ISMARA results: Hoxb13

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hoxb13

Z-value: 1.00

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Transcription factors associated with Hoxb13

Gene Symbol	Gene ID	Gene Info
Hoxb13 NCBI RGD Ensembl	ENSRNOG00000007491	homeo box B13

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hoxb13	rn6_v1_chr10_+_84031955_84031955	0.04	4.7e-01	Click!

Activity profile of Hoxb13 motif

Sorted Z-values of Hoxb13 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_223029559 Show fit	37.85	ENSRNOT00000045584	AABR07013111.1 NCBI RGD Ensembl Show fit
chr1_-_76780230 Show fit	30.99	ENSRNOT00000002046	LOC100912485 NCBI RGD Ensembl Show fit	alcohol sulfotransferase-like
chr1_-_76614279 Show fit	27.59	ENSRNOT00000041367 ENSRNOT00000089371	LOC100912485 NCBI RGD Ensembl Show fit	alcohol sulfotransferase-like
chr13_-_56693968 Show fit	26.64	ENSRNOT00000060160	AABR07021096.1 NCBI RGD Ensembl Show fit
chr6_-_77848434 Show fit	25.81	ENSRNOT00000034342	Slc25a21 NCBI RGD Ensembl Show fit	solute carrier family 25 member 21
chr19_-_37916813 Show fit	23.66	ENSRNOT00000026585	Lcat NCBI RGD Ensembl Show fit	lecithin cholesterol acyltransferase
chr9_-_4327679 Show fit	23.23	ENSRNOT00000073468	LOC100910235 NCBI RGD Ensembl Show fit	sulfotransferase 1C1-like
chr1_-_170431073 Show fit	22.65	ENSRNOT00000024710	Hpx NCBI RGD Ensembl Show fit	hemopexin
chr11_-_81639872 Show fit	21.57	ENSRNOT00000047595 ENSRNOT00000090031 ENSRNOT00000081864	Hrg NCBI RGD Ensembl Show fit	histidine-rich glycoprotein
chr1_-_76517134 Show fit	21.19	ENSRNOT00000064593 ENSRNOT00000085775	LOC100912485 NCBI RGD Ensembl Show fit	alcohol sulfotransferase-like

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb13

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	54.8	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
5.8	34.6	GO:0034757	negative regulation of iron ion transport(GO:0034757)
8.4	33.7	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
1.6	33.0	GO:0035404	histone-serine phosphorylation(GO:0035404)
3.3	32.8	GO:0034370	triglyceride-rich lipoprotein particle remodeling(GO:0034370) very-low-density lipoprotein particle remodeling(GO:0034372)
1.1	29.7	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
3.0	26.8	GO:0035092	sperm chromatin condensation(GO:0035092)
2.5	25.0	GO:0070327	thyroid hormone transport(GO:0070327)
0.4	24.9	GO:0032094	response to food(GO:0032094)
2.4	24.2	GO:0070989	oxidative demethylation(GO:0070989)

Showing 1 to 10 of 451 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	135.3	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.6	67.1	GO:0072562	blood microparticle(GO:0072562)
0.7	64.7	GO:0000786	nucleosome(GO:0000786)
0.3	37.8	GO:0001669	acrosomal vesicle(GO:0001669)
1.8	33.0	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
1.3	31.0	GO:0034364	high-density lipoprotein particle(GO:0034364)
4.3	30.4	GO:0005579	membrane attack complex(GO:0005579)
2.6	25.6	GO:0045179	apical cortex(GO:0045179)
0.2	25.4	GO:0005814	centriole(GO:0005814)
3.5	21.0	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)

Showing 1 to 10 of 171 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	107.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.4	98.0	GO:0004252	serine-type endopeptidase activity(GO:0004252)
2.8	79.2	GO:0008395	steroid hydroxylase activity(GO:0008395)
2.0	62.3	GO:0015020	glucuronosyltransferase activity(GO:0015020)
2.2	33.0	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
1.7	31.4	GO:0001848	complement binding(GO:0001848)
4.4	31.0	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.8	27.3	GO:0005310	dicarboxylic acid transmembrane transporter activity(GO:0005310)
8.7	26.2	GO:0004769	steroid delta-isomerase activity(GO:0004769)
1.9	25.9	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)

Showing 1 to 10 of 296 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	49.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.7	33.6	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.4	17.3	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.6	16.0	PID IL27 PATHWAY	IL27-mediated signaling events
0.3	14.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	10.4	PID BCR 5PATHWAY	BCR signaling pathway
0.6	9.5	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.2	7.9	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.1	7.0	PID FANCONI PATHWAY	Fanconi anemia pathway
0.2	6.2	PID IL6 7 PATHWAY	IL6-mediated signaling events

Showing 1 to 10 of 40 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	70.1	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
1.8	64.6	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
2.2	39.6	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
1.1	28.3	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.4	28.0	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
2.2	26.1	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.9	26.0	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
1.3	25.3	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
2.5	22.8	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.2	22.4	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression

Showing 1 to 10 of 89 entries

Results for Hoxb13

Z-value: 1.00

Motif logo

Transcription factors associated with Hoxb13

Activity-expression correlation:

Activity profile of Hoxb13 motif

Sorted Z-values of Hoxb13 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb13

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: