ISMARA results: Hsf4

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hsf4

Z-value: 0.94

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Transcription factors associated with Hsf4

Gene Symbol	Gene ID	Gene Info
Hsf4 NCBI RGD Ensembl	ENSRNOG00000015253	heat shock transcription factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hsf4	rn6_v1_chr19_+_37226186_37226188	-0.29	2.0e-07	Click!

Activity profile of Hsf4 motif

Sorted Z-values of Hsf4 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_170475831 Show fit	39.31	ENSRNOT00000006949	Fam209a NCBI RGD Ensembl Show fit	family with sequence similarity 209, member A
chr17_-_44834305 Show fit	30.10	ENSRNOT00000084303	Hist1h2bd NCBI RGD Ensembl Show fit	histone cluster 1, H2bd
chr9_-_14668297 Show fit	30.01	ENSRNOT00000042404	Treml2 NCBI RGD Ensembl Show fit	triggering receptor expressed on myeloid cells-like 2
chr8_-_49301125 Show fit	29.19	ENSRNOT00000091190	Cd3e NCBI RGD Ensembl Show fit	CD3e molecule
chr11_+_86094567 Show fit	24.46	ENSRNOT00000086514	LOC100361706 NCBI RGD Ensembl Show fit	lambda-chain C1-region-like
chr14_+_3058993 Show fit	24.13	ENSRNOT00000002807	Gfi1 NCBI RGD Ensembl Show fit	growth factor independent 1 transcriptional repressor
chr7_-_116106368 Show fit	23.43	ENSRNOT00000035678	Ly6k NCBI RGD Ensembl Show fit	lymphocyte antigen 6 complex, locus K
chr8_+_132828091 Show fit	20.89	ENSRNOT00000008269	Ccr9 NCBI RGD Ensembl Show fit	C-C motif chemokine receptor 9
chr1_-_89045586 Show fit	20.80	ENSRNOT00000063808	Zbtb32 NCBI RGD Ensembl Show fit	zinc finger and BTB domain containing 32
chr14_-_82347679 Show fit	20.70	ENSRNOT00000032972	Tacc3 NCBI RGD Ensembl Show fit	transforming, acidic coiled-coil containing protein 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hsf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.4	32.2	GO:0000706	meiotic DNA double-strand break processing(GO:0000706)
1.7	30.1	GO:0002227	innate immune response in mucosa(GO:0002227)
4.9	29.2	GO:0002913	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.1	29.1	GO:0070489	T cell activation(GO:0042110) T cell aggregation(GO:0070489)
8.0	24.1	GO:0070103	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.8	23.4	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
1.5	21.8	GO:0030953	astral microtubule organization(GO:0030953)
1.2	20.9	GO:0042492	gamma-delta T cell differentiation(GO:0042492)
0.6	20.5	GO:0006221	pyrimidine nucleotide biosynthetic process(GO:0006221)
0.7	19.0	GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)

Showing 1 to 10 of 167 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	41.3	GO:0005882	intermediate filament(GO:0005882)
0.4	40.9	GO:0000786	nucleosome(GO:0000786)
0.1	33.4	GO:0005813	centrosome(GO:0005813)
3.6	29.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.2	21.0	GO:0017053	transcriptional repressor complex(GO:0017053)
0.2	19.8	GO:0000781	chromosome, telomeric region(GO:0000781)
0.9	18.9	GO:0010369	chromocenter(GO:0010369)
0.0	18.4	GO:0005694	chromosome(GO:0005694)
2.3	18.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
2.9	17.3	GO:0071547	piP-body(GO:0071547)

Showing 1 to 10 of 97 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	25.7	GO:0017124	SH3 domain binding(GO:0017124)
1.4	20.9	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.1	20.4	GO:0003714	transcription corepressor activity(GO:0003714)
0.4	20.3	GO:0032934	sterol binding(GO:0032934)
5.0	19.8	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
1.6	19.8	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.9	18.5	GO:0070182	DNA polymerase binding(GO:0070182)
2.3	18.1	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.2	18.1	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
2.9	17.2	GO:0042289	MHC class II protein binding(GO:0042289)

Showing 1 to 10 of 126 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	45.8	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.4	30.8	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.6	26.0	PID AURORA A PATHWAY	Aurora A signaling
0.5	19.8	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.3	18.5	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.4	18.3	PID FANCONI PATHWAY	Fanconi anemia pathway
0.3	15.5	PID RAC1 PATHWAY	RAC1 signaling pathway
0.6	15.0	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.3	13.0	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.2	12.5	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.8	46.4	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
1.2	30.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.8	29.5	REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	Genes involved in Activation of the pre-replicative complex
1.0	24.1	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.2	23.1	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.4	20.9	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
2.1	20.8	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.6	19.8	REACTOME CA DEPENDENT EVENTS	Genes involved in Ca-dependent events
1.2	14.4	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.7	14.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)

Showing 1 to 10 of 47 entries

Results for Hsf4

Z-value: 0.94

Motif logo

Transcription factors associated with Hsf4

Activity-expression correlation:

Activity profile of Hsf4 motif

Sorted Z-values of Hsf4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hsf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: