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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Irf3

Z-value: 1.44

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Transcription factors associated with Irf3

Gene Symbol Gene ID Gene Info
Irf3
ENSRNOG00000043388 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irf3rn6_v1_chr1_+_100992405_1009924050.491.5e-20Click!

Activity profile of Irf3 motif

Sorted Z-values of Irf3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_127337791 112.16 ENSRNOT00000032015
Ifi27l2b
interferon, alpha-inducible protein 27 like 2B
chr10_-_70744315 62.24 ENSRNOT00000014865
Ccl5
C-C motif chemokine ligand 5
chr8_-_23146689 61.29 ENSRNOT00000092200
Acp5
acid phosphatase 5, tartrate resistant
chr20_+_3990820 59.75 ENSRNOT00000000528
Psmb8
proteasome subunit beta 8
chr4_-_163890801 56.79 ENSRNOT00000081946
Ly49si1
immunoreceptor Ly49si1
chr20_-_3978845 55.32 ENSRNOT00000000532
Psmb9
proteasome subunit beta 9
chr12_+_41200718 55.30 ENSRNOT00000038426
ENSRNOT00000048450
ENSRNOT00000067176
Oas1a
2'-5' oligoadenylate synthetase 1A
chr11_-_37914983 52.89 ENSRNOT00000039876
Mx1
myxovirus (influenza virus) resistance 1
chr20_-_4677034 52.13 ENSRNOT00000075244
Rn60_20_0047.3

chr20_+_3979035 51.64 ENSRNOT00000000529
Tap1
transporter 1, ATP binding cassette subfamily B member
chr3_-_171286413 47.18 ENSRNOT00000008365
ENSRNOT00000081036
Zbp1
Z-DNA binding protein 1
chr2_+_248249468 43.33 ENSRNOT00000022648
Gbp4
guanylate binding protein 4
chr11_+_67757928 42.46 ENSRNOT00000039215
Dtx3l
deltex E3 ubiquitin ligase 3L
chr15_+_34256071 40.12 ENSRNOT00000025887
Psme1
proteasome activator subunit 1
chr11_+_68105369 38.17 ENSRNOT00000046888
Parp14
poly (ADP-ribose) polymerase family, member 14
chr6_-_127653124 36.22 ENSRNOT00000047324
Serpina11
serpin family A member 11
chr18_-_25344614 36.19 ENSRNOT00000046369
Gypc
glycophorin C (Gerbich blood group)
chr15_+_31948035 34.78 ENSRNOT00000071627
AABR07017868.1

chr16_-_19942343 31.71 ENSRNOT00000087162
ENSRNOT00000091906
Bst2
bone marrow stromal cell antigen 2
chr10_-_15459897 31.67 ENSRNOT00000027518
Decr2
2,4-dienoyl-CoA reductase 2
chr12_+_41155497 31.31 ENSRNOT00000041741
Oas1g
2'-5' oligoadenylate synthetase 1G
chr1_+_169433539 30.57 ENSRNOT00000055210
Trim34
tripartite motif-containing 34
chr1_-_227505267 30.04 ENSRNOT00000028443
Ms4a7
membrane spanning 4-domains A7
chr2_-_256915563 29.55 ENSRNOT00000084873
ENSRNOT00000029990
Ifi44
interferon-induced protein 44
chr17_+_52755621 29.03 ENSRNOT00000089943
Psme1-ps1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha), pseudogene 1
chr15_+_30270740 28.89 ENSRNOT00000070991
AABR07017707.1

chr1_-_101131012 28.52 ENSRNOT00000082283
ENSRNOT00000093498
ENSRNOT00000093559
Flt3lg
Rpl13a
fms-related tyrosine kinase 3 ligand
ribosomal protein L13A
chr15_-_34269851 27.76 ENSRNOT00000026279
Psme2
proteasome activator subunit 2
chr10_+_89358376 27.43 ENSRNOT00000028067
Ifi35
interferon-induced protein 35
chr1_-_167708685 26.78 ENSRNOT00000092857
ENSRNOT00000024992
Trim21
tripartite motif-containing 21
chr1_-_214252456 26.28 ENSRNOT00000023504
Irf7
interferon regulatory factor 7
chr3_-_48604097 25.86 ENSRNOT00000009620
Ifih1
interferon induced with helicase C domain 1
chr10_-_34221928 23.86 ENSRNOT00000045545
Irgm
immunity-related GTPase M
chr1_-_101131413 23.48 ENSRNOT00000093729
Flt3lg
fms-related tyrosine kinase 3 ligand
chr5_-_173626248 22.55 ENSRNOT00000039263
Isg15
ISG15 ubiquitin-like modifier
chr18_+_55576239 22.45 ENSRNOT00000050063
LOC100910979
interferon-inducible GTPase 1-like
chr1_-_164101578 22.05 ENSRNOT00000022176
Uvrag
UV radiation resistance associated
chr13_+_71192142 21.80 ENSRNOT00000032157
Rnasel
ribonuclease L
chr12_+_42343123 21.67 ENSRNOT00000043279
Oas1i
2 ' -5 ' oligoadenylate synthetase 1I
chr10_-_88611105 21.10 ENSRNOT00000024718
Dhx58
DEXH-box helicase 58
chr20_-_5476193 20.43 ENSRNOT00000044975
Tapbp
TAP binding protein
chr9_+_81968332 20.39 ENSRNOT00000023152
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
chr3_+_114087287 19.34 ENSRNOT00000023017
B2m
beta-2 microglobulin
chr4_+_62380914 16.95 ENSRNOT00000029845
Tmem140
transmembrane protein 140
chr4_+_67165883 16.91 ENSRNOT00000012280
Rab19
RAB19, member RAS oncogene family
chr7_-_118933812 16.83 ENSRNOT00000031951
Apol9a
apolipoprotein L 9a
chr7_-_28040510 16.31 ENSRNOT00000005674
Ascl1
achaete-scute family bHLH transcription factor 1
chr7_+_2691369 15.85 ENSRNOT00000049536
Stat2
signal transducer and activator of transcription 2
chr3_-_119405453 15.41 ENSRNOT00000090355
Sppl2a
signal peptide peptidase-like 2A
chr20_+_3269284 15.04 ENSRNOT00000089044
RT1-T24-1
RT1 class I, locus T24, gene 1
chr4_-_66899914 14.69 ENSRNOT00000011481
Parp12
poly (ADP-ribose) polymerase family, member 12
chr20_+_3242470 14.30 ENSRNOT00000078110
ENSRNOT00000041502
RT1-T24-2
RT1-T24-1
RT1 class I, locus T24, gene 2
RT1 class I, locus T24, gene 1
chr8_-_63034226 13.67 ENSRNOT00000043434
Pml
promyelocytic leukemia
chr4_-_157743199 13.51 ENSRNOT00000038178
Tapbpl
TAP binding protein-like
chr2_+_240396152 13.21 ENSRNOT00000034565
Cenpe
centromere protein E
chr4_-_66062089 12.72 ENSRNOT00000018782
Zc3hav1
zinc finger CCCH-type containing, antiviral 1
chr19_-_37912027 11.47 ENSRNOT00000026462
Psmb10
proteasome subunit beta 10
chr10_+_108527740 10.88 ENSRNOT00000044983
Rnf213
ring finger protein 213
chr2_+_1410934 10.80 ENSRNOT00000013625
ENSRNOT00000080222
Erap1
endoplasmic reticulum aminopeptidase 1
chr3_-_140141679 10.44 ENSRNOT00000014632
Crnkl1
crooked neck pre-mRNA splicing factor 1
chr16_+_75744786 10.20 ENSRNOT00000032368
Xkr5
XK related 5
chr8_-_36374673 8.71 ENSRNOT00000013763
Dcps
decapping enzyme, scavenger
chr8_-_52828134 8.52 ENSRNOT00000007736
Rbm7
RNA binding motif protein 7
chr7_+_11081536 8.30 ENSRNOT00000007110
Ncln
nicalin
chr3_-_119405300 7.84 ENSRNOT00000015568
Sppl2a
signal peptide peptidase-like 2A
chr3_-_163814799 7.22 ENSRNOT00000055127
Znfx1
zinc finger, NFX1-type containing 1
chr1_+_263511537 4.99 ENSRNOT00000023396
Cutc
cutC copper transporter
chr6_+_52122318 4.09 ENSRNOT00000086432
Nampt
nicotinamide phosphoribosyltransferase
chrY_-_1238420 3.98 ENSRNOT00000092078
Ddx3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3
chr3_-_103128243 2.98 ENSRNOT00000046310
Olr779
olfactory receptor 779
chrX_-_63291371 2.90 ENSRNOT00000082421
Eif2s3
eukaryotic translation initiation factor 2 subunit gamma
chr1_-_263511505 2.46 ENSRNOT00000023215
Cox15
COX15 cytochrome c oxidase assembly homolog
chrX_-_63291107 2.20 ENSRNOT00000092019
Eif2s3
eukaryotic translation initiation factor 2 subunit gamma
chr16_+_6779281 2.00 ENSRNOT00000022865
Sfmbt1
Scm-like with four mbt domains 1
chr7_-_26361221 1.63 ENSRNOT00000011326
RGD1309995
similar to CG13957-PA
chr1_-_198008893 1.47 ENSRNOT00000025950
Il27
interleukin 27
chr1_+_230056710 1.41 ENSRNOT00000073539
Olr357
olfactory receptor 357
chr7_-_120295618 1.21 ENSRNOT00000014413
Ankrd54
ankyrin repeat domain 54
chr12_-_41266430 1.13 ENSRNOT00000001853
ENSRNOT00000081108
Oas1b
2-5 oligoadenylate synthetase 1B
chr13_+_29839867 0.01 ENSRNOT00000090623
AABR07020537.1

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
17.2 51.6 GO:0046967 cytosol to ER transport(GO:0046967) peptide antigen transport(GO:0046968)
15.6 62.2 GO:0050904 CD8-positive, alpha-beta T cell extravasation(GO:0035697) regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531) diapedesis(GO:0050904) cellular response to vitamin K(GO:0071307)
13.8 55.3 GO:1901423 response to benzene(GO:1901423)
13.0 52.0 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
10.6 31.7 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731)
10.2 61.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
9.7 19.3 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
6.8 20.4 GO:0002397 MHC class I protein complex assembly(GO:0002397)
6.8 20.4 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
6.8 13.5 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
6.7 73.5 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
5.9 52.9 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
5.9 47.0 GO:0039530 MDA-5 signaling pathway(GO:0039530)
5.5 22.0 GO:0051684 maintenance of Golgi location(GO:0051684) double-strand break repair via classical nonhomologous end joining(GO:0097680)
5.4 16.3 GO:0021529 neuroblast differentiation(GO:0014016) spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) medulla oblongata development(GO:0021550) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
4.5 22.5 GO:0032020 ISG15-protein conjugation(GO:0032020)
3.6 10.8 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
3.4 13.7 GO:0030578 PML body organization(GO:0030578) negative regulation of interleukin-1 beta secretion(GO:0050713)
3.3 26.8 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
3.1 43.3 GO:0044406 adhesion of symbiont to host(GO:0044406)
2.9 31.7 GO:0006228 UTP biosynthetic process(GO:0006228)
2.6 67.9 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
2.5 12.7 GO:0052055 modulation by symbiont of host molecular function(GO:0052055)
2.2 13.2 GO:1902101 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
2.1 23.2 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
2.1 10.4 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
1.6 42.5 GO:0010390 histone monoubiquitination(GO:0010390)
1.6 15.8 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
1.4 46.3 GO:0035458 cellular response to interferon-beta(GO:0035458)
1.2 21.8 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
1.2 10.9 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.0 85.1 GO:0019882 antigen processing and presentation(GO:0019882)
0.8 8.7 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.7 110.9 GO:0051607 defense response to virus(GO:0051607)
0.6 36.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.5 30.6 GO:0070206 protein trimerization(GO:0070206)
0.3 5.0 GO:0055070 copper ion homeostasis(GO:0055070)
0.3 4.1 GO:0009435 NAD biosynthetic process(GO:0009435)
0.2 8.3 GO:0031648 protein destabilization(GO:0031648)
0.2 2.5 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.1 36.2 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 16.8 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.1 4.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 2.0 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.0 0.6 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
22.6 67.9 GO:0008537 proteasome activator complex(GO:0008537)
21.1 126.5 GO:1990111 spermatoproteasome complex(GO:1990111)
10.8 43.3 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
10.3 72.1 GO:0042825 TAP complex(GO:0042825)
3.6 28.5 GO:0097452 GAIT complex(GO:0097452)
3.3 23.2 GO:0098553 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
3.2 19.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
2.0 13.7 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
1.1 23.5 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
1.0 13.2 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.9 23.9 GO:0001891 phagocytic cup(GO:0001891)
0.6 5.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.5 21.1 GO:0005771 multivesicular body(GO:0005771)
0.5 31.7 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.4 26.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 22.0 GO:0045335 phagocytic vesicle(GO:0045335)
0.3 36.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 21.8 GO:0016363 nuclear matrix(GO:0016363)
0.1 45.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.1 10.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 16.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 84.8 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 10.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 43.0 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 8.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 2.5 GO:0070069 cytochrome complex(GO:0070069)
0.1 79.9 GO:0005615 extracellular space(GO:0005615)
0.1 4.0 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.1 16.9 GO:0005794 Golgi apparatus(GO:0005794)
0.1 20.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 259.4 GO:0016021 integral component of membrane(GO:0016021)
0.0 102.6 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
17.2 51.6 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
11.8 47.2 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
10.4 62.2 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
9.1 64.0 GO:0061133 endopeptidase activator activity(GO:0061133)
7.9 31.7 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670) trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
6.8 20.4 GO:0046977 TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
6.3 56.4 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
4.7 126.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
3.9 23.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
3.2 61.3 GO:0003993 acid phosphatase activity(GO:0003993)
2.9 65.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
2.8 22.5 GO:0031386 protein tag(GO:0031386)
2.6 31.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.5 10.8 GO:0005138 interleukin-6 receptor binding(GO:0005138)
1.5 13.2 GO:0043515 kinetochore binding(GO:0043515)
1.2 89.9 GO:0003725 double-stranded RNA binding(GO:0003725)
1.1 13.7 GO:0050897 cobalt ion binding(GO:0050897)
1.0 4.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
1.0 8.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.8 29.3 GO:0042605 peptide antigen binding(GO:0042605)
0.7 20.4 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.5 154.0 GO:0003924 GTPase activity(GO:0003924)
0.5 33.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.4 16.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.3 21.8 GO:0019843 rRNA binding(GO:0019843)
0.3 26.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.3 36.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 44.5 GO:0042393 histone binding(GO:0042393)
0.2 56.8 GO:0030246 carbohydrate binding(GO:0030246)
0.2 19.3 GO:0001948 glycoprotein binding(GO:0001948)
0.2 8.5 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 22.0 GO:0017124 SH3 domain binding(GO:0017124)
0.1 5.0 GO:0005507 copper ion binding(GO:0005507)
0.1 2.5 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 36.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 4.0 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 18.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 21.3 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 14.7 GO:0032403 protein complex binding(GO:0032403)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 62.2 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
1.1 15.8 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.5 38.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.5 13.7 PID MYC PATHWAY C-MYC pathway
0.5 47.9 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.4 16.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.3 51.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.3 26.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.3 13.2 PID PLK1 PATHWAY PLK1 signaling events
0.2 36.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 7.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 1.5 PID IL27 PATHWAY IL27-mediated signaling events
0.1 23.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 19.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
4.1 242.2 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
3.7 52.1 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
2.8 47.2 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
2.6 140.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
1.8 57.0 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
1.7 20.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
1.2 62.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
1.0 61.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.9 10.8 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.7 21.1 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.7 8.7 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.3 58.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 5.1 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 28.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation