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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hoxc6

Z-value: 0.36

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Transcription factors associated with Hoxc6

Gene Symbol Gene ID Gene Info
Hoxc6
ENSRNOG00000016442 homeo box C6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc6rn6_v1_chr7_+_144623555_1446235550.466.8e-18Click!

Activity profile of Hoxc6 motif

Sorted Z-values of Hoxc6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_78793336 12.71 ENSRNOT00000057898
Mt1
metallothionein 1
chr10_-_59883839 12.25 ENSRNOT00000093579
Aspa
aspartoacylase
chr5_-_79008363 10.61 ENSRNOT00000010040
Kif12
kinesin family member 12
chr20_-_14025067 9.08 ENSRNOT00000093430
ENSRNOT00000074533
Ggt1
gamma-glutamyltransferase 1
chr9_+_25410669 7.79 ENSRNOT00000030912
ENSRNOT00000090920
Tfap2b
transcription factor AP-2 beta
chr9_-_4685383 7.70 ENSRNOT00000061896
Sult1c2
sulfotransferase family 1C member 2
chr4_-_176381477 6.98 ENSRNOT00000048367
Slco1a6
solute carrier organic anion transporter family, member 1a6
chr1_+_229063714 6.85 ENSRNOT00000087526
Glyat
glycine-N-acyltransferase
chr19_-_62150423 5.42 ENSRNOT00000073524
ENSRNOT00000091209
Ccdc7
coiled-coil domain containing 7
chr13_-_80968971 4.72 ENSRNOT00000004931
Mroh9
maestro heat-like repeat family member 9
chr5_+_147257678 4.65 ENSRNOT00000066268
Rnf19b
ring finger protein 19B
chr6_-_86223052 4.48 ENSRNOT00000046828
Fscb
fibrous sheath CABYR binding protein
chr2_-_205426869 4.40 ENSRNOT00000023333
Sycp1
synaptonemal complex protein 1
chr11_-_68349238 4.13 ENSRNOT00000030074
Sema5b
semaphorin 5B
chr4_-_11497531 3.60 ENSRNOT00000078799
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr7_-_145062956 3.37 ENSRNOT00000055274
RGD1563200
similar to CDNA sequence BC048502
chr8_+_115193146 3.21 ENSRNOT00000056391
Iqcf1
IQ motif containing F1
chr6_+_48452369 2.49 ENSRNOT00000044310
Myt1l
myelin transcription factor 1-like
chr13_-_73055631 2.46 ENSRNOT00000081892
Xpr1
xenotropic and polytropic retrovirus receptor 1
chrX_-_115175299 2.31 ENSRNOT00000074322
Dcx
doublecortin
chr14_+_91557601 2.25 ENSRNOT00000038733
RGD1309870
hypothetical LOC289778
chr2_-_120316600 2.15 ENSRNOT00000084521
Ccdc39
coiled-coil domain containing 39
chr1_+_101541266 2.09 ENSRNOT00000028436
Hsd17b14
hydroxysteroid (17-beta) dehydrogenase 14
chr4_-_165118062 1.96 ENSRNOT00000087219
LOC502908
Ly49s8
chr7_-_55604403 1.96 ENSRNOT00000088732
Atxn7l3b
ataxin 7-like 3B
chr4_+_79021872 1.85 ENSRNOT00000012677
ENSRNOT00000067125
Fam221a
family with sequence similarity 221, member A
chr3_-_102432479 1.82 ENSRNOT00000047270
Olr747
olfactory receptor 747
chr20_-_31402483 1.82 ENSRNOT00000033529
H2afy2
H2A histone family, member Y2
chr14_-_82171480 1.81 ENSRNOT00000021952
Nsd2
nuclear receptor binding SET domain protein 2
chrX_+_141847092 1.69 ENSRNOT00000004684
Magea11
melanoma antigen family A, 11
chr4_+_101909389 1.64 ENSRNOT00000086458
AABR07060963.2

chr3_+_173955686 1.54 ENSRNOT00000088447
Fam217b
family with sequence similarity 217, member B
chr1_+_128606770 1.50 ENSRNOT00000073355
Ttc23
tetratricopeptide repeat domain 23
chr7_+_11660934 1.47 ENSRNOT00000022336
Lmnb2
lamin B2
chr4_+_98481520 1.45 ENSRNOT00000078381
ENSRNOT00000048493
AABR07060886.1

chr2_-_105089659 1.32 ENSRNOT00000043381
Cpb1
carboxypeptidase B1
chr1_-_276012351 1.31 ENSRNOT00000045642
AABR07007000.1

chr4_-_82173207 1.30 ENSRNOT00000074167
Hoxa5
homeo box A5
chr3_-_113342675 1.28 ENSRNOT00000020130
Strc
stereocilin
chr2_-_140334912 1.21 ENSRNOT00000015067
Elf2
E74-like factor 2
chr7_+_34402738 1.18 ENSRNOT00000030985
Ccdc38
coiled-coil domain containing 38
chr12_-_44911147 1.16 ENSRNOT00000071074
ENSRNOT00000046190
Ksr2
kinase suppressor of ras 2
chr13_+_89386023 1.14 ENSRNOT00000086223
Fcgr3a
Fc fragment of IgG receptor IIIa
chr11_+_45888221 1.13 ENSRNOT00000071932
ENSRNOT00000066008
ENSRNOT00000060802
Lnp1
leukemia NUP98 fusion partner 1
chr14_+_9555264 1.11 ENSRNOT00000002928
Nkx6-1
NK6 homeobox 1
chr13_+_89385859 1.11 ENSRNOT00000047434
Fcgr3a
Fc fragment of IgG receptor IIIa
chr5_+_10178302 1.10 ENSRNOT00000009679
Sntg1
syntrophin, gamma 1
chrX_+_96863891 1.10 ENSRNOT00000085665
AABR07040284.1

chr19_-_38484611 1.04 ENSRNOT00000077960
Nfat5
nuclear factor of activated T-cells 5
chr12_+_27155587 0.92 ENSRNOT00000044800
AABR07035916.1

chr10_+_46018659 0.91 ENSRNOT00000040865
ENSRNOT00000004357
Mprip
myosin phosphatase Rho interacting protein
chr1_-_172665244 0.87 ENSRNOT00000089570
Olr264
olfactory receptor 264
chr4_-_58006839 0.77 ENSRNOT00000076645
Cep41
centrosomal protein 41
chr8_+_116307141 0.69 ENSRNOT00000037375
Rassf1
Ras association domain family member 1
chr2_-_23909016 0.58 ENSRNOT00000084044
Scamp1
secretory carrier membrane protein 1
chr1_+_227757425 0.57 ENSRNOT00000032937
ENSRNOT00000049574
Ms4a6bl
membrane-spanning 4-domains, subfamily A, member 6B-like
chr16_+_90325304 0.54 ENSRNOT00000057310
Slc10a2
solute carrier family 10 member 2
chr17_-_77527894 0.51 ENSRNOT00000032173
Bend7
BEN domain containing 7
chr8_-_87245951 0.50 ENSRNOT00000015299
Tmem30a
transmembrane protein 30A
chr3_+_16571602 0.39 ENSRNOT00000048351
LOC100361705
rCG64259-like
chr4_+_93959152 0.39 ENSRNOT00000058437
AABR07060795.1

chr7_-_90318221 0.33 ENSRNOT00000050774
Trps1
transcriptional repressor GATA binding 1
chr1_+_224933529 0.18 ENSRNOT00000088282
Wdr74
WD repeat domain 74
chr7_-_120919261 0.12 ENSRNOT00000019612
Josd1
Josephin domain containing 1
chrX_+_136460215 0.05 ENSRNOT00000093538
Arhgap36
Rho GTPase activating protein 36
chr3_-_103485806 0.02 ENSRNOT00000072524
Olr789
olfactory receptor 789

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.1 GO:0031179 peptide modification(GO:0031179)
2.1 12.7 GO:0046687 response to chromate(GO:0046687)
1.3 7.8 GO:0097070 ductus arteriosus closure(GO:0097070)
0.8 3.2 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.6 4.4 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.6 1.8 GO:0003285 septum secundum development(GO:0003285)
0.6 12.2 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.5 1.8 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.5 3.6 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.4 1.3 GO:0060764 cell-cell signaling involved in mammary gland development(GO:0060764)
0.3 6.9 GO:0006544 glycine metabolic process(GO:0006544)
0.3 2.2 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.3 1.1 GO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.2 2.5 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 7.5 GO:0008206 bile acid metabolic process(GO:0008206)
0.2 4.7 GO:0072643 interferon-gamma secretion(GO:0072643)
0.2 4.1 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.2 2.3 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094) Fc-epsilon receptor signaling pathway(GO:0038095)
0.1 2.3 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 0.9 GO:0035509 negative regulation of myosin-light-chain-phosphatase activity(GO:0035509)
0.1 1.3 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 2.1 GO:0006706 steroid catabolic process(GO:0006706)
0.1 0.8 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.5 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 1.0 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 10.6 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.7 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.4 GO:0000802 transverse filament(GO:0000802)
0.6 4.7 GO:0044194 cytolytic granule(GO:0044194)
0.4 3.6 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.3 4.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 1.8 GO:0001740 Barr body(GO:0001740)
0.2 1.5 GO:0005638 lamin filament(GO:0005638)
0.2 10.6 GO:0005871 kinesin complex(GO:0005871)
0.1 1.3 GO:0032426 stereocilium tip(GO:0032426) kinocilium(GO:0060091)
0.0 19.1 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 3.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.2 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 0.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.2 GO:0019807 aspartoacylase activity(GO:0019807)
1.5 9.1 GO:0003840 gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
1.1 6.9 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.9 3.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.7 2.1 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.6 2.5 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.5 2.3 GO:0019770 IgG receptor activity(GO:0019770)
0.3 7.8 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.3 2.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 12.7 GO:0005507 copper ion binding(GO:0005507)
0.2 1.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 10.6 GO:0003777 microtubule motor activity(GO:0003777)
0.1 4.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 7.7 GO:0008146 sulfotransferase activity(GO:0008146)
0.1 0.5 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 1.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.8 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 2.3 GO:0008017 microtubule binding(GO:0008017)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 2.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.0 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 3.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.5 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 7.7 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.3 9.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 6.9 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.1 3.6 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 4.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 2.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.5 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.1 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 2.3 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.8 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes