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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hnf4a

Z-value: 4.87

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Transcription factors associated with Hnf4a

Gene Symbol Gene ID Gene Info
ENSRNOG00000008895 hepatocyte nuclear factor 4, alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hnf4arn6_v1_chr3_+_159936856_1599368560.944.0e-152Click!

Activity profile of Hnf4a motif

Sorted Z-values of Hnf4a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_60337667 405.58 ENSRNOT00000024035
alanine-glyoxylate aminotransferase 2
chr1_-_80594136 396.22 ENSRNOT00000024800
apolipoprotein C2
chr7_-_123638702 393.99 ENSRNOT00000082473
ENSRNOT00000044470
ENSRNOT00000092017
cytochrome P450, family 2, subfamily d, polypeptide 1
chr4_-_161850875 381.34 ENSRNOT00000009467
pregnancy-zone protein
chr10_+_89285855 346.00 ENSRNOT00000028033
glucose-6-phosphatase, catalytic subunit
chr1_-_259287684 340.66 ENSRNOT00000054724
cytochrome P450, family 2, subfamily c, polypeptide 22
chr13_+_56598957 331.69 ENSRNOT00000016944
ENSRNOT00000080335
ENSRNOT00000089913
coagulation factor XIII B chain
chr1_+_100471066 322.07 ENSRNOT00000067562
aspartate dehydrogenase domain containing
chr10_+_89286047 321.04 ENSRNOT00000085831
glucose-6-phosphatase, catalytic subunit
chr1_+_20856187 314.64 ENSRNOT00000071726
small leucine-rich protein 1
chr2_+_150146234 300.34 ENSRNOT00000018761
arylacetamide deacetylase
chr7_-_123655896 293.96 ENSRNOT00000012413
cytochrome P450, family 2, subfamily d, polypeptide 2
chr10_+_56662561 290.59 ENSRNOT00000025254
asialoglycoprotein receptor 1
chr2_+_188449210 284.43 ENSRNOT00000027700
pyruvate kinase, liver and RBC
chr7_+_11490852 274.94 ENSRNOT00000044484
cAMP responsive element binding protein 3-like 3
chr1_-_258766881 274.34 ENSRNOT00000015801
cytochrome P450, family 2, subfamily c, polypeptide 12
chr1_+_100470722 274.18 ENSRNOT00000086917
aspartate dehydrogenase domain containing
chr1_-_148119857 264.99 ENSRNOT00000040325
Cytochrome P450, family 2, subfamily c, polypeptide 7-like
chr8_-_130550388 261.13 ENSRNOT00000026355
cytochrome P450, family 8, subfamily b, polypeptide 1
chr16_-_81822716 255.87 ENSRNOT00000026677
coagulation factor X
chr2_+_198965685 249.39 ENSRNOT00000000107
ENSRNOT00000091578
PDZ domain containing 1
chr6_+_33176778 245.92 ENSRNOT00000046811
ENSRNOT00000007371
apolipoprotein B
chr7_+_140781799 237.90 ENSRNOT00000087932
DnaJ heat shock protein family (Hsp40) member C22
chr14_+_22142364 235.28 ENSRNOT00000002699
sulfotransferase family 1B member 1
chr10_+_71159869 234.27 ENSRNOT00000075977
ENSRNOT00000047427
HNF1 homeobox B
chr1_-_198559568 234.10 ENSRNOT00000023080
quinolinate phosphoribosyltransferase
chr3_-_127500709 231.91 ENSRNOT00000006330
hydroxyacid oxidase 1
chr1_+_83653234 231.27 ENSRNOT00000085008
ENSRNOT00000084230
ENSRNOT00000090071
cytochrome P450, family 2, subfamily a, polypeptide 1
chr17_-_80807181 226.09 ENSRNOT00000040052
ENSRNOT00000090064
cubilin
chr5_+_160306727 221.71 ENSRNOT00000016648
agmatinase
chr13_+_82479998 219.76 ENSRNOT00000079872
coagulation factor V
chrX_-_13601069 219.41 ENSRNOT00000004686
ornithine carbamoyltransferase
chr7_-_3386522 218.05 ENSRNOT00000010760
methyltransferase like 7B
chr5_+_137357674 216.81 ENSRNOT00000092813
similar to RIKEN cDNA 2610528J11
chr6_+_128050250 215.35 ENSRNOT00000077517
ENSRNOT00000013961
Ab1-233
chr13_+_75175254 209.52 ENSRNOT00000044008
SEC16 homolog B, endoplasmic reticulum export factor
chr12_+_47407811 206.09 ENSRNOT00000001565
HNF1 homeobox A
chr19_+_37052556 202.76 ENSRNOT00000019072
carboxylesterase 2H
chr3_-_101465995 199.82 ENSRNOT00000080175
gamma-butyrobetaine hydroxylase 1
chr11_+_65022100 192.91 ENSRNOT00000003934
nuclear receptor subfamily 1, group I, member 2
chr10_+_64952119 192.72 ENSRNOT00000012154
pipecolic acid and sarcosine oxidase
chr17_-_9762813 191.51 ENSRNOT00000033749
solute carrier family 34 member 1
chr3_-_5802129 184.25 ENSRNOT00000009555
sarcosine dehydrogenase
chr13_+_93684437 182.36 ENSRNOT00000005005
kynurenine 3-monooxygenase
chr10_-_7200499 178.08 ENSRNOT00000003633
4-aminobutyrate aminotransferase
chr10_-_31790263 177.79 ENSRNOT00000059468
T-cell immunoglobulin and mucin domain containing 2
chr1_+_264741911 176.50 ENSRNOT00000019956
semaphorin 4G
chr1_-_224389389 175.38 ENSRNOT00000077408
ENSRNOT00000050010
integral membrane transport protein UST4r
chr9_+_20048121 170.70 ENSRNOT00000014791
meprin 1 subunit alpha
chr8_-_103608913 170.22 ENSRNOT00000013209
plastin 1
chr1_+_88955440 165.27 ENSRNOT00000091101
proline dehydrogenase 2
chr1_-_258877045 164.94 ENSRNOT00000071633
cytochrome P450, family 2, subfamily c, polypeptide 13
chr10_-_15459897 164.80 ENSRNOT00000027518
2,4-dienoyl-CoA reductase 2
chr15_-_34444244 163.29 ENSRNOT00000027612
cell death-inducing DFFA-like effector b
chr11_+_74057361 162.19 ENSRNOT00000048746
carboxypeptidase N subunit 2
chr14_+_7113544 160.98 ENSRNOT00000038188
hydroxysteroid (17-beta) dehydrogenase 13
chr1_+_88955135 157.54 ENSRNOT00000083550
proline dehydrogenase 2
chr2_+_227080924 156.96 ENSRNOT00000029871
fatty acid binding protein 2
chr18_-_24823837 151.46 ENSRNOT00000021405
ENSRNOT00000090390
myosin VIIb
chr4_+_100218661 140.26 ENSRNOT00000079415
transmembrane protein 150A
chr14_+_87448692 133.67 ENSRNOT00000077177
insulin-like growth factor binding protein 1
chr20_-_4542073 128.45 ENSRNOT00000000477
complement factor B
chr2_+_93669765 127.46 ENSRNOT00000045438
solute carrier family 10, member 5
chr8_-_119012671 124.03 ENSRNOT00000028435
parathyroid hormone 1 receptor
chr1_-_224698514 121.14 ENSRNOT00000024234
solute carrier family 22, member 25
chr4_-_176679815 118.75 ENSRNOT00000090122
glycogen synthase 2
chr18_-_15089988 116.25 ENSRNOT00000074116
meprin A subunit beta
chr11_+_87058616 115.31 ENSRNOT00000002576
ENSRNOT00000082855
proline dehydrogenase 1
chr10_+_65767053 115.01 ENSRNOT00000078897
vitronectin
chr2_-_225389120 111.18 ENSRNOT00000016739
ATP binding cassette subfamily D member 3
chr1_-_207811008 109.74 ENSRNOT00000080506
clarin 3
chr20_-_4508197 108.86 ENSRNOT00000086027
ENSRNOT00000000514
complement component 4A (Rodgers blood group)
chr6_+_56846789 107.66 ENSRNOT00000032108
alkylglycerol monooxygenase
chr20_-_2678141 106.29 ENSRNOT00000072377
ENSRNOT00000083833
complement component 4A (Rodgers blood group)
chr2_+_53109684 105.00 ENSRNOT00000086590
selenoprotein P
chr2_+_188449718 103.69 ENSRNOT00000065791
pyruvate kinase, liver and RBC
chr6_+_8284878 101.77 ENSRNOT00000009581
solute carrier family 3 member 1
chr1_+_14224393 101.64 ENSRNOT00000016037
PERP, TP53 apoptosis effector
chr7_+_143754892 96.43 ENSRNOT00000085896
sterol O-acyltransferase 2
chr5_+_157759416 91.82 ENSRNOT00000024063
ENSRNOT00000083629
aldo-keto reductase family 7, member A2
chr1_-_82409639 90.80 ENSRNOT00000031326
glutamate-rich 4
chr3_-_64024205 90.19 ENSRNOT00000037015
coiled-coil domain containing 141
chr1_+_242572533 89.79 ENSRNOT00000035123
transmembrane protein 252
chr14_+_77079402 89.19 ENSRNOT00000042200
solute carrier family 2 member 9
chr8_-_119265157 88.78 ENSRNOT00000056100
receptor (chemosensory) transporter protein 3
chr11_+_87204175 86.33 ENSRNOT00000000306
solute carrier family 25 member 1
chr5_+_167141875 85.83 ENSRNOT00000089314
solute carrier family 2 member 5
chr16_+_20555395 80.14 ENSRNOT00000026652
growth differentiation factor 15
chr13_+_110677810 71.37 ENSRNOT00000006340
solute carrier family 30 member 1
chr13_+_84334598 70.25 ENSRNOT00000004986
glycoprotein A33
chr2_+_60180215 67.92 ENSRNOT00000084624
prolactin receptor
chr13_+_89586283 67.85 ENSRNOT00000079355
ENSRNOT00000049873
nuclear receptor subfamily 1, group I, member 3
chr13_-_53870428 67.75 ENSRNOT00000000812
nuclear receptor subfamily 5, group A, member 2
chrX_+_54266687 67.37 ENSRNOT00000058309
LRRGT00076-like
chr4_-_22192474 65.71 ENSRNOT00000043822
ATP binding cassette subfamily B member 1A
chr4_+_62380914 64.55 ENSRNOT00000029845
transmembrane protein 140
chr5_-_137112927 64.30 ENSRNOT00000078302
protein tyrosine phosphatase, receptor type, F
chr6_+_26051396 61.83 ENSRNOT00000006452
ribokinase
chr12_-_17972737 60.98 ENSRNOT00000001783
FAM20C, golgi associated secretory pathway kinase
chr3_-_5481144 60.40 ENSRNOT00000078429
surfeit 4
chr5_+_167142182 58.39 ENSRNOT00000024054
solute carrier family 2 member 5
chr16_+_26859397 58.01 ENSRNOT00000044171
methylsterol monooxygenase 1
chr5_-_131860637 56.80 ENSRNOT00000064569
ENSRNOT00000080242
solute carrier family 5 member 9
chr1_+_142950540 56.60 ENSRNOT00000025621
solute carrier family 28 member 1
chr8_-_48582353 54.88 ENSRNOT00000011582
PDZ domain containing 3
chr4_+_88832178 54.67 ENSRNOT00000088983
ATP-binding cassette, subfamily G (WHITE), member 2
chr10_+_61432819 53.09 ENSRNOT00000003687
ENSRNOT00000092478
clustered mitochondria homolog
chr5_-_101138427 50.59 ENSRNOT00000058615
Fras1 related extracellular matrix 1
chr3_+_44806106 48.55 ENSRNOT00000035158
uridine phosphorylase 2
chr7_+_119626637 47.91 ENSRNOT00000000201
mercaptopyruvate sulfurtransferase
chr20_-_4316715 47.28 ENSRNOT00000031704
complement C4B (Chido blood group)
chr2_-_154542557 47.18 ENSRNOT00000013392
solute carrier family 33 member 1
chr4_+_49056010 43.74 ENSRNOT00000038566
cadherin-like and PC-esterase domain containing 1
chr2_-_47281421 43.37 ENSRNOT00000086114
integrin subunit alpha 1
chr12_+_2134022 42.55 ENSRNOT00000001305
calmodulin regulated spectrin-associated protein family, member 3
chr3_+_81287242 41.28 ENSRNOT00000086530
peroxisomal biogenesis factor 16
chr20_-_4368693 40.71 ENSRNOT00000000501
ring finger protein 5
chr15_+_33121273 40.59 ENSRNOT00000016020
RRAD and GEM like GTPase 2
chr19_+_26106838 40.56 ENSRNOT00000035987
hook microtubule-tethering protein 2
chr6_-_103313074 38.79 ENSRNOT00000083677
zinc finger protein 36, C3H type-like 1
chr2_+_58462588 38.74 ENSRNOT00000083799
NAD kinase 2, mitochondrial
chr8_+_23014956 37.00 ENSRNOT00000018009
protein kinase C substrate 80K-H
chr13_-_53108713 36.98 ENSRNOT00000035404
similar to hypothetical protein FLJ10901
chr2_-_154542919 36.75 ENSRNOT00000076880
solute carrier family 33 member 1
chr7_-_120077612 35.52 ENSRNOT00000011750
galectin 2
chr4_+_85551502 35.35 ENSRNOT00000087191
ENSRNOT00000015692
aquaporin 1
chr4_-_155401480 33.36 ENSRNOT00000020735
apolipoprotein B mRNA editing enzyme catalytic subunit 1
chr6_-_79306443 32.62 ENSRNOT00000030706
C-type lectin domain family 14, member A
chr10_+_62981297 32.33 ENSRNOT00000031618
EF-hand calcium binding domain 5
chr12_+_47254484 31.93 ENSRNOT00000001556
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr6_-_44363915 31.48 ENSRNOT00000085925
inhibitor of DNA binding 2, HLH protein
chr3_-_161272460 29.34 ENSRNOT00000020740
acyl-CoA thioesterase 8
chr1_+_222311253 28.16 ENSRNOT00000028749
MACRO domain containing 1
chr1_-_164659992 26.22 ENSRNOT00000024281
solute carrier organic anion transporter family, member 2b1
chr2_+_153803349 25.51 ENSRNOT00000088565
membrane metallo-endopeptidase
chr13_+_50434886 25.38 ENSRNOT00000076857
SRY box 13
chr1_-_127599257 25.26 ENSRNOT00000018436
ankyrin repeat and SOCS box-containing 7
chr8_+_79489790 25.21 ENSRNOT00000091722
protogenin
chr1_+_258210344 25.10 ENSRNOT00000001990
cytochrome P450, family 2, subfamily c, polypeptide 55-like
chr2_-_219741886 24.67 ENSRNOT00000085122
solute carrier family 35 member A3
chr8_-_85840818 23.69 ENSRNOT00000013608
eukaryotic translation elongation factor 1 alpha 1
chr11_-_69201380 23.09 ENSRNOT00000085618
myosin light chain kinase
chr15_-_46432965 19.60 ENSRNOT00000014320
GATA binding protein 4
chr8_+_70112925 19.53 ENSRNOT00000082401
multiple EGF-like-domains 11
chr6_+_22167919 18.93 ENSRNOT00000007655
NLR family, CARD domain containing 4
chr10_-_110701137 18.67 ENSRNOT00000074193
zinc finger protein 750
chr1_-_175420106 17.77 ENSRNOT00000013126
ENSRNOT00000077125
SET binding factor 2
chr12_+_41600005 17.42 ENSRNOT00000001872
phospholipase B domain containing 2
chr7_-_14054639 16.98 ENSRNOT00000039852
ilvB acetolactate synthase like
chr13_+_50434702 16.30 ENSRNOT00000032244
SRY box 13
chr3_-_45210474 16.13 ENSRNOT00000091777
coiled-coil domain containing 148
chr3_-_120106697 15.29 ENSRNOT00000020354
prominin 2
chr8_-_49271834 14.91 ENSRNOT00000085022
ubiquitination factor E4A
chr8_+_22035256 14.70 ENSRNOT00000028066
intercellular adhesion molecule 1
chr8_+_72743426 14.51 ENSRNOT00000072573
ribosomal protein S27-like
chr1_-_219745654 14.37 ENSRNOT00000054848
hypothetical protein LOC689065
chr5_+_9230984 14.25 ENSRNOT00000009136
valosin containing protein interacting protein 1
chr9_-_81565416 13.53 ENSRNOT00000083582
angio-associated, migratory cell protein
chr5_+_137257637 12.84 ENSRNOT00000093001
ELOVL fatty acid elongase 1
chr10_+_34519790 12.11 ENSRNOT00000052360
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr3_+_95133713 11.88 ENSRNOT00000067940
Wilms tumor 1
chr7_-_70842405 9.77 ENSRNOT00000047449
neurexophilin 4
chr10_-_15381691 9.08 ENSRNOT00000027439
RAB11 family interacting protein 3
chr7_-_142062870 9.00 ENSRNOT00000026531
solute carrier family 11 member 2
chr11_-_70833577 8.96 ENSRNOT00000002428
oxysterol binding protein-like 11
chr3_-_146812989 8.51 ENSRNOT00000011315
N-acetylneuraminic acid phosphatase
chr10_-_63274640 7.89 ENSRNOT00000005129
transmembrane and immunoglobulin domain containing 1
chr2_-_257376756 7.46 ENSRNOT00000065811
GIPC PDZ domain containing family, member 2
chr4_+_157181795 7.30 ENSRNOT00000017090
lysophosphatidylcholine acyltransferase 3
chr10_-_56185857 6.26 ENSRNOT00000014261
WD repeat containing, antisense to TP53
chr2_-_232178533 5.04 ENSRNOT00000082173
ENSRNOT00000055607
adaptor-related protein complex 1 associated regulatory protein
chr2_-_210873024 4.28 ENSRNOT00000026051
adenosine monophosphate deaminase 2
chrX_+_33884499 4.10 ENSRNOT00000090041
RALBP1 associated Eps domain containing protein 2
chr15_-_12513931 4.04 ENSRNOT00000010103
ataxin 7
chr13_+_48790509 3.81 ENSRNOT00000065094
ELK4, ETS transcription factor
chr3_+_154507035 3.13 ENSRNOT00000017265
regulation of nuclear pre-mRNA domain containing 1B
chr10_+_89635675 2.89 ENSRNOT00000028179
similar to SAP18
chr2_-_80293181 2.58 ENSRNOT00000016111
OTU deubiquitinase with linear linkage specificity
chr5_+_150032999 2.57 ENSRNOT00000013301
serine and arginine rich splicing factor 4
chr20_+_4162055 2.45 ENSRNOT00000081236
butyrophilin-like 3
chrX_-_157172068 2.32 ENSRNOT00000087962
dual specificity phosphatase 9
chr14_-_84937725 1.66 ENSRNOT00000083839
ubiquinol-cytochrome c reductase, complex III subunit X
chr13_+_48790767 1.15 ENSRNOT00000087504
ELK4, ETS transcription factor
chr9_+_76440186 1.00 ENSRNOT00000049479
similar to chromosome 20 open reading frame 81
chr5_+_74727494 0.51 ENSRNOT00000076683

chr10_-_89918427 0.33 ENSRNOT00000084217
dual specificity phosphatase 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf4a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
198.7 596.2 GO:0006742 NADP catabolic process(GO:0006742)
146.0 438.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
135.2 405.6 GO:0019265 glycine biosynthetic process, by transamination of glyoxylate(GO:0019265)
122.6 367.8 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
110.1 440.4 GO:0035565 regulation of pronephros size(GO:0035565)
84.2 252.5 GO:0097187 dentinogenesis(GO:0097187)
69.4 416.5 GO:0046874 quinolinate metabolic process(GO:0046874)
66.7 667.0 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
62.3 249.4 GO:0015879 carnitine transport(GO:0015879)
58.0 231.9 GO:0009441 glycolate metabolic process(GO:0009441)
53.2 1276.2 GO:0019373 epoxygenase P450 pathway(GO:0019373)
48.9 586.9 GO:0042738 exogenous drug catabolic process(GO:0042738)
48.5 388.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
48.2 192.7 GO:0006554 lysine catabolic process(GO:0006554) L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
45.2 226.1 GO:0015889 cobalamin transport(GO:0015889)
44.3 221.7 GO:0008295 spermidine biosynthetic process(GO:0008295)
43.9 219.4 GO:0006526 arginine biosynthetic process(GO:0006526)
42.6 170.2 GO:1902896 terminal web assembly(GO:1902896)
36.9 184.3 GO:0006545 glycine biosynthetic process(GO:0006545)
35.6 178.1 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
35.1 245.9 GO:0006642 triglyceride mobilization(GO:0006642)
33.6 235.3 GO:0009812 flavonoid metabolic process(GO:0009812)
33.4 300.3 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
33.3 199.8 GO:0045329 carnitine biosynthetic process(GO:0045329)
31.9 31.9 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
31.9 351.2 GO:0015747 urate transport(GO:0015747)
30.3 151.5 GO:1904970 brush border assembly(GO:1904970)
28.8 144.2 GO:0071332 fructose transport(GO:0015755) cellular response to fructose stimulus(GO:0071332)
24.4 219.8 GO:0032571 response to vitamin K(GO:0032571)
23.8 71.4 GO:0071579 regulation of zinc ion transport(GO:0071579)
23.3 209.5 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
21.6 86.3 GO:0015746 citrate transport(GO:0015746)
20.6 61.8 GO:0019303 D-ribose catabolic process(GO:0019303)
18.3 274.9 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
18.3 54.9 GO:0030824 negative regulation of cGMP metabolic process(GO:0030824)
16.4 65.7 GO:1990962 carbohydrate export(GO:0033231) daunorubicin transport(GO:0043215) response to borneol(GO:1905230) cellular response to borneol(GO:1905231) response to codeine(GO:1905233) response to quercetin(GO:1905235) drug transport across blood-brain barrier(GO:1990962) establishment of blood-retinal barrier(GO:1990963)
16.0 47.9 GO:0070814 hydrogen sulfide biosynthetic process(GO:0070814)
15.0 164.8 GO:0006228 UTP biosynthetic process(GO:0006228)
14.1 56.6 GO:1904823 purine nucleobase transmembrane transport(GO:1904823)
13.9 111.2 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
13.5 67.7 GO:0061113 pancreas morphogenesis(GO:0061113)
12.9 38.8 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
12.1 96.4 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
11.8 35.4 GO:0072237 metanephric proximal tubule development(GO:0072237)
11.7 128.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
11.5 91.8 GO:0030647 aminoglycoside antibiotic metabolic process(GO:0030647)
11.1 33.4 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
10.7 64.3 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
10.5 31.5 GO:0001966 thigmotaxis(GO:0001966)
10.5 83.9 GO:0051182 coenzyme transport(GO:0051182)
10.5 115.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
9.2 101.6 GO:0002934 desmosome organization(GO:0002934)
9.0 107.7 GO:0046485 ether lipid metabolic process(GO:0046485)
8.9 124.0 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
8.5 42.5 GO:0045218 zonula adherens maintenance(GO:0045218)
8.2 294.0 GO:0019369 arachidonic acid metabolic process(GO:0019369)
8.1 89.2 GO:0046415 urate metabolic process(GO:0046415)
8.1 48.5 GO:0044206 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) UMP salvage(GO:0044206)
8.0 215.2 GO:0006958 complement activation, classical pathway(GO:0006958)
7.9 47.3 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
7.7 38.7 GO:0006741 NADP biosynthetic process(GO:0006741)
7.7 23.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
7.5 67.9 GO:0038161 prolactin signaling pathway(GO:0038161)
7.0 28.2 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
7.0 153.6 GO:0097286 iron ion import(GO:0097286)
6.6 105.0 GO:0001887 selenium compound metabolic process(GO:0001887)
6.6 26.2 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
6.5 19.6 GO:1905204 septum secundum development(GO:0003285) embryonic heart tube anterior/posterior pattern specification(GO:0035054) negative regulation of connective tissue replacement(GO:1905204)
6.4 25.5 GO:0071492 cellular response to UV-A(GO:0071492)
6.3 6.3 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
6.2 24.7 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781)
6.1 381.3 GO:0007566 embryo implantation(GO:0007566)
5.8 127.5 GO:0015721 bile acid and bile salt transport(GO:0015721)
5.3 137.7 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
4.9 29.3 GO:0016559 peroxisome fission(GO:0016559)
4.6 23.2 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
4.4 88.8 GO:0051205 protein insertion into membrane(GO:0051205)
4.4 127.9 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
4.3 60.4 GO:0034498 early endosome to Golgi transport(GO:0034498)
4.1 40.7 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
4.0 12.1 GO:0009227 nucleotide-sugar catabolic process(GO:0009227)
4.0 80.1 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
4.0 11.9 GO:0007356 thorax and anterior abdomen determination(GO:0007356)
3.8 41.7 GO:0046643 regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
3.7 14.7 GO:0046813 receptor-mediated virion attachment to host cell(GO:0046813)
3.3 53.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
3.2 140.3 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
3.1 93.8 GO:0050892 intestinal absorption(GO:0050892)
3.1 15.3 GO:0048550 negative regulation of pinocytosis(GO:0048550)
2.9 14.3 GO:0090168 Golgi reassembly(GO:0090168)
2.8 8.5 GO:0006045 N-acetylglucosamine biosynthetic process(GO:0006045) N-acetylneuraminate biosynthetic process(GO:0046380)
2.8 90.2 GO:0051642 centrosome localization(GO:0051642)
2.8 532.1 GO:0007596 blood coagulation(GO:0007596)
2.7 18.9 GO:0070269 pyroptosis(GO:0070269)
2.6 116.2 GO:1901998 toxin transport(GO:1901998)
2.4 161.0 GO:0046889 positive regulation of lipid biosynthetic process(GO:0046889)
2.3 118.8 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
2.3 56.8 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
1.9 43.4 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
1.8 9.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
1.8 37.0 GO:0006491 N-glycan processing(GO:0006491)
1.6 58.0 GO:0016126 sterol biosynthetic process(GO:0016126)
1.5 9.0 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
1.3 40.6 GO:0045022 early endosome to late endosome transport(GO:0045022)
1.2 23.7 GO:1903427 negative regulation of reactive oxygen species biosynthetic process(GO:1903427)
1.2 286.4 GO:0031668 cellular response to extracellular stimulus(GO:0031668)
0.9 32.6 GO:0002042 cell migration involved in sprouting angiogenesis(GO:0002042)
0.9 2.6 GO:1990108 protein linear deubiquitination(GO:1990108)
0.7 19.5 GO:0010842 retina layer formation(GO:0010842)
0.7 5.0 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.7 4.3 GO:0032264 IMP salvage(GO:0032264)
0.6 3.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.6 198.2 GO:0032259 methylation(GO:0032259)
0.6 92.3 GO:0006865 amino acid transport(GO:0006865)
0.5 14.5 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.2 14.9 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.2 7.3 GO:0097006 regulation of plasma lipoprotein particle levels(GO:0097006)
0.2 13.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 2.6 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 86.1 GO:0055114 oxidation-reduction process(GO:0055114)
0.1 2.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 10.2 GO:0016042 lipid catabolic process(GO:0016042)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
107.0 642.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
24.3 170.2 GO:1990357 terminal web(GO:1990357)
19.2 115.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
15.7 157.0 GO:0045179 apical cortex(GO:0045179)
15.6 217.9 GO:0043202 lysosomal lumen(GO:0043202)
10.2 264.7 GO:0031528 microvillus membrane(GO:0031528)
9.7 48.5 GO:0045098 type III intermediate filament(GO:0045098)
9.2 219.8 GO:0031091 platelet alpha granule(GO:0031091)
8.8 35.4 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
8.1 40.6 GO:0070695 FHF complex(GO:0070695)
7.4 140.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
7.4 206.1 GO:0045120 pronucleus(GO:0045120)
7.1 542.3 GO:0005811 lipid particle(GO:0005811)
6.1 42.5 GO:0036449 microtubule minus-end(GO:0036449)
5.1 40.7 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
5.1 65.7 GO:0046581 intercellular canaliculus(GO:0046581)
5.1 667.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
4.3 2885.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
4.2 557.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
3.8 18.9 GO:0072557 IPAF inflammasome complex(GO:0072557)
3.6 268.8 GO:0031526 brush border membrane(GO:0031526)
3.2 231.8 GO:0005903 brush border(GO:0005903)
3.2 47.3 GO:0044216 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
3.1 999.5 GO:0005759 mitochondrial matrix(GO:0005759)
2.7 290.6 GO:0072562 blood microparticle(GO:0072562)
2.2 142.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
1.7 598.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
1.5 43.4 GO:0008305 integrin complex(GO:0008305)
1.3 60.4 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
1.2 313.8 GO:0005783 endoplasmic reticulum(GO:0005783)
0.9 50.6 GO:0005604 basement membrane(GO:0005604)
0.6 63.3 GO:0005795 Golgi stack(GO:0005795)
0.6 100.9 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.6 1376.7 GO:0070062 extracellular exosome(GO:0070062)
0.5 98.6 GO:0016324 apical plasma membrane(GO:0016324)
0.5 2.6 GO:0071797 LUBAC complex(GO:0071797)
0.5 13.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.4 346.8 GO:0005615 extracellular space(GO:0005615)
0.4 14.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 130.1 GO:0005635 nuclear envelope(GO:0005635)
0.4 87.6 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.3 6.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.3 1278.1 GO:0016021 integral component of membrane(GO:0016021)
0.2 72.1 GO:0005667 transcription factor complex(GO:0005667)
0.2 9.1 GO:0055037 recycling endosome(GO:0055037)
0.1 3.1 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.1 26.8 GO:0000785 chromatin(GO:0000785)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
146.0 438.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
133.4 667.0 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
132.1 396.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
97.0 388.1 GO:0004743 pyruvate kinase activity(GO:0004743)
81.1 405.6 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
76.3 381.3 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
58.5 234.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
58.0 231.9 GO:0003973 (S)-2-hydroxy-acid oxidase activity(GO:0003973)
49.2 245.9 GO:0035473 lipase binding(GO:0035473)
48.2 192.7 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
44.7 268.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
42.5 1276.2 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
41.2 164.8 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670) trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
38.6 385.7 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
38.3 191.5 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
33.6 235.3 GO:0004062 aryl sulfotransferase activity(GO:0004062)
32.3 226.1 GO:0030492 hemoglobin binding(GO:0030492)
25.8 283.7 GO:0042301 phosphate ion binding(GO:0042301)
25.6 639.8 GO:0070330 aromatase activity(GO:0070330)
22.6 67.9 GO:0004925 prolactin receptor activity(GO:0004925)
21.6 86.3 GO:0015137 citrate transmembrane transporter activity(GO:0015137)
21.2 127.5 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
20.6 596.2 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
20.3 182.4 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
18.9 56.6 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
18.7 261.1 GO:0008395 steroid hydroxylase activity(GO:0008395)
18.4 91.8 GO:0004301 epoxide hydrolase activity(GO:0004301)
17.8 88.8 GO:0031849 olfactory receptor binding(GO:0031849)
17.2 274.9 GO:0035497 cAMP response element binding(GO:0035497)
17.1 221.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
17.0 118.8 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
16.8 83.9 GO:0051185 coenzyme transporter activity(GO:0051185)
16.0 144.2 GO:0070061 fructose binding(GO:0070061)
16.0 47.9 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
15.4 107.7 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
15.0 120.4 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
15.0 300.3 GO:0004806 triglyceride lipase activity(GO:0004806)
15.0 105.0 GO:0008430 selenium binding(GO:0008430)
14.9 133.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
11.5 184.3 GO:0005542 folic acid binding(GO:0005542)
8.7 43.4 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
8.1 178.1 GO:0008483 transaminase activity(GO:0008483)
7.9 47.3 GO:0001849 complement component C1q binding(GO:0001849)
7.1 35.4 GO:0015166 polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
6.9 54.9 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
6.8 520.3 GO:0038024 cargo receptor activity(GO:0038024)
6.5 71.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)
6.3 25.1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
6.2 67.8 GO:0004887 thyroid hormone receptor activity(GO:0004887)
5.8 23.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
5.7 56.8 GO:0005412 glucose:sodium symporter activity(GO:0005412)
5.6 33.4 GO:0004126 cytidine deaminase activity(GO:0004126)
5.0 49.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
4.6 128.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
4.3 260.7 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
4.1 32.6 GO:1990430 extracellular matrix protein binding(GO:1990430)
4.1 40.7 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
4.0 206.1 GO:0001221 transcription cofactor binding(GO:0001221)
4.0 199.8 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
3.9 42.5 GO:0051011 microtubule minus-end binding(GO:0051011)
3.7 29.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
3.3 26.2 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
3.3 19.6 GO:0051525 NFAT protein binding(GO:0051525)
3.0 38.8 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
3.0 11.9 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
2.8 17.0 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
2.4 292.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
2.3 139.8 GO:0005507 copper ion binding(GO:0005507)
2.3 124.0 GO:0017046 peptide hormone binding(GO:0017046)
2.1 61.8 GO:0019200 carbohydrate kinase activity(GO:0019200)
1.8 384.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.7 58.0 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
1.6 14.5 GO:0008494 translation activator activity(GO:0008494)
1.6 237.1 GO:0030165 PDZ domain binding(GO:0030165)
1.5 24.7 GO:0005351 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
1.5 14.9 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
1.5 38.7 GO:0003951 NAD+ kinase activity(GO:0003951)
1.5 202.8 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
1.1 23.7 GO:0003746 translation elongation factor activity(GO:0003746)
1.1 151.5 GO:0003774 motor activity(GO:0003774)
1.1 4.3 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
1.0 102.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.0 198.2 GO:0008168 methyltransferase activity(GO:0008168)
1.0 58.3 GO:0030145 manganese ion binding(GO:0030145)
0.8 5.0 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.8 18.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.7 148.6 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.6 28.2 GO:0019213 deacetylase activity(GO:0019213)
0.4 15.3 GO:0015485 cholesterol binding(GO:0015485)
0.4 17.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.3 17.3 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.3 2.6 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.3 51.4 GO:0044325 ion channel binding(GO:0044325)
0.3 6.3 GO:0070034 telomerase RNA binding(GO:0070034)
0.2 16.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.2 41.3 GO:0008022 protein C-terminus binding(GO:0008022)
0.2 3.1 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.2 14.7 GO:0005178 integrin binding(GO:0005178)
0.1 2.6 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.1 27.7 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 40.6 GO:0003924 GTPase activity(GO:0003924)
0.1 5.9 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 46.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 43.5 GO:0016491 oxidoreductase activity(GO:0016491)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
29.6 1629.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
8.7 270.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
7.7 115.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
7.1 128.5 ST G ALPHA S PATHWAY G alpha s Pathway
6.0 245.9 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
5.2 1203.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
2.9 43.4 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
2.5 153.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
1.6 67.9 PID ERBB4 PATHWAY ErbB4 signaling events
1.3 86.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
1.1 171.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.9 67.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.6 38.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.5 23.1 PID AURORA B PATHWAY Aurora B signaling
0.4 19.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.3 33.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.3 11.9 PID P73PATHWAY p73 transcription factor network
0.1 6.4 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.3 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
50.5 807.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
37.8 642.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
34.9 454.1 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
26.4 343.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
23.0 896.2 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
21.8 261.1 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
20.3 182.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
18.8 226.1 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
18.1 235.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
16.3 636.6 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
15.6 233.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
12.3 221.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
6.7 133.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
6.1 54.7 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
5.9 152.5 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
5.8 93.1 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
5.6 191.4 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
4.9 29.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
4.3 234.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
3.7 37.0 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
3.6 651.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
3.2 67.9 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
3.1 214.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
2.9 35.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
2.8 62.4 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
2.6 283.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
2.5 58.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
2.5 66.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
2.3 31.9 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
2.0 38.8 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
1.8 19.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
1.6 118.8 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
1.6 129.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
1.0 18.9 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.8 80.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.7 13.0 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.5 7.3 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.3 4.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.2 6.3 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.1 12.6 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.0 0.3 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 3.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation