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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hsf4

Z-value: 0.94

Motif logo

Transcription factors associated with Hsf4

Gene Symbol Gene ID Gene Info
ENSRNOG00000015253 heat shock transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hsf4rn6_v1_chr19_+_37226186_37226188-0.292.0e-07Click!

Activity profile of Hsf4 motif

Sorted Z-values of Hsf4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_170475831 39.31 ENSRNOT00000006949
family with sequence similarity 209, member A
chr17_-_44834305 30.10 ENSRNOT00000084303
histone cluster 1, H2bd
chr9_-_14668297 30.01 ENSRNOT00000042404
triggering receptor expressed on myeloid cells-like 2
chr8_-_49301125 29.19 ENSRNOT00000091190
CD3e molecule
chr11_+_86094567 24.46 ENSRNOT00000086514
lambda-chain C1-region-like
chr14_+_3058993 24.13 ENSRNOT00000002807
growth factor independent 1 transcriptional repressor
chr7_-_116106368 23.43 ENSRNOT00000035678
lymphocyte antigen 6 complex, locus K
chr8_+_132828091 20.89 ENSRNOT00000008269
C-C motif chemokine receptor 9
chr1_-_89045586 20.80 ENSRNOT00000063808
zinc finger and BTB domain containing 32
chr14_-_82347679 20.70 ENSRNOT00000032972
transforming, acidic coiled-coil containing protein 3
chr3_+_170994038 19.84 ENSRNOT00000081823
SPO11, initiator of meiotic double stranded breaks
chr18_+_25749098 19.79 ENSRNOT00000027771
calcium/calmodulin-dependent protein kinase IV
chr4_+_170958196 18.96 ENSRNOT00000007905
phosphodiesterase 6H
chr13_-_84452181 17.33 ENSRNOT00000005060
maelstrom spermatogenic transposon silencer
chr4_-_157408176 17.24 ENSRNOT00000021915
Cd4 molecule
chr20_+_4087618 16.98 ENSRNOT00000000522
ENSRNOT00000060327
ENSRNOT00000080590
RT1 class II, locus Db1
chr8_+_79054237 16.43 ENSRNOT00000077613
meiosis-specific nuclear structural 1
chr7_-_27552078 15.60 ENSRNOT00000059538
stabilin 2
chr2_+_138194136 15.40 ENSRNOT00000014928
similar to RIKEN cDNA 1700018B24
chr1_-_227175096 15.39 ENSRNOT00000054811

chr20_+_4188766 15.06 ENSRNOT00000081438
ENSRNOT00000060378
testis specific basic protein
chr1_-_220848153 14.93 ENSRNOT00000037404
cathepsin W
chr15_-_42518855 14.75 ENSRNOT00000076451
establishment of sister chromatid cohesion N-acetyltransferase 2
chr8_-_111965889 14.72 ENSRNOT00000032376
beaded filament structural protein 2
chr1_+_141120166 14.46 ENSRNOT00000050759
Fanconi anemia, complementation group I
chr10_-_57243435 14.44 ENSRNOT00000005050
cholinergic receptor nicotinic epsilon subunit
chr9_+_10172832 14.43 ENSRNOT00000074555
acyl-CoA synthetase bubblegum family member 2
chr7_+_40318490 14.34 ENSRNOT00000081374
similar to hypothetical protein FLJ35821
chr7_-_117440342 14.23 ENSRNOT00000018528
testis-specific serine kinase 5
chr15_-_44411004 14.12 ENSRNOT00000031163
cell division cycle associated 2
chr6_-_91518996 14.01 ENSRNOT00000005835
DNA polymerase epsilon 2, accessory subunit
chr5_-_153924896 13.83 ENSRNOT00000065247
grainyhead-like transcription factor 3
chr18_+_68983545 13.63 ENSRNOT00000085317
StAR-related lipid transfer domain containing 6
chr6_+_93539271 13.18 ENSRNOT00000078791
translocase of outer mitochondrial membrane 20 homolog (yeast)-like
chr20_+_8109635 12.59 ENSRNOT00000000609
armadillo repeat containing 12
chr18_+_62174670 12.50 ENSRNOT00000025362
phorbol-12-myristate-13-acetate-induced protein 1
chr4_-_170932618 12.39 ENSRNOT00000007779
Rho GDP dissociation inhibitor beta
chr6_-_95796502 12.32 ENSRNOT00000041409
Six6 opposite strand transcript 1
chrX_+_133227660 12.29 ENSRNOT00000004591
actin-related protein T1
chr1_+_217039755 11.91 ENSRNOT00000091603
actin-like
chr2_+_231884337 11.74 ENSRNOT00000014695
zinc finger, GRF-type containing 1
chr13_-_87847263 11.74 ENSRNOT00000003650
NUF2, NDC80 kinetochore complex component
chr3_+_94035905 11.71 ENSRNOT00000014767
similar to RIKEN cDNA A930018P22
chr10_+_110346453 11.63 ENSRNOT00000054928
testis expressed 19.1
chr5_+_172275734 11.49 ENSRNOT00000064266
membrane metallo-endopeptidase-like 1
chr18_+_87415531 11.43 ENSRNOT00000072475

chr1_-_198486157 11.42 ENSRNOT00000022758
zymogen granule protein 16
chr4_+_157563990 11.40 ENSRNOT00000024618
acrosin binding protein
chr1_+_81260548 11.39 ENSRNOT00000026669
SMG9 nonsense mediated mRNA decay factor
chr18_-_68983619 11.28 ENSRNOT00000014670
similar to chromosome 18 open reading frame 54
chr15_+_32386816 11.17 ENSRNOT00000060322

chr7_+_129595192 10.92 ENSRNOT00000071151
zinc finger, DHHC-type containing 25
chr17_-_43776460 10.84 ENSRNOT00000089055
histone cluster 2, H3c2
chr4_-_115354795 10.83 ENSRNOT00000017691
CD207 molecule
chr1_+_199019517 10.72 ENSRNOT00000025419
phosphorylase kinase catalytic subunit gamma 2
chr5_-_59165160 10.55 ENSRNOT00000029035
family with sequence similarity 221, member B
chr4_-_70628470 10.36 ENSRNOT00000029319
trypsin 5
chr14_-_17225389 10.31 ENSRNOT00000052035
ADP-ribosyltransferase 3
chr10_+_74762763 10.25 ENSRNOT00000077390

chr20_+_295250 10.02 ENSRNOT00000000955
chloride intracellular channel 2
chrX_-_64036217 10.01 ENSRNOT00000078311

chr12_+_25119355 9.99 ENSRNOT00000034629
linker for activation of T cells family, member 2
chr5_+_153976535 9.64 ENSRNOT00000030881
similar to RIKEN cDNA 1700029M20
chr3_-_103745236 9.55 ENSRNOT00000006876
NUT midline carcinoma, family member 1
chr6_-_128690741 9.53 ENSRNOT00000035826
spectrin repeat containing, nuclear envelope family member 3
chr2_+_104290726 9.44 ENSRNOT00000017387
DnaJ heat shock protein family (Hsp40) member C5 beta
chr7_+_97984862 9.37 ENSRNOT00000008508
ATPase family, AAA domain containing 2
chr9_+_38544398 9.25 ENSRNOT00000016828
primase (DNA) subunit 2
chr12_+_12756452 9.20 ENSRNOT00000001382
ENSRNOT00000092462
ankyrin repeat domain 61
chr4_+_162078905 9.14 ENSRNOT00000049620
C-type lectin domain family 2 member D-related protein-like
chr1_-_89269930 9.03 ENSRNOT00000028532
free fatty acid receptor 2
chr10_-_77512032 9.00 ENSRNOT00000003295
phosphatidylcholine transfer protein
chrX_-_105793306 8.76 ENSRNOT00000015806
nuclear RNA export factor 2
chr20_+_11436267 8.74 ENSRNOT00000001631
transient receptor potential cation channel, subfamily M, member 2
chr20_-_13173774 8.64 ENSRNOT00000001704
spermatogenesis and centriole associated 1-like
chr2_-_187668677 8.56 ENSRNOT00000056898
ENSRNOT00000092563
TSSK6 activating co-chaperone
chr12_+_16912249 8.50 ENSRNOT00000085936
transmembrane protein 184A
chr9_+_81518176 8.43 ENSRNOT00000078317
ENSRNOT00000019265
ENSRNOT00000088246
ENSRNOT00000084682
actin related protein 2/3 complex, subunit 2
chr3_-_7051953 8.35 ENSRNOT00000013473
similar to hypothetical protein MGC29761
chr4_+_170820594 8.29 ENSRNOT00000032568
similar to C030030A07Rik protein
chr5_+_129052043 8.16 ENSRNOT00000013459
tetratricopeptide repeat protein 39A
chrX_+_13441558 7.99 ENSRNOT00000030170
similar to Ferritin light chain (Ferritin L subunit)
chr16_+_72216326 7.95 ENSRNOT00000051363
indoleamine 2,3-dioxygenase 1
chr12_-_51965779 7.89 ENSRNOT00000056733
replication protein A3-like
chr6_-_127248372 7.86 ENSRNOT00000085517
ankyrin repeat and SOCS box-containing 2
chr3_+_19045214 7.79 ENSRNOT00000070878

chr3_+_122928964 7.77 ENSRNOT00000074724
rCG26795-like
chr20_-_29990111 7.71 ENSRNOT00000048029
cadherin-related 23
chr20_-_12835044 7.69 ENSRNOT00000074268
speriolin-like protein
chr2_+_211880262 7.56 ENSRNOT00000038315
solute carrier family 25, member 54
chr3_-_110517163 7.56 ENSRNOT00000078037
phospholipase C, beta 2
chr19_-_10976396 7.53 ENSRNOT00000073239
NLR family, CARD domain containing 5
chr3_-_14571640 7.46 ENSRNOT00000060013
glycoprotein, alpha-galactosyltransferase 1-like 1
chr7_+_145068286 7.38 ENSRNOT00000088956
ENSRNOT00000065753
NCK associated protein 1 like
chrX_+_106230013 7.36 ENSRNOT00000067828

chr1_+_199019289 7.35 ENSRNOT00000087142
phosphorylase kinase catalytic subunit gamma 2
chr10_+_31324512 7.32 ENSRNOT00000008559
fibronectin type III domain containing 9
chr19_-_37952501 7.29 ENSRNOT00000026809
dipeptidase 3
chr1_+_221443896 7.25 ENSRNOT00000073942
transmembrane protein 262
chr5_-_155258392 7.17 ENSRNOT00000017065
complement C1q C chain
chr5_+_151343493 7.11 ENSRNOT00000077807
WAS protein family, member 2
chr4_+_157057601 7.08 ENSRNOT00000040592
Zinc finger protein 42-like
chr1_+_165506361 7.04 ENSRNOT00000024156
uncoupling protein 2
chr5_+_169288871 6.89 ENSRNOT00000055466
TNF receptor superfamily member 25
chr1_-_252461461 6.88 ENSRNOT00000026093
ankyrin repeat domain 22
chr3_+_124088157 6.86 ENSRNOT00000028876
spermine oxidase
chr8_-_63155825 6.86 ENSRNOT00000011820
TBC1 domain family, member 21
chr14_-_21252538 6.83 ENSRNOT00000005003
ameloblastin
chr1_+_146976975 6.82 ENSRNOT00000071895
X-linked lymphocyte-regulated 5C-like
chr10_+_57064482 6.81 ENSRNOT00000046807
zinc finger, MYND-type containing 15
chr20_-_44255064 6.81 ENSRNOT00000000735
WNT1 inducible signaling pathway protein 3
chr5_-_104920906 6.65 ENSRNOT00000071318
family with sequence similarity 154, member A
chr3_+_138974871 6.63 ENSRNOT00000012524
SCP2 sterol-binding domain containing 1
chr5_+_157165341 6.63 ENSRNOT00000087072
phospholipase A2, group IIC
chr5_+_129257429 6.60 ENSRNOT00000072396
tetratricopeptide repeat domain 39A
chrX_+_156227830 6.57 ENSRNOT00000083949
similar to ESO3 protein
chr15_+_27346731 6.56 ENSRNOT00000046317
olfactory receptor 1619
chr3_+_38367556 6.55 ENSRNOT00000049144
similar to developmental pluripotency associated 5
chr17_-_29895386 6.54 ENSRNOT00000048757
chromodomain Y-like
chr10_-_57436368 6.52 ENSRNOT00000056608
SLP adaptor and CSK interacting membrane protein
chr6_-_55647665 6.50 ENSRNOT00000007414
basic leucine zipper and W2 domains 2
chr3_+_149606940 6.46 ENSRNOT00000018512
BPI fold containing family A, member 3
chr5_-_127273656 6.45 ENSRNOT00000057341
DMRT-like family B with proline-rich C-terminal, 1
chr20_+_4967194 6.41 ENSRNOT00000070846
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
chr12_-_21761487 6.37 ENSRNOT00000082910
TSC22 domain family protein 4-like
chr16_-_31301880 6.30 ENSRNOT00000084847
ENSRNOT00000083943

chr13_-_79899479 6.27 ENSRNOT00000035815
similar to hypothetical protein
chrX_-_156540733 6.26 ENSRNOT00000091029
transketolase-like protein 1
chr19_+_55381565 6.23 ENSRNOT00000018923
chromatin licensing and DNA replication factor 1
chr16_+_6434468 6.21 ENSRNOT00000012906
calsequestrin-1-like
chr6_-_135112775 6.16 ENSRNOT00000086310
heat shock protein HSP 90-alpha
chr1_-_12952906 6.15 ENSRNOT00000078193
hypothetical protein LOC100360362
chr20_-_4921348 6.14 ENSRNOT00000082497
ENSRNOT00000041151
RT1 class I, locus CE4
chr7_+_70612103 6.12 ENSRNOT00000057833
Rho GTPase activating protein 9
chr4_-_161757447 6.05 ENSRNOT00000008737
FK506 binding protein 4
chr5_-_62187930 6.03 ENSRNOT00000011787
coronin 2A
chr3_+_19690016 5.87 ENSRNOT00000085460

chr10_-_7029136 5.84 ENSRNOT00000091942

chrX_+_105937118 5.82 ENSRNOT00000045591
preferentially expressed antigen in melanoma-like
chr5_+_160095427 5.81 ENSRNOT00000077609

chrX_+_106002416 5.71 ENSRNOT00000052196
leucine-rich repeat-containing protein PRAME-like
chr5_+_5866897 5.67 ENSRNOT00000011940
solute carrier organic anion transporter family, member 5A1
chr4_-_162230859 5.66 ENSRNOT00000042872
similar to osteoclast inhibitory lectin
chr10_-_56488723 5.63 ENSRNOT00000065524
transmembrane protein 95
chr8_+_22423467 5.59 ENSRNOT00000085320
interleukin enhancer binding factor 3
chr1_-_99985422 5.49 ENSRNOT00000025701
kallikrein 1-related peptidase C2
chr17_+_15762030 5.45 ENSRNOT00000089310
FYVE, RhoGEF and PH domain containing 3
chr20_+_3148665 5.39 ENSRNOT00000086026
RT1 class Ib, locus N2
chr1_+_81643816 5.32 ENSRNOT00000027214
carcinoembryonic antigen-related cell adhesion molecule 1-like
chr1_-_211196868 5.32 ENSRNOT00000022714
mitogen-activated protein kinase 1 interacting protein 1
chr1_+_89162639 5.31 ENSRNOT00000028508
ATPase H+/K+ transporting alpha subunit
chr1_-_190914610 5.22 ENSRNOT00000023189
cerebellar degeneration-related protein 2
chr8_-_12355091 5.21 ENSRNOT00000009318
centrosomal protein 57
chr8_+_2604962 5.21 ENSRNOT00000009993
caspase 1
chr20_+_3149114 5.21 ENSRNOT00000084770
RT1 class Ib, locus N2
chr3_+_2877293 5.16 ENSRNOT00000061855
lipocalin 5
chr4_+_102403451 5.16 ENSRNOT00000071605

chr9_-_15410943 5.15 ENSRNOT00000074217
cyclin D3
chr4_-_183426439 5.10 ENSRNOT00000083310
family with sequence similarity 60, member A
chr5_-_48504511 5.08 ENSRNOT00000010271
proline-rich nuclear receptor coactivator 1
chr2_-_140334912 5.06 ENSRNOT00000015067
E74-like factor 2
chr8_+_118744229 4.86 ENSRNOT00000028364
kinesin family member 9
chr1_+_279798187 4.83 ENSRNOT00000024065
pancreatic lipase
chr12_-_31323810 4.78 ENSRNOT00000001247
RAN, member RAS oncogene family
chr5_+_135574172 4.75 ENSRNOT00000023416
testis-specific kinase 2
chr16_-_20807070 4.74 ENSRNOT00000072536
cartilage oligomeric matrix protein
chr20_-_32133431 4.74 ENSRNOT00000000443
serglycin
chr2_-_84678790 4.74 ENSRNOT00000015886
chaperonin containing TCP1 subunit 5
chr9_-_65693822 4.73 ENSRNOT00000038431
amyotrophic lateral sclerosis 2 chromosome region, candidate 12
chr17_+_5311274 4.70 ENSRNOT00000067020
spermatogenesis-associated protein 31D1-like
chr3_+_155119042 4.69 ENSRNOT00000032943
ARP5 actin-related protein 5 homolog
chr14_-_81339526 4.67 ENSRNOT00000015894
G protein-coupled receptor kinase 4
chr8_+_69121682 4.57 ENSRNOT00000013461
ribosomal protein L4
chr1_+_82452469 4.57 ENSRNOT00000028026
exosome component 5
chr14_+_107767392 4.53 ENSRNOT00000012847
chaperonin containing TCP1 subunit 4
chr11_-_87858107 4.52 ENSRNOT00000002550
synaptosomal-associated protein 29
chr5_+_162385173 4.40 ENSRNOT00000048232
PRAME family member 12
chrX_-_112159458 4.39 ENSRNOT00000087403
testis expressed 13B
chr5_-_137281277 4.37 ENSRNOT00000093752
ENSRNOT00000093708
ENSRNOT00000093301
ENSRNOT00000093502
ENSRNOT00000034762
MPL proto-oncogene, thrombopoietin receptor
chr7_+_72772440 4.29 ENSRNOT00000009989
metadherin
chr11_+_70034139 4.27 ENSRNOT00000002450
uridine monophosphate synthetase
chr11_-_61530567 4.24 ENSRNOT00000076277
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr20_-_5037022 4.23 ENSRNOT00000091022
ENSRNOT00000060762
mutS homolog 5
chr15_+_52234563 4.21 ENSRNOT00000015169
receptor accessory protein 4
chr1_-_174119815 4.19 ENSRNOT00000019368
tripartite motif-containing 66
chr3_+_114102875 4.18 ENSRNOT00000023209
tripartite motif-containing 69
chr20_+_21316826 4.17 ENSRNOT00000000785
similar to RIKEN cDNA 1700040L02
chr1_-_145931583 4.15 ENSRNOT00000016433
cilia and flagella associated protein 161
chr7_+_40217991 4.11 ENSRNOT00000085684
centrosomal protein 290
chr8_+_22423890 4.09 ENSRNOT00000009354
interleukin enhancer binding factor 3
chr2_+_187708234 4.07 ENSRNOT00000026514
SMG5 nonsense mediated mRNA decay factor
chr15_+_87886783 4.05 ENSRNOT00000065710
SLAIN motif family, member 1
chr7_-_143392777 4.05 ENSRNOT00000086504
ENSRNOT00000038105
keratin 72
chr1_+_147080783 4.03 ENSRNOT00000065898
PWWP domain-containing protein MUM1-like
chr16_-_75004617 3.99 ENSRNOT00000080407
family with sequence similarity 90, member A1A
chr7_-_107203897 3.97 ENSRNOT00000086263
leucine rich repeat containing 6
chr7_-_59763219 3.94 ENSRNOT00000041210
similar to 60S ribosomal protein L12
chr11_-_27141881 3.93 ENSRNOT00000002169
chaperonin containing TCP1 subunit 8
chr11_-_36533073 3.91 ENSRNOT00000033486
LCA5L, lebercilin like
chr15_+_57709043 3.88 ENSRNOT00000030579
glutamate-rich 6B

Network of associatons between targets according to the STRING database.

First level regulatory network of Hsf4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.0 24.1 GO:0070103 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) regulation of interleukin-6-mediated signaling pathway(GO:0070103)
6.4 32.2 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
5.7 17.2 GO:0071350 interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-15(GO:0071350)
4.9 29.2 GO:0002913 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
4.2 12.5 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
4.1 12.4 GO:0071461 cellular response to redox state(GO:0071461)
4.0 7.9 GO:0002666 positive regulation of T cell tolerance induction(GO:0002666)
3.7 14.7 GO:0034421 post-translational protein acetylation(GO:0034421)
2.8 17.0 GO:0002399 MHC class II protein complex assembly(GO:0002399) peptide antigen assembly with MHC class II protein complex(GO:0002503)
2.8 14.0 GO:0042276 error-prone translesion synthesis(GO:0042276)
2.5 7.4 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
2.3 9.0 GO:0002232 leukocyte chemotaxis involved in inflammatory response(GO:0002232) cell surface pattern recognition receptor signaling pathway(GO:0002752) regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
2.1 8.5 GO:0018992 germ-line sex determination(GO:0018992)
2.1 8.4 GO:2000814 positive regulation of barbed-end actin filament capping(GO:2000814)
2.1 6.2 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163) regulation of DNA replication origin binding(GO:1902595)
1.9 7.5 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
1.7 8.7 GO:0071502 cellular response to temperature stimulus(GO:0071502) positive regulation of oxidative stress-induced neuron death(GO:1903223)
1.7 13.5 GO:1903405 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
1.7 30.1 GO:0002227 innate immune response in mucosa(GO:0002227)
1.7 11.6 GO:0010529 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) spongiotrophoblast cell proliferation(GO:0060720) cell proliferation involved in embryonic placenta development(GO:0060722)
1.6 4.7 GO:0033364 mast cell secretory granule organization(GO:0033364)
1.5 9.3 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
1.5 14.6 GO:0002371 dendritic cell cytokine production(GO:0002371)
1.5 21.8 GO:0030953 astral microtubule organization(GO:0030953)
1.4 10.0 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
1.3 5.2 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
1.3 8.9 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
1.3 10.1 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
1.2 3.7 GO:0043324 eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474) rhodopsin metabolic process(GO:0046154)
1.2 17.3 GO:0034587 piRNA metabolic process(GO:0034587)
1.2 6.2 GO:0034486 vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741)
1.2 20.9 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
1.2 9.3 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
1.1 6.9 GO:0046208 spermine catabolic process(GO:0046208)
1.1 4.6 GO:0045006 DNA deamination(GO:0045006)
1.1 3.4 GO:0036115 medium-chain fatty-acyl-CoA metabolic process(GO:0036112) fatty-acyl-CoA catabolic process(GO:0036115)
1.1 12.5 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
1.1 4.5 GO:0016240 autophagosome docking(GO:0016240)
1.1 3.2 GO:0009826 unidimensional cell growth(GO:0009826)
1.1 4.2 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
1.0 14.7 GO:0070307 lens fiber cell development(GO:0070307)
0.9 13.8 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.9 9.1 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.9 16.4 GO:0070986 left/right axis specification(GO:0070986)
0.9 9.6 GO:0030259 lipid glycosylation(GO:0030259)
0.9 7.7 GO:0050957 equilibrioception(GO:0050957)
0.8 7.6 GO:0015866 ADP transport(GO:0015866)
0.8 23.4 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.8 2.5 GO:1900095 random inactivation of X chromosome(GO:0060816) regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.8 5.4 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.8 2.3 GO:1902998 regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949) neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.7 5.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.7 2.2 GO:0021508 floor plate formation(GO:0021508) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.7 4.8 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.7 19.0 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.6 20.5 GO:0006221 pyrimidine nucleotide biosynthetic process(GO:0006221)
0.6 8.8 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.6 1.9 GO:1990091 sodium-dependent self proteolysis(GO:1990091)
0.6 8.0 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.6 2.9 GO:0036233 glycine import(GO:0036233)
0.6 7.0 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.6 1.1 GO:0001698 gastrin-induced gastric acid secretion(GO:0001698)
0.5 14.5 GO:0031572 mitotic G2 DNA damage checkpoint(GO:0007095) G2 DNA damage checkpoint(GO:0031572)
0.5 4.7 GO:0070914 UV-damage excision repair(GO:0070914)
0.5 4.7 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.5 2.6 GO:0072752 cellular response to rapamycin(GO:0072752)
0.5 2.0 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.5 4.4 GO:2000035 regulation of stem cell division(GO:2000035)
0.5 2.4 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.5 16.8 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.5 11.4 GO:0048240 sperm capacitation(GO:0048240)
0.5 4.2 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.5 1.9 GO:0034436 glycoprotein transport(GO:0034436)
0.5 2.3 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.5 1.8 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.5 19.0 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.5 3.2 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.4 4.0 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.4 5.2 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.4 1.7 GO:0030576 Cajal body organization(GO:0030576)
0.4 10.8 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 1.9 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.4 10.3 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.4 14.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.4 7.1 GO:0035855 megakaryocyte development(GO:0035855)
0.4 2.1 GO:0018065 protein-cofactor linkage(GO:0018065)
0.3 3.4 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.3 3.0 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.3 5.3 GO:0010155 regulation of proton transport(GO:0010155)
0.3 1.0 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.3 1.0 GO:0080120 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.3 5.8 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.3 4.8 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.3 1.3 GO:0071351 interleukin-18-mediated signaling pathway(GO:0035655) regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142) cellular response to interleukin-18(GO:0071351)
0.3 1.3 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.3 3.9 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.3 1.5 GO:0048254 snoRNA localization(GO:0048254)
0.3 7.1 GO:0006298 mismatch repair(GO:0006298)
0.3 3.7 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.3 3.3 GO:0070232 regulation of T cell apoptotic process(GO:0070232)
0.3 7.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.3 14.1 GO:0035307 positive regulation of protein dephosphorylation(GO:0035307)
0.3 13.7 GO:0002279 mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.2 0.7 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.2 4.7 GO:0003417 growth plate cartilage development(GO:0003417)
0.2 5.2 GO:0034453 microtubule anchoring(GO:0034453)
0.2 0.5 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.2 1.6 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.2 3.8 GO:0070831 basement membrane assembly(GO:0070831)
0.2 12.3 GO:0015914 phospholipid transport(GO:0015914)
0.2 0.6 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.2 7.3 GO:0007140 male meiosis(GO:0007140)
0.2 4.9 GO:0071801 regulation of podosome assembly(GO:0071801)
0.2 0.9 GO:0032429 regulation of phospholipase A2 activity(GO:0032429)
0.2 0.5 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.2 0.3 GO:0007412 axon target recognition(GO:0007412)
0.1 4.0 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.1 0.4 GO:1990743 protein sialylation(GO:1990743)
0.1 1.7 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.1 3.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 1.7 GO:0001711 endodermal cell fate commitment(GO:0001711)
0.1 2.5 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.1 0.6 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 14.8 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.1 3.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 1.7 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 9.3 GO:0007127 meiosis I(GO:0007127)
0.1 0.5 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.1 4.2 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.1 8.1 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 2.2 GO:0016180 snRNA processing(GO:0016180)
0.1 1.2 GO:0005513 detection of calcium ion(GO:0005513)
0.1 5.4 GO:0046847 filopodium assembly(GO:0046847)
0.1 0.6 GO:0090367 regulation of mRNA modification(GO:0090365) negative regulation of mRNA modification(GO:0090367)
0.1 12.4 GO:0007286 spermatid development(GO:0007286)
0.1 0.5 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.1 0.2 GO:0044565 dendritic cell proliferation(GO:0044565)
0.1 0.5 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.1 29.1 GO:0070489 T cell activation(GO:0042110) T cell aggregation(GO:0070489)
0.1 3.0 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 7.9 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.1 3.7 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 1.3 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 4.6 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 3.3 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.1 5.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 3.6 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.1 2.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 2.7 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.1 10.0 GO:0051607 defense response to virus(GO:0051607)
0.1 1.0 GO:0045116 protein neddylation(GO:0045116)
0.1 1.1 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.1 0.5 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.1 0.4 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.1 2.1 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 2.4 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 2.8 GO:0051028 mRNA transport(GO:0051028)
0.0 0.9 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 1.1 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.1 GO:0042362 fat-soluble vitamin biosynthetic process(GO:0042362)
0.0 0.3 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 1.8 GO:0007045 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041)
0.0 0.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 2.3 GO:0006338 chromatin remodeling(GO:0006338)
0.0 1.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.2 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.7 GO:0051568 histone H3-K4 methylation(GO:0051568)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 29.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
2.9 17.3 GO:0071547 piP-body(GO:0071547)
2.8 14.0 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
2.5 7.6 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
2.3 11.7 GO:0031262 Ndc80 complex(GO:0031262)
2.3 18.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
2.0 9.9 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
1.6 11.4 GO:0060205 cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
1.6 14.5 GO:0031209 SCAR complex(GO:0031209)
1.6 7.9 GO:0030485 smooth muscle contractile fiber(GO:0030485)
1.4 10.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
1.4 8.4 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
1.2 4.8 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
1.2 9.3 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
1.1 4.5 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
1.1 17.0 GO:0042613 MHC class II protein complex(GO:0042613)
1.0 5.2 GO:0072558 IPAF inflammasome complex(GO:0072557) NLRP1 inflammasome complex(GO:0072558) AIM2 inflammasome complex(GO:0097169)
1.0 13.5 GO:0002199 zona pellucida receptor complex(GO:0002199)
1.0 7.9 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.9 3.8 GO:0005607 laminin-2 complex(GO:0005607)
0.9 12.3 GO:0000801 central element(GO:0000801)
0.9 18.9 GO:0010369 chromocenter(GO:0010369)
0.8 6.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.8 3.8 GO:1990130 Iml1 complex(GO:1990130)
0.7 14.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.7 2.8 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.7 2.6 GO:0099522 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.6 4.2 GO:0031415 NatA complex(GO:0031415)
0.6 1.7 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.6 7.7 GO:0032426 stereocilium tip(GO:0032426)
0.5 14.7 GO:0042629 mast cell granule(GO:0042629)
0.5 8.9 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.5 8.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.5 3.0 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.5 11.4 GO:0002080 acrosomal membrane(GO:0002080)
0.4 7.6 GO:0033391 chromatoid body(GO:0033391)
0.4 40.9 GO:0000786 nucleosome(GO:0000786)
0.4 4.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.4 2.0 GO:1990716 axonemal central apparatus(GO:1990716)
0.3 2.1 GO:0030896 checkpoint clamp complex(GO:0030896)
0.3 5.1 GO:0016580 Sin3 complex(GO:0016580)
0.3 4.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.3 2.6 GO:0031931 TORC1 complex(GO:0031931)
0.3 0.9 GO:0000438 core TFIIH complex portion of holo TFIIH complex(GO:0000438)
0.3 4.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 1.1 GO:0031592 centrosomal corona(GO:0031592)
0.3 41.3 GO:0005882 intermediate filament(GO:0005882)
0.3 2.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) chromaffin granule(GO:0042583) neurofibrillary tangle(GO:0097418)
0.2 21.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 2.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 1.5 GO:0070761 pre-snoRNP complex(GO:0070761)
0.2 4.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 2.2 GO:0097542 ciliary tip(GO:0097542)
0.2 3.7 GO:0044292 dendrite terminus(GO:0044292)
0.2 0.6 GO:1990826 nucleoplasmic periphery of the nuclear pore complex(GO:1990826)
0.2 6.0 GO:0044295 axonal growth cone(GO:0044295)
0.2 1.1 GO:0070847 core mediator complex(GO:0070847)
0.2 1.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.2 5.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 10.0 GO:0034707 chloride channel complex(GO:0034707)
0.2 1.7 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 2.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.2 4.6 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 1.6 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.2 19.8 GO:0000781 chromosome, telomeric region(GO:0000781)
0.1 8.5 GO:0030667 secretory granule membrane(GO:0030667)
0.1 2.2 GO:0032039 integrator complex(GO:0032039)
0.1 4.2 GO:0000795 synaptonemal complex(GO:0000795)
0.1 2.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 4.9 GO:0002102 podosome(GO:0002102)
0.1 3.9 GO:0015030 Cajal body(GO:0015030)
0.1 10.6 GO:0001650 fibrillar center(GO:0001650)
0.1 5.4 GO:0072562 blood microparticle(GO:0072562)
0.1 1.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 0.9 GO:0071004 U1 snRNP(GO:0005685) U2-type prespliceosome(GO:0071004) prespliceosome(GO:0071010)
0.1 6.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 33.4 GO:0005813 centrosome(GO:0005813)
0.1 7.3 GO:0000776 kinetochore(GO:0000776)
0.1 0.4 GO:0061700 GATOR2 complex(GO:0061700)
0.1 6.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.7 GO:0030914 STAGA complex(GO:0030914)
0.1 6.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 5.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 2.4 GO:0031201 SNARE complex(GO:0031201)
0.0 0.4 GO:0005682 U5 snRNP(GO:0005682)
0.0 3.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 1.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.7 GO:0031519 PcG protein complex(GO:0031519)
0.0 18.4 GO:0005694 chromosome(GO:0005694)
0.0 3.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.2 GO:0042824 MHC class I peptide loading complex(GO:0042824) TAP complex(GO:0042825)
0.0 0.4 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 2.7 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 13.3 GO:0009986 cell surface(GO:0009986)
0.0 4.3 GO:0005635 nuclear envelope(GO:0005635)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 19.8 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
2.9 17.2 GO:0042289 MHC class II protein binding(GO:0042289)
2.6 7.9 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
2.3 6.9 GO:0046592 polyamine oxidase activity(GO:0046592)
2.3 18.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
2.1 14.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
1.9 7.5 GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
1.8 7.0 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
1.7 6.8 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
1.6 19.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
1.4 8.4 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
1.4 20.9 GO:0016493 C-C chemokine receptor activity(GO:0016493)
1.3 5.3 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
1.3 9.3 GO:0003896 DNA primase activity(GO:0003896)
1.3 10.3 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
1.2 6.0 GO:0032767 copper-dependent protein binding(GO:0032767)
1.2 15.6 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
1.2 4.8 GO:0070883 pre-miRNA binding(GO:0070883)
1.0 8.4 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
1.0 9.0 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.9 17.0 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.9 18.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.9 12.9 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.9 6.2 GO:0030911 TPR domain binding(GO:0030911)
0.9 8.7 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.9 3.4 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.8 14.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.8 7.6 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.8 9.1 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.8 12.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.8 4.7 GO:0005499 vitamin D binding(GO:0005499)
0.7 6.6 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.7 7.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.7 8.7 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.7 2.1 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.7 16.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.6 1.9 GO:0034041 sterol-transporting ATPase activity(GO:0034041) glycoprotein transporter activity(GO:0034437)
0.6 2.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.6 9.9 GO:0017160 Ral GTPase binding(GO:0017160)
0.4 10.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.4 1.7 GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding(GO:1990269)
0.4 20.3 GO:0032934 sterol binding(GO:0032934)
0.4 2.0 GO:0008502 melatonin receptor activity(GO:0008502)
0.4 5.2 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.4 8.0 GO:0008199 ferric iron binding(GO:0008199)
0.4 4.1 GO:0051011 microtubule minus-end binding(GO:0051011)
0.4 4.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.4 7.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.4 1.1 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.4 4.2 GO:0030983 mismatched DNA binding(GO:0030983)
0.3 12.7 GO:0042605 peptide antigen binding(GO:0042605)
0.3 1.7 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.3 10.9 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 6.9 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.3 6.9 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.3 3.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.3 1.3 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.3 2.6 GO:0008494 translation activator activity(GO:0008494)
0.3 3.9 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.3 2.1 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.3 3.7 GO:0035198 miRNA binding(GO:0035198)
0.2 4.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 2.9 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.2 18.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 2.6 GO:0008097 5S rRNA binding(GO:0008097)
0.2 1.1 GO:0033142 progesterone receptor binding(GO:0033142)
0.2 1.6 GO:0008172 S-methyltransferase activity(GO:0008172)
0.2 5.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 5.2 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 25.7 GO:0017124 SH3 domain binding(GO:0017124)
0.2 0.5 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.2 6.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 1.5 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.2 0.8 GO:0004849 uridine kinase activity(GO:0004849)
0.2 2.3 GO:0051787 misfolded protein binding(GO:0051787)
0.2 6.5 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 2.9 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 3.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 13.7 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 4.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 1.1 GO:0043515 kinetochore binding(GO:0043515)
0.1 15.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 6.7 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 20.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 4.6 GO:0004532 exoribonuclease activity(GO:0004532)
0.1 2.7 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 5.7 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.4 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.5 GO:0004586 ornithine decarboxylase activity(GO:0004586)
0.1 7.4 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 7.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 3.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.9 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 2.0 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 1.5 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 3.2 GO:0005109 frizzled binding(GO:0005109)
0.1 2.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.8 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 0.2 GO:0046979 TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.1 1.4 GO:0032452 histone demethylase activity(GO:0032452)
0.1 5.3 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 2.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 0.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 1.6 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 7.1 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 5.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 10.1 GO:0051015 actin filament binding(GO:0051015)
0.1 0.5 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 0.7 GO:0070628 proteasome binding(GO:0070628)
0.1 14.8 GO:0045296 cadherin binding(GO:0045296)
0.1 16.4 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.3 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.6 GO:0005521 lamin binding(GO:0005521)
0.0 1.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 2.7 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.9 GO:0042169 SH2 domain binding(GO:0042169)
0.0 1.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 6.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.2 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 1.1 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 0.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.6 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 2.5 GO:0003735 structural constituent of ribosome(GO:0003735)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 45.8 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.6 26.0 PID AURORA A PATHWAY Aurora A signaling
0.6 15.0 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.5 7.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.5 19.8 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.4 30.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.4 18.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.3 15.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.3 5.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.3 18.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.3 13.0 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.3 3.8 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 12.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 10.0 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.2 5.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.2 3.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.2 7.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.3 PID BARD1 PATHWAY BARD1 signaling events
0.1 2.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 2.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 2.4 PID E2F PATHWAY E2F transcription factor network
0.0 3.2 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.6 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.6 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.3 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 46.4 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
2.1 20.8 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
1.2 14.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
1.2 30.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
1.0 24.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.9 7.9 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.8 29.5 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.8 7.6 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.7 13.5 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.7 14.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.7 9.9 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.7 7.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.6 19.8 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.6 7.7 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.5 10.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.4 9.6 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.4 5.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.4 20.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.4 6.9 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.4 4.6 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.3 3.9 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.3 11.3 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.2 7.5 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 10.8 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 5.1 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.2 23.1 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.2 10.4 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 4.9 REACTOME KINESINS Genes involved in Kinesins
0.1 3.9 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 2.6 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 9.8 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 5.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.9 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 0.5 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 2.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 2.1 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 4.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 1.0 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 0.7 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 4.9 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 1.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 4.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.6 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 1.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases