ISMARA results: Hoxa9

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hoxa9_Hoxb9

Z-value: 0.81

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Transcription factors associated with Hoxa9_Hoxb9

Gene Symbol	Gene ID	Gene Info
Hoxa9 NCBI RGD Ensembl	ENSRNOG00000048146	homeobox A9
Hoxb9 NCBI RGD Ensembl	ENSRNOG00000007573	homeo box B9

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hoxa9	rn6_v1_chr4_-_82280722_82280722	0.57	2.1e-29	Click!
Hoxb9	rn6_v1_chr10_+_84119884_84119884	0.43	1.3e-15	Click!

Activity profile of Hoxa9_Hoxb9 motif

Sorted Z-values of Hoxa9_Hoxb9 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_+_20048121 Show fit	59.66	ENSRNOT00000014791	Mep1a NCBI RGD Ensembl Show fit	meprin 1 subunit alpha
chr5_-_64818813 Show fit	55.45	ENSRNOT00000009111 ENSRNOT00000086505	Aldob NCBI RGD Ensembl Show fit	aldolase, fructose-bisphosphate B
chr3_+_159902441 Show fit	40.10	ENSRNOT00000089893 ENSRNOT00000011978	Hnf4a NCBI RGD Ensembl Show fit	hepatocyte nuclear factor 4, alpha
chr4_-_51199570 Show fit	37.06	ENSRNOT00000010788	Slc13a1 NCBI RGD Ensembl Show fit	solute carrier family 13 member 1
chrX_+_110789269 Show fit	34.11	ENSRNOT00000086014	Rnf128 NCBI RGD Ensembl Show fit	ring finger protein 128, E3 ubiquitin protein ligase
chr14_-_20920286 Show fit	33.36	ENSRNOT00000004391	Slc4a4 NCBI RGD Ensembl Show fit	solute carrier family 4 member 4
chr13_+_44424689 Show fit	28.26	ENSRNOT00000005206	Acmsd NCBI RGD Ensembl Show fit	aminocarboxymuconate semialdehyde decarboxylase
chr5_-_147784311 Show fit	20.95	ENSRNOT00000074172	Fam167b NCBI RGD Ensembl Show fit	family with sequence similarity 167, member B
chr4_+_68849033 Show fit	18.98	ENSRNOT00000016912	Mgam NCBI RGD Ensembl Show fit	maltase-glucoamylase
chr3_+_140024043 Show fit	17.70	ENSRNOT00000086409	Rin2 NCBI RGD Ensembl Show fit	Ras and Rab interactor 2

Showing 1 to 10 of 193 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa9_Hoxb9

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
18.5	55.4	GO:0006116	NADH oxidation(GO:0006116)
10.0	40.1	GO:1902569	regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
2.2	37.1	GO:1902358	sulfate transmembrane transport(GO:1902358)
1.2	34.1	GO:0042036	negative regulation of cytokine biosynthetic process(GO:0042036)
1.8	33.4	GO:0015701	bicarbonate transport(GO:0015701)
0.0	28.8	GO:0006508	proteolysis(GO:0006508)
4.7	28.3	GO:0046874	quinolinate metabolic process(GO:0046874)
0.2	16.1	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0	15.3	GO:0019221	cytokine-mediated signaling pathway(GO:0019221)
2.8	13.9	GO:0060014	granulosa cell differentiation(GO:0060014)

Showing 1 to 10 of 95 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	94.0	GO:0005887	integral component of plasma membrane(GO:0005887)
11.1	55.4	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1	35.5	GO:0016323	basolateral plasma membrane(GO:0016323)
0.2	33.5	GO:0005770	late endosome(GO:0005770)
0.1	33.5	GO:0005667	transcription factor complex(GO:0005667)
0.0	30.9	GO:0070062	extracellular exosome(GO:0070062)
0.0	28.2	GO:0098796	membrane protein complex(GO:0098796)
0.2	16.4	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
1.0	14.1	GO:0012510	trans-Golgi network transport vesicle membrane(GO:0012510)
0.0	13.6	GO:0005759	mitochondrial matrix(GO:0005759)

Showing 1 to 10 of 66 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	61.0	GO:0004222	metalloendopeptidase activity(GO:0004222)
7.9	55.4	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
3.3	40.1	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
2.3	37.1	GO:0008271	secondary active sulfate transmembrane transporter activity(GO:0008271)
0.1	34.8	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
5.6	33.4	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.6	28.3	GO:0016831	carboxy-lyase activity(GO:0016831)
4.7	19.0	GO:0016160	amylase activity(GO:0016160)
0.1	16.9	GO:0003924	GTPase activity(GO:0003924)
0.3	16.1	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)

Showing 1 to 10 of 82 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	95.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.3	59.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6	34.1	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3	19.5	PID FGF PATHWAY	FGF signaling pathway
0.3	17.7	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	14.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.2	12.8	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	8.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	5.5	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	5.1	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	55.4	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
1.5	40.1	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
2.6	37.1	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
3.1	28.3	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.2	24.3	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
3.2	19.0	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.1	15.8	REACTOME SIGNALING BY FGFR	Genes involved in Signaling by FGFR
0.8	14.1	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.9	12.8	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.2	8.0	REACTOME MYOGENESIS	Genes involved in Myogenesis

Showing 1 to 10 of 30 entries

Results for Hoxa9_Hoxb9

Z-value: 0.81

Motif logo

Transcription factors associated with Hoxa9_Hoxb9

Activity-expression correlation:

Activity profile of Hoxa9_Hoxb9 motif

Sorted Z-values of Hoxa9_Hoxb9 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa9_Hoxb9

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: