.5 GO:0007031 peroxisome organization(GO:0007031)
0.0 0.1 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.2 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.3 GO:0097502 mannosylation(GO:0097502)
0.0 0.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 13.0 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 25.9 GO:0098536 deuterosome(GO:0098536)
1.7 10.2 GO:0097209 epidermal lamellar body(GO:0097209)
1.6 14.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
1.2 7.1 GO:0005608 laminin-3 complex(GO:0005608)
1.1 4.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
1.0 12.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
1.0 5.8 GO:0002081 outer acrosomal membrane(GO:0002081)
0.9 2.6 GO:0043511 inhibin complex(GO:0043511)
0.8 2.4 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.8 21.3 GO:0001533 cornified envelope(GO:0001533)
0.7 3.4 GO:1990716 axonemal central apparatus(GO:1990716)
0.7 4.7 GO:0005579 membrane attack complex(GO:0005579)
0.6 3.9 GO:0044462 cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.6 2.5 GO:0019815 B cell receptor complex(GO:0019815)
0.6 10.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.5 9.0 GO:0042581 specific granule(GO:0042581)
0.5 1.5 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.5 2.4 GO:0035061 interchromatin granule(GO:0035061)
0.4 3.1 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.4 7.4 GO:0042589 zymogen granule membrane(GO:0042589)
0.4 2.2 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.4 2.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.4 4.2 GO:0005833 hemoglobin complex(GO:0005833)
0.4 6.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 5.5 GO:0072687 meiotic spindle(GO:0072687)
0.3 3.3 GO:0044613 nuclear pore central transport channel(GO:0044613) nuclear pore nuclear basket(GO:0044615)
0.3 2.3 GO:0070449 elongin complex(GO:0070449)
0.3 1.3 GO:0002947 tumor necrosis factor receptor superfamily complex(GO:0002947)
0.3 1.9 GO:0005879 axonemal microtubule(GO:0005879)
0.3 2.7 GO:0005826 actomyosin contractile ring(GO:0005826)
0.3 0.9 GO:0061574 ASAP complex(GO:0061574)
0.3 5.5 GO:0043196 varicosity(GO:0043196)
0.2 2.0 GO:0005828 kinetochore microtubule(GO:0005828)
0.2 5.8 GO:0001891 phagocytic cup(GO:0001891)
0.2 1.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 1.9 GO:0000138 Golgi trans cisterna(GO:0000138)
0.2 23.7 GO:0072562 blood microparticle(GO:0072562)
0.2 4.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 1.6 GO:0016589 NURF complex(GO:0016589)
0.2 0.9 GO:0031262 condensed nuclear chromosome outer kinetochore(GO:0000942) Ndc80 complex(GO:0031262)
0.2 1.2 GO:0005683 U7 snRNP(GO:0005683)
0.2 0.8 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.2 2.8 GO:0045277 respiratory chain complex IV(GO:0045277)
0.2 1.4 GO:0032009 early phagosome(GO:0032009)
0.1 7.6 GO:0030286 dynein complex(GO:0030286)
0.1 0.6 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.1 1.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 1.5 GO:0002177 manchette(GO:0002177)
0.1 1.3 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 1.8 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 2.8 GO:0005581 collagen trimer(GO:0005581)
0.1 2.2 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.1 0.7 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 1.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 1.0 GO:0000796 condensin complex(GO:0000796)
0.1 10.9 GO:0031526 brush border membrane(GO:0031526)
0.1 0.6 GO:0071203 WASH complex(GO:0071203)
0.1 0.6 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.8 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.6 GO:0005687 U4 snRNP(GO:0005687)
0.1 0.6 GO:0031415 NatA complex(GO:0031415)
0.1 0.8 GO:0001940 male pronucleus(GO:0001940)
0.1 5.9 GO:0005811 lipid particle(GO:0005811)
0.1 0.2 GO:1990630 IRE1-RACK1-PP2A complex(GO:1990630)
0.1 1.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.8 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 0.6 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 1.6 GO:0031672 A band(GO:0031672)
0.1 0.2 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.1 10.2 GO:0030018 Z disc(GO:0030018)
0.1 4.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.6 GO:0097443 sorting endosome(GO:0097443)
0.1 1.5 GO:0000800 lateral element(GO:0000800)
0.1 1.0 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 9.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 50.2 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 4.3 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 0.2 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 3.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 6.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 3.4 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.7 GO:0032039 integrator complex(GO:0032039)
0.0 0.1 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.3 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.3 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.3 GO:0000346 transcription export complex(GO:0000346)
0.0 1.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.7 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.5 GO:0043296 apical junction complex(GO:0043296)
0.0 35.6 GO:0005615 extracellular space(GO:0005615)
0.0 0.3 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 3.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.3 GO:0044815 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.0 0.4 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 2.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 3.7 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.4 GO:0034451 centriolar satellite(GO:0034451)
0.0 2.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)
0.0 0.3 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.6 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
2.2 8.9 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
2.1 12.3 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
2.0 10.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
1.9 57.6 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
1.9 13.0 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
1.7 5.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
1.6 4.9 GO:0047635 L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635)
1.6 6.2 GO:0008940 nitrate reductase activity(GO:0008940)
1.4 5.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
1.4 4.2 GO:0031721 hemoglobin alpha binding(GO:0031721)
1.4 4.2 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
1.3 5.2 GO:0004452 isopentenyl-diphosphate delta-isomerase activity(GO:0004452)
1.2 8.6 GO:0048019 receptor antagonist activity(GO:0048019)
1.2 7.2 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
1.1 5.3 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
1.0 3.9 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.9 2.6 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.8 2.3 GO:0004370 glycerol kinase activity(GO:0004370)
0.7 2.2 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.7 10.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.7 8.2 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.6 2.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.6 3.2 GO:0097016 L27 domain binding(GO:0097016)
0.6 19.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.6 3.1 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.6 1.8 GO:0005503 all-trans retinal binding(GO:0005503) benzaldehyde dehydrogenase activity(GO:0019115) S-(hydroxymethyl)glutathione dehydrogenase activity(GO:0051903)
0.6 4.8 GO:0032554 purine deoxyribonucleotide binding(GO:0032554)
0.6 4.1 GO:0035375 zymogen binding(GO:0035375)
0.6 2.8 GO:1990254 keratin filament binding(GO:1990254)
0.6 3.9 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.5 6.6 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.5 2.0 GO:0004031 aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.5 1.5 GO:0001605 adrenomedullin receptor activity(GO:0001605)
0.5 1.9 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.4 1.8 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.4 14.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.4 9.6 GO:0043274 phospholipase binding(GO:0043274)
0.4 1.2 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.4 11.5 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.4 3.2 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.4 1.5 GO:0070697 activin receptor binding(GO:0070697)
0.4 1.1 GO:0070976 TIR domain binding(GO:0070976)
0.4 1.5 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.4 1.5 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.4 1.4 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.4 3.2 GO:0019841 retinol binding(GO:0019841)
0.4 6.8 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.4 1.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.4 4.9 GO:0070492 oligosaccharide binding(GO:0070492)
0.3 5.2 GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.3 1.0 GO:0016414 carnitine O-octanoyltransferase activity(GO:0008458) O-octanoyltransferase activity(GO:0016414)
0.3 1.0 GO:0019961 interferon binding(GO:0019961)
0.3 2.8 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.3 1.3 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.3 2.8 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.3 0.9 GO:0019809 spermidine binding(GO:0019809)
0.3 0.9 GO:0016015 morphogen activity(GO:0016015)
0.3 0.6 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.3 3.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.3 0.8 GO:0017113 dihydrouracil dehydrogenase (NAD+) activity(GO:0004159) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
0.3 0.8 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.3 0.8 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.3 10.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 4.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.3 1.0 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.3 8.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 2.0 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.3 3.5 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.2 5.2 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 9.9 GO:0051393 alpha-actinin binding(GO:0051393)
0.2 1.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 3.8 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 1.4 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.2 2.2 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2 0.7 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.2 1.7 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.2 24.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 1.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.2 1.6 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.2 1.0 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.2 3.0 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.2 0.6 GO:0001069 regulatory region RNA binding(GO:0001069)
0.2 0.6 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.2 2.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 0.6 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.2 0.7 GO:0030350 iron-responsive element binding(GO:0030350)
0.2 4.0 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.2 2.3 GO:1990405 protein antigen binding(GO:1990405)
0.2 0.5 GO:0003921 GMP synthase activity(GO:0003921) GMP synthase (glutamine-hydrolyzing) activity(GO:0003922)
0.2 3.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 2.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.2 3.1 GO:0001618 virus receptor activity(GO:0001618)
0.2 0.8 GO:0051373 FATZ binding(GO:0051373)
0.2 0.8 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.2 18.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.7 GO:0004974 leukotriene receptor activity(GO:0004974)
0.1 0.4 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.1 0.8 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 0.8 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 1.5 GO:0019864 IgG binding(GO:0019864)
0.1 0.5 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 1.7 GO:0048185 activin binding(GO:0048185)
0.1 1.2 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 0.9 GO:1901612 cardiolipin binding(GO:1901612)
0.1 0.5 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 2.7 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 1.1 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 2.2 GO:0005523 tropomyosin binding(GO:0005523)
0.1 10.8 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.6 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 3.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.3 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.1 1.0 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 6.3 GO:0005507 copper ion binding(GO:0005507)
0.1 0.3 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.1 0.6 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.1 1.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.1 2.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.0 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 1.5 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.1 2.6 GO:0008527 taste receptor activity(GO:0008527)
0.1 0.2 GO:0004027 alcohol sulfotransferase activity(GO:0004027) steroid sulfotransferase activity(GO:0050294)
0.1 0.6 GO:0003840 gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.1 0.3 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 2.2 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 0.6 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 1.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 3.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 0.6 GO:0034046 poly(G) binding(GO:0034046)
0.1 1.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.9 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 4.9 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 2.0 GO:0030275 LRR domain binding(GO:0030275)
0.1 0.4 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 1.4 GO:0042805 actinin binding(GO:0042805)
0.1 0.8 GO:0035325 Toll-like receptor binding(GO:0035325)
0.1 0.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.5 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 19.4 GO:0030246 carbohydrate binding(GO:0030246)
0.1 1.8 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.1 0.2 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.6 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021) vascular endothelial growth factor binding(GO:0038085)
0.1 10.1 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.1 4.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 0.4 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.1 2.3 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 1.0 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.2 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.1 1.6 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.2 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.1 4.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.2 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.0 0.7 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.5 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0032190 acrosin binding(GO:0032190)
0.0 0.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.5 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.2 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.7 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 5.0 GO:0008201 heparin binding(GO:0008201)
0.0 0.1 GO:0031763 galanin receptor binding(GO:0031763) type 2 galanin receptor binding(GO:0031765) type 3 galanin receptor binding(GO:0031766)
0.0 0.8 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 0.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 15.7 GO:0005525 GTP binding(GO:0005525)
0.0 1.4 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.8 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.6 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.2 GO:0001729 ceramide kinase activity(GO:0001729)
0.0 3.9 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 1.5 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.5 GO:0004697 protein kinase C activity(GO:0004697)
0.0 1.6 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.9 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 1.1 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.2 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.4 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 1.9 GO:0043130 ubiquitin binding(GO:0043130)
0.0 2.7 GO:0005179 hormone activity(GO:0005179)
0.0 1.8 GO:0008083 growth factor activity(GO:0008083)
0.0 2.3 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.8 GO:0005518 collagen binding(GO:0005518)
0.0 6.4 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.3 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.4 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 0.1 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.7 GO:0005496 steroid binding(GO:0005496)
0.0 0.9 GO:0005178 integrin binding(GO:0005178)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 2.2 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.3 5.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 3.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.2 3.4 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.2 2.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 8.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 0.4 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.1 5.3 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 2.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 35.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 3.7 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 0.6 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 3.3 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 2.2 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 2.2 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 13.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.7 PID E2F PATHWAY E2F transcription factor network
0.1 3.2 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 2.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 1.5 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 0.8 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 0.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.6 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.7 PID AURORA B PATHWAY Aurora B signaling
0.0 0.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.6 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.5 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.8 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 3.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 5.7 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 1.6 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.6 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.3 PID ATM PATHWAY ATM pathway
0.0 0.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.5 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.2 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 14.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.8 16.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.6 5.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.5 5.0 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.4 7.5 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.4 3.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.3 5.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 5.4 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.3 8.0 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.3 4.9 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.3 3.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 2.8 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.2 1.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 3.1 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2 0.8 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.2 10.3 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.2 1.0 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.2 1.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.2 2.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 9.8 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.1 4.7 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 1.6 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 5.0 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 1.9 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 2.9 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 5.3 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 1.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.1 REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX Genes involved in CDT1 association with the CDC6:ORC:origin complex
0.1 3.2 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 1.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.1 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 3.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 0.7 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 1.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.1 0.4 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 2.0 REACTOME KINESINS Genes involved in Kinesins
0.1 0.8 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 1.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 1.1 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.2 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 2.6 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.7 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.0 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.4 REACTOME DEFENSINS Genes involved in Defensins
0.0 0.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.7 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.8 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 1.1 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.4 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 1.1 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 1.7 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.4 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.5 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.3 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase