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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Hnf4g
Z-value: 2.70
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Transcription factors associated with Hnf4g
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hnf4g | rn6_v1_chr2_-_100372252_100372252 | 0.68 | 3.5e-45 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_123621102 Show fit | 134.30 |
ENSRNOT00000046024
|
cytochrome P450, family 2, subfamily d, polypeptide 5 |
|
| chr16_-_81834945 Show fit | 107.28 |
ENSRNOT00000037806
|
coagulation factor VII |
|
| chr7_-_123655896 Show fit | 101.23 |
ENSRNOT00000012413
|
cytochrome P450, family 2, subfamily d, polypeptide 2 |
|
| chr1_+_21525421 Show fit | 99.12 |
ENSRNOT00000017911
|
arginase 1 |
|
| chr18_-_35071619 Show fit | 94.97 |
ENSRNOT00000075695
|
serine protease inhibitor Kazal-type 3-like |
|
| chr11_-_81660395 Show fit | 94.54 |
ENSRNOT00000048739
|
fetuin B |
|
| chr4_-_30338679 Show fit | 93.70 |
ENSRNOT00000012050
|
paraoxonase 3 |
|
| chr2_-_23256158 Show fit | 89.88 |
ENSRNOT00000015336
|
betaine-homocysteine S-methyltransferase |
|
| chr11_+_65022100 Show fit | 88.05 |
ENSRNOT00000003934
|
nuclear receptor subfamily 1, group I, member 2 |
|
| chr9_+_16314173 Show fit | 87.20 |
ENSRNOT00000072812
|
glycine N-methyltransferase-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hnf4g
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 26.8 | 321.6 | GO:0042738 | exogenous drug catabolic process(GO:0042738) |
| 8.3 | 257.4 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
| 10.9 | 250.8 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 4.7 | 214.2 | GO:0006953 | acute-phase response(GO:0006953) |
| 23.4 | 211.0 | GO:0052697 | xenobiotic glucuronidation(GO:0052697) |
| 0.1 | 191.3 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 11.6 | 186.3 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 19.4 | 174.2 | GO:0015747 | urate transport(GO:0015747) |
| 21.4 | 171.4 | GO:0042904 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 26.4 | 158.4 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 1400.0 | GO:0005615 | extracellular space(GO:0005615) |
| 1.6 | 1114.4 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.4 | 792.0 | GO:0070062 | extracellular exosome(GO:0070062) |
| 4.0 | 425.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.0 | 318.1 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 25.4 | 228.3 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 2.5 | 222.5 | GO:0031526 | brush border membrane(GO:0031526) |
| 10.2 | 203.3 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 2.3 | 189.9 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 2.8 | 183.6 | GO:0044438 | microbody part(GO:0044438) peroxisomal part(GO:0044439) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 20.1 | 823.8 | GO:0070330 | aromatase activity(GO:0070330) |
| 3.3 | 727.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 3.8 | 433.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 7.6 | 235.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 21.9 | 218.5 | GO:1901702 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 25.0 | 200.4 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 6.7 | 193.7 | GO:0016638 | oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) |
| 0.1 | 191.3 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 14.0 | 181.4 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 3.4 | 174.6 | GO:0038024 | cargo receptor activity(GO:0038024) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 497.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 8.0 | 440.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 9.6 | 297.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 2.7 | 129.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 1.4 | 76.5 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 5.1 | 75.8 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.9 | 56.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 1.4 | 50.8 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 1.5 | 49.6 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 2.6 | 46.6 | ST G ALPHA S PATHWAY | G alpha s Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 791.9 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 10.2 | 295.6 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 6.6 | 256.4 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 13.4 | 255.5 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 14.2 | 241.1 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 11.3 | 202.7 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 19.5 | 194.6 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 8.7 | 183.2 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 11.9 | 178.5 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 8.9 | 168.5 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |