Project

GSE53960: rat RNA-Seq transcriptomic Bodymap

Navigation
Downloads

Results for Hoxb1

Z-value: 0.57

Motif logo

logo of

Transcription factors associated with Hoxb1

Gene Symbol Gene ID Gene Info
Hoxb1
ENSRNOG00000008506 homeo box B1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxb1rn6_v1_chr10_+_84214358_842143580.035.4e-01Click!

Activity profile of Hoxb1 motif

Sorted Z-values of Hoxb1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_8498422 21.94 ENSRNOT00000082332
Rbfox1
RNA binding protein, fox-1 homolog 1
chr3_+_51883559 20.81 ENSRNOT00000007197
Csrnp3
cysteine and serine rich nuclear protein 3
chr10_+_86340940 20.47 ENSRNOT00000073486
Pnmt
phenylethanolamine-N-methyltransferase
chr7_-_29171783 19.90 ENSRNOT00000079235
Mybpc1
myosin binding protein C, slow type
chr10_-_85974644 18.69 ENSRNOT00000006098
ENSRNOT00000082974
Cacnb1
calcium voltage-gated channel auxiliary subunit beta 1
chr1_-_215838209 18.66 ENSRNOT00000050760
Igf2
insulin-like growth factor 2
chr1_+_25173242 18.33 ENSRNOT00000016518
Clvs2
clavesin 2
chr5_-_109651730 15.85 ENSRNOT00000093032
Elavl2
ELAV like RNA binding protein 2
chr10_+_5930298 15.54 ENSRNOT00000044626
Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
chr18_+_61563053 14.41 ENSRNOT00000022845
Grp
gastrin releasing peptide
chr6_+_58468155 14.16 ENSRNOT00000091263
Etv1
ets variant 1
chr5_+_124021366 13.97 ENSRNOT00000009977
Dab1
DAB1, reelin adaptor protein
chr16_+_46731403 12.16 ENSRNOT00000017624
Tenm3
teneurin transmembrane protein 3
chr1_-_260992291 11.96 ENSRNOT00000035415
ENSRNOT00000034758
Slit1
slit guidance ligand 1
chr4_-_155275161 10.68 ENSRNOT00000032690
Rimklb
ribosomal modification protein rimK-like family member B
chr10_-_25910298 10.54 ENSRNOT00000065633
ENSRNOT00000079646
Ccng1
cyclin G1
chr5_-_12526962 10.27 ENSRNOT00000092104
St18
suppression of tumorigenicity 18
chr15_-_33285779 9.03 ENSRNOT00000036150
Cdh24
cadherin 24
chrX_+_82143789 8.56 ENSRNOT00000003724
Pou3f4
POU class 3 homeobox 4
chr6_+_26387877 7.54 ENSRNOT00000076105
Fndc4

chr19_-_43290363 7.52 ENSRNOT00000024248
St3gal2
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
chr3_-_23020441 7.35 ENSRNOT00000017651
Nr5a1
nuclear receptor subfamily 5, group A, member 1
chr19_-_37427989 6.90 ENSRNOT00000022863
Tppp3
tubulin polymerization-promoting protein family member 3
chr1_+_17602281 5.96 ENSRNOT00000075461
LOC103690149
jouberin-like
chr1_-_141470380 5.79 ENSRNOT00000065759
Plin1
perilipin 1
chr13_+_71107465 5.46 ENSRNOT00000003239
Rgs8
regulator of G-protein signaling 8
chr7_+_124680294 4.98 ENSRNOT00000014720
Mpped1
metallophosphoesterase domain containing 1
chr19_-_24614019 4.60 ENSRNOT00000005124
Scoc
short coiled-coil protein
chr3_+_116899878 4.07 ENSRNOT00000090802
ENSRNOT00000066101
Sema6d
semaphorin 6D
chr7_+_27089278 3.59 ENSRNOT00000082398
Nfyb
nuclear transcription factor Y subunit beta
chr8_+_13796021 3.11 ENSRNOT00000013927
Vstm5
V-set and transmembrane domain containing 5
chr16_-_74864816 2.48 ENSRNOT00000017164
Alg11
ALG11, alpha-1,2-mannosyltransferase
chr6_+_29061618 1.97 ENSRNOT00000092223
Atad2b
ATPase family, AAA domain containing 2B
chr8_-_82339937 1.82 ENSRNOT00000080797
Mapk6
mitogen-activated protein kinase 6
chr16_-_71203609 1.78 ENSRNOT00000088458
Nsd3
nuclear receptor binding SET domain protein 3
chr1_+_40816107 1.59 ENSRNOT00000060767
Akap12
A-kinase anchoring protein 12
chr10_-_63499390 1.56 ENSRNOT00000032934
Bhlha9
basic helix-loop-helix family, member a9
chr6_+_102392828 1.54 ENSRNOT00000089162
Rdh12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr2_-_184993341 1.46 ENSRNOT00000071580
Fam160a1
family with sequence similarity 160, member A1
chr11_-_38457373 1.35 ENSRNOT00000041177
Zfp295
zinc finger protein 295
chr1_+_229443102 0.93 ENSRNOT00000067320
Olr334
olfactory receptor 334
chr14_+_3506339 0.84 ENSRNOT00000002867
Tgfbr3
transforming growth factor beta receptor 3
chr12_-_22748860 0.73 ENSRNOT00000001923
Cldn15
claudin 15
chr15_-_8914501 0.46 ENSRNOT00000008752
Thrb
thyroid hormone receptor beta
chr1_-_169973241 0.35 ENSRNOT00000023315
Olr191-ps
olfactory receptor pseudogene 191
chr6_+_8218696 0.16 ENSRNOT00000083470
Ppm1b
protein phosphatase, Mg2+/Mn2+ dependent, 1B
chr3_+_141225290 0.10 ENSRNOT00000016351
Xrn2
5'-3' exoribonuclease 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.5 GO:0033058 directional locomotion(GO:0033058)
4.7 14.0 GO:0021812 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
3.4 20.5 GO:0042414 epinephrine metabolic process(GO:0042414)
3.0 12.0 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
2.7 18.7 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
2.0 19.9 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
1.8 7.3 GO:2000195 negative regulation of female gonad development(GO:2000195)
1.2 14.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.1 12.2 GO:0097264 self proteolysis(GO:0097264)
1.0 21.9 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.6 8.6 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.5 4.6 GO:0061635 regulation of protein complex stability(GO:0061635)
0.4 18.7 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.4 5.5 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.4 10.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095) G2 DNA damage checkpoint(GO:0031572)
0.3 7.5 GO:0097503 sialylation(GO:0097503)
0.3 18.3 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.3 0.8 GO:1902338 transforming growth factor beta receptor complex assembly(GO:0007181) cardiac fibroblast cell differentiation(GO:0060935) cardiac fibroblast cell development(GO:0060936) epicardium-derived cardiac fibroblast cell differentiation(GO:0060938) epicardium-derived cardiac fibroblast cell development(GO:0060939) negative regulation of apoptotic process involved in morphogenesis(GO:1902338) negative regulation of apoptotic process involved in development(GO:1904746)
0.2 20.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 2.5 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.2 2.0 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.2 1.6 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 5.8 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 4.1 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 14.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 6.9 GO:0046785 microtubule polymerization(GO:0046785)
0.1 0.5 GO:0007621 negative regulation of female receptivity(GO:0007621) female courtship behavior(GO:0008050)
0.1 9.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.5 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.2 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.0 1.8 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 1.8 GO:0034968 histone lysine methylation(GO:0034968)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 19.9 GO:0005859 muscle myosin complex(GO:0005859)
1.3 15.5 GO:0098839 postsynaptic density membrane(GO:0098839)
1.0 20.5 GO:0043196 varicosity(GO:0043196)
0.5 3.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.4 18.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 0.8 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.2 18.3 GO:0031901 early endosome membrane(GO:0031901)
0.2 7.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 5.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.8 GO:0032156 septin cytoskeleton(GO:0032156)
0.1 14.0 GO:0005903 brush border(GO:0005903)
0.1 5.8 GO:0005811 lipid particle(GO:0005811)
0.1 14.5 GO:0005802 trans-Golgi network(GO:0005802)
0.1 7.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 32.1 GO:0005615 extracellular space(GO:0005615)
0.0 10.5 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 6.9 GO:0005874 microtubule(GO:0005874)
0.0 0.7 GO:0016328 lateral plasma membrane(GO:0016328)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.7 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
1.9 7.5 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
1.7 12.0 GO:0048495 Roundabout binding(GO:0048495)
1.6 15.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.5 19.9 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
1.0 18.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.9 8.6 GO:0003680 AT DNA binding(GO:0003680)
0.8 18.7 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.8 2.5 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.8 18.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.7 9.0 GO:0045294 alpha-catenin binding(GO:0045294) delta-catenin binding(GO:0070097)
0.5 14.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.3 4.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 14.0 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.3 1.8 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.2 20.5 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 5.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 7.8 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 1.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 21.9 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 0.8 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.1 1.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.5 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 1.8 GO:0004707 MAP kinase activity(GO:0004707)
0.1 3.6 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 13.1 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 13.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 6.9 GO:0015631 tubulin binding(GO:0015631)
0.0 10.5 GO:0019904 protein domain specific binding(GO:0019904)
0.0 7.4 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 14.9 GO:0003723 RNA binding(GO:0003723)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 29.5 PID REELIN PATHWAY Reelin signaling pathway
0.5 14.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.4 30.6 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 10.5 PID P53 REGULATION PATHWAY p53 pathway
0.1 1.5 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 3.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 4.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 20.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.9 18.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.9 15.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.7 14.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.5 19.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.5 7.5 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.4 5.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.4 16.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.3 9.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.3 3.6 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 4.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.2 12.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 7.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 5.5 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events