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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hoxb4

Z-value: 0.73

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Transcription factors associated with Hoxb4

Gene Symbol Gene ID Gene Info
Hoxb4
ENSRNOG00000008191 homeo box B4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxb4rn6_v1_chr10_+_84167331_841673310.036.3e-01Click!

Activity profile of Hoxb4 motif

Sorted Z-values of Hoxb4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_26999795 45.95 ENSRNOT00000057872
Mypn
myopalladin
chr7_-_29171783 36.23 ENSRNOT00000079235
Mybpc1
myosin binding protein C, slow type
chr3_-_23020441 25.70 ENSRNOT00000017651
Nr5a1
nuclear receptor subfamily 5, group A, member 1
chr11_+_17538063 24.11 ENSRNOT00000031889
ENSRNOT00000090878
Chodl
chondrolectin
chr19_-_37427989 23.04 ENSRNOT00000022863
Tppp3
tubulin polymerization-promoting protein family member 3
chr1_-_215838209 22.28 ENSRNOT00000050760
Igf2
insulin-like growth factor 2
chr1_+_201620642 20.68 ENSRNOT00000093674
Dmbt1
deleted in malignant brain tumors 1
chr10_-_25910298 19.05 ENSRNOT00000065633
ENSRNOT00000079646
Ccng1
cyclin G1
chr1_+_167870452 14.15 ENSRNOT00000025027
Olr63
olfactory receptor 63
chr9_-_52238564 14.04 ENSRNOT00000005073
Col5a2
collagen type V alpha 2 chain
chrX_-_136807885 14.00 ENSRNOT00000010325
Igsf1
immunoglobulin superfamily, member 1
chr2_-_105089659 12.90 ENSRNOT00000043381
Cpb1
carboxypeptidase B1
chrX_-_142248369 11.33 ENSRNOT00000091330
Fgf13
fibroblast growth factor 13
chr5_-_7941822 11.26 ENSRNOT00000079917
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr19_-_37210412 11.22 ENSRNOT00000083097
B3gnt9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr4_+_148782479 7.54 ENSRNOT00000018133
LOC500300
similar to hypothetical protein MGC6835
chr7_+_42304534 6.63 ENSRNOT00000085097
Kitlg
KIT ligand
chrX_+_136460215 4.98 ENSRNOT00000093538
Arhgap36
Rho GTPase activating protein 36
chr10_-_44147035 3.47 ENSRNOT00000041113
Olr1424
olfactory receptor 1424
chr10_-_43998533 3.10 ENSRNOT00000047037
Olr1417
olfactory receptor 1417
chr1_+_40816107 2.89 ENSRNOT00000060767
Akap12
A-kinase anchoring protein 12
chr15_-_35264841 2.67 ENSRNOT00000073741
LOC100910060
granzyme G-like
chr7_+_79138925 2.20 ENSRNOT00000047511
AABR07057586.1

chr3_-_72171078 2.01 ENSRNOT00000009817
Serping1
serpin family G member 1
chr9_-_44617210 1.88 ENSRNOT00000074343
Lyg1
lysozyme G1
chr8_-_19586811 1.73 ENSRNOT00000091744
Olr1149
olfactory receptor 1149
chr4_+_72589565 1.63 ENSRNOT00000079349
Olr437
olfactory receptor 437
chr7_-_7753978 1.19 ENSRNOT00000048223
Olr1029
olfactory receptor 1029
chr5_-_137617258 0.80 ENSRNOT00000071641
Olfr1330-ps1
olfactory receptor 1330, pseudogene 1
chr10_+_34402482 0.42 ENSRNOT00000072317
Tpcr12
putative olfactory receptor
chr2_-_140334912 0.40 ENSRNOT00000015067
Elf2
E74-like factor 2
chr17_+_90696019 0.04 ENSRNOT00000003438
Gpr137b
G protein-coupled receptor 137B

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 25.7 GO:2000195 negative regulation of female gonad development(GO:2000195)
4.0 36.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
3.8 45.9 GO:0048739 cardiac muscle fiber development(GO:0048739)
3.5 14.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
3.2 22.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.6 11.3 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
1.3 6.6 GO:0033026 negative regulation of mast cell apoptotic process(GO:0033026) mast cell proliferation(GO:0070662) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
1.0 20.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.7 19.0 GO:0031572 mitotic G2 DNA damage checkpoint(GO:0007095) G2 DNA damage checkpoint(GO:0031572)
0.5 1.9 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.3 2.9 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.3 23.0 GO:0046785 microtubule polymerization(GO:0046785)
0.2 11.3 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.2 2.0 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 11.2 GO:0043413 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 23.9 GO:0010975 regulation of neuron projection development(GO:0010975)
0.0 26.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 14.0 GO:0005588 collagen type V trimer(GO:0005588)
3.0 36.2 GO:0005859 muscle myosin complex(GO:0005859)
1.1 20.7 GO:0042589 zymogen granule membrane(GO:0042589)
0.3 45.9 GO:0030018 Z disc(GO:0030018)
0.2 11.3 GO:0014704 intercalated disc(GO:0014704)
0.2 25.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 11.2 GO:0001650 fibrillar center(GO:0001650)
0.1 6.6 GO:0030175 filopodium(GO:0030175)
0.1 43.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 18.4 GO:0005874 microtubule(GO:0005874)
0.0 36.8 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 82.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
3.0 20.7 GO:0035375 zymogen binding(GO:0035375)
2.0 14.0 GO:0034711 inhibin binding(GO:0034711)
1.0 22.3 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.9 6.6 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.9 24.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.5 12.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.4 25.7 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.3 11.2 GO:0008378 galactosyltransferase activity(GO:0008378)
0.3 14.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 11.3 GO:0048487 beta-tubulin binding(GO:0048487)
0.2 2.9 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.9 GO:0003796 lysozyme activity(GO:0003796)
0.1 2.0 GO:0001848 complement binding(GO:0001848)
0.1 18.4 GO:0015631 tubulin binding(GO:0015631)
0.0 8.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 26.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 2.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 22.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.3 14.0 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.3 19.0 PID P53 REGULATION PATHWAY p53 pathway
0.1 20.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 6.6 PID CMYB PATHWAY C-MYB transcription factor network
0.0 11.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 22.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.9 36.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.3 25.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 14.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.3 6.6 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.2 11.2 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 2.0 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 2.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases