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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Insm1

Z-value: 0.49

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Transcription factors associated with Insm1

Gene Symbol Gene ID Gene Info

Activity profile of Insm1 motif

Sorted Z-values of Insm1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_90999506 18.14 ENSRNOT00000034401
Gfap
glial fibrillary acidic protein
chr6_-_138249382 16.19 ENSRNOT00000085678
ENSRNOT00000006912
Ighm
immunoglobulin heavy constant mu
chr2_+_262914327 14.75 ENSRNOT00000029312
Negr1
neuronal growth regulator 1
chr18_+_83777665 11.67 ENSRNOT00000018682
Cbln2
cerebellin 2 precursor
chr3_-_172537877 7.74 ENSRNOT00000072069
Ctsz
cathepsin Z
chr6_+_139405966 7.35 ENSRNOT00000088974
AABR07065693.3

chr3_+_113251778 7.34 ENSRNOT00000083005
Map1a
microtubule-associated protein 1A
chr13_-_48284408 7.22 ENSRNOT00000085967
Srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr1_+_140602542 6.84 ENSRNOT00000085570
Isg20
interferon stimulated exonuclease gene 20
chr8_-_58647933 6.68 ENSRNOT00000038830
Tnfaip8l3
TNF alpha induced protein 8 like 3
chr1_-_89360733 6.21 ENSRNOT00000028544
Mag
myelin-associated glycoprotein
chr5_+_142875773 5.71 ENSRNOT00000082120
ENSRNOT00000056496
Epha10
EPH receptor A10
chr10_-_58693754 5.66 ENSRNOT00000071764
Pitpnm3
PITPNM family member 3
chr6_+_57516713 5.51 ENSRNOT00000063874
Dgkb
diacylglycerol kinase, beta
chr19_-_19509087 4.84 ENSRNOT00000019301
Nkd1
naked cuticle homolog 1
chr7_+_37812831 4.53 ENSRNOT00000005910
Btg1
BTG anti-proliferation factor 1
chr15_+_39644851 4.50 ENSRNOT00000081373
Rcbtb1
RCC1 and BTB domain containing protein 1
chr6_+_26537707 4.36 ENSRNOT00000050102
Zfp513
zinc finger protein 513
chr3_+_154786215 4.34 ENSRNOT00000019787
Lbp
lipopolysaccharide binding protein
chr2_+_239415046 4.32 ENSRNOT00000072196
Cxxc4
CXXC finger protein 4
chr3_-_120087136 4.27 ENSRNOT00000078994
Kcnip3
potassium voltage-gated channel interacting protein 3
chr2_-_220101791 4.05 ENSRNOT00000022905
Plppr5
phospholipid phosphatase related 5
chr19_+_55094585 4.01 ENSRNOT00000068452
Zfpm1
zinc finger protein, multitype 1
chr6_-_92527711 3.90 ENSRNOT00000007529
Nin
ninein
chr1_-_197770669 3.78 ENSRNOT00000023563
Lat
linker for activation of T cells
chr20_+_2194709 3.68 ENSRNOT00000001017
Trim15
tripartite motif containing 15
chr17_-_90756048 3.63 ENSRNOT00000085669
Ero1b
endoplasmic reticulum oxidoreductase 1 beta
chr6_+_147876237 3.45 ENSRNOT00000056649
Tmem196
transmembrane protein 196
chr12_+_22026075 3.14 ENSRNOT00000029041
LOC100910838
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1-like
chr19_+_54766589 2.87 ENSRNOT00000025894
Banp
Btg3 associated nuclear protein
chrX_+_14498119 2.86 ENSRNOT00000051135
Xk
X-linked Kx blood group
chr2_-_211322719 2.74 ENSRNOT00000027493
RGD1310209
similar to KIAA1324 protein
chr3_+_103753238 2.29 ENSRNOT00000007144
Slc12a6
solute carrier family 12, member 6
chr7_-_59514939 2.19 ENSRNOT00000085579
Kcnmb4
potassium calcium-activated channel subfamily M regulatory beta subunit 4
chr15_+_46784963 2.19 ENSRNOT00000015540
Xkr6
XK related 6
chr4_-_153465203 2.14 ENSRNOT00000016776
Bid
BH3 interacting domain death agonist
chr2_+_251817694 2.08 ENSRNOT00000019964
RGD1560065
similar to RIKEN cDNA 2410004B18
chr10_+_43538160 1.88 ENSRNOT00000089217
Cnot8
CCR4-NOT transcription complex, subunit 8
chr1_+_192025357 1.82 ENSRNOT00000025072
Ubfd1
ubiquitin family domain containing 1
chr7_+_127081978 1.68 ENSRNOT00000022945
Tbc1d22a
TBC1 domain family, member 22a
chr6_+_147876557 1.67 ENSRNOT00000080090
Tmem196
transmembrane protein 196
chr20_+_46428124 1.65 ENSRNOT00000000327
Foxo3
forkhead box O3
chr1_+_171820423 1.61 ENSRNOT00000047831
Ppfibp2
PPFIA binding protein 2
chr8_-_32328819 1.58 ENSRNOT00000074457
ENSRNOT00000070818
Aplp2
amyloid beta precursor like protein 2
chrX_+_20216587 1.51 ENSRNOT00000073114
AABR07037412.2
FYVE, RhoGEF and PH domain-containing protein 1
chr1_+_89202527 1.41 ENSRNOT00000028526
Sbsn
suprabasin
chr1_+_192025710 1.36 ENSRNOT00000077457
Ubfd1
ubiquitin family domain containing 1
chr2_+_193286721 1.32 ENSRNOT00000074852
AABR07012323.1

chrX_-_154722220 1.14 ENSRNOT00000089743
ENSRNOT00000087893
Fmr1
fragile X mental retardation 1
chr4_+_113935492 1.13 ENSRNOT00000035329
LOC103692170
coiled-coil domain-containing protein 142
chr3_-_148313810 1.06 ENSRNOT00000010762
Bcl2l1
Bcl2-like 1
chr18_-_17396805 1.05 ENSRNOT00000082963
Tpgs2
tubulin polyglutamylase complex subunit 2
chr1_-_80630038 0.92 ENSRNOT00000025281
Tomm40
translocase of outer mitochondrial membrane 40
chr7_-_12424367 0.92 ENSRNOT00000060698
Midn
midnolin
chr6_+_28323647 0.90 ENSRNOT00000089093
Dnmt3a
DNA methyltransferase 3 alpha
chr1_-_154170409 0.82 ENSRNOT00000089014
Hikeshi
Hikeshi, heat shock protein nuclear import factor
chr1_+_165382690 0.81 ENSRNOT00000023802
C2cd3
C2 calcium-dependent domain containing 3
chr1_-_89488223 0.71 ENSRNOT00000028624
Fxyd1
FXYD domain-containing ion transport regulator 1
chr7_-_4293352 0.62 ENSRNOT00000047489
Olr984
olfactory receptor 984
chr15_-_56970365 0.46 ENSRNOT00000047192
Lrch1
leucine rich repeats and calponin homology domain containing 1
chr11_+_86890585 0.40 ENSRNOT00000002579
Ranbp1
RAN binding protein 1
chr2_-_128002005 0.24 ENSRNOT00000018796
Pgrmc2
progesterone receptor membrane component 2
chr18_-_61788859 0.21 ENSRNOT00000034075
ENSRNOT00000034069
Ccbe1
collagen and calcium binding EGF domains 1
chr2_+_189106039 0.05 ENSRNOT00000028210
Ube2q1
ubiquitin conjugating enzyme E2 Q1

Network of associatons between targets according to the STRING database.

First level regulatory network of Insm1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 18.1 GO:1904714 positive regulation of Schwann cell proliferation(GO:0010625) regulation of chaperone-mediated autophagy(GO:1904714)
2.4 7.2 GO:0021816 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
2.3 6.8 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
1.6 4.8 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.4 4.3 GO:0015920 lipopolysaccharide transport(GO:0015920)
1.3 4.0 GO:0071733 mitral valve formation(GO:0003192) transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
1.1 7.7 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
1.0 4.8 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.8 2.3 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.7 3.6 GO:0030070 insulin processing(GO:0030070)
0.6 6.7 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.5 6.2 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.5 2.9 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.4 3.9 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.4 1.1 GO:1905218 cellular response to astaxanthin(GO:1905218)
0.3 1.6 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.3 0.8 GO:0021997 neural plate axis specification(GO:0021997)
0.2 2.7 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.2 7.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.2 0.9 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.2 0.7 GO:1903797 positive regulation of inorganic anion transmembrane transport(GO:1903797)
0.2 1.9 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.2 6.7 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.2 0.9 GO:0044027 hypermethylation of CpG island(GO:0044027) C-5 methylation of cytosine(GO:0090116)
0.1 5.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 4.3 GO:0048266 behavioral response to pain(GO:0048266)
0.1 0.4 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 5.7 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.1 2.2 GO:0005513 detection of calcium ion(GO:0005513)
0.1 16.4 GO:0007631 feeding behavior(GO:0007631)
0.1 4.1 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.1 9.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 0.2 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) positive regulation of lymphangiogenesis(GO:1901492)
0.1 3.8 GO:0043303 mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.1 0.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 4.3 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 3.1 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.0 1.7 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 4.4 GO:0060041 retina development in camera-type eye(GO:0060041)
0.0 0.8 GO:0034605 cellular response to heat(GO:0034605)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 18.1 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
2.1 6.2 GO:0097453 mesaxon(GO:0097453) ensheathing process(GO:1990015)
0.7 8.4 GO:0044327 dendritic spine head(GO:0044327)
0.6 3.9 GO:0036449 microtubule minus-end(GO:0036449)
0.2 7.7 GO:0099738 cell cortex region(GO:0099738)
0.2 4.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 1.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 3.8 GO:0042629 mast cell granule(GO:0042629)
0.1 13.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 6.7 GO:0015030 Cajal body(GO:0015030)
0.1 0.9 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.9 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 7.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 6.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.9 GO:0001741 XY body(GO:0001741)
0.0 4.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.1 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.0 0.8 GO:0034451 centriolar satellite(GO:0034451)
0.0 2.7 GO:0005770 late endosome(GO:0005770)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 6.8 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
1.1 6.7 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
1.0 5.7 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.9 4.3 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.6 2.3 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.4 6.2 GO:0033691 sialic acid binding(GO:0033691)
0.4 5.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.4 4.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.2 3.6 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.2 0.9 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.2 7.7 GO:0004180 carboxypeptidase activity(GO:0004180)
0.2 1.1 GO:0051434 BH3 domain binding(GO:0051434)
0.2 18.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.1 GO:0035197 G-quadruplex RNA binding(GO:0002151) poly(G) binding(GO:0034046) siRNA binding(GO:0035197)
0.1 3.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 7.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 6.5 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 1.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.9 GO:0015266 protein channel activity(GO:0015266)
0.1 4.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 7.5 GO:0005518 collagen binding(GO:0005518)
0.1 9.2 GO:0030165 PDZ domain binding(GO:0030165)
0.1 1.7 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 2.9 GO:0002039 p53 binding(GO:0002039)
0.0 1.6 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.8 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 1.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 9.2 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.2 3.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 6.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 4.3 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 1.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 3.5 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 6.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.7 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.3 16.0 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 6.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.2 7.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.2 5.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 3.8 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 6.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.1 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 2.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.1 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 4.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 3.9 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 0.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import