Project
GSE53960: rat RNA-Seq transcriptomic Bodymap
Navigation
Downloads
Results for Hnf4a
Z-value: 4.87
Motif logo
Transcription factors associated with Hnf4a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hnf4a | rn6_v1_chr3_+_159936856_159936856 | 0.94 | 4.0e-152 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_60337667 Show fit | 405.58 |
ENSRNOT00000024035
|
alanine-glyoxylate aminotransferase 2 |
|
| chr1_-_80594136 Show fit | 396.22 |
ENSRNOT00000024800
|
apolipoprotein C2 |
|
| chr7_-_123638702 Show fit | 393.99 |
ENSRNOT00000082473
ENSRNOT00000044470 ENSRNOT00000092017 |
cytochrome P450, family 2, subfamily d, polypeptide 1 |
|
| chr4_-_161850875 Show fit | 381.34 |
ENSRNOT00000009467
|
pregnancy-zone protein |
|
| chr10_+_89285855 Show fit | 346.00 |
ENSRNOT00000028033
|
glucose-6-phosphatase, catalytic subunit |
|
| chr1_-_259287684 Show fit | 340.66 |
ENSRNOT00000054724
|
cytochrome P450, family 2, subfamily c, polypeptide 22 |
|
| chr13_+_56598957 Show fit | 331.69 |
ENSRNOT00000016944
ENSRNOT00000080335 ENSRNOT00000089913 |
coagulation factor XIII B chain |
|
| chr1_+_100471066 Show fit | 322.07 |
ENSRNOT00000067562
|
aspartate dehydrogenase domain containing |
|
| chr10_+_89286047 Show fit | 321.04 |
ENSRNOT00000085831
|
glucose-6-phosphatase, catalytic subunit |
|
| chr1_+_20856187 Show fit | 314.64 |
ENSRNOT00000071726
|
small leucine-rich protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hnf4a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 53.2 | 1276.2 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 66.7 | 667.0 | GO:0015760 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 198.7 | 596.2 | GO:0006742 | NADP catabolic process(GO:0006742) |
| 48.9 | 586.9 | GO:0042738 | exogenous drug catabolic process(GO:0042738) |
| 2.8 | 532.1 | GO:0007596 | blood coagulation(GO:0007596) |
| 110.1 | 440.4 | GO:0035565 | regulation of pronephros size(GO:0035565) |
| 146.0 | 438.1 | GO:0010133 | proline catabolic process to glutamate(GO:0010133) |
| 69.4 | 416.5 | GO:0046874 | quinolinate metabolic process(GO:0046874) |
| 135.2 | 405.6 | GO:0019265 | glycine biosynthetic process, by transamination of glyoxylate(GO:0019265) |
| 48.5 | 388.1 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 2885.4 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.6 | 1376.7 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.3 | 1278.1 | GO:0016021 | integral component of membrane(GO:0016021) |
| 3.1 | 999.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 5.1 | 667.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 107.0 | 642.1 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 1.7 | 598.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 4.2 | 557.9 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 7.1 | 542.3 | GO:0005811 | lipid particle(GO:0005811) |
| 0.4 | 346.8 | GO:0005615 | extracellular space(GO:0005615) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 42.5 | 1276.2 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 133.4 | 667.0 | GO:0050309 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
| 25.6 | 639.8 | GO:0070330 | aromatase activity(GO:0070330) |
| 20.6 | 596.2 | GO:0016638 | oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) |
| 6.8 | 520.3 | GO:0038024 | cargo receptor activity(GO:0038024) |
| 146.0 | 438.1 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
| 81.1 | 405.6 | GO:0008453 | alanine-glyoxylate transaminase activity(GO:0008453) |
| 132.1 | 396.2 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 97.0 | 388.1 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 38.6 | 385.7 | GO:1901702 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 29.6 | 1629.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 5.2 | 1203.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 8.7 | 270.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 6.0 | 245.9 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 1.1 | 171.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 2.5 | 153.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 7.1 | 128.5 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 7.7 | 115.0 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 1.3 | 86.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 1.6 | 67.9 | PID ERBB4 PATHWAY | ErbB4 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 23.0 | 896.2 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 50.5 | 807.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 3.6 | 651.1 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 37.8 | 642.1 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 16.3 | 636.6 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 34.9 | 454.1 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 26.4 | 343.6 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 2.6 | 283.8 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 21.8 | 261.1 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 18.1 | 235.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |