ISMARA results: Irf3

Project

GSE53960: rat RNA-Seq transcriptomic Bodymap

Navigation

Downloads

Results for Irf3

Z-value: 1.44

Motif logo

Transcription factors associated with Irf3

Gene Symbol	Gene ID	Gene Info
Irf3 NCBI RGD Ensembl	ENSRNOG00000043388	interferon regulatory factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Irf3	rn6_v1_chr1_+_100992405_100992405	0.49	1.5e-20	Click!

Activity profile of Irf3 motif

Sorted Z-values of Irf3 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_127337791 Show fit	112.16	ENSRNOT00000032015	Ifi27l2b NCBI RGD Ensembl Show fit	interferon, alpha-inducible protein 27 like 2B
chr10_-_70744315 Show fit	62.24	ENSRNOT00000014865	Ccl5 NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 5
chr8_-_23146689 Show fit	61.29	ENSRNOT00000092200	Acp5 NCBI RGD Ensembl Show fit	acid phosphatase 5, tartrate resistant
chr20_+_3990820 Show fit	59.75	ENSRNOT00000000528	Psmb8 NCBI RGD Ensembl Show fit	proteasome subunit beta 8
chr4_-_163890801 Show fit	56.79	ENSRNOT00000081946	Ly49si1 NCBI RGD Ensembl Show fit	immunoreceptor Ly49si1
chr20_-_3978845 Show fit	55.32	ENSRNOT00000000532	Psmb9 NCBI RGD Ensembl Show fit	proteasome subunit beta 9
chr12_+_41200718 Show fit	55.30	ENSRNOT00000038426 ENSRNOT00000048450 ENSRNOT00000067176	Oas1a NCBI RGD Ensembl Show fit	2'-5' oligoadenylate synthetase 1A
chr11_-_37914983 Show fit	52.89	ENSRNOT00000039876	Mx1 NCBI RGD Ensembl Show fit	myxovirus (influenza virus) resistance 1
chr20_-_4677034 Show fit	52.13	ENSRNOT00000075244	Rn60_20_0047.3 NCBI RGD Ensembl Show fit
chr20_+_3979035 Show fit	51.64	ENSRNOT00000000529	Tap1 NCBI RGD Ensembl Show fit	transporter 1, ATP binding cassette subfamily B member

Showing 1 to 10 of 80 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf3

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	110.9	GO:0051607	defense response to virus(GO:0051607)
1.0	85.1	GO:0019882	antigen processing and presentation(GO:0019882)
6.7	73.5	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
2.6	67.9	GO:0019884	antigen processing and presentation of exogenous antigen(GO:0019884)
15.6	62.2	GO:0050904	CD8-positive, alpha-beta T cell extravasation(GO:0035697) regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531) diapedesis(GO:0050904) cellular response to vitamin K(GO:0071307)
10.2	61.3	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
13.8	55.3	GO:1901423	response to benzene(GO:1901423)
5.9	52.9	GO:0003373	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
13.0	52.0	GO:0090290	positive regulation of osteoclast proliferation(GO:0090290)
17.2	51.6	GO:0046967	cytosol to ER transport(GO:0046967) peptide antigen transport(GO:0046968)

Showing 1 to 10 of 45 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	259.4	GO:0016021	integral component of membrane(GO:0016021)
21.1	126.5	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	102.6	GO:0005829	cytosol(GO:0005829)
0.1	84.8	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.1	79.9	GO:0005615	extracellular space(GO:0005615)
10.3	72.1	GO:0042825	TAP complex(GO:0042825)
22.6	67.9	GO:0008537	proteasome activator complex(GO:0008537)
0.1	45.3	GO:0005783	endoplasmic reticulum(GO:0005783)
10.8	43.3	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.1	43.0	GO:0005764	lytic vacuole(GO:0000323) lysosome(GO:0005764)

Showing 1 to 10 of 32 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	154.0	GO:0003924	GTPase activity(GO:0003924)
4.7	126.5	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
1.2	89.9	GO:0003725	double-stranded RNA binding(GO:0003725)
2.9	65.6	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
9.1	64.0	GO:0061133	endopeptidase activator activity(GO:0061133)
10.4	62.2	GO:0031726	CCR1 chemokine receptor binding(GO:0031726)
3.2	61.3	GO:0003993	acid phosphatase activity(GO:0003993)
0.2	56.8	GO:0030246	carbohydrate binding(GO:0030246)
6.3	56.4	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
17.2	51.6	GO:0015433	peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)

Showing 1 to 10 of 39 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.5	62.2	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.3	51.6	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.5	47.9	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.5	38.2	PID IL4 2PATHWAY	IL4-mediated signaling events
0.2	36.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	26.3	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.1	23.5	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.4	16.3	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
1.1	15.8	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.5	13.7	PID MYC PATHWAY	C-MYC pathway

Showing 1 to 10 of 13 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
4.1	242.2	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
2.6	140.5	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
1.2	62.2	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
1.0	61.3	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.3	58.1	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.8	57.0	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
3.7	52.1	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
2.8	47.2	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.3	28.5	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.7	21.1	REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways

Showing 1 to 10 of 15 entries

Results for Irf3

Z-value: 1.44

Motif logo

Transcription factors associated with Irf3

Activity-expression correlation:

Activity profile of Irf3 motif

Sorted Z-values of Irf3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf3

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: