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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hoxd8

Z-value: 0.61

Motif logo

Transcription factors associated with Hoxd8

Gene Symbol Gene ID Gene Info
ENSRNOG00000042480 homeobox D8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxd8rn6_v1_chr3_+_61627383_61627383-0.203.6e-04Click!

Activity profile of Hoxd8 motif

Sorted Z-values of Hoxd8 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_33606124 20.78 ENSRNOT00000065210

chr2_+_88217188 17.40 ENSRNOT00000014267
carbonic anhydrase I
chr3_-_37854561 13.89 ENSRNOT00000076095
nebulin
chr4_-_120559078 13.78 ENSRNOT00000085730
ENSRNOT00000079575
kelch repeat and BTB domain containing 12
chr11_-_60547201 11.93 ENSRNOT00000093151
B and T lymphocyte associated
chr6_-_140880070 11.69 ENSRNOT00000073779
uncharacterized LOC691828
chr18_+_32336102 11.32 ENSRNOT00000018577
fibroblast growth factor 1
chr3_-_20419417 11.10 ENSRNOT00000077772

chr11_-_60546997 10.97 ENSRNOT00000083124
ENSRNOT00000050092
B and T lymphocyte associated
chr11_+_85532526 10.77 ENSRNOT00000036565

chr9_+_73418607 10.49 ENSRNOT00000092547
microtubule-associated protein 2
chrX_-_142248369 10.02 ENSRNOT00000091330
fibroblast growth factor 13
chr1_+_227670159 9.93 ENSRNOT00000072077
membrane-spanning 4-domains, subfamily A, member 6C
chr5_-_138239306 9.62 ENSRNOT00000039305
erythroblast membrane-associated protein
chr19_-_29968424 9.55 ENSRNOT00000024981
inositol polyphosphate-4-phosphatase type II B
chr5_-_12199283 9.24 ENSRNOT00000007769
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
chr13_-_77821312 9.22 ENSRNOT00000082110

chr12_-_2245324 9.17 ENSRNOT00000001332
ENSRNOT00000001333
Fc fragment of IgE receptor II
chr2_-_170301348 9.15 ENSRNOT00000088131
sucrase-isomaltase
chrX_+_37329779 9.08 ENSRNOT00000038352
ENSRNOT00000088802
pyruvate dehydrogenase (lipoamide) alpha 1
chr4_-_41212072 8.99 ENSRNOT00000085596
protein phosphatase 1, regulatory subunit 3A
chr2_-_200003443 8.39 ENSRNOT00000024900
ENSRNOT00000088041
phosphodiesterase 4D interacting protein
chr6_-_142585188 8.36 ENSRNOT00000067437

chr1_+_122981755 8.27 ENSRNOT00000013468
necdin, MAGE family member
chr3_+_63379031 8.17 ENSRNOT00000068199
oxysterol binding protein-like 6
chr11_+_76147205 7.75 ENSRNOT00000071586
fibroblast growth factor 12
chr16_+_25773602 7.61 ENSRNOT00000047750
glyceraldehyde-3-phosphate dehydrogenase, pseudogene 2
chr13_+_92264231 7.53 ENSRNOT00000066509
ENSRNOT00000004716
spectrin, alpha, erythrocytic 1
chr7_+_42304534 7.41 ENSRNOT00000085097
KIT ligand
chr18_+_17043903 7.39 ENSRNOT00000068139
formin homology 2 domain containing 3
chr1_-_128287151 7.33 ENSRNOT00000084946
ENSRNOT00000089723
myocyte enhancer factor 2a
chr12_+_45905371 7.23 ENSRNOT00000039275
heat shock protein family B (small) member 8
chr6_+_139405966 7.16 ENSRNOT00000088974

chr20_+_34258791 7.13 ENSRNOT00000000468
solute carrier family 35, member F1
chr3_-_16753987 7.07 ENSRNOT00000091257

chr13_+_27465930 6.98 ENSRNOT00000003314
serpin family B member 10
chr4_+_93888502 6.95 ENSRNOT00000090783

chr4_-_138830117 6.83 ENSRNOT00000008403
interleukin 5 receptor subunit alpha
chr19_-_37796089 6.73 ENSRNOT00000024891
RAN binding protein 10
chrM_+_9451 6.50 ENSRNOT00000041241
mitochondrially encoded NADH dehydrogenase 3
chr6_-_142353308 6.47 ENSRNOT00000066416

chrX_+_136488691 6.46 ENSRNOT00000093432
Rho GTPase activating protein 36
chr12_+_41486076 6.38 ENSRNOT00000057242
RBPJ interacting and tubulin associated 1
chr4_+_29535852 6.36 ENSRNOT00000087619
collagen, type I, alpha 2
chr2_+_113984646 6.04 ENSRNOT00000016799
TRAF2 and NCK interacting kinase
chr4_-_30380119 6.04 ENSRNOT00000036460
paraoxonase 2
chr17_+_36691875 6.03 ENSRNOT00000074314
similar to High mobility group protein 4 (HMG-4) (High mobility group protein 2a) (HMG-2a)
chr13_-_100450209 6.02 ENSRNOT00000090712
lamin B receptor
chr15_+_41643541 6.01 ENSRNOT00000019646
ADP-ribosylation factor like GTPase 11
chr2_-_231521052 5.97 ENSRNOT00000089534
ENSRNOT00000080470
ENSRNOT00000084756
ankyrin 2
chr19_-_22194740 5.93 ENSRNOT00000086187
phosphorylase kinase regulatory subunit beta
chr6_+_139428999 5.83 ENSRNOT00000084482

chr13_-_102857551 5.80 ENSRNOT00000080309
microtubule affinity regulating kinase 1
chr8_+_100260049 5.69 ENSRNOT00000011090

chr6_-_98666007 5.36 ENSRNOT00000082695

chr18_-_85980833 5.34 ENSRNOT00000058179
suppressor of cytokine signaling 6
chrX_-_76925195 5.23 ENSRNOT00000087977
ATRX, chromatin remodeler
chr2_+_187447501 5.09 ENSRNOT00000038589
IQ motif containing GTPase activating protein 3
chr14_-_106234247 5.04 ENSRNOT00000081245
UDP-glucose pyrophosphorylase 2
chr16_+_31734944 4.97 ENSRNOT00000059673
palladin, cytoskeletal associated protein
chr8_+_133210473 4.78 ENSRNOT00000082774
chemokine (C-C motif) receptor 5
chr17_-_90071408 4.78 ENSRNOT00000071978
decaprenyl diphosphate synthase subunit 1
chr4_+_168752133 4.77 ENSRNOT00000010289
apolipoprotein L domain containing 1
chr9_+_10941613 4.75 ENSRNOT00000070794
semaphorin 6B
chrM_+_9870 4.70 ENSRNOT00000044582
mitochondrially encoded NADH 4L dehydrogenase
chr4_+_163349125 4.50 ENSRNOT00000084823
killer cell lectin-like receptor, family E, member 1
chr4_-_163402561 4.36 ENSRNOT00000091890
killer cell lectin like receptor K1
chr9_+_73378057 4.35 ENSRNOT00000043627
ENSRNOT00000045766
ENSRNOT00000092445
ENSRNOT00000037974
microtubule-associated protein 2
chr3_+_123031307 4.28 ENSRNOT00000080379
protein tyrosine phosphatase, receptor type, A
chr7_-_15073052 4.14 ENSRNOT00000037708
zinc finger protein 799
chrM_+_2740 3.95 ENSRNOT00000047550
mitochondrially encoded NADH dehydrogenase 1
chr17_-_79085076 3.94 ENSRNOT00000057851
family with sequence similarity 171, member A1
chr10_-_85725429 3.89 ENSRNOT00000005471
ribosomal protein L23
chr16_+_84465656 3.89 ENSRNOT00000043188
LRRGT00175
chr2_+_86996497 3.85 ENSRNOT00000042058
zinc finger protein 455
chr11_-_70585053 3.84 ENSRNOT00000086955
zinc finger protein 148
chr20_+_18594037 3.83 ENSRNOT00000000753
transcription factor A, mitochondrial
chr4_-_107443853 3.77 ENSRNOT00000066666

chr17_+_69761118 3.67 ENSRNOT00000023739
aldo-keto reductase family 1, member C3
chr1_-_101095594 3.65 ENSRNOT00000027944
Fc fragment of IgG receptor and transporter
chr2_+_239415046 3.64 ENSRNOT00000072196
CXXC finger protein 4
chr2_-_209001895 3.61 ENSRNOT00000055960
similar to Hypothetical protein MGC58999
chr1_-_99632845 3.60 ENSRNOT00000049123
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 pseudogene
chr2_-_127710448 3.56 ENSRNOT00000093733
major facilitator superfamily domain containing 8
chr13_-_94859390 3.53 ENSRNOT00000005467
ENSRNOT00000079763

chr14_-_41786084 3.45 ENSRNOT00000059439
glutaredoxin and cysteine rich domain containing 1
chr5_+_6373583 3.43 ENSRNOT00000084749

chr4_-_148437961 3.40 ENSRNOT00000082907
arachidonate 5-lipoxygenase
chr9_+_52687868 3.31 ENSRNOT00000083864
WD repeat domain 75
chr13_-_91735361 3.24 ENSRNOT00000058090
Fc fragment of IgE receptor Ia
chr4_+_88026033 3.24 ENSRNOT00000074905
vomeronasal 1 receptor 80
chr5_+_116420690 3.23 ENSRNOT00000087089
nuclear factor I/A
chr1_+_65409829 3.23 ENSRNOT00000046796
vomeronasal 2 receptor, 19
chrX_-_40086870 3.23 ENSRNOT00000010027
small muscle protein, X-linked
chr1_-_90149991 3.23 ENSRNOT00000076987
similar to RIKEN cDNA 4931406P16
chr1_+_72692105 3.16 ENSRNOT00000032439
transmembrane protein 150B
chr1_+_196095214 3.16 ENSRNOT00000080741
similar to ribosomal protein S15a
chrX_+_20520034 3.12 ENSRNOT00000093170
family with sequence similarity 120C
chr4_+_68635581 3.10 ENSRNOT00000016217
single stranded DNA binding protein 1
chrX_-_120521871 2.98 ENSRNOT00000080863
LRRGT00025-like
chr2_+_145174876 2.94 ENSRNOT00000040631
mab-21 like 1
chr19_-_56983807 2.91 ENSRNOT00000043529
cytochrome c oxidase subunit VIc, pseudogene
chr7_+_37101391 2.86 ENSRNOT00000029764
early endosome antigen 1
chrX_+_54390733 2.84 ENSRNOT00000004977
similar to chromosome X open reading frame 21
chr13_+_43818010 2.83 ENSRNOT00000005532
centrosomal protein of 170 kDa-like
chr15_+_39638510 2.81 ENSRNOT00000037800
RCC1 and BTB domain containing protein 1
chr16_-_40025401 2.81 ENSRNOT00000066639
ankyrin repeat and SOCS box-containing 5
chr12_+_47590154 2.75 ENSRNOT00000045946
GIT ArfGAP 2
chrX_+_26440584 2.72 ENSRNOT00000087293
ENSRNOT00000005328
amelogenin, X-linked
chr11_-_82366505 2.69 ENSRNOT00000041326
similar to ribosomal protein L27a
chr9_+_67774150 2.62 ENSRNOT00000091060
inducible T-cell co-stimulator
chr18_+_47456327 2.60 ENSRNOT00000020030
serum response factor binding protein 1
chr9_-_11108741 2.56 ENSRNOT00000072357
coiled-coil domain containing 94
chr16_+_48513432 2.56 ENSRNOT00000044934
similar to NADH-ubiquinone oxidoreductase B9 subunit (Complex I-B9) (CI-B9)
chr14_-_24080470 2.52 ENSRNOT00000002745
transmembrane protease, serine 11f
chr3_-_78545135 2.51 ENSRNOT00000081552
olfactory receptor 710
chr2_+_86996798 2.49 ENSRNOT00000070821
zinc finger protein 455
chr14_-_6284145 2.48 ENSRNOT00000044065
zinc finger protein 951
chr14_-_6358720 2.48 ENSRNOT00000048419
zinc finger protein 951
chrX_+_123770337 2.44 ENSRNOT00000092554
NFKB activating protein
chr1_-_3849080 2.43 ENSRNOT00000045301
similar to ribosomal protein L27a
chr6_+_42656616 2.40 ENSRNOT00000007169
nucleolar protein 10
chr1_+_248132090 2.39 ENSRNOT00000022056
interleukin 33
chr3_-_8955538 2.39 ENSRNOT00000040570
similar to 60S ribosomal protein L38
chr9_+_71915421 2.36 ENSRNOT00000020447
phosphoinositide kinase, FYVE-type zinc finger containing
chr17_-_35130045 2.33 ENSRNOT00000089878
vacuolar ATPase assembly integral membrane protein VMA21-like
chr5_-_100977902 2.29 ENSRNOT00000077429
zinc finger, DHHC-type containing 21
chr10_+_67810655 2.27 ENSRNOT00000064285
proteasome 26S subunit, non-ATPase 11
chr8_-_21453190 2.27 ENSRNOT00000078192
zinc finger protein 26
chr6_-_38007162 2.25 ENSRNOT00000044583

chr3_+_77414999 2.24 ENSRNOT00000047910
olfactory receptor 659
chr1_+_198409360 2.16 ENSRNOT00000013691
ENSRNOT00000091295
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr20_-_6257604 2.15 ENSRNOT00000092489
serine/threonine kinase 38
chrX_-_11750323 2.06 ENSRNOT00000004303
similar to 60S ribosomal protein L37a
chr15_+_24078280 2.02 ENSRNOT00000015511
ENSRNOT00000063807
mitogen-activated protein kinase 1 interacting protein 1-like
chr3_+_75265525 1.97 ENSRNOT00000013319
olfactory receptor 554
chr7_-_143167772 1.95 ENSRNOT00000011374
keratin 85
chr15_-_93765498 1.93 ENSRNOT00000093297
MYC binding protein 2, E3 ubiquitin protein ligase
chr3_-_104018861 1.87 ENSRNOT00000008387
cholinergic receptor, muscarinic 5
chr1_-_228263198 1.87 ENSRNOT00000028572
olfactory receptor 1874
chr8_-_61836796 1.82 ENSRNOT00000064903
ENSRNOT00000084009
COMM domain containing 4
chr11_+_65743892 1.80 ENSRNOT00000085226

chr8_+_5790034 1.80 ENSRNOT00000061887
matrix metallopeptidase 27
chr5_-_16995521 1.76 ENSRNOT00000080197
short chain dehydrogenase/reductase family 16C, member 6
chr5_+_165724027 1.75 ENSRNOT00000018000
castor zinc finger 1
chr4_+_156324922 1.74 ENSRNOT00000039463
vomeronasal 2 receptor, 48
chr8_-_118436894 1.73 ENSRNOT00000073395
ATR-interacting protein-like
chr8_+_1459526 1.70 ENSRNOT00000034503
kelch repeat and BTB domain containing 3
chr8_+_41336340 1.68 ENSRNOT00000072049
olfactory receptor 1225
chr13_-_32427177 1.63 ENSRNOT00000044628
cadherin 19
chr17_+_53965562 1.55 ENSRNOT00000090387
geranylgeranyl diphosphate synthase 1
chr18_-_43945273 1.52 ENSRNOT00000088900
DTW domain containing 2
chr10_-_87286387 1.51 ENSRNOT00000044206
keratin 28
chr14_+_62609484 1.50 ENSRNOT00000003017
GUF1 homolog, GTPase
chr8_+_18795525 1.49 ENSRNOT00000050430
olfactory receptor 1124
chr2_-_96509424 1.48 ENSRNOT00000090866
zinc finger, C2HC-type containing 1A
chr5_-_166116516 1.47 ENSRNOT00000079919
ENSRNOT00000080888
kinesin family member 1B
chr3_-_74448279 1.47 ENSRNOT00000043964
olfactory receptor 527
chr20_-_399933 1.42 ENSRNOT00000000953
olfactory receptor 1671
chr2_+_127525285 1.40 ENSRNOT00000093247
inturned planar cell polarity protein
chr5_+_152680407 1.37 ENSRNOT00000076864
stathmin 1
chr18_+_35384743 1.33 ENSRNOT00000076143
ENSRNOT00000074593
serine protease inhibitor Kazal-type 5-like
chr2_-_61698007 1.31 ENSRNOT00000049559
LRRGT00045
chr4_-_66955732 1.29 ENSRNOT00000084282
lysine (K)-specific demethylase 7A
chr11_+_43710705 1.22 ENSRNOT00000075812
olfactory receptor 1560
chr12_+_38377034 1.22 ENSRNOT00000088002
CAP-GLY domain containing linker protein 1
chr13_-_67206688 1.20 ENSRNOT00000003630
ENSRNOT00000090693
phospholipase A2 group IVA
chr5_-_162751128 1.11 ENSRNOT00000068281
similar to novel protein similar to esterases
chr3_+_163767173 1.11 ENSRNOT00000010806
DEAD-box helicase 27
chr1_+_229480184 1.11 ENSRNOT00000044115
olfactory receptor 387
chr10_+_67810810 1.06 ENSRNOT00000079156
proteasome 26S subunit, non-ATPase 11
chr5_-_16995304 1.06 ENSRNOT00000061780
short chain dehydrogenase/reductase family 16C, member 6
chrX_-_124252447 1.05 ENSRNOT00000061546
reproductive homeobox 12
chr3_-_74815509 1.04 ENSRNOT00000045173
olfactory receptor 499
chrX_+_74824504 1.03 ENSRNOT00000048963
similar to 60S ribosomal protein L38
chr14_+_6221085 1.00 ENSRNOT00000068215

chr3_-_77677349 0.99 ENSRNOT00000084989
olfactory receptor 669
chr3_+_21983841 0.99 ENSRNOT00000043621
similar to 40S ribosomal protein S16
chr3_+_146980923 0.96 ENSRNOT00000011654
NSFL1 cofactor
chr1_+_273854248 0.96 ENSRNOT00000044827
ENSRNOT00000017600
ENSRNOT00000086496
adducin 3
chr3_+_31802999 0.94 ENSRNOT00000041305

chr3_+_16311578 0.89 ENSRNOT00000010341
olfactory receptor 409
chr11_+_43143882 0.88 ENSRNOT00000041445
olfactory receptor 1528
chr4_+_32541706 0.87 ENSRNOT00000050827
succinate dehydrogenase complex assembly factor 3
chr17_+_2690062 0.85 ENSRNOT00000024937
olfactory receptor 1653
chr20_-_32076503 0.85 ENSRNOT00000000441
Suv3 like RNA helicase
chr7_-_8060373 0.81 ENSRNOT00000071699
olfactory receptor 798
chr1_-_164977633 0.76 ENSRNOT00000029629
ring finger protein 169
chr10_-_88000423 0.75 ENSRNOT00000076787
ENSRNOT00000046751
ENSRNOT00000091394
keratin 32
chr4_-_151428894 0.74 ENSRNOT00000010556
adiponectin receptor 2
chr6_+_18880737 0.73 ENSRNOT00000003432
alkB homolog 8, tRNA methyltransferase
chr3_+_48106099 0.70 ENSRNOT00000007218
solute carrier family 4 member 10
chr10_-_44147035 0.70 ENSRNOT00000041113
olfactory receptor 1424
chr3_-_77883067 0.69 ENSRNOT00000087979
olfactory receptor 677
chr3_-_73934208 0.56 ENSRNOT00000013038
olfactory receptor 513
chr11_-_83300409 0.56 ENSRNOT00000029255
VPS8 CORVET complex subunit
chr10_-_63274640 0.50 ENSRNOT00000005129
transmembrane and immunoglobulin domain containing 1
chr1_-_168930776 0.48 ENSRNOT00000021468
olfactory receptor 52Z1-like
chr11_-_45688560 0.41 ENSRNOT00000081508
olfactory receptor 1536
chr15_-_65507968 0.30 ENSRNOT00000046240
calmodulin 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxd8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
3.0 8.9 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
2.3 11.3 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
2.1 22.9 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
1.8 7.3 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
1.7 5.2 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
1.7 5.0 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
1.6 4.8 GO:2000464 positive regulation of astrocyte chemotaxis(GO:2000464)
1.5 7.7 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
1.5 6.0 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.5 7.4 GO:0033026 negative regulation of mast cell apoptotic process(GO:0033026) mast cell proliferation(GO:0070662) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
1.4 10.0 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
1.3 9.2 GO:0051712 positive regulation of killing of cells of other organism(GO:0051712)
1.2 3.7 GO:0016488 response to jasmonic acid(GO:0009753) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of isoprenoid metabolic process(GO:0019747) cellular response to jasmonic acid stimulus(GO:0071395)
1.1 3.2 GO:0045401 positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.8 3.4 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
0.7 9.2 GO:0009744 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.6 2.4 GO:0061517 microglial cell activation involved in immune response(GO:0002282) negative regulation of immunoglobulin secretion(GO:0051025) macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518)
0.6 1.8 GO:0042706 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.6 3.9 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.5 9.5 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.5 1.5 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.5 7.4 GO:0051639 actin filament network formation(GO:0051639)
0.5 17.4 GO:0006730 one-carbon metabolic process(GO:0006730)
0.4 6.0 GO:0007256 activation of JNKK activity(GO:0007256)
0.4 5.1 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.4 14.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.4 1.9 GO:0007207 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.4 4.8 GO:0042118 endothelial cell activation(GO:0042118)
0.3 1.4 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.3 3.3 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.3 3.1 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.3 4.8 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.3 6.8 GO:0032674 regulation of interleukin-5 production(GO:0032674)
0.3 6.5 GO:0009642 response to light intensity(GO:0009642)
0.3 1.5 GO:0019520 aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521)
0.3 5.0 GO:0003334 keratinocyte development(GO:0003334)
0.3 2.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.3 0.9 GO:0000958 mitochondrial mRNA catabolic process(GO:0000958) positive regulation of mitochondrial RNA catabolic process(GO:0000962)
0.3 3.6 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.3 8.3 GO:0007413 axonal fasciculation(GO:0007413)
0.3 3.4 GO:0048563 post-embryonic organ morphogenesis(GO:0048563)
0.3 1.3 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.2 1.2 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.2 7.5 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.2 2.2 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.2 3.3 GO:0043248 proteasome assembly(GO:0043248)
0.2 2.5 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.2 6.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.2 1.9 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.2 3.2 GO:0072189 ureter development(GO:0072189)
0.2 4.3 GO:0048714 positive regulation of oligodendrocyte differentiation(GO:0048714)
0.2 2.3 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 2.6 GO:0002517 T cell tolerance induction(GO:0002517)
0.2 0.9 GO:0034552 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.2 1.2 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1 2.7 GO:0070166 enamel mineralization(GO:0070166)
0.1 4.0 GO:0033194 response to hydroperoxide(GO:0033194)
0.1 2.9 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.1 2.4 GO:0032288 myelin assembly(GO:0032288)
0.1 1.4 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 6.0 GO:0032392 DNA geometric change(GO:0032392)
0.1 6.0 GO:0016126 sterol biosynthetic process(GO:0016126)
0.1 0.1 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 0.7 GO:0061042 vascular wound healing(GO:0061042)
0.1 2.4 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.1 2.7 GO:0048266 behavioral response to pain(GO:0048266)
0.1 4.7 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 4.1 GO:0021762 substantia nigra development(GO:0021762)
0.1 0.7 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 5.9 GO:0044042 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.1 1.0 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 5.3 GO:0050868 negative regulation of T cell activation(GO:0050868)
0.1 0.6 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 3.6 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1 0.8 GO:2000780 negative regulation of double-strand break repair(GO:2000780)
0.0 2.6 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 5.8 GO:0030010 establishment of cell polarity(GO:0030010)
0.0 0.7 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.2 GO:0060014 granulosa cell differentiation(GO:0060014)
0.0 6.0 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 2.1 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.0 2.9 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 3.2 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 0.2 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 1.1 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 7.1 GO:0006869 lipid transport(GO:0006869)
0.0 1.5 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 3.2 GO:0006941 striated muscle contraction(GO:0006941)
0.0 1.7 GO:0000077 DNA damage checkpoint(GO:0000077)
0.0 0.1 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 1.5 GO:0045727 positive regulation of translation(GO:0045727)
0.0 3.4 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 3.1 GO:0019439 aromatic compound catabolic process(GO:0019439)
0.0 5.6 GO:0006412 translation(GO:0006412)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
1.7 5.2 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
1.7 15.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.8 3.2 GO:0005927 muscle tendon junction(GO:0005927)
0.8 7.5 GO:0014731 spectrin(GO:0008091) spectrin-associated cytoskeleton(GO:0014731) cuticular plate(GO:0032437)
0.7 5.9 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.5 2.9 GO:0044308 axonal spine(GO:0044308)
0.4 8.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.4 3.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.3 3.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.3 1.0 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.3 6.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.3 15.1 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 7.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.3 0.9 GO:0045025 mitochondrial degradosome(GO:0045025)
0.3 3.4 GO:0060091 kinocilium(GO:0060091)
0.3 1.8 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 14.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 6.0 GO:0031430 M band(GO:0031430)
0.2 2.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.2 5.3 GO:0001772 immunological synapse(GO:0001772)
0.2 1.5 GO:0071821 FANCM-MHF complex(GO:0071821)
0.1 49.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 1.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 12.4 GO:0030175 filopodium(GO:0030175)
0.1 13.9 GO:0030018 Z disc(GO:0030018)
0.1 5.6 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 6.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 8.7 GO:0030016 myofibril(GO:0030016)
0.1 2.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 2.6 GO:0030686 90S preribosome(GO:0030686)
0.1 6.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.6 GO:0033263 CORVET complex(GO:0033263)
0.1 20.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.2 GO:0042588 zymogen granule(GO:0042588)
0.0 4.2 GO:0005882 intermediate filament(GO:0005882)
0.0 9.2 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 12.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 1.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.8 GO:0035861 site of double-strand break(GO:0035861)
0.0 7.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 4.3 GO:0043235 receptor complex(GO:0043235)
0.0 1.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 2.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.2 GO:0005840 ribosome(GO:0005840)
0.0 0.2 GO:0000800 lateral element(GO:0000800)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 23.4 GO:0004064 arylesterase activity(GO:0004064)
3.2 9.5 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
3.1 9.2 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
2.3 9.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
2.3 9.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
1.7 6.7 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
1.6 4.8 GO:0071791 chemokine (C-C motif) ligand 5 binding(GO:0071791)
1.4 11.2 GO:0070087 chromo shadow domain binding(GO:0070087)
1.2 3.7 GO:0045550 geranylgeranyl reductase activity(GO:0045550)
1.1 3.4 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
1.1 7.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
1.0 5.0 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557)
0.8 5.1 GO:0032027 myosin light chain binding(GO:0032027)
0.8 3.2 GO:0019767 IgE receptor activity(GO:0019767)
0.7 5.9 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.7 3.6 GO:0019770 IgG receptor activity(GO:0019770)
0.7 2.7 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.6 3.9 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.6 14.8 GO:0002162 dystroglycan binding(GO:0002162)
0.6 11.3 GO:0044548 S100 protein binding(GO:0044548)
0.6 15.1 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 5.8 GO:0050321 tau-protein kinase activity(GO:0050321)
0.4 9.9 GO:0008301 DNA binding, bending(GO:0008301)
0.4 1.9 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.4 4.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 1.3 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.3 1.5 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.3 2.4 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.3 3.6 GO:0008061 chitin binding(GO:0008061)
0.3 2.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.3 8.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 1.5 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.2 10.0 GO:0048487 beta-tubulin binding(GO:0048487)
0.2 8.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.2 0.7 GO:0055100 adiponectin binding(GO:0055100)
0.2 0.7 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.2 4.4 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 3.4 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 2.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 6.0 GO:0030507 spectrin binding(GO:0030507)
0.1 6.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.3 GO:0031997 N-terminal myristoylation domain binding(GO:0031997) calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099567)
0.1 2.9 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 2.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 4.8 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 2.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 6.8 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 7.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 7.7 GO:0044325 ion channel binding(GO:0044325)
0.0 5.4 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 11.6 GO:0030246 carbohydrate binding(GO:0030246)
0.0 4.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.8 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 2.0 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 3.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 2.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.5 GO:0043022 ribosome binding(GO:0043022)
0.0 5.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.7 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.0 2.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.0 GO:0005080 protein kinase C binding(GO:0005080)
0.0 2.6 GO:0005125 cytokine activity(GO:0005125)
0.0 1.4 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 7.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 1.0 GO:0051117 ATPase binding(GO:0051117)
0.0 3.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.8 PID IL5 PATHWAY IL5-mediated signaling events
0.3 9.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.3 14.8 PID LKB1 PATHWAY LKB1 signaling events
0.2 7.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.2 8.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 7.2 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 9.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 1.4 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 6.0 PID TNF PATHWAY TNF receptor signaling pathway
0.1 5.1 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 8.3 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 6.7 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 3.2 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 4.8 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 25.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 2.7 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 3.9 PID P53 REGULATION PATHWAY p53 pathway
0.0 2.0 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.2 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 8.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.7 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 2.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 9.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
1.0 4.8 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.9 11.3 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.9 11.9 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.6 9.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.6 12.7 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.4 25.5 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.4 7.3 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.4 13.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.3 7.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.3 6.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.3 6.8 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.2 1.2 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.2 7.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.3 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 4.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 5.0 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.1 3.3 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 1.9 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 6.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 3.9 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 2.7 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 2.2 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 1.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation