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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hoxb2_Dlx2

Z-value: 0.54

Motif logo

Transcription factors associated with Hoxb2_Dlx2

Gene Symbol Gene ID Gene Info
ENSRNOG00000008365 homeobox B2
ENSRNOG00000001519 distal-less homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Dlx2rn6_v1_chr3_-_58181971_581819710.351.3e-10Click!
Hoxb2rn6_v1_chr10_+_84200880_842008800.171.7e-03Click!

Activity profile of Hoxb2_Dlx2 motif

Sorted Z-values of Hoxb2_Dlx2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_84064427 22.86 ENSRNOT00000046364
zinc finger protein 711
chr5_+_33784715 20.59 ENSRNOT00000035685
solute carrier family 7 member 13
chr8_+_33239139 19.56 ENSRNOT00000011589
Rho GTPase activating protein 32
chr9_-_30844199 18.23 ENSRNOT00000017169
collagen type XIX alpha 1 chain
chr8_-_78233430 17.15 ENSRNOT00000083220
cingulin-like 1
chr1_+_198383201 16.44 ENSRNOT00000037405
seizure related 6 homolog like 2
chr4_-_17594598 16.27 ENSRNOT00000008936
semaphorin 3E
chr6_+_58468155 12.98 ENSRNOT00000091263
ets variant 1
chr1_-_279277339 12.97 ENSRNOT00000023667
GDNF family receptor alpha 1
chr11_+_58624198 12.32 ENSRNOT00000002091
growth associated protein 43
chr18_-_26656879 11.05 ENSRNOT00000086729
erythrocyte membrane protein band 4.1 like 4A
chr16_+_2706428 10.87 ENSRNOT00000077117
interleukin 17 receptor D
chr17_+_47721977 10.80 ENSRNOT00000080800
amphiphysin-like
chr2_-_158156444 10.48 ENSRNOT00000088559
ventricular zone expressed PH domain-containing 1
chr16_+_50049828 10.04 ENSRNOT00000034448
family with sequence similarity 149, member A
chrX_+_118197217 9.64 ENSRNOT00000090922
5-hydroxytryptamine receptor 2C
chr8_-_14880644 9.40 ENSRNOT00000015977
FAT atypical cadherin 3
chr17_-_9762813 9.35 ENSRNOT00000033749
solute carrier family 34 member 1
chr17_+_11683862 9.07 ENSRNOT00000024766
msh homeobox 2
chrX_-_32095867 8.72 ENSRNOT00000049947
ENSRNOT00000080730
angiotensin I converting enzyme 2
chr1_+_13595295 8.69 ENSRNOT00000079250
NHS-like 1
chr2_-_35104963 8.41 ENSRNOT00000018058
regulator of G-protein signaling 7-binding protein
chr8_-_45137893 8.30 ENSRNOT00000010743
similar to hypothetical protein FLJ23554
chr2_-_158156150 8.13 ENSRNOT00000016621
ventricular zone expressed PH domain-containing 1
chr2_+_23289374 7.92 ENSRNOT00000090666
ENSRNOT00000032783
dimethylglycine dehydrogenase
chr7_+_78558701 7.90 ENSRNOT00000006393
regulating synaptic membrane exocytosis 2
chr3_-_66417741 7.74 ENSRNOT00000007662
neuronal differentiation 1
chr16_+_46731403 7.61 ENSRNOT00000017624
teneurin transmembrane protein 3
chr18_-_31343797 7.48 ENSRNOT00000081850
protocadherin 1
chr12_-_2174131 7.48 ENSRNOT00000001313
Purkinje cell protein 2
chr12_-_29743705 7.44 ENSRNOT00000001185
calneuron 1
chr8_-_87419564 7.42 ENSRNOT00000015365
filamin A interacting protein 1
chr16_-_39476025 7.37 ENSRNOT00000014312
glycoprotein m6a
chr2_+_18392142 7.23 ENSRNOT00000043196
hyaluronan and proteoglycan link protein 1
chr1_+_87224677 7.11 ENSRNOT00000028070
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr1_-_215033460 7.07 ENSRNOT00000044565
dual specificity phosphatase 8
chr18_-_6781841 6.85 ENSRNOT00000077606
ENSRNOT00000048109
aquaporin 4
chr11_-_782954 6.32 ENSRNOT00000040065
Eph receptor A3
chr4_+_2055615 6.27 ENSRNOT00000007646
ring finger protein 32
chr5_-_93244202 6.20 ENSRNOT00000075474
protein tyrosine phosphatase, receptor type, D
chr2_-_261337163 5.98 ENSRNOT00000030341
TNNI3 interacting kinase
chr13_+_70157522 5.88 ENSRNOT00000036906
apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4
chr16_+_23553647 5.84 ENSRNOT00000041994
pleckstrin and Sec7 domain containing 3
chr10_-_87248572 5.82 ENSRNOT00000066637
ENSRNOT00000085677
keratin 26
chr7_-_76488216 5.77 ENSRNOT00000080024
neurocalcin delta
chr12_-_10335499 5.76 ENSRNOT00000071567
WAS protein family, member 3
chr18_+_30592794 5.56 ENSRNOT00000027133
protocadherin beta 22
chr14_-_19072677 5.56 ENSRNOT00000060548
similar to alpha-fetoprotein
chr2_+_18354542 5.54 ENSRNOT00000042958
hyaluronan and proteoglycan link protein 1
chrX_-_40086870 5.43 ENSRNOT00000010027
small muscle protein, X-linked
chr13_+_57243877 5.42 ENSRNOT00000083693
potassium sodium-activated channel subfamily T member 2
chrX_+_33895769 5.42 ENSRNOT00000085993
ENSRNOT00000079365
RALBP1 associated Eps domain containing protein 2
chr10_-_91661558 5.37 ENSRNOT00000043156

chr13_-_76049363 5.23 ENSRNOT00000075865
ENSRNOT00000007455
BMP/retinoic acid inducible neural specific 2
chr4_-_55011415 5.17 ENSRNOT00000056996
glutamate metabotropic receptor 8
chr20_-_25826658 5.13 ENSRNOT00000057950
ENSRNOT00000084660
catenin alpha 3
chr3_-_51612397 5.10 ENSRNOT00000081401
sodium voltage-gated channel alpha subunit 3
chr5_+_6373583 5.03 ENSRNOT00000084749

chr3_+_48096954 5.00 ENSRNOT00000068238
ENSRNOT00000064344
ENSRNOT00000044638
solute carrier family 4 member 10
chr17_+_63635086 5.00 ENSRNOT00000020634
disco-interacting protein 2 homolog C
chr5_+_58855773 4.99 ENSRNOT00000072869
RUN and SH3 domain containing 2
chr2_-_236480502 4.86 ENSRNOT00000015020
sphingomyelin synthase 2
chr1_+_44311513 4.85 ENSRNOT00000065386
T-cell lymphoma invasion and metastasis 2
chr4_+_158088505 4.75 ENSRNOT00000026643
von Willebrand factor
chr7_+_42269784 4.75 ENSRNOT00000008471
ENSRNOT00000007231
KIT ligand
chr11_+_45751812 4.74 ENSRNOT00000079336
similar to Dermal papilla derived protein 7
chr15_+_106434177 4.69 ENSRNOT00000015271
FERM, ARH/RhoGEF and pleckstrin domain protein 1
chr20_+_25990656 4.68 ENSRNOT00000081254
leucine rich repeat transmembrane neuronal 3
chrM_+_7006 4.63 ENSRNOT00000043693
mitochondrially encoded cytochrome c oxidase II
chr3_+_117421604 4.63 ENSRNOT00000008860
ENSRNOT00000008857
solute carrier family 12 member 1
chr2_+_266315036 4.61 ENSRNOT00000055245
wntless Wnt ligand secretion mediator
chr3_+_45683993 4.61 ENSRNOT00000038983
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr2_+_22950018 4.58 ENSRNOT00000071804
homer scaffolding protein 1
chr4_+_172942020 4.54 ENSRNOT00000072450
LIM domain only 3
chr16_+_54332660 4.45 ENSRNOT00000037685
microtubule associated tumor suppressor 1
chrX_+_110789269 4.32 ENSRNOT00000086014
ring finger protein 128, E3 ubiquitin protein ligase
chr3_+_128828331 4.25 ENSRNOT00000045393
phospholipase C, beta 4
chr19_+_53044379 4.22 ENSRNOT00000072369
forkhead box C2
chr4_-_89695928 4.19 ENSRNOT00000039316
GPRIN family member 3
chr2_-_5577369 4.16 ENSRNOT00000093420
nuclear receptor subfamily 2, group F, member 1
chr15_+_11298478 4.13 ENSRNOT00000007672
leucine rich repeat containing 3B
chr3_-_14229067 4.09 ENSRNOT00000025534
ENSRNOT00000092865
complement C5
chr3_-_148932878 4.01 ENSRNOT00000013881
nucleolar protein 4-like
chr9_-_85243001 3.99 ENSRNOT00000020219
secretogranin II
chr9_+_73378057 3.99 ENSRNOT00000043627
ENSRNOT00000045766
ENSRNOT00000092445
ENSRNOT00000037974
microtubule-associated protein 2
chr7_+_42304534 3.90 ENSRNOT00000085097
KIT ligand
chr8_+_33514042 3.89 ENSRNOT00000081614
ENSRNOT00000081525
potassium voltage-gated channel subfamily J member 1
chr17_-_84247038 3.87 ENSRNOT00000068553
nebulette
chr6_-_71199110 3.86 ENSRNOT00000081883
protein kinase D1
chr18_+_30435119 3.84 ENSRNOT00000027190
protocadherin beta 8
chr3_+_151335292 3.84 ENSRNOT00000073642
matrix metallopeptidase 24
chr19_-_58735173 3.82 ENSRNOT00000030077
pecanex homolog 2 (Drosophila)
chrM_+_11736 3.79 ENSRNOT00000048767
mitochondrially encoded NADH dehydrogenase 5
chr8_-_53816447 3.77 ENSRNOT00000011454
tetratricopeptide repeat domain 12
chr14_+_37130743 3.75 ENSRNOT00000031756
leucine rich repeat containing 66
chr18_+_30474947 3.72 ENSRNOT00000027188
protocadherin beta 9
chr5_-_164714145 3.72 ENSRNOT00000055680
mitofusin-2-like
chr4_-_64330996 3.70 ENSRNOT00000016088
pleiotrophin
chr18_+_30509393 3.67 ENSRNOT00000043846
protocadherin beta 12
chr18_+_81821127 3.67 ENSRNOT00000058199
F-box protein 15
chr9_+_95501778 3.64 ENSRNOT00000086805
secreted phosphoprotein 2
chr11_+_24266345 3.60 ENSRNOT00000046973
junctional adhesion molecule 2
chr1_-_67065797 3.57 ENSRNOT00000048152
vomeronasal 1 receptor 46
chr7_-_69982592 3.56 ENSRNOT00000040010
similar to developmental pluripotency associated 5
chr3_+_48106099 3.50 ENSRNOT00000007218
solute carrier family 4 member 10
chr19_+_25043680 3.50 ENSRNOT00000043971
adhesion G protein-coupled receptor L1
chr4_+_94696965 3.40 ENSRNOT00000064696
glutamate ionotropic receptor delta type subunit 2
chr7_-_107203897 3.30 ENSRNOT00000086263
leucine rich repeat containing 6
chr4_-_82173207 3.24 ENSRNOT00000074167
homeo box A5
chr3_+_140024043 3.22 ENSRNOT00000086409
Ras and Rab interactor 2
chr1_+_242572533 3.21 ENSRNOT00000035123
transmembrane protein 252
chr1_-_250626844 3.19 ENSRNOT00000077135
N-acylsphingosine amidohydrolase 2
chr5_-_28130803 3.16 ENSRNOT00000093186
solute carrier family 26 member 7
chr9_+_73418607 3.13 ENSRNOT00000092547
microtubule-associated protein 2
chr5_-_102743417 3.12 ENSRNOT00000067389
basonuclin 2
chr3_-_161917285 3.10 ENSRNOT00000025150
cadherin 22
chr9_-_44419998 3.07 ENSRNOT00000091397
ENSRNOT00000083747
testis specific 10
chr2_-_57935334 3.04 ENSRNOT00000022319
ENSRNOT00000085599
ENSRNOT00000077790
ENSRNOT00000035821
solute carrier family 1 member 3
chr6_-_3355339 3.02 ENSRNOT00000084602
mitogen-activated protein kinase kinase kinase kinase 3
chrM_+_9451 3.00 ENSRNOT00000041241
mitochondrially encoded NADH dehydrogenase 3
chr9_+_81566074 2.99 ENSRNOT00000074131
ENSRNOT00000046229
ENSRNOT00000090383
paroxysmal nonkinesigenic dyskinesia
chrM_+_9870 2.98 ENSRNOT00000044582
mitochondrially encoded NADH 4L dehydrogenase
chr1_-_48825364 2.97 ENSRNOT00000024213
1-acylglycerol-3-phosphate O-acyltransferase 4
chr6_-_114476723 2.93 ENSRNOT00000005162
deiodinase, iodothyronine, type II
chr15_-_20783063 2.92 ENSRNOT00000083268
bone morphogenetic protein 4
chr7_-_52404774 2.89 ENSRNOT00000082100
neuron navigator 3
chr1_+_70260041 2.88 ENSRNOT00000020416
zinc finger, imprinted 1
chr9_+_95398237 2.88 ENSRNOT00000025879
transient receptor potential cation channel, subfamily M, member 8
chr10_-_91986632 2.82 ENSRNOT00000087824
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
chr10_-_16731898 2.81 ENSRNOT00000028186
CREB3 regulatory factor
chr10_+_90230711 2.79 ENSRNOT00000055185
transmembrane and ubiquitin-like domain containing 2
chr9_+_73493027 2.78 ENSRNOT00000074427
ENSRNOT00000089478
unc-80 homolog, NALCN activator
chr1_+_185210922 2.72 ENSRNOT00000055120
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
chr2_-_30634243 2.72 ENSRNOT00000077537
MARVEL domain containing 2
chr8_-_17524839 2.70 ENSRNOT00000081679
N-acetylated alpha-linked acidic dipeptidase 2
chr2_+_145174876 2.68 ENSRNOT00000040631
mab-21 like 1
chr1_-_173764246 2.67 ENSRNOT00000019690
ENSRNOT00000086944
LIM domain only 1
chr3_-_77227036 2.66 ENSRNOT00000072638
olfactory receptor 4P4-like
chr3_+_14889510 2.62 ENSRNOT00000080760
DAB2 interacting protein
chr2_-_144467912 2.59 ENSRNOT00000040002
cyclin A1
chr11_-_28478360 2.57 ENSRNOT00000032663
claudin 17
chr2_+_136993208 2.57 ENSRNOT00000040187
ENSRNOT00000066542
protocadherin 10
chr5_-_117754571 2.56 ENSRNOT00000011405
dedicator of cytokinesis 7
chr20_+_1749716 2.56 ENSRNOT00000048856
olfactory receptor 1735
chr5_-_28131133 2.55 ENSRNOT00000067331
solute carrier family 26 member 7
chr14_+_37116492 2.55 ENSRNOT00000002921
sarcoglycan, beta
chr18_-_31109025 2.53 ENSRNOT00000026381
FCH and double SH3 domains 1
chr6_+_73553210 2.52 ENSRNOT00000006562
A-kinase anchoring protein 6
chr5_-_150704117 2.47 ENSRNOT00000067455
sestrin 2
chr4_-_150485781 2.45 ENSRNOT00000008763
zinc finger protein 248
chr2_+_206314213 2.43 ENSRNOT00000056068
BCL2-like 15
chr6_-_7058314 2.43 ENSRNOT00000045996
3-hydroxyanthranilate 3,4-dioxygenase
chr8_+_106449321 2.42 ENSRNOT00000018622
retinol binding protein 1
chr4_+_25686392 2.39 ENSRNOT00000061199
claudin 12
chr2_+_225645568 2.38 ENSRNOT00000017878
ATP binding cassette subfamily A member 4
chr7_-_68549763 2.35 ENSRNOT00000078014
solute carrier family 16 member 7
chr12_-_5682608 2.33 ENSRNOT00000076483
FRY microtubule binding protein
chr3_-_102672294 2.33 ENSRNOT00000030909
olfactory receptor 760
chr3_+_95715193 2.33 ENSRNOT00000089525
paired box 6
chr2_+_226563050 2.32 ENSRNOT00000065111
breast cancer anti-estrogen resistance 3
chr2_-_96509424 2.32 ENSRNOT00000090866
zinc finger, C2HC-type containing 1A
chr4_+_68656928 2.32 ENSRNOT00000016232
taste receptor, type 2, member 108
chr7_+_44009069 2.31 ENSRNOT00000005523
MGAT4 family, member C
chr12_+_30606161 2.30 ENSRNOT00000093601
septin 14
chr2_-_33025271 2.30 ENSRNOT00000074941
microtubule associated serine/threonine kinase family member 4
chr12_-_52658275 2.28 ENSRNOT00000041981
zinc finger protein 605
chr15_+_56666012 2.28 ENSRNOT00000013408
5-hydroxytryptamine receptor 2A
chr2_+_66940057 2.22 ENSRNOT00000043050
cadherin 9
chr5_-_28164326 2.19 ENSRNOT00000088165
solute carrier family 26 member 7
chrX_+_111735820 2.19 ENSRNOT00000086948
FERM and PDZ domain containing 3
chr2_-_188559882 2.15 ENSRNOT00000088199
tripartite motif-containing 46
chr1_+_87563975 2.14 ENSRNOT00000088772
zinc finger protein 30
chrX_+_159158194 2.09 ENSRNOT00000043820
ENSRNOT00000001169
ENSRNOT00000083502
four and a half LIM domains 1
chr14_-_16903242 2.07 ENSRNOT00000003001
shroom family member 3
chr12_+_41486076 2.03 ENSRNOT00000057242
RBPJ interacting and tubulin associated 1
chrX_+_65040775 2.02 ENSRNOT00000081354
zinc finger CCCH-type containing 12B
chrM_+_10160 2.01 ENSRNOT00000042928
mitochondrially encoded NADH dehydrogenase 4
chr2_+_72006099 2.00 ENSRNOT00000034044
cadherin 12
chr1_-_261371508 1.99 ENSRNOT00000019978
arginine vasopressin-induced 1
chr6_+_101532518 1.99 ENSRNOT00000075054
gephyrin
chr2_+_144861455 1.97 ENSRNOT00000093284
ENSRNOT00000019748
ENSRNOT00000072110
doublecortin-like kinase 1
chr2_+_51672722 1.95 ENSRNOT00000016485
fibroblast growth factor 10
chr2_-_46544457 1.93 ENSRNOT00000015680
follistatin
chr4_-_135069970 1.92 ENSRNOT00000008221
contactin 3
chr5_-_12526962 1.91 ENSRNOT00000092104
suppression of tumorigenicity 18
chr6_+_106496992 1.91 ENSRNOT00000086136
ENSRNOT00000058181
regulator of G-protein signaling 6
chr8_-_39551700 1.91 ENSRNOT00000091894
ENSRNOT00000076025
PBX/knotted 1 homeobox 2
chr3_-_57646572 1.91 ENSRNOT00000076202
methyltransferase like 8
chr6_+_28382962 1.91 ENSRNOT00000016976
proopiomelanocortin
chr19_+_39229754 1.91 ENSRNOT00000050612
vacuolar protein sorting 4 homolog A
chr4_-_176909075 1.89 ENSRNOT00000067489
ATP binding cassette subfamily C member 9
chrX_+_65040934 1.89 ENSRNOT00000044006
zinc finger CCCH-type containing 12B
chr14_-_21128505 1.85 ENSRNOT00000004776
RUN and FYVE domain containing 3
chr3_+_149643481 1.84 ENSRNOT00000020713
BPI fold containing family A, member 5
chr8_-_104593625 1.82 ENSRNOT00000016625
zinc finger and BTB domain containing 38
chr5_-_130085838 1.81 ENSRNOT00000035252
ELAV like RNA binding protein 4
chr8_-_128754514 1.81 ENSRNOT00000025019
C-X3-C motif chemokine receptor 1
chr14_-_72380330 1.80 ENSRNOT00000082653
ENSRNOT00000081878
ENSRNOT00000006727
cytoplasmic polyadenylation element binding protein 2
chr5_-_117612123 1.79 ENSRNOT00000065112
dedicator of cytokinesis 7
chr2_+_248398917 1.79 ENSRNOT00000045855
guanylate binding protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb2_Dlx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 11.9 GO:0007208 phospholipase C-activating serotonin receptor signaling pathway(GO:0007208)
3.1 9.4 GO:0097187 dentinogenesis(GO:0097187) regulation of sodium-dependent phosphate transport(GO:2000118)
3.0 9.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of mesenchymal cell apoptotic process(GO:2001055)
2.9 8.7 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051) tryptophan transport(GO:0015827) positive regulation of gap junction assembly(GO:1903598)
2.6 7.9 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
2.1 6.3 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
1.9 3.9 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
1.7 8.6 GO:0070668 negative regulation of mast cell apoptotic process(GO:0033026) mast cell proliferation(GO:0070662) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
1.7 6.8 GO:0060354 negative regulation of cell adhesion molecule production(GO:0060354)
1.5 7.7 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
1.5 4.6 GO:0032978 protein insertion into membrane from inner side(GO:0032978)
1.5 4.6 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
1.3 5.2 GO:0060435 bronchiole development(GO:0060435)
1.3 3.9 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
1.2 3.7 GO:0060221 retinal rod cell differentiation(GO:0060221)
1.2 12.3 GO:0016198 axon choice point recognition(GO:0016198)
1.1 13.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.1 4.2 GO:0072011 apoptotic process involved in outflow tract morphogenesis(GO:0003275) positive regulation of vascular wound healing(GO:0035470) glomerular endothelium development(GO:0072011) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
1.0 3.0 GO:0098972 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
1.0 2.9 GO:0072098 intermediate mesoderm development(GO:0048389) regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994) pattern specification involved in mesonephros development(GO:0061227) anterior/posterior pattern specification involved in kidney development(GO:0072098) ureter urothelium development(GO:0072190) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) cardiac jelly development(GO:1905072) negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137)
0.9 2.8 GO:1902211 regulation of prolactin signaling pathway(GO:1902211)
0.9 2.7 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.9 16.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.8 1.7 GO:0071298 cellular response to L-ascorbic acid(GO:0071298)
0.8 2.5 GO:1904504 regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.8 2.4 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.8 2.4 GO:0006649 phospholipid transfer to membrane(GO:0006649)
0.8 2.3 GO:0021917 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.8 3.9 GO:0089700 protein kinase D signaling(GO:0089700)
0.8 3.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.8 6.0 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.7 5.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.7 2.8 GO:0035494 SNARE complex disassembly(GO:0035494)
0.7 1.4 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.7 4.1 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.7 2.7 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.7 2.0 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.7 2.6 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.6 7.1 GO:0097264 self proteolysis(GO:0097264)
0.6 5.1 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.6 1.9 GO:0036258 multivesicular body assembly(GO:0036258) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.6 2.5 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.6 4.4 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.6 6.2 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.6 7.9 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.6 1.8 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.6 3.0 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.6 4.8 GO:0070417 cellular response to cold(GO:0070417)
0.6 2.3 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.6 2.9 GO:0050955 thermoception(GO:0050955)
0.6 9.7 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.6 4.5 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.5 6.0 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.5 5.1 GO:0046684 response to pyrethroid(GO:0046684)
0.5 16.4 GO:0015701 bicarbonate transport(GO:0015701)
0.5 1.9 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.5 2.3 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.5 1.8 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.4 1.8 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.4 17.0 GO:0001953 negative regulation of cell-matrix adhesion(GO:0001953)
0.4 1.3 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.4 1.8 GO:0002933 lipid hydroxylation(GO:0002933) alkaloid catabolic process(GO:0009822)
0.4 0.9 GO:0060769 embryonic skeletal limb joint morphogenesis(GO:0036023) positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769)
0.4 4.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.4 1.2 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.4 4.7 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.4 1.9 GO:0060327 cytoplasmic actin-based contraction involved in cell motility(GO:0060327)
0.4 13.9 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.4 3.3 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.4 2.9 GO:0042447 hormone catabolic process(GO:0042447)
0.4 9.4 GO:0010842 retina layer formation(GO:0010842)
0.4 0.7 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.3 6.1 GO:0031643 positive regulation of myelination(GO:0031643)
0.3 1.7 GO:0071692 protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
0.3 3.0 GO:0009642 response to light intensity(GO:0009642)
0.3 3.0 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.3 2.5 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.3 2.4 GO:0006776 vitamin A metabolic process(GO:0006776)
0.3 3.8 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.3 3.4 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.3 1.9 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.3 3.5 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.2 4.0 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.2 5.8 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 0.5 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.2 4.2 GO:0007602 phototransduction(GO:0007602)
0.2 0.9 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.2 3.0 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 0.7 GO:0016203 muscle attachment(GO:0016203) olfactory nerve morphogenesis(GO:0021627) olfactory nerve structural organization(GO:0021629)
0.2 1.3 GO:0051660 establishment of centrosome localization(GO:0051660)
0.2 3.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 5.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.2 2.7 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.2 13.4 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.2 7.4 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.2 1.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.2 4.2 GO:0097062 dendritic spine maintenance(GO:0097062)
0.2 22.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 4.2 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.2 0.5 GO:0002397 MHC class I protein complex assembly(GO:0002397)
0.2 1.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.2 0.5 GO:0070212 protein poly-ADP-ribosylation(GO:0070212) regulation of telomeric DNA binding(GO:1904742)
0.1 3.1 GO:0043586 tongue development(GO:0043586)
0.1 1.4 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 2.2 GO:0099612 protein localization to axon(GO:0099612)
0.1 0.4 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) protein K33-linked deubiquitination(GO:1990168)
0.1 1.7 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 3.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 6.6 GO:0032570 response to progesterone(GO:0032570)
0.1 1.1 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.1 1.8 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.1 1.4 GO:0048733 sebaceous gland development(GO:0048733)
0.1 0.4 GO:0060023 soft palate development(GO:0060023)
0.1 3.7 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 2.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 12.9 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.1 0.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 5.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 14.0 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.1 2.5 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 5.7 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 0.6 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 1.8 GO:0042036 negative regulation of cytokine biosynthetic process(GO:0042036)
0.1 2.1 GO:0003254 regulation of membrane depolarization(GO:0003254)
0.1 2.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 2.7 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.1 1.1 GO:0046599 regulation of centriole replication(GO:0046599)
0.1 0.8 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 1.4 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.1 1.3 GO:0097503 sialylation(GO:0097503)
0.1 0.3 GO:0030397 membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.1 30.7 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 4.2 GO:0035690 cellular response to drug(GO:0035690)
0.1 3.8 GO:0046849 bone remodeling(GO:0046849)
0.1 0.5 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.9 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.0 0.9 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 1.2 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 4.6 GO:0006941 striated muscle contraction(GO:0006941)
0.0 1.1 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 1.8 GO:0042220 response to cocaine(GO:0042220)
0.0 0.6 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.8 GO:0042753 negative regulation of NF-kappaB import into nucleus(GO:0042347) positive regulation of circadian rhythm(GO:0042753)
0.0 0.3 GO:0060539 diaphragm development(GO:0060539)
0.0 1.8 GO:0014909 smooth muscle cell migration(GO:0014909)
0.0 1.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 3.2 GO:0006665 sphingolipid metabolic process(GO:0006665)
0.0 0.3 GO:0042048 olfactory behavior(GO:0042048)
0.0 1.0 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.4 GO:1901099 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 4.4 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 1.7 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.9 GO:0048278 vesicle docking(GO:0048278)
0.0 5.8 GO:0006397 mRNA processing(GO:0006397)
0.0 2.0 GO:0051168 nuclear export(GO:0051168)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 15.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
1.6 4.9 GO:0045203 intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203)
1.5 12.3 GO:0032584 growth cone membrane(GO:0032584)
1.1 5.4 GO:0005927 muscle tendon junction(GO:0005927)
0.9 2.6 GO:1990032 parallel fiber(GO:1990032)
0.8 2.5 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.8 4.8 GO:0033093 Weibel-Palade body(GO:0033093)
0.6 3.2 GO:0071953 elastic fiber(GO:0071953)
0.5 2.7 GO:0061689 tricellular tight junction(GO:0061689)
0.5 1.9 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.4 1.8 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.4 2.2 GO:1990769 proximal neuron projection(GO:1990769)
0.4 2.5 GO:0016012 sarcoglycan complex(GO:0016012)
0.3 6.0 GO:0005916 fascia adherens(GO:0005916)
0.3 2.5 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.3 0.9 GO:0014801 longitudinal sarcoplasmic reticulum(GO:0014801)
0.3 4.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 1.9 GO:0090543 Flemming body(GO:0090543)
0.3 0.8 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.3 8.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 4.0 GO:0031045 dense core granule(GO:0031045)
0.3 7.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 5.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.3 9.9 GO:0060077 inhibitory synapse(GO:0060077)
0.3 17.1 GO:0016459 myosin complex(GO:0016459)
0.2 11.8 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 7.6 GO:0046930 pore complex(GO:0046930)
0.2 1.4 GO:0071438 invadopodium membrane(GO:0071438)
0.2 1.8 GO:0042788 polysomal ribosome(GO:0042788)
0.2 8.1 GO:0044295 axonal growth cone(GO:0044295)
0.2 1.3 GO:0016272 prefoldin complex(GO:0016272)
0.2 2.3 GO:0070852 cell body fiber(GO:0070852)
0.2 1.8 GO:0071437 invadopodium(GO:0071437)
0.2 1.7 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 5.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 3.9 GO:0000421 autophagosome membrane(GO:0000421)
0.1 6.3 GO:0016235 aggresome(GO:0016235)
0.1 0.4 GO:0005592 collagen type XI trimer(GO:0005592)
0.1 5.3 GO:0043034 costamere(GO:0043034)
0.1 13.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.5 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.1 0.6 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 4.4 GO:0008180 COP9 signalosome(GO:0008180)
0.1 16.7 GO:0001650 fibrillar center(GO:0001650)
0.1 1.3 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 9.4 GO:0031526 brush border membrane(GO:0031526)
0.1 7.0 GO:0031594 neuromuscular junction(GO:0031594)
0.1 8.7 GO:0042734 presynaptic membrane(GO:0042734)
0.1 2.8 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 1.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 6.3 GO:0030175 filopodium(GO:0030175)
0.1 3.7 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.2 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 3.4 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.1 0.9 GO:0005675 holo TFIIH complex(GO:0005675)
0.1 5.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 2.8 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 7.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 4.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 2.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 16.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.9 GO:0060170 ciliary membrane(GO:0060170)
0.0 5.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 2.3 GO:0030427 site of polarized growth(GO:0030427)
0.0 0.5 GO:0030008 TRAPP complex(GO:0030008)
0.0 20.2 GO:0043025 neuronal cell body(GO:0043025)
0.0 4.8 GO:0043296 apical junction complex(GO:0043296)
0.0 29.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 5.6 GO:0030425 dendrite(GO:0030425)
0.0 0.9 GO:0031201 SNARE complex(GO:0031201)
0.0 0.3 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 3.0 GO:0030027 lamellipodium(GO:0030027)
0.0 1.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 4.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 3.8 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.1 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.4 GO:0071565 nBAF complex(GO:0071565)
0.0 0.3 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 8.3 GO:0016607 nuclear speck(GO:0016607)
0.0 1.4 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 7.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.1 GO:0031514 motile cilium(GO:0031514)
0.0 1.8 GO:0072562 blood microparticle(GO:0072562)
0.0 2.2 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.1 GO:0005814 centriole(GO:0005814)
0.0 1.7 GO:0005770 late endosome(GO:0005770)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 11.9 GO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding(GO:0071886)
2.8 11.3 GO:0035727 lysophosphatidic acid binding(GO:0035727)
2.2 8.7 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
1.9 9.4 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
1.5 4.6 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
1.4 4.1 GO:0031714 C5a anaphylatoxin chemotactic receptor binding(GO:0031714)
1.4 10.9 GO:0030368 interleukin-17 receptor activity(GO:0030368)
1.3 5.2 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
1.3 16.3 GO:0030215 semaphorin receptor binding(GO:0030215)
1.2 8.6 GO:0005173 stem cell factor receptor binding(GO:0005173)
1.2 3.7 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.0 6.0 GO:0031013 troponin I binding(GO:0031013)
1.0 3.9 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
1.0 4.9 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.9 4.6 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.7 4.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.6 6.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.6 1.9 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.6 3.0 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.6 3.0 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.6 5.1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.6 1.7 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.5 3.2 GO:0017040 ceramidase activity(GO:0017040)
0.5 7.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.5 4.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.5 3.0 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.5 2.0 GO:0008940 nitrate reductase activity(GO:0008940)
0.5 7.9 GO:0005542 folic acid binding(GO:0005542)
0.5 6.8 GO:0015250 water channel activity(GO:0015250)
0.5 1.9 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.5 2.4 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.5 2.3 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.5 12.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.4 1.8 GO:0019002 GMP binding(GO:0019002)
0.4 2.6 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.4 11.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 2.5 GO:0070728 leucine binding(GO:0070728)
0.4 2.0 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.4 1.8 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.3 1.7 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.3 1.4 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.3 2.7 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.3 5.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 1.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.3 8.5 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.3 2.5 GO:0043495 protein anchor(GO:0043495)
0.3 6.9 GO:0042056 chemoattractant activity(GO:0042056)
0.3 3.9 GO:0005523 tropomyosin binding(GO:0005523)
0.2 3.0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 7.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 3.0 GO:0050811 GABA receptor binding(GO:0050811)
0.2 2.3 GO:0003680 AT DNA binding(GO:0003680)
0.2 5.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 5.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 2.8 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.2 4.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.2 1.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 3.9 GO:0004697 protein kinase C activity(GO:0004697)
0.2 4.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.2 13.6 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.2 1.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.2 5.1 GO:0031402 sodium ion binding(GO:0031402)
0.2 5.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.2 2.4 GO:0019841 retinol binding(GO:0019841)
0.2 3.5 GO:0015643 toxic substance binding(GO:0015643)
0.2 5.9 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.2 0.9 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.2 21.1 GO:0005178 integrin binding(GO:0005178)
0.2 7.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 1.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.2 2.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.2 0.5 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.2 3.4 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.2 4.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 3.6 GO:0017091 AU-rich element binding(GO:0017091)
0.1 1.9 GO:0048185 activin binding(GO:0048185)
0.1 1.9 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 4.4 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 0.9 GO:0000405 bubble DNA binding(GO:0000405)
0.1 4.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 34.2 GO:0030695 GTPase regulator activity(GO:0030695)
0.1 12.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.0 GO:0002162 dystroglycan binding(GO:0002162)
0.1 9.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 2.4 GO:0019825 oxygen binding(GO:0019825)
0.1 2.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.8 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 8.9 GO:0005262 calcium channel activity(GO:0005262)
0.1 1.3 GO:0005123 death receptor binding(GO:0005123)
0.1 0.7 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 1.8 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 6.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 3.6 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 39.5 GO:0005509 calcium ion binding(GO:0005509)
0.1 7.5 GO:0003774 motor activity(GO:0003774)
0.1 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 5.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.9 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 1.8 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 4.5 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 4.0 GO:0051015 actin filament binding(GO:0051015)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 1.0 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.6 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 2.2 GO:0044325 ion channel binding(GO:0044325)
0.0 0.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 1.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.9 GO:0003924 GTPase activity(GO:0003924)
0.0 0.1 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 2.0 GO:0015631 tubulin binding(GO:0015631)
0.0 0.7 GO:0043130 ubiquitin binding(GO:0043130)
0.0 2.9 GO:0031625 ubiquitin protein ligase binding(GO:0031625)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 13.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.4 18.6 NABA COLLAGENS Genes encoding collagen proteins
0.3 13.0 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.3 12.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.3 3.9 PID IGF1 PATHWAY IGF1 pathway
0.3 19.6 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.3 14.4 PID NCADHERIN PATHWAY N-cadherin signaling events
0.3 6.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.2 6.7 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.2 8.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 2.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.2 7.1 PID ILK PATHWAY Integrin-linked kinase signaling
0.2 2.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 4.6 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 7.1 PID LKB1 PATHWAY LKB1 signaling events
0.1 5.8 PID FGF PATHWAY FGF signaling pathway
0.1 4.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 1.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 4.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 3.2 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.7 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 3.4 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 4.9 PID BMP PATHWAY BMP receptor signaling
0.1 2.6 PID RAS PATHWAY Regulation of Ras family activation
0.1 0.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 13.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 0.7 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 2.4 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 1.1 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 0.6 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.1 3.6 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.1 3.0 PID TNF PATHWAY TNF receptor signaling pathway
0.1 2.3 PID CDC42 PATHWAY CDC42 signaling events
0.1 1.9 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.8 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 2.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 16.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.9 11.9 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.6 6.8 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.5 13.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.5 4.8 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.4 5.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.4 8.3 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.3 9.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.3 18.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.3 2.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.2 9.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 5.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 5.1 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.2 5.8 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.2 2.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 2.0 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.2 2.6 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 2.8 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 3.8 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.1 2.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 4.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 1.9 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 4.2 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.1 1.9 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 3.0 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 1.0 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 3.2 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 4.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 1.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 5.8 REACTOME SIGNALING BY FGFR Genes involved in Signaling by FGFR
0.1 3.6 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.9 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 3.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.9 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 1.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.3 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 3.0 REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES Genes involved in Transmission across Chemical Synapses
0.0 1.1 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters