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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hoxc10

Z-value: 0.43

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Transcription factors associated with Hoxc10

Gene Symbol Gene ID Gene Info
Hoxc10
ENSRNOG00000016149 homeo box C10

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc10rn6_v1_chr7_+_144577465_144577465-0.091.0e-01Click!

Activity profile of Hoxc10 motif

Sorted Z-values of Hoxc10 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_77485113 12.44 ENSRNOT00000080254
Tnr
tenascin R
chr5_+_117698764 10.94 ENSRNOT00000011486
Angptl3
angiopoietin-like 3
chr2_-_154418920 9.95 ENSRNOT00000076326
Plch1
phospholipase C, eta 1
chr15_-_14737704 9.33 ENSRNOT00000011307
Synpr
synaptoporin
chr13_+_42220251 9.22 ENSRNOT00000078185
AABR07020815.1

chr14_-_20920286 8.89 ENSRNOT00000004391
Slc4a4
solute carrier family 4 member 4
chr2_-_154418629 8.74 ENSRNOT00000076274
ENSRNOT00000076165
Plch1
phospholipase C, eta 1
chr13_+_44424689 7.99 ENSRNOT00000005206
Acmsd
aminocarboxymuconate semialdehyde decarboxylase
chr1_-_211923929 7.65 ENSRNOT00000054887
Nkx6-2
NK6 homeobox 2
chr3_+_159902441 7.48 ENSRNOT00000089893
ENSRNOT00000011978
Hnf4a
hepatocyte nuclear factor 4, alpha
chr15_-_23969011 7.41 ENSRNOT00000014821
Gch1
GTP cyclohydrolase 1
chr1_-_43638161 6.34 ENSRNOT00000024460
Ipcef1
interaction protein for cytohesin exchange factors 1
chr3_+_69549673 6.19 ENSRNOT00000043974
Zfp804a
zinc finger protein 804A
chr5_+_167141875 6.04 ENSRNOT00000089314
Slc2a5
solute carrier family 2 member 5
chr12_-_35979193 5.68 ENSRNOT00000071104
Tmem132b
transmembrane protein 132B
chr10_-_66848388 5.04 ENSRNOT00000018891
Omg
oligodendrocyte-myelin glycoprotein
chr7_-_140437467 4.94 ENSRNOT00000087181
Fkbp11
FK506 binding protein 11
chr20_-_9876008 4.89 ENSRNOT00000001537
Tff2
trefoil factor 2
chr3_-_141411170 4.86 ENSRNOT00000017364
Nkx2-2
NK2 homeobox 2
chr10_-_40953467 4.64 ENSRNOT00000092189
Glra1
glycine receptor, alpha 1
chr5_+_167142182 4.61 ENSRNOT00000024054
Slc2a5
solute carrier family 2 member 5
chr20_-_54517709 4.25 ENSRNOT00000076234
Grik2
glutamate ionotropic receptor kainate type subunit 2
chr7_-_143420027 3.90 ENSRNOT00000082863
Krt2
keratin 2
chr1_-_89369960 3.20 ENSRNOT00000028545
Hamp
hepcidin antimicrobial peptide
chr10_-_87954055 3.12 ENSRNOT00000018048
Krt34
keratin 34
chr10_-_71382058 3.11 ENSRNOT00000043148
Dusp14
dual specificity phosphatase 14
chr3_+_59981959 2.96 ENSRNOT00000030460
Sp9
Sp9 transcription factor
chr3_+_21114856 2.77 ENSRNOT00000044947
Olr423
olfactory receptor 423
chr19_-_14945302 2.71 ENSRNOT00000079391
AABR07042936.2

chr7_-_143228060 2.67 ENSRNOT00000088923
ENSRNOT00000012640
Krt75
keratin 75
chr8_-_93390305 2.59 ENSRNOT00000056930
Ibtk
inhibitor of Bruton tyrosine kinase
chr11_-_28614260 2.51 ENSRNOT00000074102
Krtap26-1
keratin associated protein 26-1
chr3_-_105663457 2.49 ENSRNOT00000067646
Zfp770
zinc finger protein 770
chr11_+_80255790 2.47 ENSRNOT00000002522
Bcl6
B-cell CLL/lymphoma 6
chr1_-_134867001 2.33 ENSRNOT00000090149
Chd2
chromodomain helicase DNA binding protein 2
chr10_-_87962846 2.25 ENSRNOT00000018176
Krt31
keratin 31
chr20_-_5064469 2.22 ENSRNOT00000001120
Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr17_-_43689311 2.19 ENSRNOT00000028779
Hist1h2bcl1
histone cluster 1, H2bc-like 1
chrX_-_9999401 1.88 ENSRNOT00000060992
Gpr82
G protein-coupled receptor 82
chr10_+_56411028 1.71 ENSRNOT00000085772
AABR07029862.1

chr9_+_66058047 1.66 ENSRNOT00000071819
Cdk15
cyclin-dependent kinase 15
chr3_+_137154086 1.61 ENSRNOT00000034252
Otor
otoraplin
chr18_+_29966245 1.55 ENSRNOT00000074028
Pcdha4
protocadherin alpha 4
chr6_-_38007162 1.52 ENSRNOT00000044583
AABR07063632.1

chr1_+_70437776 1.50 ENSRNOT00000020448
Olr3
olfactory receptor 3
chr5_-_153840178 1.46 ENSRNOT00000025075
Nipal3
NIPA-like domain containing 3
chr10_+_10761477 1.36 ENSRNOT00000004176
Rogdi
rogdi homolog
chr10_+_84031955 1.27 ENSRNOT00000009934
Hoxb13
homeo box B13
chr1_+_260798239 1.18 ENSRNOT00000036791
Lcor
ligand dependent nuclear receptor corepressor
chr10_-_87500919 1.09 ENSRNOT00000084798
Krtap1-5
keratin associated protein 1-5
chr7_-_143167772 1.09 ENSRNOT00000011374
Krt85
keratin 85
chr10_-_87153982 1.06 ENSRNOT00000014414
Krt222
keratin 222
chr9_+_20048121 0.99 ENSRNOT00000014791
Mep1a
meprin 1 subunit alpha
chr14_-_105069565 0.98 ENSRNOT00000067365
AABR07016578.1

chr3_-_79121620 0.97 ENSRNOT00000087141
Olr741
olfactory receptor 741
chr3_+_76179214 0.76 ENSRNOT00000071281
LOC686677
similar to olfactory receptor 1161
chr7_-_143187594 0.76 ENSRNOT00000011732
ENSRNOT00000083466
Krt84
keratin 84
chr16_-_85464002 0.67 ENSRNOT00000037018
AABR07026596.1

chr13_+_26463404 0.56 ENSRNOT00000061779
LOC103690041
serpin B12-like
chr19_-_34752695 0.54 ENSRNOT00000052018
Nr3c2
nuclear receptor subfamily 3, group C, member 2
chr1_+_8310577 0.54 ENSRNOT00000015131
Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr3_+_67538289 0.48 ENSRNOT00000009839
Dnajc10
DnaJ heat shock protein family (Hsp40) member C10
chr19_-_22194740 0.41 ENSRNOT00000086187
Phkb
phosphorylase kinase regulatory subunit beta
chr1_+_99616447 0.40 ENSRNOT00000029197
Klk14
kallikrein related-peptidase 14
chr18_+_29124428 0.27 ENSRNOT00000073131
Igip
IgA-inducing protein
chr16_+_70074672 0.18 ENSRNOT00000073167
ENSRNOT00000035638
AABR07026271.1

chr15_-_34693034 0.17 ENSRNOT00000083314
Mcpt8
mast cell protease 8
chr3_-_76135475 0.13 ENSRNOT00000007712
Olr604
olfactory receptor 604
chr10_-_87484935 0.05 ENSRNOT00000016752
Krtap3-1
keratin associated protein 3-1
chr2_-_178521038 0.04 ENSRNOT00000033107
Rxfp1
relaxin/insulin-like family peptide receptor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc10

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.4 GO:0014916 regulation of lung blood pressure(GO:0014916)
2.2 10.9 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
2.1 10.7 GO:0015755 fructose transport(GO:0015755)
2.1 12.4 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
1.9 7.5 GO:0042977 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
1.6 4.9 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
1.5 7.6 GO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
1.3 8.0 GO:0046874 quinolinate metabolic process(GO:0046874)
0.8 3.2 GO:0034760 negative regulation of iron ion transmembrane transport(GO:0034760) cellular response to bile acid(GO:1903413)
0.7 4.9 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.6 2.5 GO:0032763 regulation of mast cell cytokine production(GO:0032763) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.6 4.6 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.3 8.9 GO:0015701 bicarbonate transport(GO:0015701)
0.2 3.9 GO:0003334 keratinocyte development(GO:0003334)
0.2 1.3 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.2 4.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.2 0.5 GO:0031959 mineralocorticoid receptor signaling pathway(GO:0031959)
0.2 5.0 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.1 2.3 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 4.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 1.5 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.1 18.7 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.1 2.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 2.6 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1 2.2 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.1 1.6 GO:0001502 cartilage condensation(GO:0001502)
0.0 0.4 GO:0007320 insemination(GO:0007320)
0.0 0.5 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 2.9 GO:0042476 odontogenesis(GO:0042476)
0.0 2.2 GO:0006334 nucleosome assembly(GO:0006334)
0.0 3.0 GO:0035113 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
0.0 2.7 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 12.4 GO:0072534 perineuronal net(GO:0072534)
0.7 4.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.4 9.3 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.3 3.2 GO:0045179 apical cortex(GO:0045179)
0.1 3.9 GO:0001533 cornified envelope(GO:0001533)
0.1 4.6 GO:0060077 inhibitory synapse(GO:0060077)
0.1 5.7 GO:0045095 keratin filament(GO:0045095)
0.1 5.1 GO:0005882 intermediate filament(GO:0005882)
0.1 0.4 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 9.4 GO:0042383 sarcolemma(GO:0042383)
0.0 10.9 GO:0005769 early endosome(GO:0005769)
0.0 8.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 7.4 GO:0031965 nuclear membrane(GO:0031965)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 8.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.2 GO:0000786 nucleosome(GO:0000786)
0.0 1.6 GO:0005657 replication fork(GO:0005657)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 18.7 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
1.5 4.6 GO:0030977 taurine binding(GO:0030977)
1.2 10.9 GO:0004859 phospholipase inhibitor activity(GO:0004859)
1.2 10.7 GO:0070061 fructose binding(GO:0070061)
1.1 7.4 GO:0019238 cyclohydrolase activity(GO:0019238)
0.7 3.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.6 7.5 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.6 4.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.4 8.9 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.3 4.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.3 2.6 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.2 2.5 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.2 8.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 2.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.2 2.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 4.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 4.9 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 12.4 GO:0005178 integrin binding(GO:0005178)
0.1 1.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 0.4 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 3.2 GO:0005507 copper ion binding(GO:0005507)
0.0 4.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.5 GO:0051787 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) misfolded protein binding(GO:0051787)
0.0 2.3 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 6.5 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 7.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 12.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 5.0 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 2.6 PID BCR 5PATHWAY BCR signaling pathway
0.0 10.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.3 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 8.0 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.6 10.7 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.6 7.4 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.5 12.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.3 4.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 4.6 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 8.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 5.0 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)