ISMARA results: Irf2_Irf1_Irf8_Irf9

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 4.08

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Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Gene Symbol	Gene ID	Gene Info
Irf2 NCBI RGD Ensembl	ENSRNOG00000009824	interferon regulatory factor 2
Irf1 NCBI RGD Ensembl	ENSRNOG00000008144	interferon regulatory factor 1
Irf8 NCBI RGD Ensembl	ENSRNOG00000017869	interferon regulatory factor 8
Irf9 NCBI RGD Ensembl	ENSRNOG00000019478	interferon regulatory factor 9
Irf7 NCBI RGD Ensembl	ENSRNOG00000017414	interferon regulatory factor 7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Irf1	rn6_v1_chr10_+_39109522_39109522	0.91	5.2e-123	Click!
Irf7	rn6_v1_chr1_-_214252456_214252456	0.88	1.2e-105	Click!
Irf9	rn6_v1_chr15_+_34282936_34282936	0.85	6.3e-91	Click!
Irf8	rn6_v1_chr19_+_54314865_54314865	0.77	4.0e-63	Click!
Irf2	rn6_v1_chr16_-_48692476_48692476	0.69	8.2e-47	Click!

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_-_3978845 Show fit	283.69	ENSRNOT00000000532	Psmb9 NCBI RGD Ensembl Show fit	proteasome subunit beta 9
chr4_+_153805993 Show fit	234.55	ENSRNOT00000056174	Usp18 NCBI RGD Ensembl Show fit	ubiquitin specific peptidase 18
chr10_+_34277993 Show fit	232.98	ENSRNOT00000055872 ENSRNOT00000003343	Ifi47 NCBI RGD Ensembl Show fit	interferon gamma inducible protein 47
chr3_-_171286413 Show fit	207.24	ENSRNOT00000008365 ENSRNOT00000081036	Zbp1 NCBI RGD Ensembl Show fit	Z-DNA binding protein 1
chr1_-_214252456 Show fit	187.13	ENSRNOT00000023504	Irf7 NCBI RGD Ensembl Show fit	interferon regulatory factor 7
chr16_-_19942343 Show fit	185.56	ENSRNOT00000087162 ENSRNOT00000091906	Bst2 NCBI RGD Ensembl Show fit	bone marrow stromal cell antigen 2
chr10_+_108527740 Show fit	184.93	ENSRNOT00000044983	Rnf213 NCBI RGD Ensembl Show fit	ring finger protein 213
chr11_-_37914983 Show fit	173.91	ENSRNOT00000039876	Mx1 NCBI RGD Ensembl Show fit	myxovirus (influenza virus) resistance 1
chr7_-_117300662 Show fit	173.25	ENSRNOT00000006376	Parp10 NCBI RGD Ensembl Show fit	poly (ADP-ribose) polymerase family, member 10
chr5_-_58198782 Show fit	166.60	ENSRNOT00000023951	Ccl21 NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 21
chr20_+_3990820 Show fit	164.66	ENSRNOT00000000528	Psmb8 NCBI RGD Ensembl Show fit	proteasome subunit beta 8
chr11_+_67757928 Show fit	164.03	ENSRNOT00000039215	Dtx3l NCBI RGD Ensembl Show fit	deltex E3 ubiquitin ligase 3L
chr20_-_27682861 Show fit	159.60	ENSRNOT00000057317	Fam26f NCBI RGD Ensembl Show fit	family with sequence similarity 26, member F
chr5_-_173626248 Show fit	159.33	ENSRNOT00000039263	Isg15 NCBI RGD Ensembl Show fit	ISG15 ubiquitin-like modifier
chr20_+_3979035 Show fit	151.65	ENSRNOT00000000529	Tap1 NCBI RGD Ensembl Show fit	transporter 1, ATP binding cassette subfamily B member
chr19_-_37912027 Show fit	150.35	ENSRNOT00000026462	Psmb10 NCBI RGD Ensembl Show fit	proteasome subunit beta 10
chr18_+_55576239 Show fit	146.89	ENSRNOT00000050063	LOC100910979 NCBI RGD Ensembl Show fit	interferon-inducible GTPase 1-like
chr2_+_248276709 Show fit	145.19	ENSRNOT00000068683	Gbp2 NCBI RGD Ensembl Show fit	guanylate binding protein 2
chr5_-_163167299 Show fit	144.67	ENSRNOT00000022478	Tnfrsf1b NCBI RGD Ensembl Show fit	TNF receptor superfamily member 1B
chr11_+_68105369 Show fit	142.11	ENSRNOT00000046888	Parp14 NCBI RGD Ensembl Show fit	poly (ADP-ribose) polymerase family, member 14
chr2_-_256915563 Show fit	140.98	ENSRNOT00000084873 ENSRNOT00000029990	Ifi44 NCBI RGD Ensembl Show fit	interferon-induced protein 44
chr10_+_31880918 Show fit	140.13	ENSRNOT00000059448	Timd4 NCBI RGD Ensembl Show fit	T-cell immunoglobulin and mucin domain containing 4
chr7_+_116889572 Show fit	129.97	ENSRNOT00000075917	Gsdmd NCBI RGD Ensembl Show fit	gasdermin D
chr1_-_167708685 Show fit	120.60	ENSRNOT00000092857 ENSRNOT00000024992	Trim21 NCBI RGD Ensembl Show fit	tripartite motif-containing 21
chr3_-_37480984 Show fit	118.14	ENSRNOT00000030373	Nmi NCBI RGD Ensembl Show fit	N-myc (and STAT) interactor
chr20_-_1878126 Show fit	112.60	ENSRNOT00000000995	Ubd NCBI RGD Ensembl Show fit	ubiquitin D
chr1_-_166677026 Show fit	112.05	ENSRNOT00000026644 ENSRNOT00000076714	Art2b NCBI RGD Ensembl Show fit	ADP-ribosyltransferase 2b
chr2_+_209097927 Show fit	109.97	ENSRNOT00000023807	Dennd2d NCBI RGD Ensembl Show fit	DENN domain containing 2D
chr4_+_67165883 Show fit	108.97	ENSRNOT00000012280	Rab19 NCBI RGD Ensembl Show fit	RAB19, member RAS oncogene family
chr1_+_226897625 Show fit	108.82	ENSRNOT00000029443	Slc15a3 NCBI RGD Ensembl Show fit	solute carrier family 15 member 3
chr8_+_2604962 Show fit	104.61	ENSRNOT00000009993	Casp1 NCBI RGD Ensembl Show fit	caspase 1
chr6_-_127337791 Show fit	102.20	ENSRNOT00000032015	Ifi27l2b NCBI RGD Ensembl Show fit	interferon, alpha-inducible protein 27 like 2B
chr20_-_3166569 Show fit	101.78	ENSRNOT00000091390	AABR07044362.1 NCBI RGD Ensembl Show fit
chr13_+_93684437 Show fit	101.10	ENSRNOT00000005005	Kmo NCBI RGD Ensembl Show fit	kynurenine 3-monooxygenase
chr10_-_34221928 Show fit	100.94	ENSRNOT00000045545	Irgm NCBI RGD Ensembl Show fit	immunity-related GTPase M
chr14_-_43992587 Show fit	99.49	ENSRNOT00000003425	Rhoh NCBI RGD Ensembl Show fit	ras homolog family member H
chr10_-_70342411 Show fit	99.43	ENSRNOT00000076269 ENSRNOT00000076477	Slfn13 NCBI RGD Ensembl Show fit	schlafen family member 13
chr10_+_43613931 Show fit	97.38	ENSRNOT00000039335	Igtp NCBI RGD Ensembl Show fit	interferon gamma induced GTPase
chr15_+_60084918 Show fit	96.77	ENSRNOT00000012632	Epsti1 NCBI RGD Ensembl Show fit	epithelial stromal interaction 1
chr2_+_248178389 Show fit	96.30	ENSRNOT00000037339	Gbp5 NCBI RGD Ensembl Show fit	guanylate binding protein 5
chrX_+_14578264 Show fit	94.59	ENSRNOT00000038994	Cybb NCBI RGD Ensembl Show fit	cytochrome b-245 beta chain
chr3_-_160802433 Show fit	94.05	ENSRNOT00000076191	Slpi NCBI RGD Ensembl Show fit	secretory leukocyte peptidase inhibitor
chr20_+_3995544 Show fit	93.11	ENSRNOT00000000527	Tap2 NCBI RGD Ensembl Show fit	transporter 2, ATP binding cassette subfamily B member
chr20_+_3167079 Show fit	92.44	ENSRNOT00000001035	RT1-N3 NCBI RGD Ensembl Show fit	RT1 class Ib, locus N3
chr20_-_5476193 Show fit	91.32	ENSRNOT00000044975	Tapbp NCBI RGD Ensembl Show fit	TAP binding protein
chr14_+_17210733 Show fit	90.79	ENSRNOT00000003075	Cxcl10 NCBI RGD Ensembl Show fit	C-X-C motif chemokine ligand 10
chr9_-_92616165 Show fit	90.57	ENSRNOT00000056995	Sp110 NCBI RGD Ensembl Show fit	SP110 nuclear body protein
chr16_-_20383337 Show fit	90.15	ENSRNOT00000025977	Il12rb1 NCBI RGD Ensembl Show fit	interleukin 12 receptor subunit beta 1
chr4_-_66062089 Show fit	87.06	ENSRNOT00000018782	Zc3hav1 NCBI RGD Ensembl Show fit	zinc finger CCCH-type containing, antiviral 1
chr8_+_116754178 Show fit	86.67	ENSRNOT00000068295 ENSRNOT00000084429	Uba7 NCBI RGD Ensembl Show fit	ubiquitin-like modifier activating enzyme 7
chr1_+_247519939 Show fit	86.36	ENSRNOT00000034421	Cd274 NCBI RGD Ensembl Show fit	CD274 molecule
chr4_-_157743199 Show fit	85.35	ENSRNOT00000038178	Tapbpl NCBI RGD Ensembl Show fit	TAP binding protein-like
chr11_+_38035611 Show fit	84.88	ENSRNOT00000087603 ENSRNOT00000002695	Mx2 NCBI RGD Ensembl Show fit	MX dynamin like GTPase 2
chr20_-_5212624 Show fit	84.78	ENSRNOT00000074261	LOC103689996 NCBI RGD Ensembl Show fit	antigen peptide transporter 2
chr2_+_248249468 Show fit	83.99	ENSRNOT00000022648	Gbp4 NCBI RGD Ensembl Show fit	guanylate binding protein 4
chr2_-_44981458 Show fit	82.19	ENSRNOT00000014134	Gzma NCBI RGD Ensembl Show fit	granzyme A
chr1_+_169433539 Show fit	82.02	ENSRNOT00000055210	Trim34 NCBI RGD Ensembl Show fit	tripartite motif-containing 34
chr11_+_38035450 Show fit	81.90	ENSRNOT00000083067	Mx2 NCBI RGD Ensembl Show fit	MX dynamin like GTPase 2
chr10_+_70417108 Show fit	80.36	ENSRNOT00000079325	Slfn4 NCBI RGD Ensembl Show fit	schlafen 4
chr1_+_277190964 Show fit	80.27	ENSRNOT00000080511	Casp7 NCBI RGD Ensembl Show fit	caspase 7
chr10_-_107424710 Show fit	79.85	ENSRNOT00000004320	Lgals3bp NCBI RGD Ensembl Show fit	galectin 3 binding protein
chr8_+_96551245 Show fit	79.29	ENSRNOT00000039850	Bcl2a1 NCBI RGD Ensembl Show fit	BCL2-related protein A1
chr10_+_70411738 Show fit	78.95	ENSRNOT00000078046	Slfn4 NCBI RGD Ensembl Show fit	schlafen 4
chr20_-_4698718 Show fit	78.77	ENSRNOT00000047527	RT1-CE7 NCBI RGD Ensembl Show fit	RT1 class I, locus CE7
chr6_-_45669148 Show fit	78.72	ENSRNOT00000010092	Rsad2 NCBI RGD Ensembl Show fit	radical S-adenosyl methionine domain containing 2
chr1_+_247562202 Show fit	77.99	ENSRNOT00000021614	Pdcd1lg2 NCBI RGD Ensembl Show fit	programmed cell death 1 ligand 2
chr10_+_58860940 Show fit	77.19	ENSRNOT00000056551 ENSRNOT00000074523	XAF1 NCBI RGD Ensembl Show fit	XIAP associated factor-1
chr4_-_66899914 Show fit	75.75	ENSRNOT00000011481	Parp12 NCBI RGD Ensembl Show fit	poly (ADP-ribose) polymerase family, member 12
chr15_+_34256071 Show fit	74.97	ENSRNOT00000025887	Psme1 NCBI RGD Ensembl Show fit	proteasome activator subunit 1
chr1_+_252906234 Show fit	74.13	ENSRNOT00000031025	Ifit3 NCBI RGD Ensembl Show fit	interferon-induced protein with tetratricopeptide repeats 3
chr9_-_54327958 Show fit	73.76	ENSRNOT00000019465	Stat1 NCBI RGD Ensembl Show fit	signal transducer and activator of transcription 1
chr1_-_101131413 Show fit	73.48	ENSRNOT00000093729	Flt3lg NCBI RGD Ensembl Show fit	fms-related tyrosine kinase 3 ligand
chr1_+_140601791 Show fit	73.31	ENSRNOT00000091588	Isg20 NCBI RGD Ensembl Show fit	interferon stimulated exonuclease gene 20
chr5_-_56536772 Show fit	72.32	ENSRNOT00000060765	Ddx58 NCBI RGD Ensembl Show fit	DEXD/H-box helicase 58
chr4_+_179398621 Show fit	71.67	ENSRNOT00000049474 ENSRNOT00000067506	Lrmp NCBI RGD Ensembl Show fit	lymphoid-restricted membrane protein
chr15_+_18710492 Show fit	71.62	ENSRNOT00000012532	Dnase1l3 NCBI RGD Ensembl Show fit	deoxyribonuclease 1-like 3
chr7_+_118685181 Show fit	71.49	ENSRNOT00000068221	Apol3 NCBI RGD Ensembl Show fit	apolipoprotein L, 3
chr19_-_55367353 Show fit	71.23	ENSRNOT00000091139	Piezo1 NCBI RGD Ensembl Show fit	piezo-type mechanosensitive ion channel component 1
chr10_-_5251809 Show fit	70.82	ENSRNOT00000085479	Ciita NCBI RGD Ensembl Show fit	class II, major histocompatibility complex, transactivator
chr17_-_32661865 Show fit	70.15	ENSRNOT00000022194	Serpinb9 NCBI RGD Ensembl Show fit	serpin family B member 9
chr10_-_66229311 Show fit	69.91	ENSRNOT00000016897	Lgals5 NCBI RGD Ensembl Show fit	lectin, galactose binding, soluble 5
chr10_-_57064600 Show fit	68.72	ENSRNOT00000032926	Cxcl16 NCBI RGD Ensembl Show fit	C-X-C motif chemokine ligand 16
chr20_+_3146856 Show fit	68.52	ENSRNOT00000050159	RT1-N2 NCBI RGD Ensembl Show fit	RT1 class Ib, locus N2
chr8_+_116857684 Show fit	67.88	ENSRNOT00000026711	Mst1 NCBI RGD Ensembl Show fit	macrophage stimulating 1
chr10_-_5253336 Show fit	66.45	ENSRNOT00000085310	Ciita NCBI RGD Ensembl Show fit	class II, major histocompatibility complex, transactivator
chr20_-_3793985 Show fit	66.21	ENSRNOT00000049540 ENSRNOT00000086293	RT1-CE16 NCBI RGD Ensembl Show fit	RT1 class I, locus CE16
chr3_+_114087287 Show fit	66.16	ENSRNOT00000023017	B2m NCBI RGD Ensembl Show fit	beta-2 microglobulin
chr5_-_58183017 Show fit	65.88	ENSRNOT00000020982	Ccl19 NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 19
chr1_+_221538104 Show fit	64.80	ENSRNOT00000028527	Batf2 NCBI RGD Ensembl Show fit	basic leucine zipper ATF-like transcription factor 2
chr4_+_163174487 Show fit	64.62	ENSRNOT00000088108	Clec9a NCBI RGD Ensembl Show fit	C-type lectin domain family 9, member A
chr7_+_124460358 Show fit	62.82	ENSRNOT00000014089	Tspo NCBI RGD Ensembl Show fit	translocator protein
chrX_+_11648989 Show fit	61.81	ENSRNOT00000041003	Bcor NCBI RGD Ensembl Show fit	BCL6 co-repressor
chr4_-_88649216 Show fit	61.31	ENSRNOT00000058626	Herc6 NCBI RGD Ensembl Show fit	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr1_-_252922486 Show fit	60.88	ENSRNOT00000076802	Ifit1bl NCBI RGD Ensembl Show fit	interferon-induced protein with tetratricopeptide repeats 1B-like
chr1_-_169463760 Show fit	60.30	ENSRNOT00000023100	Trim30c NCBI RGD Ensembl Show fit	tripartite motif-containing 30C
chr18_+_56071478 Show fit	58.98	ENSRNOT00000025344 ENSRNOT00000025354	Cd74 NCBI RGD Ensembl Show fit	CD74 molecule
chr20_+_11436267 Show fit	58.88	ENSRNOT00000001631	Trpm2 NCBI RGD Ensembl Show fit	transient receptor potential cation channel, subfamily M, member 2
chr16_-_48692476 Show fit	58.65	ENSRNOT00000013118	Irf2 NCBI RGD Ensembl Show fit	interferon regulatory factor 2
chr2_-_207300854 Show fit	58.43	ENSRNOT00000018061	Mov10 NCBI RGD Ensembl Show fit	Mov10 RISC complex RNA helicase
chr4_+_162934195 Show fit	58.39	ENSRNOT00000090939	Clec2g NCBI RGD Ensembl Show fit	C-type lectin domain family 2, member G
chr17_-_43640387 Show fit	58.27	ENSRNOT00000087731	Hist1h1c NCBI RGD Ensembl Show fit	histone cluster 1 H1 family member c
chr7_-_28932641 Show fit	58.13	ENSRNOT00000059487	Dram1 NCBI RGD Ensembl Show fit	DNA-damage regulated autophagy modulator 1
chr17_-_44840131 Show fit	57.24	ENSRNOT00000083417	Hist1h3b NCBI RGD Ensembl Show fit	histone cluster 1, H3b
chr20_-_1818800 Show fit	56.75	ENSRNOT00000000990	RT1-M3-1 NCBI RGD Ensembl Show fit	RT1 class Ib, locus M3, gene 1
chr16_+_50111306 Show fit	56.60	ENSRNOT00000019302	Cyp4v3 NCBI RGD Ensembl Show fit	cytochrome P450, family 4, subfamily v, polypeptide 3
chr12_+_41200718 Show fit	56.18	ENSRNOT00000038426 ENSRNOT00000048450 ENSRNOT00000067176	Oas1a NCBI RGD Ensembl Show fit	2'-5' oligoadenylate synthetase 1A
chr13_-_102643223 Show fit	55.77	ENSRNOT00000003155	Hlx NCBI RGD Ensembl Show fit	H2.0-like homeobox
chr8_-_124399494 Show fit	55.46	ENSRNOT00000037883	Tgfbr2 NCBI RGD Ensembl Show fit	transforming growth factor, beta receptor 2
chr15_+_36809361 Show fit	55.17	ENSRNOT00000076667	Parp4 NCBI RGD Ensembl Show fit	poly (ADP-ribose) polymerase family, member 4
chr3_-_48604097 Show fit	55.11	ENSRNOT00000009620	Ifih1 NCBI RGD Ensembl Show fit	interferon induced with helicase C domain 1
chr12_+_42343123 Show fit	54.95	ENSRNOT00000043279	Oas1i NCBI RGD Ensembl Show fit	2 ' -5 ' oligoadenylate synthetase 1I
chr4_-_163403653 Show fit	54.87	ENSRNOT00000088151	Klrk1 NCBI RGD Ensembl Show fit	killer cell lectin like receptor K1
chr2_-_241545250 Show fit	54.54	ENSRNOT00000073875	Bank1 NCBI RGD Ensembl Show fit	B-cell scaffold protein with ankyrin repeats 1
chr10_-_110274768 Show fit	54.52	ENSRNOT00000054931	Sectm1a NCBI RGD Ensembl Show fit	secreted and transmembrane 1A
chr1_-_227441442 Show fit	53.99	ENSRNOT00000028433	Ms4a1 NCBI RGD Ensembl Show fit	membrane spanning 4-domains A1
chr3_+_161519743 Show fit	53.71	ENSRNOT00000055148	Cd40 NCBI RGD Ensembl Show fit	CD40 molecule
chr10_+_89358376 Show fit	53.57	ENSRNOT00000028067	Ifi35 NCBI RGD Ensembl Show fit	interferon-induced protein 35
chr7_+_118685022 Show fit	53.51	ENSRNOT00000089135	Apol3 NCBI RGD Ensembl Show fit	apolipoprotein L, 3
chr4_+_162493908 Show fit	53.34	ENSRNOT00000072064	Clec2d NCBI RGD Ensembl Show fit	C-type lectin domain family 2, member D
chr12_+_41341417 Show fit	51.22	ENSRNOT00000072024 ENSRNOT00000091460	Oas2 NCBI RGD Ensembl Show fit	2'-5' oligoadenylate synthetase 2
chr20_+_5374985 Show fit	50.90	ENSRNOT00000052270	RT1-A2 NCBI RGD Ensembl Show fit	RT1 class Ia, locus A2
chr10_+_76343847 Show fit	50.90	ENSRNOT00000055674	Trim25 NCBI RGD Ensembl Show fit	tripartite motif-containing 25
chr20_-_1339488 Show fit	50.00	ENSRNOT00000041074	RT1-M2 NCBI RGD Ensembl Show fit	RT1 class Ib, locus M2
chr20_-_4935887 Show fit	49.90	ENSRNOT00000064734	RT1-CE4 NCBI RGD Ensembl Show fit	RT1 class I, locus CE4
chr20_-_35450513 Show fit	49.70	ENSRNOT00000087342	Man1a1 NCBI RGD Ensembl Show fit	mannosidase, alpha, class 1A, member 1
chr1_-_213811901 Show fit	49.08	ENSRNOT00000020265	Ifitm3 NCBI RGD Ensembl Show fit	interferon induced transmembrane protein 3
chr18_+_55685613 Show fit	48.07	ENSRNOT00000040116	MGC105567 NCBI RGD Ensembl Show fit	similar to cDNA sequence BC023105
chr20_-_4935372 Show fit	47.82	ENSRNOT00000050099 ENSRNOT00000047779	RT1-CE3 NCBI RGD Ensembl Show fit RT1-CE4 NCBI RGD Ensembl Show fit	RT1 class I, locus CE3 RT1 class I, locus CE4
chr16_-_19349080 Show fit	47.51	ENSRNOT00000038494	Hsh2d NCBI RGD Ensembl Show fit	hematopoietic SH2 domain containing
chr4_-_163214678 Show fit	47.39	ENSRNOT00000091602	Clec1a NCBI RGD Ensembl Show fit	C-type lectin domain family 1, member A
chr3_-_176744377 Show fit	47.35	ENSRNOT00000017787	Helz2 NCBI RGD Ensembl Show fit	helicase with zinc finger 2, transcriptional coactivator
chr20_-_4542073 Show fit	46.96	ENSRNOT00000000477	Cfb NCBI RGD Ensembl Show fit	complement factor B
chr1_-_101131012 Show fit	46.86	ENSRNOT00000082283 ENSRNOT00000093498 ENSRNOT00000093559	Flt3lg NCBI RGD Ensembl Show fit Rpl13a NCBI RGD Ensembl Show fit	fms-related tyrosine kinase 3 ligand ribosomal protein L13A
chr11_-_14304603 Show fit	46.53	ENSRNOT00000040202 ENSRNOT00000082143	Samsn1 NCBI RGD Ensembl Show fit	SAM domain, SH3 domain and nuclear localization signals, 1
chr8_-_128026841 Show fit	46.43	ENSRNOT00000018341	Myd88 NCBI RGD Ensembl Show fit	myeloid differentiation primary response 88
chr1_-_167093560 Show fit	45.88	ENSRNOT00000027301	Il18bp NCBI RGD Ensembl Show fit	interleukin 18 binding protein
chr4_-_72074683 Show fit	45.81	ENSRNOT00000071511	Fam115c NCBI RGD Ensembl Show fit	family with sequence similarity 115, member C
chr12_+_41155497 Show fit	45.28	ENSRNOT00000041741	Oas1g NCBI RGD Ensembl Show fit	2'-5' oligoadenylate synthetase 1G
chr10_+_64737022 Show fit	44.96	ENSRNOT00000017071 ENSRNOT00000093232 ENSRNOT00000017042 ENSRNOT00000093244	Lgals9 NCBI RGD Ensembl Show fit	galectin 9
chr16_+_72401887 Show fit	44.40	ENSRNOT00000074449	LOC100910163 NCBI RGD Ensembl Show fit	uncharacterized LOC100910163
chr9_+_92618352 Show fit	44.34	ENSRNOT00000034603	Sp140 NCBI RGD Ensembl Show fit	SP140 nuclear body protein
chr20_-_4896970 Show fit	44.14	ENSRNOT00000061114 ENSRNOT00000060980	RT1-CE7 NCBI RGD Ensembl Show fit RT1-CE5 NCBI RGD Ensembl Show fit	RT1 class I, locus CE7 RT1 class I, locus CE5
chr3_-_17081510 Show fit	44.02	ENSRNOT00000063862	AABR07051562.1 NCBI RGD Ensembl Show fit
chr20_-_157861 Show fit	44.02	ENSRNOT00000084461	RT1-CE10 NCBI RGD Ensembl Show fit	RT1 class I, locus CE10
chr9_+_65620658 Show fit	43.71	ENSRNOT00000084498	Casp8 NCBI RGD Ensembl Show fit	caspase 8
chr20_+_5414448 Show fit	43.51	ENSRNOT00000078972 ENSRNOT00000080900	RT1-A1 NCBI RGD Ensembl Show fit	RT1 class Ia, locus A1
chr4_+_149261044 Show fit	43.33	ENSRNOT00000066670	Cxcl12 NCBI RGD Ensembl Show fit	C-X-C motif chemokine ligand 12
chr2_-_189254628 Show fit	42.52	ENSRNOT00000028234	Il6r NCBI RGD Ensembl Show fit	interleukin 6 receptor
chr8_-_85803433 Show fit	42.36	ENSRNOT00000081544 ENSRNOT00000073286	Mb21d1 NCBI RGD Ensembl Show fit	Mab-21 domain containing 1
chr2_+_1410934 Show fit	42.13	ENSRNOT00000013625 ENSRNOT00000080222	Erap1 NCBI RGD Ensembl Show fit	endoplasmic reticulum aminopeptidase 1
chr10_-_70744315 Show fit	41.94	ENSRNOT00000014865	Ccl5 NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 5
chr10_-_88611105 Show fit	41.78	ENSRNOT00000024718	Dhx58 NCBI RGD Ensembl Show fit	DEXH-box helicase 58
chr4_-_163049084 Show fit	41.24	ENSRNOT00000091644	Cd69 NCBI RGD Ensembl Show fit	Cd69 molecule
chr20_-_4561062 Show fit	41.19	ENSRNOT00000065044 ENSRNOT00000092698 ENSRNOT00000060607	Cfb NCBI RGD Ensembl Show fit C2 NCBI RGD Ensembl Show fit	complement factor B complement C2
chr20_-_157665 Show fit	41.14	ENSRNOT00000048858 ENSRNOT00000079494	RT1-CE10 NCBI RGD Ensembl Show fit	RT1 class I, locus CE10
chr4_-_163890801 Show fit	41.13	ENSRNOT00000081946	Ly49si1 NCBI RGD Ensembl Show fit	immunoreceptor Ly49si1
chr15_+_34552410 Show fit	40.96	ENSRNOT00000027802	Khnyn NCBI RGD Ensembl Show fit	KH and NYN domain containing
chr3_-_119405453 Show fit	40.67	ENSRNOT00000090355	Sppl2a NCBI RGD Ensembl Show fit	signal peptide peptidase-like 2A
chr8_-_63034226 Show fit	40.64	ENSRNOT00000043434	Pml NCBI RGD Ensembl Show fit	promyelocytic leukemia
chr5_+_157222636 Show fit	40.62	ENSRNOT00000022579	Pla2g2d NCBI RGD Ensembl Show fit	phospholipase A2, group IID
chr4_+_14001761 Show fit	40.49	ENSRNOT00000076519	Cd36 NCBI RGD Ensembl Show fit	CD36 molecule
chr1_-_101236065 Show fit	39.86	ENSRNOT00000066834	Cd37 NCBI RGD Ensembl Show fit	CD37 molecule
chr15_+_24141651 Show fit	39.78	ENSRNOT00000082304	Lgals3 NCBI RGD Ensembl Show fit	galectin 3
chr15_+_57241968 Show fit	39.56	ENSRNOT00000082191	Lcp1 NCBI RGD Ensembl Show fit	lymphocyte cytosolic protein 1
chr4_+_70689737 Show fit	39.23	ENSRNOT00000018852	Prss2 NCBI RGD Ensembl Show fit	protease, serine, 2
chr16_+_50016857 Show fit	39.22	ENSRNOT00000035781	Tlr3 NCBI RGD Ensembl Show fit	toll-like receptor 3
chr4_-_21920651 Show fit	38.97	ENSRNOT00000066211	Tmem243 NCBI RGD Ensembl Show fit	transmembrane protein 243
chr1_-_227505267 Show fit	38.92	ENSRNOT00000028443	Ms4a7 NCBI RGD Ensembl Show fit	membrane spanning 4-domains A7
chr10_+_94944436 Show fit	38.77	ENSRNOT00000078968	Milr1 NCBI RGD Ensembl Show fit	mast cell immunoglobulin-like receptor 1
chr7_-_140401686 Show fit	38.73	ENSRNOT00000083955	Fkbp11 NCBI RGD Ensembl Show fit	FK506 binding protein 11
chr1_-_47331412 Show fit	38.22	ENSRNOT00000046746	Ezr NCBI RGD Ensembl Show fit	ezrin
chr16_+_72388880 Show fit	37.64	ENSRNOT00000072459	LOC684871 NCBI RGD Ensembl Show fit	similar to Protein C8orf4 (Thyroid cancer protein 1) (TC-1)
chr20_-_4921348 Show fit	37.59	ENSRNOT00000082497 ENSRNOT00000041151	RT1-CE4 NCBI RGD Ensembl Show fit	RT1 class I, locus CE4
chr4_+_62380914 Show fit	37.39	ENSRNOT00000029845	Tmem140 NCBI RGD Ensembl Show fit	transmembrane protein 140
chrX_+_54390733 Show fit	37.32	ENSRNOT00000004977	RGD1565785 NCBI RGD Ensembl Show fit	similar to chromosome X open reading frame 21
chr2_-_105089659 Show fit	37.31	ENSRNOT00000043381	Cpb1 NCBI RGD Ensembl Show fit	carboxypeptidase B1
chr1_+_140602542 Show fit	36.90	ENSRNOT00000085570	Isg20 NCBI RGD Ensembl Show fit	interferon stimulated exonuclease gene 20
chr15_-_34269851 Show fit	36.66	ENSRNOT00000026279	Psme2 NCBI RGD Ensembl Show fit	proteasome activator subunit 2
chr20_+_3176107 Show fit	36.24	ENSRNOT00000001036	RT1-S3 NCBI RGD Ensembl Show fit	RT1 class Ib, locus S3
chr3_-_160738927 Show fit	36.06	ENSRNOT00000043470	Slpil2 NCBI RGD Ensembl Show fit	antileukoproteinase-like 2
chr20_+_3155652 Show fit	35.41	ENSRNOT00000042882	RT1-S2 NCBI RGD Ensembl Show fit	RT1 class Ib, locus S2
chr1_-_73619356 Show fit	35.22	ENSRNOT00000074352	Lilrb3 NCBI RGD Ensembl Show fit	leukocyte immunoglobulin like receptor B3
chr6_-_1466201 Show fit	34.95	ENSRNOT00000089185	Eif2ak2 NCBI RGD Ensembl Show fit	eukaryotic translation initiation factor 2-alpha kinase 2
chr8_-_23146689 Show fit	34.76	ENSRNOT00000092200	Acp5 NCBI RGD Ensembl Show fit	acid phosphatase 5, tartrate resistant
chr20_+_44680449 Show fit	34.71	ENSRNOT00000000728	Traf3ip2 NCBI RGD Ensembl Show fit	Traf3 interacting protein 2
chr3_-_160739137 Show fit	34.45	ENSRNOT00000075836	Slpil2 NCBI RGD Ensembl Show fit	antileukoproteinase-like 2
chr5_+_79382096 Show fit	34.33	ENSRNOT00000085461	Tmem268 NCBI RGD Ensembl Show fit	transmembrane protein 268
chr9_-_14668297 Show fit	34.20	ENSRNOT00000042404	Treml2 NCBI RGD Ensembl Show fit	triggering receptor expressed on myeloid cells-like 2
chr2_+_186776644 Show fit	34.13	ENSRNOT00000046778	Fcrl3 NCBI RGD Ensembl Show fit	Fc receptor-like 3
chr13_+_48426820 Show fit	34.09	ENSRNOT00000048391	Ctse NCBI RGD Ensembl Show fit	cathepsin E
chr4_+_70776046 Show fit	34.02	ENSRNOT00000040403	Prss1 NCBI RGD Ensembl Show fit	protease, serine 1
chr20_-_5179217 Show fit	33.65	ENSRNOT00000065940 ENSRNOT00000092443	Lst1 NCBI RGD Ensembl Show fit	leukocyte specific transcript 1
chr19_+_15033108 Show fit	33.28	ENSRNOT00000021812	Ces1d NCBI RGD Ensembl Show fit	carboxylesterase 1D
chr17_-_31780120 Show fit	32.81	ENSRNOT00000058388	AABR07027450.1 NCBI RGD Ensembl Show fit
chr4_+_102351036 Show fit	32.62	ENSRNOT00000079277	AABR07060994.1 NCBI RGD Ensembl Show fit
chr10_-_4257868 Show fit	32.36	ENSRNOT00000035886	Tnfrsf17 NCBI RGD Ensembl Show fit	TNF receptor superfamily member 17
chr9_+_65534704 Show fit	32.35	ENSRNOT00000016730	Cflar NCBI RGD Ensembl Show fit	CASP8 and FADD-like apoptosis regulator
chr19_+_15195565 Show fit	32.33	ENSRNOT00000090865 ENSRNOT00000078874	Ces1d NCBI RGD Ensembl Show fit	carboxylesterase 1D
chr4_+_101687327 Show fit	31.93	ENSRNOT00000082501	AABR07060957.1 NCBI RGD Ensembl Show fit
chr2_-_210550490 Show fit	31.65	ENSRNOT00000081835 ENSRNOT00000025222 ENSRNOT00000086403	Csf1 NCBI RGD Ensembl Show fit	colony stimulating factor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
81.6	244.8	GO:0046968	cytosol to ER transport(GO:0046967) peptide antigen transport(GO:0046968)
70.9	283.7	GO:1901423	response to benzene(GO:1901423)
61.9	185.6	GO:0002731	negative regulation of dendritic cell cytokine production(GO:0002731)
61.5	122.9	GO:0002481	antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
58.1	232.5	GO:0097026	dendritic cell dendrite assembly(GO:0097026)
57.8	173.3	GO:0070212	regulation of chromatin assembly(GO:0010847) protein poly-ADP-ribosylation(GO:0070212)
53.8	269.1	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
49.2	246.0	GO:0032020	ISG15-protein conjugation(GO:0032020)
49.1	98.1	GO:0002589	regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
41.0	123.1	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
37.9	340.7	GO:0003373	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
37.4	112.1	GO:0019677	NAD catabolic process(GO:0019677)
36.7	110.2	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
36.7	256.6	GO:0070269	pyroptosis(GO:0070269)
32.9	394.4	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
31.8	127.2	GO:0019805	quinolinate biosynthetic process(GO:0019805)
31.5	94.6	GO:1904845	response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
31.0	1052.9	GO:0035458	cellular response to interferon-beta(GO:0035458)
30.1	120.3	GO:0090290	positive regulation of osteoclast proliferation(GO:0090290)
30.0	90.1	GO:0035722	interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
29.5	118.1	GO:0045349	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
27.6	165.4	GO:0045345	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
26.8	214.5	GO:0032727	positive regulation of interferon-alpha production(GO:0032727)
26.3	131.3	GO:2001181	positive regulation of interleukin-10 secretion(GO:2001181)
26.2	78.7	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
21.9	65.6	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
20.8	186.8	GO:2000051	negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
18.5	55.5	GO:0003430	growth plate cartilage chondrocyte growth(GO:0003430)
18.3	54.9	GO:2000502	stimulatory C-type lectin receptor signaling pathway(GO:0002223) negative regulation of natural killer cell chemotaxis(GO:2000502)
18.1	108.8	GO:0035672	oligopeptide transmembrane transport(GO:0035672)
18.1	36.2	GO:0002428	antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
17.5	577.5	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
16.3	179.6	GO:0046598	positive regulation of viral entry into host cell(GO:0046598)
16.2	113.2	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
16.1	80.3	GO:0072733	response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
15.5	46.4	GO:0045351	type I interferon biosynthetic process(GO:0045351)
15.5	61.8	GO:0000414	regulation of histone H3-K36 methylation(GO:0000414)
15.3	122.1	GO:0032621	interleukin-18 production(GO:0032621)
14.8	73.8	GO:0042270	protection from natural killer cell mediated cytotoxicity(GO:0042270)
14.7	58.9	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
14.1	112.6	GO:0070842	aggresome assembly(GO:0070842)
13.9	55.8	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
13.3	279.1	GO:0035634	response to stilbenoid(GO:0035634)
13.3	39.9	GO:0030886	negative regulation of myeloid dendritic cell activation(GO:0030886)
13.3	39.8	GO:1903769	negative regulation of cell proliferation in bone marrow(GO:1903769)
12.4	62.1	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
12.0	84.0	GO:0032074	negative regulation of nuclease activity(GO:0032074)
11.7	46.9	GO:0039534	negative regulation of MDA-5 signaling pathway(GO:0039534)
11.7	58.4	GO:0035279	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
11.1	99.5	GO:0060763	mammary duct terminal end bud growth(GO:0060763)
11.0	21.9	GO:2000520	regulation of immunological synapse formation(GO:2000520)
10.8	43.3	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237) response to ultrasound(GO:1990478)
10.5	62.8	GO:0010266	response to vitamin B1(GO:0010266)
10.5	83.6	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
10.3	30.8	GO:0070946	neutrophil mediated killing of gram-positive bacterium(GO:0070946)
10.3	30.8	GO:0060369	positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
10.2	30.6	GO:0007356	thorax and anterior abdomen determination(GO:0007356)
10.2	30.5	GO:2000501	natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501) positive regulation of natural killer cell chemotaxis(GO:2000503)
9.8	29.4	GO:0070175	positive regulation of enamel mineralization(GO:0070175)
9.6	38.2	GO:1902896	terminal web assembly(GO:1902896)
9.5	19.1	GO:0001803	type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
9.5	47.5	GO:0051902	negative regulation of mitochondrial depolarization(GO:0051902)
9.5	19.0	GO:0002584	negative regulation of antigen processing and presentation of peptide antigen(GO:0002584)
8.9	44.4	GO:1900019	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
8.8	26.3	GO:0045625	regulation of T-helper 1 cell differentiation(GO:0045625)
8.6	94.8	GO:0006957	complement activation, alternative pathway(GO:0006957)
8.5	144.7	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
8.5	85.0	GO:0071357	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
8.5	42.4	GO:0071360	cellular response to exogenous dsRNA(GO:0071360)
8.4	33.7	GO:0050672	negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
8.3	8.3	GO:0051025	negative regulation of immunoglobulin secretion(GO:0051025)
8.1	16.2	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
7.8	31.4	GO:0016332	establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
7.8	15.5	GO:0097198	histone H3-K36 trimethylation(GO:0097198)
7.7	30.8	GO:1902263	apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
7.7	145.7	GO:0019884	antigen processing and presentation of exogenous antigen(GO:0019884)
7.5	60.4	GO:0002634	regulation of germinal center formation(GO:0002634)
7.5	7.5	GO:1902623	negative regulation of neutrophil migration(GO:1902623)
7.5	59.7	GO:0033590	response to cobalamin(GO:0033590)
7.5	164.0	GO:0010390	histone monoubiquitination(GO:0010390)
7.5	29.8	GO:0030221	basophil differentiation(GO:0030221)
7.3	58.3	GO:0016584	nucleosome positioning(GO:0016584)
7.2	86.9	GO:0006309	apoptotic DNA fragmentation(GO:0006309)
7.0	21.1	GO:0051105	regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106) protein localization to site of double-strand break(GO:1990166)
7.0	35.0	GO:1903300	negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
6.9	20.7	GO:0002149	hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
6.7	94.3	GO:0010818	T cell chemotaxis(GO:0010818)
6.7	33.6	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
6.6	26.3	GO:1990375	baculum development(GO:1990375)
6.4	51.2	GO:0018377	protein myristoylation(GO:0018377)
6.3	25.3	GO:0097527	necroptotic signaling pathway(GO:0097527)
6.2	18.6	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
6.1	54.5	GO:1900165	negative regulation of interleukin-6 secretion(GO:1900165)
6.0	229.6	GO:0045071	negative regulation of viral genome replication(GO:0045071)
5.9	5.9	GO:1905072	cardiac jelly development(GO:1905072)
5.8	34.8	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
5.8	34.7	GO:0002230	positive regulation of defense response to virus by host(GO:0002230)
5.7	62.7	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
5.7	17.1	GO:1905204	response to selenite ion(GO:0072714) negative regulation of connective tissue replacement(GO:1905204)
5.7	17.0	GO:0036378	calcitriol biosynthetic process from calciol(GO:0036378)
5.6	28.0	GO:0016098	monoterpenoid metabolic process(GO:0016098)
5.6	16.8	GO:0033625	positive regulation of integrin activation(GO:0033625)
5.6	5.6	GO:0018307	enzyme active site formation(GO:0018307)
5.5	71.3	GO:1902187	negative regulation of viral release from host cell(GO:1902187)
5.3	53.2	GO:1900115	extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
5.2	10.4	GO:0070634	transepithelial ammonium transport(GO:0070634)
5.1	20.5	GO:1903463	regulation of mitotic cell cycle DNA replication(GO:1903463)
4.8	24.2	GO:2000327	positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
4.8	28.7	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
4.8	57.3	GO:0036462	TRAIL-activated apoptotic signaling pathway(GO:0036462)
4.6	13.9	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
4.6	23.0	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
4.6	18.3	GO:0060155	platelet dense granule organization(GO:0060155)
4.6	18.3	GO:0007296	vitellogenesis(GO:0007296)
4.5	13.5	GO:0061357	positive regulation of Wnt protein secretion(GO:0061357)
4.4	13.1	GO:1903544	positive regulation of bicellular tight junction assembly(GO:1903348) response to butyrate(GO:1903544)
4.3	17.4	GO:0043987	histone H3-S10 phosphorylation(GO:0043987)
4.3	17.1	GO:0001692	histamine metabolic process(GO:0001692) positive regulation of interleukin-8 biosynthetic process(GO:0045416)
4.3	34.1	GO:1902916	positive regulation of protein polyubiquitination(GO:1902916)
4.0	16.2	GO:0000320	re-entry into mitotic cell cycle(GO:0000320)
3.9	3.9	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
3.9	11.8	GO:0032066	nucleolus to nucleoplasm transport(GO:0032066)
3.8	11.4	GO:1903719	regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
3.8	7.5	GO:0003330	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
3.7	11.2	GO:0003249	left ventricular cardiac muscle tissue morphogenesis(GO:0003220) cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) gonad morphogenesis(GO:0035262) nephrogenic mesenchyme morphogenesis(GO:0072134)
3.6	10.9	GO:0042631	cellular response to water deprivation(GO:0042631)
3.6	25.1	GO:0048245	eosinophil chemotaxis(GO:0048245)
3.6	10.7	GO:0046947	hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
3.6	53.5	GO:0042832	defense response to protozoan(GO:0042832)
3.5	7.0	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
3.5	31.3	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
3.5	10.4	GO:0007161	calcium-independent cell-matrix adhesion(GO:0007161) interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) regulation of transforming growth factor-beta secretion(GO:2001201)
3.5	159.8	GO:0019882	antigen processing and presentation(GO:0019882)
3.4	27.6	GO:2000406	positive regulation of T cell migration(GO:2000406)
3.4	40.6	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
3.3	10.0	GO:0035444	nickel cation transport(GO:0015675) vanadium ion transport(GO:0015676) lead ion transport(GO:0015692) nickel cation transmembrane transport(GO:0035444)
3.3	46.3	GO:0001867	complement activation, lectin pathway(GO:0001867)
3.3	69.3	GO:0006491	N-glycan processing(GO:0006491)
3.2	9.7	GO:1901492	positive regulation of lymphangiogenesis(GO:1901492)
3.1	9.4	GO:0000715	nucleotide-excision repair, DNA damage recognition(GO:0000715)
3.1	12.4	GO:0080154	regulation of fertilization(GO:0080154)
3.0	12.2	GO:0002188	translation reinitiation(GO:0002188)
3.0	60.0	GO:0032689	negative regulation of interferon-gamma production(GO:0032689)
3.0	38.8	GO:0033004	negative regulation of mast cell activation(GO:0033004)
3.0	65.5	GO:0030574	collagen catabolic process(GO:0030574)
3.0	17.8	GO:0001835	blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
3.0	3.0	GO:0038172	interleukin-33-mediated signaling pathway(GO:0038172)
2.9	14.6	GO:0071409	cellular response to cycloheximide(GO:0071409)
2.9	8.6	GO:0033184	positive regulation of histone ubiquitination(GO:0033184)
2.8	8.5	GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
2.8	8.5	GO:2001245	regulation of phosphatidylcholine biosynthetic process(GO:2001245)
2.8	11.2	GO:0006272	leading strand elongation(GO:0006272)
2.8	8.3	GO:0033306	phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173)
2.8	16.6	GO:0090367	negative regulation of mRNA modification(GO:0090367)
2.7	5.4	GO:1905146	lysosomal protein catabolic process(GO:1905146)
2.6	10.6	GO:1990481	mRNA pseudouridine synthesis(GO:1990481)
2.6	2.6	GO:0003104	positive regulation of glomerular filtration(GO:0003104)
2.6	7.8	GO:0032380	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
2.6	10.4	GO:0070102	interleukin-6-mediated signaling pathway(GO:0070102)
2.6	46.5	GO:0002820	negative regulation of adaptive immune response(GO:0002820)
2.6	7.7	GO:0090271	positive regulation of fibroblast growth factor production(GO:0090271)
2.6	7.7	GO:0042706	eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
2.5	10.1	GO:0035655	interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
2.5	10.1	GO:0045916	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
2.5	7.4	GO:0036451	cap mRNA methylation(GO:0036451)
2.5	7.4	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
2.4	14.7	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
2.4	4.8	GO:0010637	negative regulation of mitochondrial fusion(GO:0010637)
2.4	36.0	GO:0050832	defense response to fungus(GO:0050832)
2.4	26.3	GO:0032897	negative regulation of viral transcription(GO:0032897)
2.3	7.0	GO:0006045	N-acetylglucosamine biosynthetic process(GO:0006045) N-acetylneuraminate biosynthetic process(GO:0046380)
2.3	126.2	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
2.3	9.0	GO:0046098	guanine metabolic process(GO:0046098)
2.2	29.2	GO:0051764	actin crosslink formation(GO:0051764)
2.2	6.6	GO:0071461	cellular response to redox state(GO:0071461)
2.2	6.6	GO:0090361	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
2.2	21.9	GO:0019720	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
2.2	10.9	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
2.2	8.6	GO:0032919	spermine acetylation(GO:0032919)
2.2	6.5	GO:1902748	positive regulation of lens fiber cell differentiation(GO:1902748)
2.1	6.4	GO:0046726	positive regulation by virus of viral protein levels in host cell(GO:0046726)
2.1	156.0	GO:0048286	lung alveolus development(GO:0048286)
2.0	6.1	GO:0097298	regulation of nucleus size(GO:0097298)
2.0	202.4	GO:0051607	defense response to virus(GO:0051607)
2.0	8.1	GO:0071284	cellular response to lead ion(GO:0071284)
2.0	8.0	GO:0046292	formaldehyde metabolic process(GO:0046292)
2.0	8.0	GO:0019477	lysine catabolic process(GO:0006554) L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
2.0	17.8	GO:0042699	follicle-stimulating hormone signaling pathway(GO:0042699)
1.9	17.5	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
1.9	25.1	GO:0051601	exocyst localization(GO:0051601)
1.9	26.8	GO:0010838	positive regulation of keratinocyte proliferation(GO:0010838)
1.9	5.7	GO:0045716	positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
1.9	24.6	GO:0016446	somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
1.8	31.2	GO:0048242	epinephrine secretion(GO:0048242)
1.8	7.3	GO:0018214	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
1.8	3.6	GO:0033685	negative regulation of luteinizing hormone secretion(GO:0033685)
1.8	8.9	GO:0015838	amino-acid betaine transport(GO:0015838)
1.8	5.3	GO:0033386	geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
1.8	14.1	GO:0042994	cytoplasmic sequestering of transcription factor(GO:0042994)
1.7	20.9	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
1.7	12.0	GO:0002326	B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152)
1.7	6.8	GO:1903385	regulation of homophilic cell adhesion(GO:1903385)
1.7	1.7	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
1.7	5.0	GO:0043091	L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
1.6	102.0	GO:0007004	RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004)
1.6	24.3	GO:0042448	progesterone metabolic process(GO:0042448)
1.6	19.2	GO:0006958	complement activation, classical pathway(GO:0006958)
1.5	19.9	GO:0002227	innate immune response in mucosa(GO:0002227)
1.5	7.6	GO:0010032	meiotic chromosome condensation(GO:0010032)
1.5	31.8	GO:0016578	histone deubiquitination(GO:0016578)
1.5	6.0	GO:1903576	response to L-arginine(GO:1903576)
1.5	10.2	GO:0015722	canalicular bile acid transport(GO:0015722)
1.4	2.8	GO:2000857	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
1.4	27.2	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
1.3	5.4	GO:0021785	branchiomotor neuron axon guidance(GO:0021785)
1.3	9.2	GO:0097428	protein maturation by iron-sulfur cluster transfer(GO:0097428)
1.3	9.2	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
1.3	5.2	GO:0043328	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
1.3	11.7	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
1.3	10.3	GO:0019388	galactose catabolic process(GO:0019388)
1.3	13.9	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
1.2	11.1	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
1.2	3.6	GO:2000853	negative regulation of corticosterone secretion(GO:2000853)
1.2	22.5	GO:0031581	hemidesmosome assembly(GO:0031581)
1.2	3.5	GO:0043605	cellular amide catabolic process(GO:0043605)
1.2	14.0	GO:0035814	negative regulation of renal sodium excretion(GO:0035814)
1.2	141.2	GO:0042157	lipoprotein metabolic process(GO:0042157)
1.2	9.3	GO:0019372	lipoxygenase pathway(GO:0019372)
1.2	2.3	GO:0035789	cell migration involved in metanephros development(GO:0035788) metanephric mesenchymal cell migration(GO:0035789) positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) regulation of metanephric mesenchymal cell migration(GO:2000589) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
1.1	3.4	GO:0070914	UV-damage excision repair(GO:0070914)
1.1	10.9	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
1.1	3.3	GO:0090521	glomerular visceral epithelial cell migration(GO:0090521)
1.1	9.6	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
1.1	15.9	GO:0043312	neutrophil degranulation(GO:0043312)
1.0	5.2	GO:1902951	negative regulation of dendritic spine maintenance(GO:1902951)
1.0	55.7	GO:0070206	protein trimerization(GO:0070206)
1.0	6.2	GO:0006449	regulation of translational termination(GO:0006449)
1.0	6.2	GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
1.0	6.1	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
1.0	3.1	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
1.0	3.0	GO:0019343	cysteine biosynthetic process via cystathionine(GO:0019343)
1.0	9.9	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
1.0	22.6	GO:0046825	regulation of protein export from nucleus(GO:0046825)
1.0	7.8	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
1.0	70.2	GO:0034440	fatty acid oxidation(GO:0019395) lipid oxidation(GO:0034440)
1.0	31.0	GO:0010718	positive regulation of epithelial to mesenchymal transition(GO:0010718)
1.0	5.8	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.9	3.7	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.9	3.7	GO:1902683	regulation of receptor localization to synapse(GO:1902683)
0.9	0.9	GO:0009730	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.9	4.6	GO:0003383	apical constriction(GO:0003383)
0.9	17.7	GO:0045671	negative regulation of osteoclast differentiation(GO:0045671)
0.9	13.1	GO:0042407	cristae formation(GO:0042407)
0.9	6.8	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.8	31.1	GO:0002224	toll-like receptor signaling pathway(GO:0002224)
0.8	14.5	GO:0046415	urate metabolic process(GO:0046415)
0.8	5.5	GO:0035988	chondrocyte proliferation(GO:0035988)
0.8	6.3	GO:1900113	negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.8	12.4	GO:0045653	negative regulation of megakaryocyte differentiation(GO:0045653)
0.8	17.8	GO:0071353	cellular response to interleukin-4(GO:0071353)
0.8	13.1	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.8	6.1	GO:0042795	snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.8	4.6	GO:2000400	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.8	29.7	GO:0002260	lymphocyte homeostasis(GO:0002260)
0.8	15.2	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095) G2 DNA damage checkpoint(GO:0031572)
0.7	36.5	GO:0050715	positive regulation of cytokine secretion(GO:0050715)
0.7	8.2	GO:0006337	nucleosome disassembly(GO:0006337)
0.7	10.3	GO:0017121	phospholipid scrambling(GO:0017121)
0.7	13.1	GO:0072520	seminiferous tubule development(GO:0072520)
0.7	26.3	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.7	5.7	GO:0051315	attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.7	5.0	GO:0071373	cellular response to luteinizing hormone stimulus(GO:0071373)
0.7	39.6	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.7	22.5	GO:0030101	natural killer cell activation(GO:0030101)
0.7	18.2	GO:0006270	DNA replication initiation(GO:0006270)
0.7	10.3	GO:0006622	protein targeting to lysosome(GO:0006622)
0.7	18.6	GO:0000027	ribosomal large subunit assembly(GO:0000027)
0.7	4.7	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.7	2.7	GO:0090234	regulation of kinetochore assembly(GO:0090234)
0.7	10.6	GO:0060992	response to fungicide(GO:0060992)
0.7	2.0	GO:0032825	positive regulation of natural killer cell differentiation(GO:0032825)
0.6	8.3	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
0.6	25.1	GO:0019915	lipid storage(GO:0019915)
0.6	55.8	GO:0042098	T cell proliferation(GO:0042098)
0.6	26.7	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.6	13.5	GO:0060216	definitive hemopoiesis(GO:0060216)
0.6	7.3	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.6	4.7	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.6	3.5	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.6	8.1	GO:0060124	positive regulation of growth hormone secretion(GO:0060124)
0.6	18.3	GO:0006695	cholesterol biosynthetic process(GO:0006695)
0.5	2.7	GO:0010990	regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.5	8.5	GO:0097286	iron ion import(GO:0097286)
0.5	3.2	GO:0060965	negative regulation of gene silencing by miRNA(GO:0060965)
0.5	3.2	GO:0090435	protein localization to nuclear envelope(GO:0090435)
0.5	2.1	GO:1904158	axonemal central apparatus assembly(GO:1904158)
0.5	6.9	GO:0010839	negative regulation of keratinocyte proliferation(GO:0010839)
0.5	11.6	GO:0044783	mitotic G1 DNA damage checkpoint(GO:0031571) G1 DNA damage checkpoint(GO:0044783)
0.5	12.7	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.5	4.5	GO:0048820	hair follicle maturation(GO:0048820)
0.5	84.9	GO:0045087	innate immune response(GO:0045087)
0.5	12.5	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.5	5.5	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.5	1.5	GO:0002329	pre-B cell differentiation(GO:0002329)
0.5	4.5	GO:0021707	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.5	26.3	GO:0019319	hexose biosynthetic process(GO:0019319)
0.5	3.8	GO:0007000	nucleolus organization(GO:0007000)
0.5	4.8	GO:2000234	positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.5	8.6	GO:0006336	DNA replication-independent nucleosome assembly(GO:0006336)
0.5	1.9	GO:0061484	hematopoietic stem cell homeostasis(GO:0061484)
0.5	4.7	GO:0006308	DNA catabolic process(GO:0006308)
0.5	1.8	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.4	2.6	GO:0045196	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.4	3.7	GO:2000641	regulation of early endosome to late endosome transport(GO:2000641)
0.4	6.4	GO:0050830	defense response to Gram-positive bacterium(GO:0050830)
0.4	11.3	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
0.4	6.8	GO:0009404	toxin metabolic process(GO:0009404)
0.4	13.2	GO:0050873	brown fat cell differentiation(GO:0050873)
0.4	3.6	GO:0048280	vesicle fusion with Golgi apparatus(GO:0048280)
0.4	5.1	GO:0031163	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.4	4.1	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.4	5.2	GO:0032801	receptor catabolic process(GO:0032801)
0.4	6.3	GO:0006509	membrane protein ectodomain proteolysis(GO:0006509)
0.4	6.3	GO:0034067	protein localization to Golgi apparatus(GO:0034067)
0.3	20.3	GO:0002250	adaptive immune response(GO:0002250)
0.3	75.8	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
0.3	12.4	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.3	7.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.3	12.9	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.3	10.5	GO:1903317	regulation of protein processing(GO:0070613) regulation of protein maturation(GO:1903317)
0.3	10.4	GO:0006767	water-soluble vitamin metabolic process(GO:0006767)
0.3	0.3	GO:0007493	endodermal cell fate determination(GO:0007493)
0.3	20.4	GO:0006006	glucose metabolic process(GO:0006006)
0.3	2.8	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.3	4.3	GO:0060746	parental behavior(GO:0060746)
0.3	10.1	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.3	3.0	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.3	1.8	GO:0051255	spindle midzone assembly(GO:0051255)
0.3	4.5	GO:0014877	response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.3	15.4	GO:0019228	neuronal action potential(GO:0019228)
0.3	2.6	GO:0030575	nuclear body organization(GO:0030575)
0.3	2.3	GO:2000001	regulation of DNA damage checkpoint(GO:2000001)
0.3	53.5	GO:0006898	receptor-mediated endocytosis(GO:0006898)
0.3	3.6	GO:0007256	activation of JNKK activity(GO:0007256)
0.3	8.9	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
0.3	1.1	GO:0035992	tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.3	1.9	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.3	14.2	GO:0006334	nucleosome assembly(GO:0006334)
0.3	6.4	GO:0045638	negative regulation of myeloid cell differentiation(GO:0045638)
0.3	19.9	GO:0034968	histone lysine methylation(GO:0034968)
0.3	1.3	GO:0032262	pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) UMP salvage(GO:0044206)
0.2	5.0	GO:0009250	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.2	16.8	GO:0090630	activation of GTPase activity(GO:0090630)
0.2	6.1	GO:0033119	negative regulation of RNA splicing(GO:0033119)
0.2	13.9	GO:2000177	regulation of neural precursor cell proliferation(GO:2000177)
0.2	2.9	GO:0042574	retinal metabolic process(GO:0042574)
0.2	6.5	GO:0060976	coronary vasculature development(GO:0060976)
0.2	14.6	GO:0051209	release of sequestered calcium ion into cytosol(GO:0051209) negative regulation of sequestering of calcium ion(GO:0051283)
0.2	1.9	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.2	1.2	GO:0006689	ganglioside catabolic process(GO:0006689)
0.2	1.2	GO:0001927	exocyst assembly(GO:0001927) entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)
0.2	5.4	GO:0048662	negative regulation of smooth muscle cell proliferation(GO:0048662)
0.2	0.5	GO:2000398	regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398)
0.2	7.0	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.2	7.4	GO:0006998	nuclear envelope organization(GO:0006998)
0.2	4.1	GO:0006879	cellular iron ion homeostasis(GO:0006879)
0.2	0.3	GO:0034374	low-density lipoprotein particle remodeling(GO:0034374)
0.2	2.9	GO:0031648	protein destabilization(GO:0031648)
0.2	2.4	GO:0046519	sphingoid metabolic process(GO:0046519)
0.2	6.0	GO:0009615	response to virus(GO:0009615)
0.2	7.9	GO:0031016	pancreas development(GO:0031016)
0.1	53.3	GO:0043547	positive regulation of GTPase activity(GO:0043547)
0.1	3.6	GO:0030520	intracellular estrogen receptor signaling pathway(GO:0030520)
0.1	2.5	GO:0050918	positive chemotaxis(GO:0050918)
0.1	15.4	GO:0008202	steroid metabolic process(GO:0008202)
0.1	0.3	GO:0016598	protein arginylation(GO:0016598)
0.1	4.2	GO:0071427	mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1	0.8	GO:0071732	cellular response to nitric oxide(GO:0071732)
0.1	11.6	GO:0045471	response to ethanol(GO:0045471)
0.1	0.8	GO:0018022	peptidyl-lysine methylation(GO:0018022)
0.1	2.3	GO:0097502	mannosylation(GO:0097502)
0.1	0.4	GO:0006353	DNA-templated transcription, termination(GO:0006353)
0.1	0.8	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.1	3.1	GO:0018149	peptide cross-linking(GO:0018149)
0.1	0.7	GO:1900264	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1	2.6	GO:0042274	ribosomal small subunit biogenesis(GO:0042274)
0.1	1.2	GO:0031297	replication fork processing(GO:0031297)
0.1	1.1	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	1.2	GO:0030488	tRNA methylation(GO:0030488)
0.0	5.5	GO:0006260	DNA replication(GO:0006260)
0.0	1.4	GO:0043966	histone H3 acetylation(GO:0043966)
0.0	1.2	GO:0007052	mitotic spindle organization(GO:0007052)
0.0	0.1	GO:0033005	positive regulation of mast cell activation(GO:0033005)
0.0	0.4	GO:0016180	snRNA processing(GO:0016180)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
99.8	598.7	GO:1990111	spermatoproteasome complex(GO:1990111)
60.1	420.9	GO:0042825	TAP complex(GO:0042825)
57.3	229.2	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
56.7	56.7	GO:0032398	MHC class Ib protein complex(GO:0032398)
37.2	111.6	GO:0008537	proteasome activator complex(GO:0008537)
33.5	234.6	GO:0072559	NLRP3 inflammasome complex(GO:0072559)
31.4	501.9	GO:0042612	MHC class I protein complex(GO:0042612)
22.1	22.1	GO:0097169	AIM2 inflammasome complex(GO:0097169)
20.3	61.0	GO:0005896	interleukin-6 receptor complex(GO:0005896) ciliary neurotrophic factor receptor complex(GO:0070110)
20.3	101.4	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
19.7	59.0	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
14.7	14.7	GO:0020003	symbiont-containing vacuole(GO:0020003)
14.6	58.3	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
10.6	232.4	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
10.6	31.7	GO:1990682	CSF1-CSF1R complex(GO:1990682)
9.9	198.4	GO:0043196	varicosity(GO:0043196)
9.6	38.2	GO:0036398	TCR signalosome(GO:0036398) microspike(GO:0044393)
9.0	89.7	GO:0043020	NADPH oxidase complex(GO:0043020)
8.5	59.8	GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
7.0	48.9	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
5.5	16.6	GO:1990826	nucleoplasmic periphery of the nuclear pore complex(GO:1990826)
5.4	16.2	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
5.4	262.9	GO:0016235	aggresome(GO:0016235)
5.1	25.7	GO:0031262	Ndc80 complex(GO:0031262)
5.0	140.5	GO:0001891	phagocytic cup(GO:0001891)
5.0	189.5	GO:0001772	immunological synapse(GO:0001772)
4.6	18.3	GO:0031904	endosome lumen(GO:0031904)
4.5	13.6	GO:1990622	CHOP-ATF3 complex(GO:1990622)
4.4	30.8	GO:0097136	Bcl-2 family protein complex(GO:0097136)
4.0	15.9	GO:0044194	cytolytic granule(GO:0044194)
4.0	71.2	GO:0031258	lamellipodium membrane(GO:0031258)
3.9	23.5	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
3.5	10.4	GO:0005577	fibrinogen complex(GO:0005577)
3.4	10.2	GO:0046691	intracellular canaliculus(GO:0046691)
3.4	131.9	GO:0005771	multivesicular body(GO:0005771)
3.4	84.6	GO:0035327	transcriptionally active chromatin(GO:0035327)
3.3	6.7	GO:0044279	other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
3.3	10.0	GO:0070826	paraferritin complex(GO:0070826)
3.1	9.4	GO:0000110	nucleotide-excision repair factor 1 complex(GO:0000110)
2.7	5.4	GO:0031166	integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
2.6	192.6	GO:0005811	lipid particle(GO:0005811)
2.5	5.0	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
2.4	259.1	GO:0016605	PML body(GO:0016605)
2.4	19.0	GO:0042613	MHC class II protein complex(GO:0042613)
2.3	11.4	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
2.1	4.3	GO:0032059	bleb(GO:0032059)
2.1	612.1	GO:0009897	external side of plasma membrane(GO:0009897)
2.1	8.3	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
2.1	6.2	GO:0044614	nuclear pore cytoplasmic filaments(GO:0044614)
1.9	13.1	GO:0061617	MICOS complex(GO:0061617)
1.9	11.2	GO:0032444	activin responsive factor complex(GO:0032444)
1.7	24.4	GO:0005832	chaperonin-containing T-complex(GO:0005832)
1.7	10.4	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
1.7	5.2	GO:0000814	ESCRT II complex(GO:0000814)
1.7	42.8	GO:0042629	mast cell granule(GO:0042629)
1.7	111.5	GO:0005876	spindle microtubule(GO:0005876)
1.7	18.2	GO:0042555	MCM complex(GO:0042555)
1.6	23.6	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
1.6	146.9	GO:0000786	nucleosome(GO:0000786)
1.5	7.3	GO:0044530	supraspliceosomal complex(GO:0044530)
1.4	11.2	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
1.4	10.9	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
1.3	18.4	GO:0016580	Sin3 complex(GO:0016580)
1.3	12.6	GO:0043202	lysosomal lumen(GO:0043202)
1.3	135.3	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
1.2	22.5	GO:0030056	hemidesmosome(GO:0030056)
1.2	6.2	GO:0035032	phosphatidylinositol 3-kinase complex, class III(GO:0035032)
1.2	123.2	GO:0072562	blood microparticle(GO:0072562)
1.2	891.4	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
1.1	85.0	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
1.1	8.8	GO:0031080	nuclear pore outer ring(GO:0031080)
1.1	26.3	GO:0000145	exocyst(GO:0000145)
1.1	74.2	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
1.1	3.3	GO:0044611	nuclear pore inner ring(GO:0044611)
1.1	440.9	GO:0005764	lytic vacuole(GO:0000323) lysosome(GO:0005764)
1.1	14.9	GO:0070938	contractile ring(GO:0070938)
1.0	3.1	GO:1990589	ATF4-CREB1 transcription factor complex(GO:1990589)
1.0	5.2	GO:0033588	Elongator holoenzyme complex(GO:0033588)
1.0	25.6	GO:0009925	basal plasma membrane(GO:0009925)
1.0	29.4	GO:0008180	COP9 signalosome(GO:0008180)
1.0	7.6	GO:0044815	DNA packaging complex(GO:0044815)
1.0	4.8	GO:0034455	t-UTP complex(GO:0034455)
0.9	13.1	GO:0008278	cohesin complex(GO:0008278)
0.9	65.6	GO:0032587	ruffle membrane(GO:0032587)
0.9	19.0	GO:0035861	site of double-strand break(GO:0035861)
0.9	30.7	GO:0002102	podosome(GO:0002102)
0.9	39.3	GO:0031519	PcG protein complex(GO:0031519)
0.9	5.2	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.8	3.4	GO:0070545	PeBoW complex(GO:0070545)
0.8	23.7	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.8	13.4	GO:0071011	precatalytic spliceosome(GO:0071011)
0.8	15.4	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.8	16.9	GO:0005732	small nucleolar ribonucleoprotein complex(GO:0005732)
0.7	9.6	GO:0000801	central element(GO:0000801)
0.7	16.2	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.7	34.7	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.7	10.3	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.7	22.0	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.7	8.2	GO:0071564	npBAF complex(GO:0071564)
0.7	45.4	GO:0030863	cortical cytoskeleton(GO:0030863)
0.7	584.8	GO:0005730	nucleolus(GO:0005730)
0.7	21.5	GO:0005801	cis-Golgi network(GO:0005801)
0.6	5.8	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.6	6.3	GO:0005721	pericentric heterochromatin(GO:0005721)
0.6	12.5	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)
0.6	11.8	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.6	727.1	GO:0005615	extracellular space(GO:0005615)
0.6	42.4	GO:0016363	nuclear matrix(GO:0016363)
0.6	65.5	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.6	44.4	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.6	36.5	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.6	3.5	GO:0031932	TORC2 complex(GO:0031932)
0.6	13.8	GO:0031304	intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.6	4.5	GO:0070187	telosome(GO:0070187)
0.6	3.4	GO:0033202	Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.6	1378.9	GO:0005829	cytosol(GO:0005829)
0.5	8.6	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.4	1.3	GO:0045098	type III intermediate filament(GO:0045098)
0.4	58.8	GO:0005925	focal adhesion(GO:0005925)
0.4	3.0	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.3	152.0	GO:0005783	endoplasmic reticulum(GO:0005783)
0.3	15.3	GO:0005913	cell-cell adherens junction(GO:0005913)
0.3	2.3	GO:0000242	pericentriolar material(GO:0000242)
0.3	6.1	GO:0008023	transcription elongation factor complex(GO:0008023)
0.3	2.3	GO:0030014	CCR4-NOT complex(GO:0030014)
0.2	10.0	GO:0001750	photoreceptor outer segment(GO:0001750)
0.2	3.1	GO:0001533	cornified envelope(GO:0001533)
0.2	1.8	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1	0.7	GO:0005663	DNA replication factor C complex(GO:0005663)
0.1	1.2	GO:0071821	FANCM-MHF complex(GO:0071821)
0.1	7.1	GO:0036064	ciliary basal body(GO:0036064)
0.1	5.7	GO:0005923	bicellular tight junction(GO:0005923)
0.1	2.6	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.1	1.1	GO:0031201	SNARE complex(GO:0031201)
0.1	1.3	GO:0005884	actin filament(GO:0005884)
0.0	0.4	GO:0032039	integrator complex(GO:0032039)
0.0	0.5	GO:0030131	clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
81.6	244.8	GO:0015433	peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
53.6	214.6	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
45.2	135.5	GO:0046977	TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
42.4	84.8	GO:0015440	peptide-transporting ATPase activity(GO:0015440)
36.3	108.8	GO:0015322	proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
32.9	65.9	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)
25.7	592.1	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
23.3	116.4	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
22.0	110.2	GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
21.7	195.7	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
21.6	86.5	GO:0005143	interleukin-12 receptor binding(GO:0005143)
21.1	570.4	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
20.1	260.9	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
18.7	112.1	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
18.6	130.0	GO:1901612	cardiolipin binding(GO:1901612)
16.4	65.6	GO:0004771	sterol esterase activity(GO:0004771)
15.9	111.6	GO:0061133	endopeptidase activator activity(GO:0061133)
15.5	46.4	GO:0070976	TIR domain binding(GO:0070976)
15.5	185.6	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
15.4	123.3	GO:0031386	protein tag(GO:0031386)
15.2	61.0	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
14.2	170.7	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
14.1	84.7	GO:0048030	disaccharide binding(GO:0048030)
13.9	527.0	GO:0042605	peptide antigen binding(GO:0042605)
13.8	124.5	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
12.6	62.8	GO:0008503	benzodiazepine receptor activity(GO:0008503)
11.6	243.7	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
11.2	33.6	GO:0004478	methionine adenosyltransferase activity(GO:0004478)
11.1	55.5	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
10.6	296.8	GO:0008009	chemokine activity(GO:0008009)
10.6	31.7	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
10.1	40.3	GO:0008265	Mo-molybdopterin cofactor sulfurase activity(GO:0008265)
10.0	59.8	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
9.8	59.0	GO:0042289	MHC class II protein binding(GO:0042289)
8.9	26.8	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
8.9	26.7	GO:0004769	steroid delta-isomerase activity(GO:0004769)
8.7	43.3	GO:0005138	interleukin-6 receptor binding(GO:0005138)
8.5	17.1	GO:0050785	advanced glycation end-product receptor activity(GO:0050785)
8.4	92.3	GO:0008641	small protein activating enzyme activity(GO:0008641)
8.1	40.5	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
7.6	45.9	GO:0048019	receptor antagonist activity(GO:0048019)
7.0	112.6	GO:0070628	proteasome binding(GO:0070628)
6.9	68.9	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
6.9	20.6	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
6.7	60.2	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
6.3	18.8	GO:0004556	alpha-amylase activity(GO:0004556)
6.1	18.3	GO:0035651	AP-3 adaptor complex binding(GO:0035651)
6.0	78.1	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
5.8	35.0	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
5.7	79.3	GO:0051400	BH domain binding(GO:0051400)
5.7	50.9	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
5.4	16.2	GO:0030626	U12 snRNA binding(GO:0030626)
5.3	26.3	GO:0031798	type 1 metabotropic glutamate receptor binding(GO:0031798)
5.0	40.2	GO:0035184	histone threonine kinase activity(GO:0035184)
5.0	1501.0	GO:0003924	GTPase activity(GO:0003924)
4.6	18.6	GO:0004687	myosin light chain kinase activity(GO:0004687)
4.6	23.1	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
4.5	13.5	GO:0031852	mu-type opioid receptor binding(GO:0031852)
4.4	17.5	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
4.3	30.1	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
3.9	274.2	GO:0003725	double-stranded RNA binding(GO:0003725)
3.9	31.3	GO:0047134	protein-disulfide reductase activity(GO:0047134)
3.7	25.8	GO:0050700	CARD domain binding(GO:0050700)
3.7	36.5	GO:0019957	C-C chemokine binding(GO:0019957)
3.6	97.1	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
3.6	10.7	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
3.5	10.4	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
3.2	19.5	GO:0004126	cytidine deaminase activity(GO:0004126)
3.2	15.9	GO:0030348	syntaxin-3 binding(GO:0030348)
3.1	68.8	GO:0032183	SUMO binding(GO:0032183)
3.1	30.8	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
3.1	207.9	GO:0030971	receptor tyrosine kinase binding(GO:0030971)
3.0	54.9	GO:0042288	MHC class I protein binding(GO:0042288)
3.0	33.5	GO:0030346	protein phosphatase 2B binding(GO:0030346)
3.0	27.2	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
3.0	12.0	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
3.0	12.0	GO:0070644	vitamin D response element binding(GO:0070644)
3.0	11.8	GO:0004165	dodecenoyl-CoA delta-isomerase activity(GO:0004165)
3.0	20.7	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
2.9	14.6	GO:0002151	G-quadruplex RNA binding(GO:0002151)
2.9	8.6	GO:0019809	spermidine binding(GO:0019809)
2.9	8.6	GO:0031731	CCR6 chemokine receptor binding(GO:0031731)
2.8	14.0	GO:1990829	C-rich single-stranded DNA binding(GO:1990829)
2.8	139.3	GO:0001786	phosphatidylserine binding(GO:0001786)
2.7	16.0	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
2.7	16.0	GO:0048039	ubiquinone binding(GO:0048039)
2.5	200.9	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
2.5	7.4	GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
2.5	7.4	GO:0016508	long-chain-enoyl-CoA hydratase activity(GO:0016508) testosterone dehydrogenase [NAD(P)] activity(GO:0030283)
2.4	9.6	GO:0016416	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
2.4	38.2	GO:0044548	S100 protein binding(GO:0044548)
2.4	229.8	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
2.4	105.8	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
2.3	7.0	GO:0009384	N-acylmannosamine kinase activity(GO:0009384)
2.3	7.0	GO:0005171	hepatocyte growth factor receptor binding(GO:0005171)
2.3	9.3	GO:0004052	arachidonate 12-lipoxygenase activity(GO:0004052)
2.3	27.2	GO:0042609	CD4 receptor binding(GO:0042609)
2.3	6.8	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
2.2	31.2	GO:0030550	acetylcholine receptor inhibitor activity(GO:0030550)
2.1	8.5	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
2.1	10.4	GO:0045340	mercury ion binding(GO:0045340)
2.1	29.1	GO:0023026	MHC class II protein complex binding(GO:0023026)
2.1	10.3	GO:0004614	phosphoglucomutase activity(GO:0004614)
2.0	8.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
2.0	15.8	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
2.0	9.8	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
1.9	23.0	GO:0070008	serine-type exopeptidase activity(GO:0070008)
1.9	53.7	GO:0008395	steroid hydroxylase activity(GO:0008395)
1.9	17.2	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
1.9	34.1	GO:0004190	aspartic-type endopeptidase activity(GO:0004190)
1.9	5.6	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
1.8	7.3	GO:0032558	adenyl deoxyribonucleotide binding(GO:0032558)
1.8	65.2	GO:0051539	4 iron, 4 sulfur cluster binding(GO:0051539)
1.8	25.0	GO:0017154	semaphorin receptor activity(GO:0017154)
1.7	20.9	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
1.7	34.8	GO:0008199	ferric iron binding(GO:0008199)
1.7	12.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
1.7	36.0	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
1.7	116.4	GO:0038024	cargo receptor activity(GO:0038024)
1.7	8.6	GO:0045322	unmethylated CpG binding(GO:0045322)
1.7	40.6	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
1.7	11.7	GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
1.7	8.3	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.6	91.8	GO:0000049	tRNA binding(GO:0000049)
1.6	32.3	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
1.6	11.1	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
1.6	3.1	GO:0001225	RNA polymerase II transcription coactivator binding(GO:0001225)
1.5	4.5	GO:1990955	G-rich single-stranded DNA binding(GO:1990955)
1.5	301.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.5	433.9	GO:0030246	carbohydrate binding(GO:0030246)
1.5	10.2	GO:0003720	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
1.5	40.9	GO:0001784	phosphotyrosine binding(GO:0001784)
1.4	14.5	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
1.4	21.6	GO:0004806	triglyceride lipase activity(GO:0004806)
1.4	24.2	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
1.4	7.0	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
1.4	88.8	GO:0019843	rRNA binding(GO:0019843)
1.4	8.3	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
1.4	76.5	GO:0004520	endodeoxyribonuclease activity(GO:0004520)
1.3	5.2	GO:0089720	caspase binding(GO:0089720)
1.3	8.9	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
1.3	3.8	GO:0001716	L-amino-acid oxidase activity(GO:0001716)
1.3	6.3	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
1.2	30.8	GO:0070840	dynein complex binding(GO:0070840)
1.2	6.1	GO:0035241	protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
1.2	10.9	GO:0043515	kinetochore binding(GO:0043515)
1.2	40.8	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
1.2	3.6	GO:0004995	tachykinin receptor activity(GO:0004995)
1.1	7.8	GO:0015526	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
1.1	5.3	GO:0004337	dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
1.0	3.1	GO:0009019	tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
1.0	23.3	GO:0070064	proline-rich region binding(GO:0070064)
1.0	45.5	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
1.0	92.6	GO:0031490	chromatin DNA binding(GO:0031490)
1.0	68.4	GO:0033613	activating transcription factor binding(GO:0033613)
1.0	4.0	GO:0000822	inositol hexakisphosphate binding(GO:0000822)
1.0	171.3	GO:0061135	endopeptidase regulator activity(GO:0061135)
1.0	3.0	GO:0002114	interleukin-33 receptor activity(GO:0002114)
1.0	2.9	GO:0000253	3-keto sterol reductase activity(GO:0000253)
1.0	69.2	GO:0001948	glycoprotein binding(GO:0001948)
1.0	4.8	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.9	164.0	GO:0042393	histone binding(GO:0042393)
0.9	32.9	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.9	14.6	GO:0001671	ATPase activator activity(GO:0001671)
0.9	3.6	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.9	22.9	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.9	9.7	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.9	13.1	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.9	24.4	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.9	27.3	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.8	17.5	GO:0005112	Notch binding(GO:0005112)
0.8	9.9	GO:0017166	vinculin binding(GO:0017166)
0.8	5.5	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.8	60.4	GO:0031072	heat shock protein binding(GO:0031072)
0.8	2.3	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.8	3.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.8	15.1	GO:0005212	structural constituent of eye lens(GO:0005212)
0.7	5.1	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
0.7	2.9	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.7	22.9	GO:0003678	DNA helicase activity(GO:0003678)
0.7	5.5	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.7	26.7	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.6	1.8	GO:0070052	collagen V binding(GO:0070052)
0.6	2.3	GO:0002046	opsin binding(GO:0002046)
0.5	8.2	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.5	2.6	GO:1903763	gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.5	21.4	GO:0004601	peroxidase activity(GO:0004601)
0.5	15.4	GO:0005248	voltage-gated sodium channel activity(GO:0005248)
0.5	6.1	GO:0031491	nucleosome binding(GO:0031491)
0.5	5.5	GO:0004180	carboxypeptidase activity(GO:0004180)
0.5	38.1	GO:0005178	integrin binding(GO:0005178)
0.5	5.9	GO:0017160	Ral GTPase binding(GO:0017160)
0.4	13.4	GO:0050699	WW domain binding(GO:0050699)
0.4	1.8	GO:0060698	endoribonuclease inhibitor activity(GO:0060698)
0.4	8.2	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.4	1.7	GO:0003989	acetyl-CoA carboxylase activity(GO:0003989)
0.4	19.3	GO:0016835	carbon-oxygen lyase activity(GO:0016835)
0.4	4.1	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.4	5.5	GO:0008198	ferrous iron binding(GO:0008198)
0.4	346.4	GO:0008270	zinc ion binding(GO:0008270)
0.4	8.1	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.4	5.0	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4	3.0	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.4	102.3	GO:0003712	transcription cofactor activity(GO:0003712)
0.4	10.4	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
0.3	3.3	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.3	13.9	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.3	7.2	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
0.3	8.1	GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.3	3.4	GO:0003995	acyl-CoA dehydrogenase activity(GO:0003995)
0.3	9.4	GO:0003684	damaged DNA binding(GO:0003684)
0.3	1.5	GO:0004875	complement receptor activity(GO:0004875)
0.3	1.8	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.3	1.2	GO:0052796	exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.3	29.0	GO:0004497	monooxygenase activity(GO:0004497)
0.3	2.8	GO:0070412	R-SMAD binding(GO:0070412)
0.3	4.4	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3	2.8	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2	1.9	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.2	4.3	GO:0017049	GTP-Rho binding(GO:0017049)
0.2	6.0	GO:0030515	snoRNA binding(GO:0030515)
0.2	1.1	GO:0042731	PH domain binding(GO:0042731)
0.2	9.4	GO:0008375	acetylglucosaminyltransferase activity(GO:0008375)
0.2	0.8	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.2	0.7	GO:0042974	retinoic acid receptor binding(GO:0042974)
0.1	3.1	GO:0071889	14-3-3 protein binding(GO:0071889)
0.1	34.6	GO:0005096	GTPase activator activity(GO:0005096)
0.1	0.4	GO:0001042	RNA polymerase I core binding(GO:0001042)
0.1	1.3	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	2.4	GO:0004402	histone acetyltransferase activity(GO:0004402)
0.1	1.4	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.1	2.3	GO:0000030	mannosyltransferase activity(GO:0000030)
0.1	1.2	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.1	8.1	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.1	0.7	GO:0043142	single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1	1.7	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.1	1.3	GO:0019200	carbohydrate kinase activity(GO:0019200)
0.1	4.6	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.0	1.3	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	1.3	GO:0016763	transferase activity, transferring pentosyl groups(GO:0016763)
0.0	0.5	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.3	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.0	4.9	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.0	0.3	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.3	GO:0016755	transferase activity, transferring amino-acyl groups(GO:0016755)
0.0	0.8	GO:0019842	vitamin binding(GO:0019842)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
12.2	218.8	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
9.6	250.7	PID IL27 PATHWAY	IL27-mediated signaling events
9.2	101.4	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
6.6	99.0	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
6.0	107.3	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
4.1	77.1	ST G ALPHA S PATHWAY	G alpha s Pathway
4.0	214.5	PID IL12 2PATHWAY	IL12-mediated signaling events
3.8	30.8	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
3.6	85.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
3.5	38.9	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
3.4	119.8	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
2.9	176.6	PID IL4 2PATHWAY	IL4-mediated signaling events
2.8	104.6	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
2.6	36.1	PID IL23 PATHWAY	IL23-mediated signaling events
2.5	42.7	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
2.5	84.7	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
2.5	94.5	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
2.4	75.4	PID ALK1 PATHWAY	ALK1 signaling events
2.4	52.7	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
2.4	116.4	PID BCR 5PATHWAY	BCR signaling pathway
2.2	336.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
2.0	47.8	PID MYC PATHWAY	C-MYC pathway
2.0	25.8	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
1.9	9.7	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
1.9	26.8	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
1.9	97.1	PID RAC1 PATHWAY	RAC1 signaling pathway
1.9	153.1	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
1.5	36.5	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
1.4	26.6	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
1.3	13.1	PID NECTIN PATHWAY	Nectin adhesion pathway
1.3	40.7	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
1.1	310.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
1.1	243.1	NABA MATRISOME ASSOCIATED	Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
1.0	120.9	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
1.0	16.0	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
1.0	8.6	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.9	22.5	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.9	38.2	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.9	20.5	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.8	12.1	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.8	24.4	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.7	4.4	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.7	6.1	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.7	13.9	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.6	21.4	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.6	8.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.6	4.4	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.6	25.4	PID E2F PATHWAY	E2F transcription factor network
0.6	2.3	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5	19.8	PID CMYB PATHWAY	C-MYB transcription factor network
0.5	22.4	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.5	10.2	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.4	11.1	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.4	14.6	PID ILK PATHWAY	Integrin-linked kinase signaling
0.4	12.8	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.4	10.0	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.4	20.2	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.4	3.0	PID IL1 PATHWAY	IL1-mediated signaling events
0.4	10.0	PID CONE PATHWAY	Visual signal transduction: Cones
0.3	4.1	PID ARF 3PATHWAY	Arf1 pathway
0.2	2.6	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.2	5.5	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.2	6.6	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.2	2.5	PID CD40 PATHWAY	CD40/CD40L signaling
0.2	2.6	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2	5.0	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.2	5.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	1.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	3.8	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.1	1.8	PID FANCONI PATHWAY	Fanconi anemia pathway
0.0	2.2	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	7.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	1.1	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	0.3	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.0	0.3	PID RAS PATHWAY	Regulation of Ras family activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
31.8	1907.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
22.1	66.2	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
20.3	263.5	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
20.2	222.0	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
16.9	286.9	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
13.7	164.4	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
12.2	61.0	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
11.5	577.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
11.2	358.2	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
11.0	22.1	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
10.7	512.4	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
9.5	104.6	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
8.4	135.1	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
6.5	39.2	REACTOME DEFENSINS	Genes involved in Defensins
6.3	88.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
6.3	69.1	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
6.0	54.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
5.8	58.3	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
5.8	46.4	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
4.9	126.5	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
4.8	180.6	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
4.3	143.0	REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
4.3	34.2	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
4.1	20.5	REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT	Genes involved in p53-Independent G1/S DNA damage checkpoint
3.6	138.0	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
3.5	55.8	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
3.1	18.8	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
3.1	49.5	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
2.5	22.2	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
2.3	25.8	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
1.9	11.7	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
1.9	108.7	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
1.8	62.3	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
1.8	35.9	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
1.7	19.2	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
1.7	20.9	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
1.7	18.2	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
1.6	24.4	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
1.6	25.0	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
1.5	266.7	REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	Genes involved in Class I MHC mediated antigen processing & presentation
1.4	32.1	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
1.4	23.0	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
1.4	134.1	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.3	38.1	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
1.3	34.0	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
1.2	29.9	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
1.2	33.6	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
1.2	4.7	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
1.0	24.2	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
1.0	60.6	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
1.0	14.6	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.9	9.0	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.9	10.6	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.9	133.7	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.8	10.2	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.8	9.7	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.8	10.4	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.8	8.6	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.8	10.9	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.8	15.3	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.7	5.2	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.7	17.8	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.7	5.8	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.7	18.6	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.7	18.6	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.7	19.1	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.7	5.6	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.7	11.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.7	11.2	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.7	11.7	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.7	46.9	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.7	18.8	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.7	6.7	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.7	4.0	REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA	Genes involved in Activation of Chaperones by ATF6-alpha
0.6	30.5	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.6	7.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.6	6.8	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.6	6.2	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.6	23.6	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.5	5.3	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.5	13.6	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.5	2.9	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.5	13.1	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.5	15.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	3.6	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.4	8.3	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.4	5.6	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.4	9.4	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock
0.4	12.0	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.4	4.9	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.3	7.3	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.3	2.3	REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	Genes involved in Downstream signal transduction
0.3	15.6	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.3	3.2	REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.3	29.2	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.3	17.3	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.3	2.8	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2	1.4	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.2	4.1	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2	11.7	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	3.0	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.1	2.6	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.1	1.7	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1	1.5	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.1	2.3	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1	1.4	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	0.8	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.1	1.2	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.0	0.7	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.0	0.4	REACTOME RNA POL I TRANSCRIPTION INITIATION	Genes involved in RNA Polymerase I Transcription Initiation

Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 4.08

Motif logo

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Activity-expression correlation:

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: