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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Hsf1
Z-value: 0.79
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Transcription factors associated with Hsf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hsf1 | rn6_v1_chr7_+_117538523_117538523 | 0.12 | 2.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_17225389 Show fit | 33.85 |
ENSRNOT00000052035
|
ADP-ribosyltransferase 3 |
|
| chr10_+_70262361 Show fit | 29.86 |
ENSRNOT00000064625
ENSRNOT00000076973 |
unc-45 myosin chaperone B |
|
| chr6_-_94980004 Show fit | 19.56 |
ENSRNOT00000006373
|
reticulon 1 |
|
| chr6_-_127248372 Show fit | 17.78 |
ENSRNOT00000085517
|
ankyrin repeat and SOCS box-containing 2 |
|
| chr8_+_70603249 Show fit | 15.35 |
ENSRNOT00000067016
ENSRNOT00000072486 |
immunoglobulin superfamily, DCC subclass, member 4 |
|
| chr5_+_58393233 Show fit | 13.46 |
ENSRNOT00000000142
|
DnaJ heat shock protein family (Hsp40) member B5 |
|
| chr4_-_161757447 Show fit | 12.19 |
ENSRNOT00000008737
|
FK506 binding protein 4 |
|
| chr7_+_11737293 Show fit | 11.51 |
ENSRNOT00000046059
|
leucine rich repeat and Ig domain containing 3 |
|
| chr9_+_10172832 Show fit | 10.53 |
ENSRNOT00000074555
|
acyl-CoA synthetase bubblegum family member 2 |
|
| chr8_+_55178289 Show fit | 10.35 |
ENSRNOT00000059127
|
crystallin, alpha B |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hsf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 33.8 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.5 | 28.1 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.2 | 17.8 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.0 | 14.8 | GO:0030182 | neuron differentiation(GO:0030182) |
| 0.1 | 13.5 | GO:0006986 | response to unfolded protein(GO:0006986) |
| 0.7 | 12.2 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.0 | 11.5 | GO:0007409 | axonogenesis(GO:0007409) |
| 0.2 | 11.0 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.1 | 10.5 | GO:0001676 | long-chain fatty acid metabolic process(GO:0001676) |
| 1.3 | 10.3 | GO:0007021 | tubulin complex assembly(GO:0007021) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 68.2 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.5 | 19.6 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 2.2 | 17.8 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.3 | 12.2 | GO:0044295 | axonal growth cone(GO:0044295) |
| 1.3 | 11.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.2 | 10.3 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.8 | 10.1 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.1 | 9.1 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 8.8 | GO:0030315 | T-tubule(GO:0030315) |
| 1.1 | 7.7 | GO:0031415 | NatA complex(GO:0031415) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 36.4 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 4.2 | 33.8 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
| 0.9 | 19.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 17.1 | GO:0005549 | odorant binding(GO:0005549) |
| 0.1 | 15.5 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.2 | 13.0 | GO:0051087 | chaperone binding(GO:0051087) |
| 2.4 | 12.2 | GO:0032767 | copper-dependent protein binding(GO:0032767) |
| 0.4 | 11.7 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.2 | 11.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.9 | 10.5 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 10.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 7.6 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 7.5 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 2.3 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.1 | 1.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 0.9 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.5 | 11.0 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.5 | 10.1 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.1 | 9.7 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.4 | 7.6 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.1 | 5.8 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.3 | 4.9 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 4.9 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.3 | 2.8 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.0 | 0.9 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |