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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Hoxb7
Z-value: 3.83
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Transcription factors associated with Hoxb7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hoxb7 | rn6_v1_chr10_+_84135116_84135116 | 0.06 | 2.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hoxb7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.8 | 1098.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 24.1 | 457.8 | GO:0021860 | pyramidal neuron development(GO:0021860) |
| 11.3 | 440.2 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 5.9 | 342.4 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 30.1 | 331.0 | GO:0097264 | self proteolysis(GO:0097264) |
| 8.5 | 299.2 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 41.2 | 288.7 | GO:0045196 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) |
| 18.8 | 262.9 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 7.5 | 246.7 | GO:0031114 | negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114) |
| 12.7 | 241.5 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 988.4 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 71.4 | 642.4 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 9.1 | 618.4 | GO:0014704 | intercalated disc(GO:0014704) |
| 5.6 | 581.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 19.4 | 523.8 | GO:0043194 | axon initial segment(GO:0043194) |
| 2.9 | 498.8 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 11.4 | 466.6 | GO:0044295 | axonal growth cone(GO:0044295) |
| 12.1 | 386.2 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 15.0 | 344.9 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 2.0 | 340.7 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 812.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.7 | 511.0 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 57.8 | 462.4 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 4.3 | 439.5 | GO:0005262 | calcium channel activity(GO:0005262) |
| 14.6 | 410.0 | GO:0031402 | sodium ion binding(GO:0031402) |
| 14.4 | 404.5 | GO:0005452 | inorganic anion exchanger activity(GO:0005452) |
| 37.7 | 339.5 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 47.7 | 333.8 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 6.7 | 313.5 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 13.1 | 301.3 | GO:0002162 | dystroglycan binding(GO:0002162) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 234.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 3.1 | 210.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 2.7 | 192.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 3.0 | 145.6 | NABA COLLAGENS | Genes encoding collagen proteins |
| 3.4 | 133.9 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 2.9 | 113.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.7 | 104.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 4.7 | 99.7 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 1.6 | 98.7 | PID NOTCH PATHWAY | Notch signaling pathway |
| 3.8 | 97.9 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 22.8 | 638.8 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 22.8 | 387.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 21.4 | 342.5 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 9.6 | 336.3 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 2.6 | 247.7 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 7.7 | 207.2 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 3.3 | 192.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 3.8 | 191.2 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 3.8 | 184.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 2.7 | 161.4 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |