ISMARA results: Hoxa10

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hoxa10

Z-value: 0.87

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Transcription factors associated with Hoxa10

Gene Symbol	Gene ID	Gene Info
Hoxa10 NCBI RGD Ensembl	ENSRNOG00000057650	homeobox A10

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hoxa10	rn6_v1_chr4_-_82295470_82295470	-0.38	2.2e-12	Click!

Activity profile of Hoxa10 motif

Sorted Z-values of Hoxa10 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_+_14151343 Show fit	32.06	ENSRNOT00000061687 ENSRNOT00000076573 ENSRNOT00000077219 ENSRNOT00000008319	Cd36 NCBI RGD Ensembl Show fit	CD36 molecule
chr1_-_197821936 Show fit	24.05	ENSRNOT00000055027	Cd19 NCBI RGD Ensembl Show fit	CD19 molecule
chr11_-_54514441 Show fit	23.13	ENSRNOT00000002673	Retnlg NCBI RGD Ensembl Show fit	resistin-like gamma
chr4_+_98370797 Show fit	22.28	ENSRNOT00000031991	AABR07060872.1 NCBI RGD Ensembl Show fit
chr2_+_88217188 Show fit	21.91	ENSRNOT00000014267	Car1 NCBI RGD Ensembl Show fit	carbonic anhydrase I
chr6_-_140880070 Show fit	20.40	ENSRNOT00000073779	LOC691828 NCBI RGD Ensembl Show fit	uncharacterized LOC691828
chr4_+_14071507 Show fit	20.35	ENSRNOT00000066224 ENSRNOT00000075962	Cd36 NCBI RGD Ensembl Show fit RGD1565355 NCBI RGD Ensembl Show fit	CD36 molecule similar to fatty acid translocase/CD36
chr4_+_14213587 Show fit	18.97	ENSRNOT00000067543	LOC103690020 NCBI RGD Ensembl Show fit	platelet glycoprotein 4-like
chr7_+_83373022 Show fit	18.78	ENSRNOT00000057146 ENSRNOT00000005958	Pkhd1l1 NCBI RGD Ensembl Show fit	polycystic kidney and hepatic disease 1-like 1
chr5_-_58198782 Show fit	17.32	ENSRNOT00000023951	Ccl21 NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 21

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa10

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.7	52.4	GO:2000334	blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
8.1	40.4	GO:0002408	myeloid dendritic cell chemotaxis(GO:0002408)
1.7	24.0	GO:0006968	cellular defense response(GO:0006968)
0.6	21.9	GO:0006730	one-carbon metabolic process(GO:0006730)
0.5	18.8	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
4.3	17.0	GO:0002337	B-1a B cell differentiation(GO:0002337)
0.7	15.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.1	13.7	GO:0021987	cerebral cortex development(GO:0021987)
0.9	13.5	GO:0015671	oxygen transport(GO:0015671)
2.2	13.4	GO:1900041	negative regulation of interleukin-2 secretion(GO:1900041)

Showing 1 to 10 of 87 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	56.6	GO:0031526	brush border membrane(GO:0031526)
0.1	41.9	GO:0009897	external side of plasma membrane(GO:0009897)
0.1	19.9	GO:0005667	transcription factor complex(GO:0005667)
0.0	19.0	GO:0005929	cilium(GO:0005929)
1.2	13.5	GO:0005833	hemoglobin complex(GO:0005833)
3.4	13.4	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.0	13.1	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.3	12.2	GO:0008180	COP9 signalosome(GO:0008180)
0.3	11.4	GO:0051233	spindle midzone(GO:0051233)
0.1	10.1	GO:0005884	actin filament(GO:0005884)

Showing 1 to 10 of 45 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.5	52.4	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
0.2	32.4	GO:0005179	hormone activity(GO:0005179)
1.7	21.9	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.1	20.6	GO:0005057	receptor signaling protein activity(GO:0005057)
1.3	18.8	GO:0017154	semaphorin receptor activity(GO:0017154)
4.3	17.0	GO:0001225	RNA polymerase II transcription coactivator binding(GO:0001225)
0.0	16.5	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.4	15.6	GO:0008009	chemokine activity(GO:0008009) CCR chemokine receptor binding(GO:0048020)
0.1	15.0	GO:0030246	carbohydrate binding(GO:0030246)
0.1	14.0	GO:0003823	antigen binding(GO:0003823)

Showing 1 to 10 of 71 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	41.1	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.1	30.5	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	11.1	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.2	10.3	PID BCR 5PATHWAY	BCR signaling pathway
0.2	10.1	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	7.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.7	6.7	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2	6.1	PID IL23 PATHWAY	IL23-mediated signaling events
0.1	4.8	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.1	4.6	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events

Showing 1 to 10 of 22 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	49.1	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
0.7	36.7	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.4	22.6	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.4	19.9	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.3	15.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.3	12.2	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	11.5	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.3	9.6	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1	8.6	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.4	6.7	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21

Showing 1 to 10 of 34 entries

Results for Hoxa10

Z-value: 0.87

Motif logo

Transcription factors associated with Hoxa10

Activity-expression correlation:

Activity profile of Hoxa10 motif

Sorted Z-values of Hoxa10 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa10

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: