ISMARA results: Hoxa2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hoxa2

Z-value: 1.45

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Transcription factors associated with Hoxa2

Gene Symbol	Gene ID	Gene Info

Activity profile of Hoxa2 motif

Sorted Z-values of Hoxa2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_+_3293599 Show fit	81.87	ENSRNOT00000081999 ENSRNOT00000047118 ENSRNOT00000020427	Erc2 NCBI RGD Ensembl Show fit	ELKS/RAB6-interacting/CAST family member 2
chr3_-_45169118 Show fit	37.24	ENSRNOT00000086371	Ccdc148 NCBI RGD Ensembl Show fit	coiled-coil domain containing 148
chr10_-_96131880 Show fit	37.01	ENSRNOT00000004578	Cacng5 NCBI RGD Ensembl Show fit	calcium voltage-gated channel auxiliary subunit gamma 5
chr6_+_132242328 Show fit	36.94	ENSRNOT00000081088	Cyp46a1 NCBI RGD Ensembl Show fit	cytochrome P450, family 46, subfamily a, polypeptide 1
chr3_+_159368273 Show fit	36.67	ENSRNOT00000041688	Sgk2 NCBI RGD Ensembl Show fit	serum/glucocorticoid regulated kinase 2
chr9_-_89193821 Show fit	36.59	ENSRNOT00000090881	Sphkap NCBI RGD Ensembl Show fit	SPHK1 interactor, AKAP domain containing
chr16_-_7007051 Show fit	32.80	ENSRNOT00000023984	Itih3 NCBI RGD Ensembl Show fit	inter-alpha trypsin inhibitor, heavy chain 3
chr2_+_228544418 Show fit	32.62	ENSRNOT00000013030	Tram1l1 NCBI RGD Ensembl Show fit	translocation associated membrane protein 1-like 1
chr11_+_80358211 Show fit	32.46	ENSRNOT00000002519	Sst NCBI RGD Ensembl Show fit	somatostatin
chr4_-_184096806 Show fit	30.77	ENSRNOT00000055433	LOC100362344 NCBI RGD Ensembl Show fit	mKIAA1238 protein-like

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	235.7	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.6	101.7	GO:0007416	synapse assembly(GO:0007416)
1.9	61.7	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
2.0	46.3	GO:0035435	phosphate ion transmembrane transport(GO:0035435)
2.4	43.4	GO:0090129	positive regulation of synapse maturation(GO:0090129)
2.5	39.6	GO:0051923	sulfation(GO:0051923)
0.4	38.9	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.9	37.0	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
2.6	36.9	GO:0016127	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.2	34.7	GO:0007411	axon guidance(GO:0007411)

Showing 1 to 10 of 280 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	258.3	GO:0016021	integral component of membrane(GO:0016021)
2.0	110.5	GO:0048786	presynaptic active zone(GO:0048786)
0.1	93.9	GO:0005739	mitochondrion(GO:0005739)
2.7	69.6	GO:0043194	axon initial segment(GO:0043194)
0.2	62.7	GO:0098793	presynapse(GO:0098793)
0.1	55.6	GO:0043025	neuronal cell body(GO:0043025)
0.2	41.3	GO:0030424	axon(GO:0030424)
1.2	37.0	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.6	34.0	GO:0016328	lateral plasma membrane(GO:0016328)
0.5	32.8	GO:0031903	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Showing 1 to 10 of 117 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	126.4	GO:0004984	olfactory receptor activity(GO:0004984)
0.3	109.6	GO:0005549	odorant binding(GO:0005549)
0.5	70.1	GO:0030165	PDZ domain binding(GO:0030165)
1.0	61.7	GO:0051018	protein kinase A binding(GO:0051018)
0.4	58.3	GO:0008017	microtubule binding(GO:0008017)
0.5	53.9	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
16.9	50.7	GO:0072590	N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
4.6	46.3	GO:0005436	sodium:phosphate symporter activity(GO:0005436)
1.6	45.4	GO:0015020	glucuronosyltransferase activity(GO:0015020)
8.8	44.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)

Showing 1 to 10 of 216 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	47.5	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.6	33.3	PID BMP PATHWAY	BMP receptor signaling
0.7	26.8	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.4	25.1	PID LKB1 PATHWAY	LKB1 signaling events
0.4	23.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.5	20.1	ST G ALPHA I PATHWAY	G alpha i Pathway
0.3	13.0	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.3	11.6	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.4	11.5	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.1	10.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network

Showing 1 to 10 of 30 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	92.7	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.7	42.0	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation
1.0	40.7	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
3.1	36.9	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.7	34.3	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.7	33.9	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
1.2	26.5	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.2	25.1	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.7	22.4	REACTOME KINESINS	Genes involved in Kinesins
1.3	20.7	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors

Showing 1 to 10 of 81 entries

Results for Hoxa2

Z-value: 1.45

Motif logo

Transcription factors associated with Hoxa2

Activity profile of Hoxa2 motif

Sorted Z-values of Hoxa2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: