ISMARA results: Hnf1b

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Hnf1b

Z-value: 6.05

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Transcription factors associated with Hnf1b

Gene Symbol	Gene ID	Gene Info
Hnf1b NCBI RGD Ensembl	ENSRNOG00000002598	HNF1 homeobox B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hnf1b	rn6_v1_chr10_+_71159869_71159984	0.70	2.4e-48	Click!

Activity profile of Hnf1b motif

Sorted Z-values of Hnf1b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr13_-_91427575 Show fit	662.96	ENSRNOT00000012092	Apcs NCBI RGD Ensembl Show fit	amyloid P component, serum
chr14_-_19132208 Show fit	605.47	ENSRNOT00000060535	Afm NCBI RGD Ensembl Show fit	afamin
chr14_+_20266891 Show fit	572.17	ENSRNOT00000004174	Gc NCBI RGD Ensembl Show fit	group specific component
chr17_+_69588085 Show fit	566.81	ENSRNOT00000064884	Akr1c12l1 NCBI RGD Ensembl Show fit	aldo-keto reductase family 1, member C12-like 1
chr1_+_189289957 Show fit	493.73	ENSRNOT00000020587	Acsm1 NCBI RGD Ensembl Show fit	acyl-CoA synthetase medium-chain family member 1
chr11_-_81639872 Show fit	466.41	ENSRNOT00000047595 ENSRNOT00000090031 ENSRNOT00000081864	Hrg NCBI RGD Ensembl Show fit	histidine-rich glycoprotein
chr17_-_69711689 Show fit	451.98	ENSRNOT00000041925	Akr1c12 NCBI RGD Ensembl Show fit	aldo-keto reductase family 1, member C12
chr6_+_80188943 Show fit	451.28	ENSRNOT00000059335	Mia2 NCBI RGD Ensembl Show fit	melanoma inhibitory activity 2
chr17_-_43543172 Show fit	434.42	ENSRNOT00000080684 ENSRNOT00000029626 ENSRNOT00000082719	Slc17a3 NCBI RGD Ensembl Show fit	solute carrier family 17 member 3
chr3_+_159936856 Show fit	429.68	ENSRNOT00000078703	Hnf4a NCBI RGD Ensembl Show fit	hepatocyte nuclear factor 4, alpha

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	1147.5	GO:0055114	oxidation-reduction process(GO:0055114)
107.4	966.5	GO:0052697	xenobiotic glucuronidation(GO:0052697)
10.3	883.5	GO:0006637	acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
50.2	854.1	GO:0035435	phosphate ion transmembrane transport(GO:0035435)
80.3	803.3	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
195.3	781.3	GO:0042977	regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
248.7	746.1	GO:0010133	proline catabolic process to glutamate(GO:0010133)
36.8	699.5	GO:1902572	negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
138.1	690.7	GO:0043152	induction of bacterial agglutination(GO:0043152)
165.7	663.0	GO:0052422	modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422) regulation of exo-alpha-sialidase activity(GO:1903015)

Showing 1 to 10 of 111 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
27.3	3109.3	GO:0072562	blood microparticle(GO:0072562)
2.0	2645.4	GO:0005615	extracellular space(GO:0005615)
0.9	1842.8	GO:0070062	extracellular exosome(GO:0070062)
5.8	741.3	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
1.6	700.4	GO:0005743	mitochondrial inner membrane(GO:0005743)
5.0	699.5	GO:0001669	acrosomal vesicle(GO:0001669)
86.3	690.7	GO:0005577	fibrinogen complex(GO:0005577)
1.8	689.9	GO:0005667	transcription factor complex(GO:0005667)
1.9	632.3	GO:0016324	apical plasma membrane(GO:0016324)
87.1	609.8	GO:0005579	membrane attack complex(GO:0005579)

Showing 1 to 10 of 48 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	1381.7	GO:0016491	oxidoreductase activity(GO:0016491)
11.7	1326.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
40.1	1242.5	GO:0015020	glucuronosyltransferase activity(GO:0015020)
53.1	1114.9	GO:0034185	apolipoprotein binding(GO:0034185)
110.4	883.5	GO:0003996	acyl-CoA ligase activity(GO:0003996)
71.2	854.1	GO:0005436	sodium:phosphate symporter activity(GO:0005436)
160.7	803.3	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
65.1	781.3	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
248.7	746.1	GO:0004657	proline dehydrogenase activity(GO:0004657)
5.1	667.5	GO:0030674	protein binding, bridging(GO:0030674)

Showing 1 to 10 of 91 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
45.8	2520.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
4.7	1091.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
22.3	690.7	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
11.5	379.3	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
7.4	305.0	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
6.6	245.6	PID CD40 PATHWAY	CD40/CD40L signaling
3.3	193.2	PID FGF PATHWAY	FGF signaling pathway
4.0	174.1	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
2.3	160.4	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.7	136.1	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
67.5	1283.2	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
61.8	989.3	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
21.6	974.2	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
15.2	958.2	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation
34.2	924.1	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
4.7	837.4	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
19.7	649.7	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
31.2	624.6	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
29.0	609.8	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
13.5	538.6	REACTOME AMYLOIDS	Genes involved in Amyloids

Showing 1 to 10 of 37 entries

Results for Hnf1b

Z-value: 6.05

Motif logo

Transcription factors associated with Hnf1b

Activity-expression correlation:

Activity profile of Hnf1b motif

Sorted Z-values of Hnf1b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: